Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98269 | Target Info | |||
| Target Name | Caspase-1 (CASP1) | ||||
| Synonyms |
P45; Interleukin-1 beta-converting enzyme; Interleukin-1 beta converting enzyme; Interleukin-1 beta convertase; IL1BCE; IL1BC; IL-1BC; IL-1 beta-converting enzyme; IL-1 beta converting enzyme; ICE; CASP-1
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | CASP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 56 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ac-DEVD-CHO
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|
Investigative | Compound Info | ||
| Synonyms |
169332-60-9; Caspase-3 Inhibitor I; N-acetyl-asp-glu-val-asp-al; acetyl-aspartyl-glutamyl-valyl-aspartal; Ac-Asp-Glu-Val-Asp-Aldehyde; AC-ASP-GLU-VAL-ASP-H; CHEMBL417149; CHEBI:59385; 184179-08-6; (4S,7S,10S,13S)-7-(2-carboxyethyl)-4-(carboxymethyl)-13-formyl-10-isopropyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid; acetyl-Asp-Glu-Val-Asp-aldehyde; acetyl-Asp-Glu-Val-Asp aldehyde; N-acetyl-Asp-Glu-Val-Asp aldehyde; N-acetyl-Asp-Glu-Val-Asp-aldehyde
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|
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200653; SCHEMBL4156239; Pyrrolidine Isatin Analogue 11g; BDBM10335; 1-[(6-fluoropyridin-3-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Berkchaetorubramine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3758580; BDBM50142071; J3.512.516G
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18c; CHEMBL200813; SCHEMBL4153093; BDBM10341; 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62187; BDBM50297258; 5-{2-[(Methyl-phenyl-amino)-methyl]-pyrrolidine-1-sulfonyl}-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21d; CHEMBL198755; BDBM10352
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762352; BDBM50340532
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18h; CHEMBL196855; SCHEMBL4158993; BDBM10346; (S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethyl-azetidine1-sulfonyl)-1H-indole-2,3-dione; 1-[(2-fluoropyridin-4-yl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18d; CHEMBL382084; SCHEMBL4149360; BDBM10342; 1-[(4-methylsulfanylphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373012; SCHEMBL4143079; Pyrrolidine Isatin Analogue 11h; BDBM10336; 1-[(2-fluoropyridin-4-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-5-(2-((2,4-Difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762365; BDBM50340545
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(S)-5-(2-((2,4-Difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762364; BDBM50340544
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18g; CHEMBL370012; SCHEMBL4152385; BDBM10345; (S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethyl-azetidine1-sulfonyl)-1H-indole-2,3-dione; 1-[(6-fluoropyridin-3-yl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200220; SCHEMBL4154263; Pyrrolidine Isatin Analogue 11d; BDBM10332
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-3-[(S)-2-((S)-2-{[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionyl]-methyl-amino}-3-methyl-butyrylamino)-propionylamino]-4-oxo-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77260; BDBM50283351
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|
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| Activity |
Ki = 50000 nM
|
[6] | |||
| Compound Name |
Acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200476; Pyrrolidine Isatin Analogue 11e; BDBM10333; 1-(4-Acetoxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372994; SCHEMBL4140312; Pyrrolidine Isatin Analogue 11i; BDBM10337; 1-[(6-fluoropyridin-2-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(3R)-3-[[(2S)-2-[[(2S)-3-Methyl-2-(naphthalene-2-carbonylamino)butanoyl]amino]propanoyl]amino]-6-phenylhexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589551; BDBM50308234; (R)-3-((S)-2-((S)-2-(2-naphthamido)-3-methylbutanamido)propanamido)-6-phenylhexanoic acid
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372607; SCHEMBL2260281; Pyrrolidine Isatin Analogue 11c; BDBM10331; 1-[(4-fluorophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213759; WC-II-89; SCHEMBL15029245; BDBM50192784; (S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(S)-1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762347; BDBM50340527
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-[2-(1-naphthyl)ethylsulfonylamino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL167557; SCHEMBL7383234; BDBM50139701; 3-Benzyloxycarbonylamino-5-(2-naphthalen-1-yl-ethanesulfonylamino)-4-oxo-pentanoic acid; 5-(2-naphthalen-1-ylethylsulfonylamino)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
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|
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| Activity |
IC50 = 55600 nM
|
[9] | |||
| Compound Name |
3-Chloro-6-phenyl-pyridazine-4-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
3-chloro-6-phenylpyridazine-4-carboxamide; CHEMBL6484; 3-Chloro-4-(aminocarbonyl)-6-phenylpyridazine; SCHEMBL1752817; BDBM50291531; MFCD24386166; ZINC25965569; AKOS023291668; AS-5733; KS-00003H60
