Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97035 | Target Info | |||
| Target Name | Tyrosinase (TYR) | ||||
| Synonyms |
Tumor rejection antigen AB; SK29-AB; Monophenol monooxygenase; LB24-AB
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| Target Type | Successful Target | ||||
| Gene Name | TYR | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-tert-butylbenzene-1,4-diol
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Investigative | Compound Info | ||
| Synonyms |
Tert-Butylhydroquinone; tert-Butylhydroquinone; 1948-33-0; TBHQ; 2-tert-Butylhydroquinone; T-BUTYLHYDROQUINONE; MTBHQ; t-Butyl hydroquinone; 2-tert-Butyl-1,4-benzenediol; 2-t-Butylhydroquinone; Mono-tert-butylhydroquinone; Sustane; Tenox TBHQ; tert-Butyl-1,4-benzenediol; Mono-tertiarybutylhydroquinone; Hydroquinone, tert-butyl-; Banox 20BA; 1,4-Benzenediol, 2-(1,1-dimethylethyl)-; tertiary-Butylhydroquinone; 2-(1,1-Dimethylethyl)-1,4-benzenediol; 2-tert-Butyl(1,4)hydroquinone; 2-(tert-butyl)benzene-1,4-diol
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| Activity |
IC50 = 54200 nM
|
[1] | |||
| Compound Name |
1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one
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Investigative | Compound Info | ||
| Synonyms |
3654-49-7; (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one; 1,5-Bis(4-hydroxyphenyl)penta-1,4-dien-3-one; Bis-1,5-(4-Hydroxyphenyl)-1,4-Pentadien-3-one; 1,5-Bis-(4-hydroxyphenyl)-1,4-pentadien-3-one; CHEMBL129134; EINECS 222-896-4; AC1O5NFJ; 1,5-Di(p-hydroxyphenyl)-1,4-pentadien-3-one; 1,5-BIS(4-HYDROXYPHENYL)-1,4-PENTADIEN-3-ONE; 4,4'-Dihydroxydistyrylketon; ZINC6092599; BDBM50067044; AKOS015962226; CD-1056; M064; CC-03405; AC-16155; A823289; C-35230; 654B497; 1,5-Bis-(4-hydroxy-phenyl)-penta-1,4-dien-3-one; W-106603
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| Activity |
IC50 = 79050 nM
|
[2] | |||
| Compound Name |
4-Isopropylbenzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
cuminaldehyde; cuminic aldehyde; cumaldehyde; cuminal; p-cumic aldehyde; Cumic aldehyde; Benzaldehyde, 4-(1-methylethyl)-; Cuminyl aldehyde; P-ISOPROPYLBENZALDEHYDE; p-Isopropylbenzenecarboxaldehyde; 4-(1-Methylethyl)benzaldehyde; Benzaldehyde, p-isopropyl-; 4-(Methylethyl)benzaldehyde; P-isopropyl benzaldehyde; p-Cuminic aldehyde; 4-Isopropylbenzenecarboxylate; 4-(Propan-2-Yl)Benzaldehyde; 4-propan-2-ylbenzaldehyde; MFCD00006953; 4-Isopropyl-benzaldehyde; NSC 4886; UNII-O0893NC35F; CHEMBL161577; O0893NC35F; 4-Isopropylbenzaldehyde, 98%; FEMA No. 2341; EINECS 204-516-9; BRN 0636547; Cuminadlehyde; Cuminaldehyd; Cumal; Cumin aldehyde; AI3-01853; 4-iPr-Benzaldehyde; 4isopropylbenzaldehyde; Cuminaldehyde, 98%; p-iso-Propylbenzaldehyde; p-isopropyl-Benzaldehyde; 4(isopropyl)benzaldehyde; 4-isopropyl benzaldehyde; ACMC-1BVEJ; 4-(isopropyl)benzaldehyde; DSSTox_CID_1974; p-Isopropylbenzaldehyde, f; 4(2-propyl)-benzaldehyde; bmse000508; EC 204-516-9; DSSTox_RID_76435; DSSTox_GSID_21974; SCHEMBL87226; 4-07-00-00723 (Beilstein Handbook Reference); KSC176K3D; p-(1-methylethyl)benzaldehyde; 4-Isopropylphenylcarboxaldehyde; (4-isopropyl-phenyl)-methanone; DTXSID9021974; WLN: VHR DY1 & 1; CTK0H6531; NSC4886; Cuminaldehyde, analytical standard; ZINC968248; HY-Y0790; NSC-4886; Cuminaldehyde, >=98%, FCC, FG; Tox21_300712; ANW-17932; BDBM50139366; s5089; SBB040237; STL194065; AKOS000119738; AC-2430; CCG-266191; Cuminal p-(1-methylethyl)benzaldehyde; MCULE-4415970320; NCGC00248148-01; NCGC00257518-01; AS-12957; DB-041645; CS-0015770; FT-0624115; I0168; ST50213395; C06577; Q419952; W-108440; F2190-0632
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
Cycloorbicoside G
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372097; BDBM50176696
