Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94627 | Target Info | |||
| Target Name | Solute carrier family 28 member 2 (SLC28A2) | ||||
| Synonyms |
hCNT2; Sodium/purine nucleoside co-transporter; Sodium/nucleoside cotransporter 2; Sodium-coupled nucleoside transporter 2; SPNT; Na(+)/nucleoside cotransporter 2; Concentrative nucleoside transporter 2; CNT2; CNT 2
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| Target Type | Literature-reported Target | ||||
| Gene Name | SLC28A2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phlorizin
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Investigative | Compound Info | ||
| Synonyms |
Phlorizin; Phloridzin; 60-81-1; Phlorhizin; Phlorizoside; Floridzin; Phlorrhizin; Phloretin 2'-glucoside; Phlorrhizen; Phloridzosid; Phlorizine; UNII-CU9S17279X; Phloretin-2'-O-beta-glucoside; AI3-19835; NSC 2833; Phloridzin dihydrate; EINECS 200-487-1; Phloretin-2'-beta-glucoside; CHEBI:8113; CHEMBL245067; IOUVKUPGCMBWBT-QNDFHXLGSA-N; CU9S17279X; 2'-(beta-D-Glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone; 1-[2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone; 1-Propanone, 1-(2-(b
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
Adenosine-derived inhibitor, 6
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL473365; SCHEMBL6765512; BDBM32372; (2R,3R,4S,5R)-2-[6-amino-8-(benzylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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| Activity |
IC50 = 52000 nM
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[2] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-methylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427677; BDBM50085543
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| Activity |
IC50 = 65000 nM
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[2] | |||
| Compound Name |
5'-o-Acetyladenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427691; SCHEMBL219554; adenosine 5'-methylcarboxamide; BDBM50085525; ZINC13547650; [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl acetate; ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl acetate
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl ethyl carbonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427696; SCHEMBL7925039; BDBM50085465
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hexanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427693; BDBM50085500
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-benzylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427701; BDBM50085446
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl 2-phenylacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427694; BDBM50085467
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-methoxyphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427683; BDBM50085535
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-pentylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427700; BDBM50085447
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-methylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427699; BDBM50085462
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl methyl carbonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427695; BDBM50085466
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl benzyl carbonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427698; BDBM50085463
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Propionyl adenylate
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Investigative | Compound Info | ||
| Synonyms |
5'-O-propanoyladenosine; Ado-5'-ethylcarboxylate; adenosine-5'-ethylcarboxamide; CHEMBL3427692; SCHEMBL11519682; BDBM82052; [3h]adenosine 5'-ethylcarboxamide; Q27144702
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-[(2-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427688; BDBM50085529
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl pentyl carbonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427697; BDBM50085464
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL7226454; CHEMBL1096694
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Floxuridine
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Approved | Compound Info | ||
| Synonyms |
floxuridine; 50-91-9; 2'-Deoxy-5-fluorouridine; 5-Fluorodeoxyuridine; Fluorodeoxyuridine; Floxuridin; FUDR; Fluoruridine deoxyribose; Deoxyfluorouridine; 5-Fluoro-2'-deoxyuridine; FdUrd; Floxuridinum; Floxiridina; 5FdU; 5-fluoro-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione; 5-Fluoro-2-desoxyuridine; 5 Fluorodeoxyuridine; Floxuridinum [INN-Latin]; FDUR; Floxiridina [INN-Spanish]; beta-5-Fluoro-2'-deoxyuridine; 5-Fluoro-2-deoxyuridine; 5-FdUrd; 5-Fluorouracil deoxyriboside; Sterile fudr (TN); Floxuridine/5-fluorouracil
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| Activity |
IC50 > 1000000 nM
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[2] | |||
| Compound Name |
Tecadenoson
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Discontinued in Phase 3 | Compound Info | ||
| Synonyms |
CVT-510; 204512-90-3; UNII-GZ1X96601Z; CHEMBL392149; GZ1X96601Z; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol; BDBM50224766; Tecadenoson [USAN:INN]; Tecadenoson (USAN/INN); AC1L4KMO; SCHEMBL246787; GTPL5592; CHEMBL356254; DTXSID80174415; BDBM50138530; DB04954; N6-[3-(R)-tetrahydrofuranyl]adenosine; HY-19661; Adenosine, N-(3R)-tetrahydro-3-furanyl-; LS-190860; Adenosine, N-(3R)-tetrahydro-3-furanyl)-; CS-0016174; D06019; CVT-510; N-(3-Tetrahydrofuranyl)-6-aminopurine riboside; Selenocompounds
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| Activity |
Ki = 231000 nM
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[3] | |||
| Compound Name |
CID 59034940
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427669; SCHEMBL6761618; BDBM50085546; (2R,3R,4S,5R)-2-[6-amino-8-(2-phenylethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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| Activity |
IC50 = 233000 nM
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[2] | |||
| Compound Name |
CID 54553601
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427668; SCHEMBL6744321; BDBM50085544; (2R,3R,4S,5R)-2-(6-amino-8-anilinopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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| Activity |
IC50 = 289000 nM
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[2] | |||
| Compound Name |
Adenosine, 8-[(3-phenylpropyl)amino]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427670; SCHEMBL6760526; BDBM50085547; (2R,3R,4S,5R)-2-[6-amino-8-(3-phenylpropylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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| Activity |
IC50 = 536000 nM
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[2] | |||
| Compound Name |
7,8,3'-Trihydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
7,8-dihydroxy-2-(3-hydroxyphenyl)chromen-4-one; 7,8-dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one; CHEMBL225513; 4H-1-Benzopyran-4-one, 7,8-dihydroxy-2-(3-hydroxyphenyl)-; TNP00054; 3',7,8-Trihydroxyflavone; 7,8,3''-Trihydroxyflavone; 7,8,3'-Trihydroxy Flavone; SCHEMBL4649946; CTK4C0843; ZINC39320; DTXSID00350274; BDBM50157558; MFCD00143512; AKOS024282399; MCULE-1925242226; NCGC00017190-01; NCGC00017190-02; NCGC00142444-01; ST056013; FT-0707045; J-007031; 7,8-dihydroxy-2-(3-hydroxyphenyl)-4H-benzopyran-4-one
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| Activity |
IC50 > 1000000 nM
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[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21. | ||||
| REF 2 | Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. | ||||
| REF 3 | Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22. | ||||
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