Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96144 | Target Info | |||
| Target Name | DNA topoisomerase II (TOP2) | ||||
| Synonyms |
TOP2; DNA topoisomerase 2
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| Target Type | Successful Target | ||||
| Gene Name | TOP2A; TOP2B | ||||
| Biochemical Class | ATP-hydrolyzing DNA topoisomerase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 82 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
BE-13793C
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|
Terminated | Compound Info | ||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277008; BDBM50076922
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)oxy]benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL320495; BDBM50470359
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Edotecarin
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Investigative | Compound Info | ||
| Synonyms |
J-107088; UNII-1V8X590XDP; PF-804950; 1V8X590XDP; CHEMBL435191; Edotecarina; E'dotecarine; Edotecarin [USAN:INN]; Edotecarinum [INN-Latin]; E'dotecarine [INN-French]; C29H28N4O11; Edotecarin (USAN/INN); J 107088; SCHEMBL5177060; ZINC3946372; BDBM50086570; CS-6688; DB04882; HY-13618; Z1880; D03954; Q27095555
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428453; BDBM50076930
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433855; BDBM50086574
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
13-(Ethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277011; BDBM50076942
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5,21-Dihydroxy-13-(methylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277667; BDBM50076940
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]propanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL283766; BDBM50076938
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135970; BDBM50086559
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334337; BDBM50086557
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
13-(Dimethylamino)-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278071; BDBM50076939
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5,21-Dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21108; BDBM50073855
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338967; BDBM50086569
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]formamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL282436; BDBM50076943
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL135491; BDBM50086571
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434237; BDBM50086572
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|
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277039; BDBM50076921
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL278101; BDBM50076931
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135492; BDBM50086563; J-109534
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL20255; BDBM50076925
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406901; BDBM50086558
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]methanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277408; BDBM50076924
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2S,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133209; BDBM50086567
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21263; BDBM50076932
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2R,3R,4S,5S)-5-(1,2-Dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135881; BDBM50086565
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5,21-Dihydroxy-13-[(3-hydroxyphenyl)methylamino]-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL282655; BDBM50076933
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5,21-Dihydroxy-13-(2-hydroxyethylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL20811; BDBM50076920
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335940; BDBM50086564
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-Isopropylcarbamic acid 4-[(acridin-9-yl)thio]benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109880; BDBM50470376
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
4-[[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL279035; BDBM50076944
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2R,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)oxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL405405; BDBM50086555
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[(2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029060; BDBM50403823
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132533; BDBM50086575
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
13-Amino-5,21-dihydroxy-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21265; BDBM50076923
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL134536; BDBM50086561