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| Activity |
IC50 = 54640 nM
|
[4] | |||
| Compound Name |
Fortuneanoside D
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL526100; BDBM50269343; 2,4''-dihydroxy-3'',5''-dimethoxy-(1,1''-biphenyl)-3-O-beta-d-glucoside
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| Activity |
IC50 = 70000 nM
|
[5] | |||
| Compound Name |
(8S,9R,10R,13R,14S,16R,17R)-17-[(2S)-2,6-Dihydroxy-6-methyl-3-oxoheptan-2-yl]-16-hydroxy-4,4,9,13,14-pentamethyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione
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Investigative | Compound Info | ||
| Synonyms |
Bryoamaride; CHEMBL449483; BDBM50370694; ZINC49833277
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| Activity |
IC50 = 85010 nM
|
[4] | |||
| Compound Name |
1-Hydroxy-5-[(Z)-(6-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978212; BDBM50205807
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| Activity |
IC50 = 85300 nM
|
[6] | |||
| Compound Name |
7H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline-7-carboxaldehyde,5,6,7a,8-tetrahydro-, (7aR)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170090; AC1L4K2V; N-Formylanonaine; (-)-N-Formylanonaine; DTXSID901003446; BDBM50322068; 5,6,7a,8-Tetrahydro-2H,7H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline-7-carbaldehyde
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| Activity |
EC50 = 90000 nM
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[7] | |||
| Compound Name |
Cyclosieversioside
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378140; BDBM50176701
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| Activity |
IC50 = 92250 nM
|
[4] | |||
| Compound Name |
1-[(Z)-2-(2,4-Dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221300; NCGC00025194-01; Tocris-1509; SCHEMBL17675325; ZINC7999104; BDBM50193670; cis-2,4,3',5'-tetramethoxystilbene; (Z)-2,3',4,5'-Tetramethoxystilbene; cis-2,4,3'',5''-tetramethoxystilbene
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
trans-2,3''-Dimethoxy-4,5''-dihydroxystilbene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219219; SCHEMBL17675461; SCHEMBL17675463; BDBM50193672; 4-[(E)-2-(3-hydroxy-5-methoxyphenyl)ethenyl]-3-methoxyphenol
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
2,3',4,5'-Tetramethoxystilbene
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Investigative | Compound Info | ||
| Synonyms |
(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene; 2,4,3',5'-tetramethoxystilbene; (E)-2,3',4,5'-tetramethoxystilbene; CHEMBL46909; 1-[(E)-2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene; Benzene, 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-; SR-01000597603; Cytochrome P450 1B1 Inhibitor, TMS; 3,5,2',4'-tetramethoxy-trans-stilbene; Oxyresveratrol tetramethyl ether; SCHEMBL4366766; 1-[2,(3,5-Dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene; HMS3412F17; HMS3648A21; HMS3676F17; BCP21292; EX-A1015; ZINC3875137; 1747AB; BDBM50108052; MFCD03428621; AKOS015967529; CS-5626; VZ20197; Trans-2,3',4,5'-tetramethoxystilbene; trans-2,4,3',5'-tetramethoxystilbene; AS-71536; HY-19340; trans-2,4,3'',5''-tetramethoxystilbene; B6768; 1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene; S-7732; 144T921; 2,4,3',5'-tetramethoxystilbene, >=98% (HPLC); J-015362; SR-01000597603-1; SR-01000597603-2; BRD-K45988865-001-01-0; (E)-4,5'-(ethene-1,2-diyl)bis(1,3-dimethoxybenzene); (E)?-?1-?(3,?5-?Dimethoxystyryl)?-?2,?4-?dimethoxybenzene; 1-[(E)-2-(3,5-dimethoxyphenyl)vinyl]-2,4-dimethoxybenzene; 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxybenzene; Benzene,1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