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| Activity |
IC50 = 57000 nM
|
[10] | |||
| Compound Name |
4-[4-[2-[[(1R)-1-Carboxy-2-oxoethyl]sulfamoyl]phenoxy]phenyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL96069
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
(S)-1-(4-Hydroxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217220; BDBM50200307
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|
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| Activity |
IC50 ~ 60000 nM
|
[12] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-(indan-1-ylmethylsulfonylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL167544; SCHEMBL7381544; BDBM50139703; 3-Benzyloxycarbonylamino-5-(indan-1-ylmethanesulfonylamino)-4-oxo-pentanoic acid; 5-(2,3-dihydro-1H-inden-1-ylmethylsulfonylamino)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
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| Activity |
Ki = 65000 nM
|
[9] | |||
| Compound Name |
3-Chloro-6-(4-methoxyphenyl)pyridazine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL6538; 3-Chloro-6-(4-methoxy-phenyl)-pyridazine-4-carboxylic acid amide; BDBM50291540; ZINC25965378
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| Activity |
IC50 = 66000 nM
|
[10] | |||
| Compound Name |
(S)-3-(Benzyloxycarbonylamino)-4-oxo-5-(2-phenylacetamidooxy)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223038; BDBM50325270
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|
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| Activity |
Ki = 66500 nM
|
[13] | |||
| Compound Name |
3-Allyloxycarbonylamino-4-oxo-5-(3-phenyl-propylamino)-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31140; BDBM50284731
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|
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| Activity |
Ki = 67000 nM
|
[14] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-(benzyl-phenethyl-amino)-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31817; BDBM50284723
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|
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| Activity |
Ki = 68000 nM
|
[14] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-(1,2-diphenyl-ethylamino)-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL31053; BDBM50284729
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| Activity |
Ki = 70000 nM
|
[14] | |||
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
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| Activity |
IC50 = 70794.58 nM
|
[15] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-(phenethylsulfonylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL422379; SCHEMBL7375206; BDBM50139698; 3-Benzyloxycarbonylamino-4-oxo-5-(2-phenyl-ethanesulfonylamino)-pentanoic acid; 4-oxo-5-(2-phenylethylsulfonylamino)-3-(phenylmethoxycarbonylamino)pentanoic acid
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| Activity |
IC50 = 73000 nM
|
[9] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-benzylcarbamoyloxy-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30927; BDBM50284725
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| Activity |
Ki = 74000 nM
|
[14] | |||
| Compound Name |
(S)-3-(Benzyloxycarbonylamino)-5-(2-(naphthalen-1-yl)acetamidooxy)-4-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223105; BDBM50325272
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| Activity |
Ki = 84000 nM
|
[13] | |||
| Compound Name |
(S)-3-(Benzyloxycarbonylamino)-4-oxo-5-(2-oxopyrrolidin-1-yloxy)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222970; BDBM50325264
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| Activity |
Ki = 87200 nM
|
[13] | |||
| Compound Name |
Berkedrimane B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011680; Rel-Berkedrimane B; SCHEMBL17307615; BDBM50379300; ZINC36378985
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| Activity |
IC50 = 90000 nM
|
[16] | |||
| Compound Name |
(S)-3-Allyloxycarbonylamino-4-oxo-5-[(E)-(3-phenyl-acryloyl)oxy]-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30983; BDBM50284719
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|
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| Activity |
Ki = 90000 nM
|
[14] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-(methyl-phenethyl-amino)-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30989; BDBM50284728
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|
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-(benzhydryl-amino)-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL30420; BDBM50284730
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|
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168471; SCHEMBL3913553; BDBM50124010; ZINC13493521
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|
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
3-Allyloxycarbonylamino-5-benzylamino-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL286945; BDBM50284721
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|
