Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96299 | Target Info | |||
| Target Name | Wnt protein (WNT) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[(Thiophen-2-ylmethylamino)methyl]-1,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419715; SCHEMBL14638278; BDBM50439829; 2-((Thiophen-2-ylmethylamino)methyl)-7,8-dihydro-3H-pyrano[4,3-d]pyrimidin-4(5H)-one; 2-{[(Thiophen-2-ylmethyl)-amino]-methyl}3,5,7,8-tetrahydro-pyrano[4,3-d]pyrimidin-4-one
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|
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| Activity | Wnt 3a protein |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
N-Ethyl-N-[(4-oxo-1,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419713; SCHEMBL14645150; BDBM50439831
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|
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| Activity | Wnt 3a protein |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419714; BDBM50439830
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|
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| Activity | Wnt 3a protein |
IC50 ~ 50000 nM
|
[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J Med Chem. 2013 Aug 22;56(16):6495-511. | ||||
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