Gnetucleistol D
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219050; SCHEMBL17675281; SCHEMBL17675282; BDBM50193668; ZINC40576475; (E)-2-Methoxy-stilbene-4,3',5'-triol; trans-2-methoxy-4,3'',5''-trihydroxystilbene; Q17299982
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
2,4,3',5'-Tetramethoxybibenzyl
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222164; SCHEMBL16888436; 2,4,3'',5''-tetramethoxybibenzyl; BDBM50193673; 1-[2-(2,4-dimethoxyphenyl)ethyl]-3,5-dimethoxybenzene
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
trans-4,3''-Dimethoxy-2,5''-dihydroxystilbene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218269; SCHEMBL17675467; SCHEMBL17675470; BDBM50193669; 2-[(E)-2-(3-hydroxy-5-methoxyphenyl)ethenyl]-5-methoxyphenol
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Cyclocarposide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201643; BDBM50176698
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| Activity |
IC50 = 102390 nM
|
[4] | |||
| Compound Name |
5-[(Z)-(4,6-Dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-hydroxypyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3969839; BDBM50205806
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| Activity |
IC50 = 119000 nM
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[6] | |||
| Compound Name |
1-Hydroxy-5-[(Z)-(4-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3907670; BDBM50205815
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| Activity |
IC50 = 120000 nM
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[6] | |||
| Compound Name |
2-Hydroxypyridine 1-oxide
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Investigative | Compound Info | ||
| Synonyms |
2-Pyridinol-1-oxide; 2-Hydroxypyridine N-Oxide; Hydroxypyridinone; 2-Hydroxypyridine-N-oxide; 1-hydroxypyridin-2(1H)-one; Pyridinol, 1-oxide; 2-Pyridinol, 1-oxide; 1-hydroxypyridin-2-one; 2-Pyridinol 1-oxide; 1-hydroxy-1,2-dihydropyridin-2-one; 1-Hydroxy-2-pyridone; MFCD00006195; 2(1H)-Pyridinone, hydroxy-; 2-Pyridinol N-oxide; UNII-YO3915897S; 1-hydroxy-2(1h)-pyridinone; CHEMBL81398; 1-hydroxy-2-(1H)-pyridone; CHEMBL3898657; YO3915897S; Hydroxyl-2-pyridone; 2-Hydroxypyridine-N-oxide, 97%; N-Hydroxyl-2-pyridone; 2-Hydroxypridine-N-oxide; n-hydroxypyridone; n-hydroxy-pyridone; EINECS 212-506-0; NSC406972; N-hydroxy-2-pyridon; N-hydroxy-2-pyridone; pyridin-2-ol 1-oxide; ACMC-1BOLD; 2-HydroxypyridineN-Oxide; 2-hydroxypyridin-1-oxide; 2-hydroxypyridine-1-oxide; 2-hydroxy-pyridin-1-oxide; 2-hydroxy-pyridine N-oxide; 1-hydroxyhydropyridin-2-one; 2-Hydroxy-pyridine-N-oxide; 1-hydroxy-2(1H)-pyridone; NCIOpen2_003773; SCHEMBL40240; KSC120O9N; HPNO; 2-Pyridinol-1-Oxide; SCHEMBL112186; 1-Hydroxypyridine-2(1H)-one; CTK0C0796; CTK7H4052; 2(1H)-Pyridinone, 1-hydroxy-; DTXSID70231622; ZINC331625; ZINC391094; BCP13006; CS-M0760; KS-000008ZZ; ANW-19365; BDBM50057413; BDBM50205814; SBB004329; AKOS000121480; AKOS006273363; AC-5082; LS21131; MCULE-1310193547; NE39440; NSC-406972; AK-46730; AS-17882; BR-46730; SC-45012; SY019070; 2-Pyridinol 1-oxide, >=98.0% (N); AB0004978; DB-025301; AM20061694; FT-0636819; FT-0693752; V2326; M-3607; 67013-EP2298772A1; 67013-EP2308839A1; AC-907/25004409; AC-907/25014064; Pyridinium,1,2-dihydroxy-,1-hydroxide,inner salt; Q-101944; Q27294618; Z1342115512; OXY-PYRION 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS
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| Activity |
Ki = 128000 nM
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[6] | |||
| Compound Name |
Fortuneanoside E
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL498291; BDBM50269344; 3,4''-dihydroxy-3'',5''-dimethoxy-(1,1''-biphenyl)-4-O-beta-d-glucoside
