Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92557 | Target Info | |||
| Target Name | Branched-chain-amino-acid transaminase 1 (BCAT1) | ||||
| Synonyms |
Protein ECA39; ECA39; Branched-chain-amino-acid aminotransferase, cytosolic; BCT1; BCAT(c)
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| Target Type | Literature-reported Target | ||||
| Gene Name | BCAT1 | ||||
| Biochemical Class | Transaminase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N''-[(4-Methylphenyl)sulfonyl]dibenzo[b,d]furan-2-carbohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL380652; BDBM50172938
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
5-Methoxy-N''-(phenylsulfonyl)-1H-indole-2-carbohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL378801; BDBM50172939
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| Activity |
IC50 = 56800 nM
|
[1] | |||
| Compound Name |
2-Prop-2-ynylsulfanyl-5-thiophen-2-yl-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1825197; BDBM50353008
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| Activity |
IC50 = 105000 nM
|
[2] | |||
| Compound Name |
N'-[(1E)-(Dimethylamino)methylidene]benzenesulfonohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1825198; HMS1669M04; BDBM50353009; AKOS005097060; CCG-254568; 6D-016
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| Activity |
IC50 = 150000 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Oxo-3-phenylphthalazine-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1825199; BDBM50353010
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| Activity |
IC50 = 360000 nM
|
[2] | |||
| Compound Name |
4-Chloro-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1825200; 4-chloro-6-oxo-1-phenyl-1,6-dihydro-3-pyridazinecarbonitrile; Oprea1_139736; SCHEMBL15422556; ZINC1385292; BDBM50353011; MFCD00141173; AKOS015992511; MCULE-4847623512; KS-000035B2; 3F-011
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| Activity |
IC50 = 650000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. | ||||
| REF 2 | Cracking the molecular weight barrier: fragment screening of an aminotransferase using an NMR-based functional assay. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5248-50. | ||||
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