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Allyloxycarbonylamino-6-[3-(1H-imidazol-2-yl)-naphthalen-2-yl]-4-oxo-hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL416941; BDBM50284746
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|
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| Activity |
Ki ~ 100000 nM
|
[18] | |||
| Compound Name |
3-Allyloxycarbonylamino-4-oxo-8-phenyl-octanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL286893; BDBM50284720
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|
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
Berkedrimane A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011679; Rel-Berkedrimane A; BDBM50379299
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|
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| Activity |
IC50 = 100000 nM
|
[16] | |||
| Compound Name |
(S)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-4-oxo-4-phenyl-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313999; BDBM50281178
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|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(S)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-4-cyclohexyl-4-oxo-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330721; BDBM50281179
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|
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| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
3-Chloro-6-pyridin-4-yl-pyridazine-4-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6475; SCHEMBL10844529; BDBM50291529; 3-chloro-6-pyridin-4-ylpyridazine-4-carbonitrile
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| Activity |
IC50 = 110000 nM
|
[10] | |||
| Compound Name |
(S)-3-(Benzyloxycarbonylamino)-4-oxo-5-(5-phenylpentyloxy)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1222544; BDBM50325242
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| Activity |
Ki = 119000 nM
|
[13] | |||
| Compound Name |
3-Benzyloxycarbonylamino-4-oxo-9-phenyl-nonanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL167433; BDBM50139696
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|
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| Activity |
Ki = 119000 nM
|
[9] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-(2-cyclohexylethylsulfonylamino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL354101; SCHEMBL7387245; BDBM50139697; 3-Benzyloxycarbonylamino-5-(2-cyclohexyl-ethanesulfonylamino)-4-oxo-pentanoic acid; 5-(2-cyclohexylethylsulfonylamino)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
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| Activity |
IC50 = 136000 nM
|
[9] | |||
| Compound Name |
(R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-5-oxo-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL34031; SCHEMBL5686688; BDBM50070496
Click to Show/Hide
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||||
| Activity |
IC50 = 142000 nM
|
[1] | |||
| Compound Name |
Berkchaetoazaphilone A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759333; BDBM50142040; J3.512.513B
Click to Show/Hide
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||||
| Activity |
IC50 = 150000 nM
|
[3] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-(benzylsulfonylamino)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166048; SCHEMBL7380824; BDBM50139700; 3-Benzyloxycarbonylamino-4-oxo-5-phenylmethanesulfonylamino-pentanoic acid; 5-(benzylsulfonylamino)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
Click to Show/Hide
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||||
| Activity |
IC50 = 168000 nM
|
[9] | |||
| Compound Name |
3-(Benzyloxycarbonylamino)-4-oxo-5-(1-naphthylsulfonylamino)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168724; SCHEMBL7384347; BDBM50139694; 3-Benzyloxycarbonylamino-5-(naphthalene-1-sulfonylamino)-4-oxo-pentanoic acid; 5-(naphthalen-1-ylsulfonylamino)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 174000 nM
|
[9] | |||
| Compound Name |
3-(2-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308500; BDBM50091562
Click to Show/Hide
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||||
| Activity |
IC50 = 200000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 50 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Benzyloxycarbonylamino-4-oxo-5-(3-phenyl-propane-1-sulfonylamino)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165763; SCHEMBL7598647; BDBM50139693; 4-oxo-3-(phenylmethoxycarbonylamino)-5-(3-phenylpropylsulfonylamino)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 245000 nM
|
[9] | |||
| Compound Name |
3-Chloro-6-pyridin-4-yl-pyridazine-4-carboxylic acid dimethylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268455; BDBM50291542
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
4-Pyridazinecarboxamide, 3,6-dichloro-N-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267835; 3,6-dichloro-N-methylpyridazine-4-carboxamide; SCHEMBL15687877; BDBM50291546; AKOS013517572; 3, 6-dichloro-N-methylpyridazine-4-carboxamide; 3,6-Dichloro-pyridazine-4-carboxylic acid methylamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