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| Activity |
IC50 = 140000 nM
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[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Levodopa
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Approved | Compound Info | ||
| Synonyms |
Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion
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| Activity |
IC50 = 8400000 nM
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[9] | |||
| Compound Name |
Resveratrol
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Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| Activity |
IC50 = 3680000 nM
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[10] | |||
| Compound Name |
Go-Y022
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Investigative | Compound Info | ||
| Synonyms |
Go-Y022; CHEMBL128729; 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one; (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one; Hylin; AC1O6FK4; 1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one; SCHEMBL1493282; ZINC6483730; BDBM50067028; 1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one; 1,5-bis-(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one; (1E,4E)-1,5-bis(4-hydroxy-3-methoxy-phenyl)penta-1,4-dien-3-one
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| Activity |
IC50 > 250000 nM
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[2] | |||
| Compound Name |
7-hydroxycoumarin
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Investigative | Compound Info | ||
| Synonyms |
Umbelliferone; 93-35-6; 7-Hydroxy-2H-chromen-2-one; Skimmetin; Hydrangin; 7-hydroxycoumarine; 7-Oxycoumarin; Umbelliferon; Skimmetine; Hydrangine; 2H-1-Benzopyran-2-one, 7-hydroxy-; 7-Hydroxy-2H-1-benzopyran-2-one; Coumarin, 7-hydroxy-; beta-Umbelliferone; 7-hydroxychromen-2-one; 7 HC; UNII-60Z60NTL4G; 7-hydroxy-coumarin; NSC 19790; CCRIS 3591; NSC19790; EINECS 202-240-3; 7H-1-Benzopyran-7-one, 2-hydroxy-; BRN 0127683; CHEMBL51628; AI3-38054; 7-hydroxy-1-benzopyran-2-one; 7-HC; 60Z60NTL4G; CHEBI:27510; UMBELLIFERONE
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| Activity |
IC50 = 420000 nM
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[10] | |||
| Compound Name |
7-hydroxy-3-phenyl-2H-chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
7-hydroxy-3-phenyl-2H-chromen-2-one; 6468-96-8; 3-Phenylumbelliferone; 7-Hydroxy-3-phenylcoumarin; 7-hydroxy-3-phenylchromen-2-one; 3-phenyl-7-hydroxycoumarin; CHEMBL153505; 7-Hydroxy-3-phenyl-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one,7-hydroxy-3-phenyl-; 7-Hydroxy-3-phenyl-chromen-2-one; EN300-36438; AE-641/01995035; AC1NU2DD; MLS001167019; SCHEMBL591688; AC1Q797K; ZINC58069; CTK5C1589; cid_5393176; DTXSID60419831; MolPort-000-870-829; RIPZCQZTVDNJHQ-UHFFFAOYSA-N; HMS2955O07; BB_NC-01950; SBB042221; STL033560; MFCD00037574
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| Activity |
IC50 > 10000000 nM
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[10] | |||
| Compound Name |
Arbutin
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Investigative | Compound Info | ||
| Synonyms |
