Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T00477 Target Info
Target Name Serine Racemase (SRR)
Synonyms L-serine dehydratase; L-serine ammonia-lyase; D-serine dehydratase; D-serine ammonia-lyase
Target Type Literature-reported Target
Gene Name SRR
Biochemical Class Racemases and epimerase
UniProt ID
SRR_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Pyridoxal phosphate Ligand Info
Structure Description X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor PDB:3L6B
Method X-ray diffraction Resolution 1.50 Å Mutation Yes [1]
PDB Sequence
AQYDISFADV
12
EKAHINIRDS
22
IHLTPVLTSS
32
ILNQLTGRNL
42
FFKCELFQKT
52

GSFKIRGALN
62
AVRSLVRKPK
77
AVVTHSSGNH
87
GQALTYAAKL
97
EGIPAYIVVP
107

QTAPDCKKLA
117
IQAYGASIVY
127
CEPSDESREN
137
VAKRVTEETE
147
GIMVHPNQEP
157

AVIAGQGTIA
167
LEVLNQVPLV
177
DALVVPVGGG
187
GMLAGIAITV
197
KALKPSVKVY
207

AAEPSNADDC
217
YQSKLKGKLM
227
PNLYPPETIA
237
DGVKSSIGLN
247
TWPIIRDLVD
257

DIFTVTEDEI
267
KCATQLVWER
277
MKLLIEPTAG
287
VGVAAVLSQH
297
FQTVSPEVKN
307

ICIVLSGGNV
317
DLTSSITWVK
327
QA
Residue
Distance (Å)
SER54
4.248
PHE55
3.415
LYS56
1.539
ASN86
2.913
PRO153
4.843
ASN154
4.046
PRO183
3.857
VAL184
3.783
GLY185
2.802
GLY186
3.013
GLY187
2.780
Residue
Distance (Å)
GLY188
2.836
MET189
2.886
LEU190
4.876
GLY239
4.039
VAL240
3.642
GLU283
3.692
THR285
3.234
ALA286
4.918
SER313
2.744
GLY314
3.629
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References  Top
REF 1 The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81.

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