3-Methylsulfanyl-6-pyridin-4-yl-pyridazine-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6734; BDBM50291530
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
3-Methoxy-6-pyridin-4-yl-pyridazine-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6930; BDBM50291528
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
3-Chloro-6-(4-chloro-phenyl)-5-methyl-pyridazine-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6805; BDBM50291534
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
6-Pyridin-4-yl-pyridazine-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7086; BDBM50291533
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
3-Carbamoyl-2-chlor-5-(pyrid-4-yl)pyridin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL6581; SCHEMBL11158644; BDBM50291527; 2-chloro-5-pyridin-4-ylpyridine-3-carboxamide; 6-Chloro-[3,4'']bipyridinyl-5-carboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[10] | |||
| Compound Name |
5-Benzenesulfonylamino-3-benzyloxycarbonylamino-4-oxo-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL166476; SCHEMBL7382883; BDBM50139691; 5-(benzenesulfonamido)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 291000 nM
|
[9] | |||
| Compound Name |
(S)-3-(Benzyloxycarbonylamino)-5-(3-(naphthalen-1-yl)propanamidooxy)-4-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223106; BDBM50325273
Click to Show/Hide
|
||||
| Activity |
Ki = 298000 nM
|
[13] | |||
| Compound Name |
5-[(2S)-2-(Ethoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348697; BDBM50431509
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
1-(4-Fluorobutyl)-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359188; BDBM50031596
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-[(2S)-3-Fluoro-2-hydroxypropyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524017; BDBM50258335; (S)-1-[(S)-3-Fluoro-2-hydroxypropyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(4-vinylbenzyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513663; BDBM50258694
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216071; SCHEMBL8263984; BDBM50200312
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
1-Butyl-7-chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359199; BDBM50031607
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293034; (s)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 31; SCHEMBL4156846; Pyrrolidine Isatin Analogue 11a; BDBM10320; DB08213; Q27097439; (S)-1-methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; 1-Methyl-5-[[(2S)-2-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[9-(oxiran-2-yl)nonyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521984; BDBM50258378; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[9-(oxiran-2-yl)nonyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386510; BDBM50200310; 1-[4-[2-(Tosyloxy)ethoxy]benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200677; 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione; SCHEMBL4152857; Pyrrolidine Isatin Analogue 11b; BDBM10330; 1-(4-Methoxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217822; BDBM50200313
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
(S)-5-[1-(2-Phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386464; BDBM50200304
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[[4-(oxiran-2-ylmethoxy)phenyl]methyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494220; BDBM50258381; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-ylmethoxy)benzyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
Caspase-3/7 Inhibitor I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60190; 5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin; Isatin Sulfonamide 16; SCHEMBL3681388; BDBM10305; DTXSID50431688; ZINC3871900; MFCD22581511; A14919; J-014451; (S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isatin; 5-[[(2S)-2-(Methoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-[[4-(3-Fluoro-2-hydroxypropoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466422; BDBM50258698; (S)-1-[4-(3-Fluoro-2-hydroxypropoxy)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[2-(3-methoxypropyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348696; BDBM50431510
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
(S)-1-[4-(Allyloxy)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467252; BDBM50258696
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-(2-Bromoethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385930; BDBM50200315; 1-[4-(2-Bromoethoxy)benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
5-[(2S)-2-(Ethoxymethyl)pyrrolidin-1-yl]sulfonyl-1-(4-fluorobutyl)indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348699; BDBM50431507
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
(S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512101; BDBM50258667
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523666; BDBM50258379