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-4-methylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL21267; BDBM50076941
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2S,4R,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)oxan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL334461; BDBM50086556
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| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-[(4-Methoxyacridin-9-yl)thio]benzene-1-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111735; BDBM50470363
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
2-Cyano-N-[5,21-dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL278526; BDBM50076929
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-10-(2,6-Dimethyl-4-pyridinyl)-8,9-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45881; SCHEMBL9305610; BDBM50212863
Click to Show/Hide
|
||||
| Activity |
EC50 = 50000 nM
|
[4] | |||
| Compound Name |
13-(1,3-Dihydroxypropan-2-ylamino)-6,20-dihydroxy-3-[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338966; BDBM50086560
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5,21-Dihydroxy-13-(propylamino)-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21096; BDBM50076936
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[5,21-Dihydroxy-12,14-dioxo-3-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaen-13-yl]-2-hydroxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL21221; BDBM50076927
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2R,3R,4S,5R)-5-(1,2-Dihydroxyethyl)-3,4-dihydroxyoxolan-2-yl]-13-(1,3-dihydroxypropan-2-ylamino)-6,20-dihydroxy-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17(22),18,20-nonaene-12,14-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336626; BDBM50086566
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-Cyclopropyl-6,8-difluoro-4-oxo-7-pyridin-3-ylquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327663; BDBM50231255; 1,4-Dihydro-1-cyclopropyl-4-oxo-6,8-difluoro-7-(pyridin-3-yl)quinoline-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 52000 nM
|
[5] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-3-yl)-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97315; SCHEMBL9853203; BDBM50231259
Click to Show/Hide
|
||||
| Activity |
EC50 = 53000 nM
|
[5] | |||
| Compound Name |
(8Ar,9R)-5-[(7-amino-8-hydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344478; BDBM50471913
Click to Show/Hide
|
||||
| Activity |
EC50 = 56000 nM
|
[6] | |||
| Compound Name |
(2S)-7-Fluoro-2-methyl-10-oxo-6-pyridin-4-yl-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL296812; SCHEMBL9118039; BDBM50212862
Click to Show/Hide
|
||||
| Activity |
EC50 = 57000 nM
|
[4] | |||
| Compound Name |
(2S)-7-Fluoro-6-isoquinolin-6-yl-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45923; BDBM50212870
Click to Show/Hide
|
||||
| Activity |
EC50 = 58000 nM
|
[4] | |||
| Compound Name |
(4S)-4-[(5R,8S,9S,10R,13R,14S,17R)-3-Hydroxy-5,10,13-trimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138325
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[7] | |||
| Compound Name |
(2S)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-4,10-dioxo-4lambda4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48059; SCHEMBL9305503; BDBM50212892
Click to Show/Hide
|
||||
| Activity |
EC50 = 62000 nM
|
[4] | |||
| Compound Name |
Methyl (10S,13R,14R,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426087; BDBM50474905
Click to Show/Hide
|
||||
| Activity |
IC50 = 66510 nM
|
[8] | |||
| Compound Name |
1,4-Dihydro-1-tert-butyl-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid sodium salt
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419703; BDBM50231252
Click to Show/Hide
|
||||
| Activity |
EC50 = 74000 nM
|
[5] | |||
| Compound Name |
N,N'-Digalloyl-1,2-phenylenediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47027; CTK1J9640; DTXSID40432422; BDBM50142519; Benzamide, N,N'-1,2-phenylenebis[3,4,5-trihydroxy-; N-[2-(3,4,5-triihydroxy-benzoylamino)-phenyl]-3,4,5-trihydroxy-benzamide
Click to Show/Hide
|
||||
| Activity |
Ki = 74100 nM
|
[9] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinoline-4-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130604; BDBM50212819
Click to Show/Hide
|
||||
| Activity |
EC50 = 76000 nM
|
[10] | |||
| Compound Name |
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-3-oxo-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthrene-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191001; BDBM50474908
Click to Show/Hide
|
||||
| Activity |
IC50 = 83230 nM
|
[8] | |||
| Compound Name |