Arbutoside; Uvasol; Ursin; p-Arbutin; 4-Hydroxyphenyl beta-D-glucopyranoside; p-Hydroxyphenyl beta-D-glucoside; beta-Arbutin; p-Hydroxyphenyl beta-D-glucopyranoside; Hydroquinone-O-beta-D-glucopyranoside; 4-Hydroxyphenyl-beta-D-glucopyranoside; UNII-C5INA23HXF; Hydroquinone beta-D-glucopyranoside; Hydroquinone-glucose; Hydroquinone; A-D-glucopyranoside; hydroquinone O-beta-D-glucopyranoside; MFCD00016915; C5INA23HXF; CHEMBL232202; Arbutin, 95%; 4-Hydroxyphenyl-.beta.-D-glucopyranoside; Arbutine; Arbutyne; Hydroquinone-beta-D-glucopyranoside; DSSTox_CID_20152; DSSTox_RID_79450; DSSTox_GSID_40152; Ericolin; C12H16O7; NSC 4036; SR-05000002157; NSC-4036; CCRIS 9273; b-D-Glucopyranoside, 4-hydroxyphenyl; HSDB 7661; NCGC00095599-01; EINECS 207-850-3; beta-D-Glucopyranoside, 4-hydroxyphenyl; BRN 0089673; Spectrum_000786; SpecPlus_000314; Arbutin, >=98%; Prestwick3_001026; Spectrum2_000662; Spectrum3_001233; Spectrum4_001474; Spectrum5_000147; bmse000365; Arbutin (Uva, p-Arbutin); Arbutin, analytical standard; SCHEMBL36351; Arbutin - Uva - p-Arbutin; BSPBio_001211; BSPBio_002706; Hydroquinone-beta-D-glucoside; KBioGR_002047; KBioSS_001266; SPECTRUM300539; 5-17-07-00110 (Beilstein Handbook Reference); MLS002207046; DivK1c_006410; SPBio_000723; BPBio1_001333; MEGxp0_001504; DTXSID7040152; KBio1_001354; KBio2_001266; KBio2_003834; KBio2_006402; KBio3_002206; hydroquinone O--D-glucopyranoside; HMS2098M13; HMS3715M13; ZINC518554; HY-N0192; 4-Hydroxyphenyl-beta-glucopyranoside; Tox21_111509; Tox21_302428; BDBM50219502; CA0139; CCG-38565; s2263; AKOS015965305; Tox21_111509_1; DB11217; KS-5252; SDCCGMLS-0066538.P001; KS-00000L08; SMP1_000028; NCGC00166076-02; NCGC00166076-03; NCGC00166076-04; NCGC00166076-07; NCGC00255705-01; AC-20183; I(2)-D-Glucopyranoside, 4-hydroxyphenyl; SMR001233417; A0522; AB00443586; N1714; SW199492-2; A-9320; C06186; beta-D-Glucopyranoside, 4-hydroxyphenyl- (9CI); 497A767; Q416446; SR-05000002157-2; SR-05000002157-4; 4E19B706-2013-4401-A1FC-A154DADF42B4
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| Activity |
IC50 = 230000 nM
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[5] | |||
| Compound Name |
2,6-Bis(4-hydroxybenzylidene)cyclohexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482409; (2E,6E)-2,6-bis[(4-hydroxyphenyl)methylidene]cyclohexan-1-one; (2E,6E)-2,6-bis(4-hydroxybenzylidene)cyclohexanone; NSC622203; 2,6-Bis-(4-hydroxy-benzylidene)-cyclohexanone; SCHEMBL14473217; ZINC4603546; BDBM50264832; STK030579; AKOS005380679; NSC-622203; ST50993783; 2,6-Bis[(E)-4-hydroxybenzylidene]cyclohexanone; 2,6-bis[(4-hydroxyphenyl)methylene]cyclohexan-1-one
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| Activity |
IC50 > 250000 nM
|
[2] | |||
| Compound Name |
(1E,4E)-1,5-Bis(4-fluorophenyl)penta-1,4-dien-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476220; trans,trans-Bis(4-fluorobenzal)acetone; trans,trans-Bis(4-fluorobenzylidene)acetone; trans,trans-1,5-Bis(4-fluorophenyl)-1,4-pentadien-3-one; Bis(4-fluorostyryl) ketone; SCHEMBL2126010; SCHEMBL2126013; 1,4-Pentadien-3-one, 1,5-bis(4-fluorophenyl)-, (E,E)-; HMS1416N15; ZINC1081487; BDBM50266759; MFCD00298485; AKOS001325278; trans,trans-Bis(4-fluorostyryl) Ketone; AS-68770; ST45113576; 1,5-BIS-(4-fluoro-phenyl)penta-1,4-dien-3-one; F0401-0086
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| Activity |
IC50 > 250000 nM
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[2] | |||
| Compound Name |
1,5-Bis(2-fluoro-4-methoxyphenyl)penta-1,4-dien-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL25209; BDBM50296394; ZINC43504623
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| Activity |
IC50 > 250000 nM
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[2] | |||
| Compound Name |
2,6-Bis(4-chlorobenzylidene)cyclohexanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL474918; 2,6-Bis-(4-chloro-benzylidene)-cyclohexanone; (2E,6E)-2,6-bis(4-chlorobenzylidene)cyclohexanone; NSC54916; HMS550L22; (2E,6E)-2,6-bis[(4-chlorophenyl)methylidene]cyclohexan-1-one; ZINC4482191; BDBM50296395; NSC-54916; NSC622703; STK327396; AKOS000576139; CCG-244193; MCULE-1515730474; NSC-622703; 2,6-Bis(p-chlorobenzylidene)cyclohexanone; 2,6-Bis-(4-chlorobenzylidene)cyclohexan-1-one; 2,6-Bis[(E)-4-chlorobenzylidene]cyclohexanone