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[2-(oxiran-2-yl)ethyl]indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493374; BDBM50258336; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[2-(oxiran-2-yl)ethyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384023; SCHEMBL2259426; BDBM50200305; (S)-1-(4-iodobenzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[(4-iodophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
(S)-1-[(S)-2,3-Dihydroxypropyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511723; BDBM50258699
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
7-Chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359198; BDBM50031606
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-Butyl-5-[2-(3-methoxypropyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348695; BDBM50431511
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
7-Bromo-1-(4-hydroxybutyl)-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359197; BDBM50031605
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-(3-Fluoropropyl)-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359187; BDBM50031595
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-[[4-(2-Bromo-1-fluoroethyl)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467251; BDBM50258695; (S)-1-[4-(2-Bromo-1-fluoroethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(3,4-Dihydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466423; BDBM50258700
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62993; (s)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 29; Pyrrolidine Isatin Analogue 10; SCHEMBL2263591; BDBM10318; 5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione; 5-[[2alpha-(Phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-(Tert-butyldimethylsilyloxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217821; BDBM50200314
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[12] | |||
| Compound Name |
7-Fluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359201; BDBM50031609
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
1-Butyl-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359186; BDBM50031594
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(undec-10-enyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513513; BDBM50258669
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
1-(4-Hydroxybutyl)-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359189; BDBM50031597
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[22] | |||
| Compound Name |
(S)-1-(But-3-enyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL468088; BDBM50258668
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
1-[[4-(1-Fluoro-2-hydroxyethyl)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492385; BDBM50258380; (S)-1-[4-(1-Fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(S)-1-(4-Fluoro-3-hydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493375; BDBM50258337
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
3-Benzyloxycarbonylamino-5-methanesulfonylamino-4-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL167666; SCHEMBL7382418; BDBM50139692; 5-(methanesulfonamido)-4-oxo-3-(phenylmethoxycarbonylamino)pentanoic acid
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| Activity |
Ki = 735000 nM
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[9] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 9 | The design and synthesis of sulfonamides as caspase-1 inhibitors. Bioorg Med Chem Lett. 2004 Feb 9;14(3):809-12. | ||||
| REF 10 | 3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1beta converting enzyme inhibitor. Bioorg Med Chem Lett. 1997 Apr 22;7(8):1003-6. | ||||
| REF 11 | Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2779-82. | ||||
| REF 12 | 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem. 2006 Nov 16;49(23):6704-15. | ||||
| REF 13 | Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5089-94. | ||||
| REF 14 | Inhibition of interleukin-1beta converting enzyme by N-Acyl-aspartic acid ketones. Bioorg Med Chem Lett. 1995 Jul 6;5(13):1405-8. | ||||
| REF 15 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 16 | Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum. J Nat Prod. 2012 Feb 24;75(2):262-6. | ||||
| REF 17 | Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor. J Med Chem. 2003 Feb 27;46(5):868-71. | ||||
| REF 18 | Inhibition of interleukin-1beta converting enzyme by N-acyl-aspartyl aryloxymethyl ketones. Bioorg Med Chem Lett. 1995 Jul 6;5(13):1409-14. | ||||
| REF 19 | Phenylalkyl ketones as potent reversible inhibitors of interleukin-1beta converting enzyme. Bioorg Med Chem Lett. 1993 Dec;3(12):2689-92. | ||||
| REF 20 | Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery. J Med Chem. 2000 Sep 7;43(18):3351-71. | ||||
| REF 21 | Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents. Bioorg Med Chem. 2013 Apr 1;21(7):2025-36. | ||||
| REF 22 | Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis. J Med Chem. 2014 Nov 26;57(22):9383-95. | ||||
| REF 23 | Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem. 2009 Jun 11;52(11):3484-95. | ||||
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