Anticancer agent 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333026; SCHEMBL6556690; BDBM50471780; HY-128689; CS-0098035; 4-(aminomethyl)-1-[[2-(diethylamino)ethyl]amino]-thioxanthen-9-one; 4-(aminomethyl)-1-[2-(diethylamino)ethylamino]thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-(aminomethyl)-9H-thioxanthen-9-one; 4-(aminomethyl) -1-[[2-(diethylamino) ethyl]amino]-thioxanthen-9-one; 4-(aminomethyl) -1-[[2-(diethylamino)ethyl]amino]-thioxanthen-9-one; 4-(aminomethyl)-1-[[2-(diethylamino) ethyl]amino]-thioxanthen-9-one; 4-(aminomethyl)-l-[[2-(diethylamino) ethyl]amino]-thioxanthen-9-one
Click to Show/Hide
|
||||
| Activity |
EC50 = 90000 nM
|
[11] | |||
| Compound Name |
N-[(E)-[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-ylidene]amino]quinolin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132213; BDBM50212818
Click to Show/Hide
|
||||
| Activity |
EC50 = 92000 nM
|
[10] | |||
| Compound Name |
4-[(Acridin-9-yl)oxy]benzene-1-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109743; BDBM50470356; ZINC13603428
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[(Acridin-9-yl)thio]benzene-1-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111502; BDBM50470368; ZINC13603439
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Isopropylcarbamic acid 4-[(4-methoxyacridin-9-yl)oxy]benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109534; BDBM50470366
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(5S,5Ar,8aR,9R)-5-[(8-amino-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142016; BDBM50471908
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-Isopropylcarbamic acid 4-[(4-methoxyacridin-9-yl)thio]benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108493; BDBM50470377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Succinic acid hydrogen 3-[(3-carboxypropanoyl)amino]-5-[(acridin-9-yl)amino]benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109468; BDBM50470370
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(5S,5Ar,8aR,9R)-5-[4-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL140036; BDBM50471916
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(5S,5Ar,8aR,9R)-5-[[8-(dimethylamino)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL433875; BDBM50471909
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(5S,5Ar,8aR,9R)-5-[[8-(2-aminoethylamino)-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336443; BDBM50471914
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(5S,5Ar,8aR,9R)-5-[[(6S)-8-amino-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344226; BDBM50471910
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-Methylcarbamic acid 4-[(4-methoxyacridin-9-yl)thio]benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109922; BDBM50470358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7991; BDBM50213796
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(10R,13R,14R,17R)-2-Chloro-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193002; BDBM50474903
Click to Show/Hide
|
||||
| Activity |
IC50 = 106800 nM
|
[8] | |||
| Compound Name |
7-(2,6-Dimethylpyridin-4-yl)-1-ethyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94671; BDBM50231261; 1,4-Dihydro-1-ethyl-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 110000 nM
|
[5] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(2-phenylethyl)quinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7999; BDBM50213814
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 120000 nM
|
[12] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-phenylquinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7704; BDBM50213291
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 120000 nM
|
[12] | |||
| Compound Name |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxospiro[4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-2,1'-cyclopropane]-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45605; BDBM50212889
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 130000 nM
|
[4] | |||
| Compound Name |
7-(2,6-Dimethylpyridin-4-yl)-6,8-difluoro-4-oxothiochromene-3-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL544553; BDBM50231285
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 140000 nM
|
[5] | |||
| Compound Name |
(10S,13R,14R,17R)-17-[(2R,5R)-5,6-Dihydroxy-6-methylheptan-2-yl]-4,4,10,13,14-pentamethyl-5,6,7,8,12,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190841; BDBM50474906
Click to Show/Hide
|
||||
| Activity |
IC50 = 149970 nM
|
[8] | |||
| Compound Name |
(13S)-8-(2,6-Dimethylpyridin-4-yl)-7-fluoro-13-methyl-4-oxo-10-oxa-1-azatricyclo[7.4.1.05,14]tetradeca-2,5,7,9(14)-tetraene-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295775; BDBM50212891
Click to Show/Hide
|
||||
| Activity |
EC50 = 150000 nM
|
[4] | |||
| Compound Name |
N-[(7S)-1,2-Dihydroxy-3-methoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61573; BDBM50471657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[13] | |||
| Compound Name |