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| Activity |
IC50 > 250000 nM
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[2] | |||
| Compound Name |
4-Methoxybenzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
P-ANISALDEHYDE; Anisic aldehyde; Anisaldehyde; p-Methoxybenzaldehyde; 4-Anisaldehyde; Benzaldehyde, 4-methoxy-; Aubepine; p-Anisic aldehyde; p-Formylanisole; Crategine; Obepin; para-anisaldehyde; 4-Methoxy-benzaldehyde; 4-methoxy benzaldehyde; anisal; MFCD00003385; NSC 5590; UNII-9PA5V6656V; p-methoxy benzaldehyde; CHEMBL161598; FEMA 2670; 9PA5V6656V; p-Anisaldehyde, 99+%; DSSTox_CID_6997; DSSTox_RID_78277; DSSTox_GSID_26997; Formylanisole, p-; Caswell No. 051E; p-Anisaldehyde,p-Methoxybenzaldhyde; CCRIS 821; 4-Methoxybenzaldhyde; FEMA No. 2670; p-Methoxybenzaldehyde (natural); HSDB 2641; EINECS 204-602-6; anisaldehyd; Anis aldehyde; AI3-00223; 4-methoxybenzaldehye; 4-methoxybezaldehyde; EINECS 256-891-3; Anisaldehyde (para); Anisaldehyde solution; p-Methoxybenzafdehyde; P-Anisaldehyde,(S); 4-methoxylbenzaldehyde; p-Anisaldehyde, 8CI; AN1SALDEHYDE; 4-methoxybenzylaldehyde; BRN 0471382; p-anisaldehyde solution; para-methoxybenzaldehyde; p-Anisaldehyde, 98%; PubChem22535; p-Anisaldehyde, Reagent; ACMC-1BAZN; para-methoxy benzaldehyde; 4-(methyloxy)benzaldehyde; bmse010130; WLN: VHR DO1; EC 204-602-6; SCHEMBL1100; Methoxybenzaldehyde (Related); KSC174M6D; MLS002152921; NATURAL ANISIC ALDEHYDE; p-Methoxybenzylidenemalonitrile; 4-methoxybenzene carboxaldehyde; p-Methoxy Benzaldehyde, Natural; DTXSID2026997; CTK0H4661; EBD1062; NSC5590; HMS3039F08; ZINC157146; p-Anisaldehyde, analytical standard; HY-Y0740; KS-000002NI; NSC-5590; p-Anisaldehyde, natural, 98%, FG; Tox21_201943; Tox21_303331; ANW-18100; BBL027436; BDBM50139370; s5086; SBB040224; STL194068; AKOS000118814; AS02988; CCG-214805; CS-W020189; MCULE-9537754812; p-Anisaldehyde (4-Methoxybenzaldehyde); p-Anisaldehyde, for synthesis, 98.0%; NCGC00090807-01; NCGC00090807-02; NCGC00257076-01; NCGC00259492-01; p-Anisaldehyde, >=97.5%, FCC, FG; AC-10379; AK-72956; BR-72956; CS-11005; SC-26765; SMR001224521; SY001689; DB-012818; A0480; BENZALDEHYDE,4-METHOXY MFC8 H8 O2; FT-0617622; FT-0662227; FT-0662228; ST50213373; C10761; M-6033; 29578-EP2284160A1; 29578-EP2292628A2; 29578-EP2305695A2; 29578-EP2305696A2; 29578-EP2305697A2; 29578-EP2305698A2; 29578-EP2308838A1; 29578-EP2311825A1; 29578-EP2311842A2; 79582-EP2287153A1; 79582-EP2292628A2; 79582-EP2298755A1; 79582-EP2305695A2; 79582-EP2305696A2; 79582-EP2305697A2; 79582-EP2305698A2; 79582-EP2374783A1; 79582-EP2377841A1; 4-08-00-00252 (Beilstein Handbook Reference); A805017; Q174937; Q-100105; F2190-0575
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| Activity |
IC50 = 320000 nM
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[3] | |||
| Compound Name |
CID 44559660
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513957; ZINC3914600; BDBM50242238
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| Activity |
IC50 = 333000 nM
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[11] | |||
| Compound Name |
Fortuneanoside C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL497445; BDBM50269342; 4''-hydroxy-3'',5''-dimethoxy-(1,1''-biphenyl)-2-O-beta-d-glucoside
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| Activity |
IC50 = 450000 nM
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[5] | |||
| Compound Name |
Benzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