1,4-Dihydro-1-cyclopropyl-4-oxo-6,8-difluoro-7-(4-methylpiperazino)quinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47255; SCHEMBL7821381; BDBM50231249; 1-cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid; 1-cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydro-3-quinolincarboxylic; 1-Cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 150000 nM
|
[5] | |||
| Compound Name |
2-[[1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxoquinolin-3-yl]methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7392; BDBM50213802
Click to Show/Hide
|
||||
| Activity |
EC50 = 200000 nM
|
[12] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 46 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SR-271425
Click to Show/Hide
|
Discontinued in Phase 1 | Compound Info | ||
| Synonyms |
BCN-326862; SW-71425; WIN-71425; 1-[2-(Diethylamino)ethylamino]-4-(formamidomethyl)-7-methoxy-9H-thioxanthen-9-one
Click to Show/Hide
|
||||
| Activity |
EC50 > 480000 nM
|
[11] | |||
| Compound Name |
PD-117596
Click to Show/Hide
|
Terminated | Compound Info | ||
| Synonyms |
PD-117596-2
Click to Show/Hide
|
||||
| Activity |
EC50 = 340000 nM
|
[5] | |||
| Compound Name |
Cholesterol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
cholesterol; 57-88-5; Cholesterin; Cholest-5-en-3beta-ol; Cholesteryl alcohol; Cholestrin; Dusoran; Cordulan; Dusoline; Cholesterine; Hydrocerin; Cholestrol; Kathro; Dythol; Lanol; Super hartolan; Provitamin D; Cholesterol base H; Lidinite; Nimco cholesterol base H; Lidinit; Wool alcohols B. P.; (-)-Cholesterol; Tegolan (VAN); Cholest-5-en-3-beta-ol; 5:6-Cholesten-3beta-ol; Tegolan; 3beta-Hydroxycholest-5-ene; 5-Cholesten-3beta-ol; Cholest-5-en-3-ol (3beta)-; 3-beta-Hydroxycholest-5-ene; (3beta)-cholest-5-en-3-ol; CCRIS 2834; Dastar; HSDB 7
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
N-[[14-[2-(Diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30053; SCHEMBL7496668; BDBM50214094
Click to Show/Hide
|
||||
| Activity |
EC50 > 210000 nM
|
[14] | |||
| Compound Name |
N-[[1-[2-(Diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL121547; SCHEMBL7046822; BDBM50471788
Click to Show/Hide
|
||||
| Activity |
EC50 > 210000 nM
|
[11] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-3-(naphthalen-1-ylmethyl)quinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267017; BDBM50213296
Click to Show/Hide
|
||||
| Activity |
EC50 > 210000 nM
|
[12] | |||
| Compound Name |
1-Cyclopropyl-3-[[4-(dimethylamino)phenyl]methyl]-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7689; BDBM50213808
Click to Show/Hide
|
||||
| Activity |
EC50 > 210000 nM
|
[12] | |||
| Compound Name |
N,N-Diethyl-2-[10-(methylaminomethyl)-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-14-yl]ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30099; BDBM50213997; N-Methyl-2-[2-(diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-methanamine
Click to Show/Hide
|
||||
| Activity |
EC50 > 220000 nM
|
[14] | |||
| Compound Name |
Methyl N-[[1-[2-(diethylamino)ethylamino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL333641; SCHEMBL6556787; BDBM50471785; methyl N-[[1-[[2-(diethylamino) ethyl]amino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]carbamate; methyl N-[[1-[[2-(diethylamino)ethyl]amino]-7-methoxy-9-oxothioxanthen-4-yl]-methyl]carbamate; methyl N-[[1-[[2-(diethylamino)ethyl]amino]-7-methoxy-9-oxothioxanthen-4-yl]methyl]carbamate
Click to Show/Hide
|
||||
| Activity |
EC50 > 220000 nM
|
[11] | |||
| Compound Name |
Methyl N-[[14-[2-(diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL29836; BDBM50214149
Click to Show/Hide
|
||||
| Activity |
EC50 > 220000 nM
|
[14] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-2-phenylquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319529; BDBM50231250
Click to Show/Hide
|
||||
| Activity |
EC50 > 220000 nM
|
[5] | |||
| Compound Name |
3-(Cyclohexylmethyl)-1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoroquinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL7722; BDBM50213797
Click to Show/Hide
|
||||
| Activity |
EC50 > 230000 nM
|
[12] | |||
| Compound Name |
N-[[14-[2-(Diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25908; SCHEMBL7494012; BDBM50213995
Click to Show/Hide
|
||||
| Activity |
EC50 > 230000 nM
|
[14] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-phenylquinolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97638; BDBM50231248; 1,4-Dihydro-1-cyclopropyl-2-phenyl-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline
Click to Show/Hide
|
||||
| Activity |
EC50 > 240000 nM
|
[5] | |||
| Compound Name |
[[2-[2-(Diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-yl]methyl]carbamic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27542; SCHEMBL7493287; BDBM50213998
Click to Show/Hide
|
||||
| Activity |
EC50 > 240000 nM
|
[14] | |||
| Compound Name |
N-[[14-[2-(Diethylamino)ethyl]-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-10-yl]methyl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL280609; BDBM50213994; N-[[2-[2-(Diethylamino)ethyl]-9-methoxy-2H-[1]benzothiopyrano[4,3,2-cd]indazol-5-yl]methyl]formamide
Click to Show/Hide
|
||||
| Activity |
EC50 > 240000 nM
|
[14] | |||
| Compound Name |
(2-(Diethylamino)ethyl]-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL281022; BDBM50214093; 2-[2-(Diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-methanamine
Click to Show/Hide
|
||||
| Activity |
EC50 > 250000 nM
|
[14] | |||
| Compound Name |
2-[10-(Aminomethyl)-4-methoxy-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-14-yl]-N,N-diethylethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27064; BDBM50214092; (2-(Diethylamino)ethy]-9-methoxy-2H-[1]-benzothiopyrano[4,3,2-cd]indazole-5-methanamine; 2-[2-(Diethylamino)ethyl]-9-methoxy-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-methanamine
Click to Show/Hide
|
||||
| Activity |
EC50 > 260000 nM
|
[14] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-2-methyl-4-oxoquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96705; BDBM50231260
Click to Show/Hide
|
||||
| Activity |
EC50 > 260000 nM
|
[5] | |||
| Compound Name |
N-[[14-[2-(Diethylamino)ethyl]-8-thia-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl]methyl]formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287205; BDBM50213999; N-[[2-[2-(Diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole-5-yl]methyl]formamide
Click to Show/Hide
|
||||
| Activity |
EC50 > 260000 nM
|
[14] | |||
| Compound Name |
(2R)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49545; CTK0I0978; DTXSID50435146; Win-58161-2; BDBM50212861
Click to Show/Hide
|
||||
| Activity |
EC50 > 260000 nM
|
[4] | |||
| Compound Name |
1-[[2-(Diethylamino)ethyl]amino]-4-[(methylamino)methyl]thioxanthen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330996; SCHEMBL6556790; BDBM50471787; 1-[2-(diethylamino)ethylamino]-4-(methylaminomethyl)thioxanthen-9-one; 1-[[2-(Diethylamino)ethyl]amino]-4-[(methylamino)methyl]-9H-thioxanthen-9-one
Click to Show/Hide
|
||||
| Activity |
EC50 > 270000 nM
|
[11] | |||
| Compound Name |
(2S)-6-(2,6-Dimethylpyridin-4-yl)-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49666; BDBM50212864
Click to Show/Hide
|
||||
| Activity |
EC50 > 290000 nM
|
[4] | |||
| Compound Name |
1,4-Dihydro-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94321; BDBM50231256; 7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-1H-quinoline-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[5] | |||
| Compound Name |
(2S)-6-(2,6-Dimethylpyridin-4-yl)-2-ethyl-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL49381; SCHEMBL10515996; BDBM50212871
Click to Show/Hide
|
||||
| Activity |
EC50 = 420000 nM
|
[4] | |||
| Compound Name |
1-Cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-5-phenylsulfanylquinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL96509; SCHEMBL1385535; BDBM50231262
Click to Show/Hide
|
||||
| Activity |
EC50 > 420000 nM
|
[5] | |||
| Compound Name |
1,4-Dihydro-1-(4-fluorophenyl)-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328719; BDBM50231253
Click to Show/Hide
|
||||
| Activity |
EC50 > 430000 nM
|
[5] | |||
| Compound Name |
[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354794; BDBM50097532; (5alpha-Cholestane-3beta-yloxy)acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
Dihydrocholesterol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
beta-Cholestanol; 5alpha-Cholestan-3beta-ol; Zymostanol; 5alpha-Cholestanol; CHOLESTANOL; Cholestan-3beta-ol; Dihydrocholesterin; Cholestan-3-ol, (3beta,5alpha)-; 5-alpha-Cholestan-3-beta-ol; Cholestan-3-ol, (3b,5a)-; 3beta-Hydroxy-5alpha-cholestane; 3beta-Cholestanol; UNII-8M308U816E; MFCD00066413; NSC 18188; (5alpha)-cholestan-3beta-ol; (3beta,5alpha)-cholestan-3-ol; 8M308U816E; Epicholestanol; Cholestan-3-ol, (3.beta.,5.alpha.)-; Cholestanol (VAN); 3beta-Hydroxycholestane; 5alpha-Dihydrocholesterol; Cholestan-3-ol, (3.beta.)- #; 5a-Cholestanol; Cholestan-3b-ol; EINECS 201-315-8; 3b-Hydroxycholestane; 5a-Dihydrocholesterol; 5a-Cholestan-3b-ol; 3b-Hydroxy-5a-cholestane; bmse000541; (3b,5a)-Cholestan-3-ol; SCHEMBL133951; (5 )-cholestan-3 -ol; (+)-Dihydrocholesterol solution; CHEMBL1289436; CTK3E8365; 5^a-Cholestan-3^b-ol, 98%; DTXSID40883258; ZINC4262223; ANW-41621; LMST01010077; s5123; 5alpha-Cholestan-3beta-ol, >=95%; Cholestane, 3beta-hydroxy-, 5alpha-; AKOS016036214; ACN-048867; CCG-268506; AS-58118; HY-107819; CS-0030696; Q27159255; 1814DD66-70FE-4610-86FB-FA8455101768; Cholestanol, United States Pharmacopeia (USP) Reference Standard; Cholestanol solution, certified reference material, 10 mg/mL in chloroform
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189703; SCHEMBL16306859; BDBM50153106