Benzoic aldehyde; Phenylmethanal; Benzenecarbonal; Benzenecarboxaldehyde; Artificial almond oil; Benzenemethylal; Benzaldehyde FFC; Benzene carbaldehyde; Oil Of bitter almond; Benzene carboxaldehyde; Almond artificial essential oil; benzanoaldehyde; Benzylaldehyde; Benzoyl hydride; Caswell No. 076; Synthetic oil of bitter almond; Artificial essential oil of almond; NCI-C56133; benzaldehyd; Benzadehyde; Benzyaldehyde; FEMA No. 2127; Phenylformaldehyde; NSC 7917; Artificial bitter almond oil; UNII-TA269SD04T; Benzaldehyde [NF]; Ethereal oil of bitter almonds; Benzoic acid aldehyde; CHEMBL15972; TA269SD04T; Phenylmethanal benzenecarboxaldehyde; Benzaldehyde (NF); MFCD00003299; NCGC00091819-01; NCGC00091819-02; DSSTox_CID_134; DSSTox_RID_79432; DSSTox_GSID_39241; Benzaldehyde (natural); Benzaldhyde; BDBM50139371; Bitter almond oil, synthetic; CCRIS 2376; HSDB 388; EINECS 202-860-4; UN1990; EPA Pesticide Chemical Code 008601; benzaidehyde; benzaldehvde; benzaldehye; benzaldeyde; Bitter almond; phenyl-methanone; AI3-09931; Benzene methylal; Aromatic aldehyde; Benzoylwasserstoff; (phenyl)methanone; Benzaldehyde,(S); PhCHO; Benzaldehyde Natural; Natural Benzaldehyde; WLN: VHR; SCHEMBL573; bitter almond oil synthetic; EC 202-860-4; ACMC-1C91Y; ghl.PD_Mitscher_leg0.170; KSC176K2J; Benzaldehyde, AR, >=99%; Benzaldehyde, LR, >=99%; BIDD:ER0249; DTXSID8039241; BDBM60953; Benzaldehyde, analytical standard; CTK0H6524; KS-00000WWW; Artifical essential oil of almond; NSC7917; Ald3-H_000012; ZINC895145; Benzaldehyde, >=98%, FG, FCC; NSC-7917; Ald3.1-H_000160; Ald3.1-H_000479; Ald3.1-H_000798; Tox21_113069; Tox21_113244; Tox21_200634; ANW-14310; MFCD00801585; s5574; STL194067; Benzaldehyde, for synthesis, 95.0%; AKOS000119172; Benzaldehyde [UN1990] [Class 9]; CCG-266041; LS41490; MCULE-7744113682; NA 1989; Benzaldehyde, purum, >=98.0% (GC); Benzaldehyde, ReagentPlus(R), >=99%; NCGC00091819-03; NCGC00258188-01; PS-11959; SC-19173; Benzaldehyde, natural, >=98%, FCC, FG; NATURAL RSTD CASSIA OIL DIST FLAVOR; DB-023673; B2379; Benzaldehyde, SAJ special grade, >=98.0%; FT-0622622; FT-0622626; Benzaldehyde, Vetec(TM) reagent grade, 98%; 5044-EP2269979A1; 5044-EP2269990A1; 5044-EP2272491A1; 5044-EP2272827A1; 5044-EP2275404A1; 5044-EP2275411A2; 5044-EP2275412A1; 5044-EP2277858A1; 5044-EP2277865A1; 5044-EP2277878A1; 5044-EP2281818A1; 5044-EP2284157A1; 5044-EP2286915A2; 5044-EP2287152A2; 5044-EP2287159A1; 5044-EP2289868A1; 5044-EP2292593A2; 5044-EP2295402A2; 5044-EP2295410A1; 5044-EP2295441A2; 5044-EP2298767A1; 5044-EP2298776A1; 5044-EP2301534A1; 5044-EP2301536A1; 5044-EP2301538A1; 5044-EP2305625A1; 5044-EP2305629A1; 5044-EP2305662A1; 5044-EP2305679A1; 5044-EP2305687A1; 5044-EP2305769A2; 5044-EP2305808A1; 5044-EP2308562A2; 5044-EP2311451A1; 5044-EP2311455A1; 5044-EP2311806A2; 5044-EP2311840A1; 5044-EP2314295A1; 5044-EP2314586A1; 5044-EP2314587A1; 5044-EP2314593A1; 5044-EP2316450A1; 5044-EP2316832A1; 5044-EP2316833A1; 5044-EP2371831A1; 5044-EP2374454A1; 5044-EP2374783A1; 5044-EP2377841A1; 5044-EP2380871A1; Benzaldehyde 1000 microg/mL in Dichloromethane; Benzaldehyde on polystyrene, 0.8-1.5 mmol/g; Benzaldehyde, puriss. p.a., >=99.0% (GC); C00193; C00261; D02314; 53585-EP2305651A1; 53585-EP2308854A1; 125826-EP2287158A1; 125826-EP2295422A2; A800226; Q372524; SR-01000944375; Benzaldehyde, purified by redistillation, >=99.5%; SR-01000944375-1; F1294-0144
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| Activity |
IC50 = 820000 nM
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[3] | |||
| Compound Name |
Fortuneanoside B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL497444; BDBM50269341; 4''-hydroxy-2,3'',5''-trimethoxy-(1,1''-biphenyl)-2''-O-beta-d-glucoside
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| Activity |
IC50 = 2210000 nM
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[5] | |||
| Compound Name |
Salicylaldehyde
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Investigative | Compound Info | ||
| Synonyms |
2-Hydroxybenzaldehyde; o-Hydroxybenzaldehyde; Benzaldehyde, 2-hydroxy-; Salicylal; o-Formylphenol; Salicylic aldehyde; 2-Formylphenol; Salicyladehyde; 2-HYDROXY-BENZALDEHYDE; Benzaldehyde, o-hydroxy-; Salicylaldehyd; Salizylaldehyd; Benzaldehyde, hydroxy-; salicyl aldehyde; MFCD00003317; NSC 49178; UNII-17K64GZH20; 2-hydroxy benzaldehyde; CHEMBL108925; 17K64GZH20; Salicylaldehyde, 99%; DSSTox_CID_1792; DSSTox_RID_76329; 2,4-Cyclohexadien-1-one, 6-(hydroxymethylene)-; DSSTox_GSID_21792; Hydroxybenzaldehyde; FEMA No. 3004; CCRIS 7451; HSDB 721; EINECS 201-961-0; BRN 0471388; salicylylaldehyde; AI3-02174; hydroxylbenzaldehyde; hydroxy benzaldehyde; hydroxyl benzaldehyde; 2-hyroxy-benzaldehyde; 2-oxidanylbenzaldehyde; o-hydroxy benzaldehyde; Salicylaldehyde, 8CI; 2- hydroxybenzaldehyde; ACMC-20me6q; WLN: VHR BQ; bmse000677; EC 201-961-0; SCHEMBL15395; 4-08-00-00176 (Beilstein Handbook Reference); KSC204S9R; Salicylaldehyde, >=98%, FG; DTXSID1021792; CTK0D4077; CTK1A4998; FEMA 3004; Salicylaldehyde, p.a., 99.0%; ZINC896073; ACMC-209783; BCP31374; CS-D1188; NSC49178; Salicylaldehyde, analytical standard; Tox21_201737; Tox21_302929; ANW-13633; BBL027432; BDBM50139367; NSC-49178; NSC187662; RW2543; Salicylaldehyde, reagent grade, 98%; SBB040225; STL194289; AKOS000119187; 2-hydroxybenzaldehyde (salicylaldehyde); AS03003; EBD2205190; MCULE-8965879140; NSC-187662; KS-0000005P; NCGC00249108-01; NCGC00256460-01; NCGC00259286-01; AS-13997; SC-18113; FT-0648915; S0275; Salicylaldehyde, redist., >=99.0% (GC); ST50213374; 7293-EP2270014A1; 7293-EP2281563A1; 7293-EP2301933A1; 7293-EP2308872A1; 7293-EP2311807A1; 7293-EP2311827A1; 7293-EP2316459A1; 7293-EP2316829A1; 90S028; C06202; H-3700; 96428-EP2295429A1; 96428-EP2305629A1; 116358-EP2374783A1; 116358-EP2377841A1; A843413; Q414492; F2190-0607
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| Activity |
IC50 = 3300000 nM
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[3] | |||
| Compound Name |
3-(3,5-Dihydroxyphenyl)-7-hydroxycoumarin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL200198; BDBM50176525; 7-hydroxy-3-(3'',5''-dihydroxyphenyl)coumarin
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| Activity |
IC50 > 10000000 nM
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[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1476-8. | ||||
| REF 2 | Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities. Eur J Med Chem. 2009 Aug;44(8):3195-200. | ||||
| REF 3 | 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor. Bioorg Med Chem Lett. 2004 Feb 9;14(3):681-3. | ||||
| REF 4 | New tyrosinase inhibitors selected by atomic linear indices-based classification models. Bioorg Med Chem Lett. 2006 Jan 15;16(2):324-30. | ||||
| REF 5 | Biphenyl glycosides from the fruit of Pyracantha fortuneana. J Nat Prod. 2006 Jul;69(7):1022-4. | ||||
| REF 6 | 2-Hydroxypyridine- N-oxide-Embedded Aurones as Potent Human Tyrosinase Inhibitors. ACS Med Chem Lett. 2016 Nov 17;8(1):55-60. | ||||
| REF 7 | (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant. Bioorg Med Chem. 2010 Jul 15;18(14):5241-7. | ||||
| REF 8 | Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3. | ||||
| REF 9 | Identification of oxidation product of arbutin in mushroom tyrosinase assay system. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2409-12. | ||||
| REF 10 | New halogenated phenylcoumarins as tyrosinase inhibitors. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3342-5. | ||||
| REF 11 | Acetophenone derivatives from Acronychia pedunculata. J Nat Prod. 2003 Jul;66(7):990-3. | ||||
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