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]ethane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3138039
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-[2-(Diethylamino)ethylamino]-7-methoxy-4-(methylaminomethyl)thioxanthen-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL332805; SCHEMBL6556664; BDBM50471778
Click to Show/Hide
|
||||
| Activity |
EC50 > 500000 nM
|
[11] | |||
| Compound Name |
[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364611; BDBM50153113
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
2-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188403; SCHEMBL9456417; BDBM50153118
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
2-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185640; SCHEMBL9456505; BDBM50153114
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-[(3S,10R,13R,17R)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364431; BDBM50153112
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-[(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-ethane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189088; BDBM50153108
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(3S,10R,13R,17R)-17-((E)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186373; SCHEMBL15694752; BDBM50153109
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
2-[(3S,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-3-yloxy]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL875595; CHEMBL3138442
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2,2-dimethyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45755; BDBM50212865
Click to Show/Hide
|
||||
| Activity |
EC50 = 510000 nM
|
[4] | |||
| Compound Name |
1-[[2-(Diethylamino)ethyl]amino]-4-(formylaminomethyl)-9H-thioxanthene-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120915; SCHEMBL6556689; BDBM50471782; N-[[1-[2-(diethylamino)ethylamino]-9-oxothioxanthen-4-yl]methyl]formamide
Click to Show/Hide
|
||||
| Activity |
EC50 = 510000 nM
|
[11] | |||
| Compound Name |
1,4-Dihydro-1-(2-fluoroethyl)-4-oxo-6,8-difluoro-7-(2,6-dimethylpyridin-4-yl)quinoline-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319939; BDBM50231251
Click to Show/Hide
|
||||
| Activity |
EC50 > 530000 nM
|
[5] | |||
| Compound Name |
(2R)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50551; SCHEMBL10516237; BDBM50212867
Click to Show/Hide
|
||||
| Activity |
EC50 > 540000 nM
|
[4] | |||
| Compound Name |
6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL542357; BDBM50212866
Click to Show/Hide
|
||||
| Activity |
EC50 > 560000 nM
|
[4] | |||
| Compound Name |
1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45887; SCHEMBL9720517; Win-52522; BDBM50212869; 7-(2,6-dimethylpyridin-4-yl)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 > 570000 nM
|
[4] | |||
| Compound Name |
(2S)-6-(2,6-Dimethylpyridin-4-yl)-7-fluoro-2-methyl-10-oxo-1,4-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43881; BDBM50212868
Click to Show/Hide
|
||||
| Activity |
EC50 = 730000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg Med Chem Lett. 1999 May 3;9(9):1219-24. | ||||
| REF 2 | 9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships. J Med Chem. 1995 Aug 18;38(17):3226-35. | ||||
| REF 3 | Synthesis and biological activities of NB-506 analogues modified at the glucose group. Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22. | ||||
| REF 4 | Relationship of structure of bridged (2,6-dimethyl-4-pyridinyl)quinolones to mammalian topoisomerase II inhibition. Bioorg Med Chem Lett. 1993 Aug;3(8):1711-6. | ||||
| REF 5 | Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives. J Med Chem. 1993 Sep 17;36(19):2801-9. | ||||
| REF 6 | Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41(23):4475-85. | ||||
| REF 7 | Molecular design of cholesterols as inhibitors of DNA polymerase alpha. J Med Chem. 2004 Sep 23;47(20):4971-4. | ||||
| REF 8 | Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II. Bioorg Med Chem Lett. 2005 Jun 15;15(12):2966-9. | ||||
| REF 9 | Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1669-72. | ||||
| REF 10 | Potent mammalian topoisomerase II inhibitors: 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-substituted-quinolines. Bioorg Med Chem Lett. 1995 Feb 16;5(4):399-404. | ||||
| REF 11 | Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives. J Med Chem. 1998 Sep 10;41(19):3645-54. | ||||
| REF 12 | 3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II. Bioorg Med Chem Lett. 1995 May 4;5(9):1021-6. | ||||
| REF 13 | Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors. J Med Chem. 1998 May 21;41(11):1956-61. | ||||
| REF 14 | Cyclic variations of SR 233377 (WIN 33377) and effects on antitumor activity. Bioorg Med Chem Lett. 1996 Jun 18;6(12):1345-50. | ||||
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