Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91959 | Target Info | |||
| Target Name | NAD-dependent deacetylase sirtuin-3 (SIRT3) | ||||
| Synonyms |
hSIRT3; SIR2L3; SIR2-like protein 3; Regulatory protein SIR2 homolog 3
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SIRT3 | ||||
| Biochemical Class | Sirtuin family. Class I subfamily | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 49 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
SEN-196
Click to Show/Hide
|
Phase 2 | Compound Info | ||
| Synonyms |
EX-527; SEN-0014196; SIRT1 inhibitors (Huntingtons disease), Elixir/Siena; Sirtuin-1 inhibitors (oral, Huntington's disease), Elixir/Siena
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
US9359293, TB
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103198; CHEMBL3968962; BDBM234206; US9359293, TB
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[2] | |||
| Compound Name |
US9359293, TM
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103197; CHEMBL3940508; BDBM234208; US9359293, TM
Click to Show/Hide
|
||||
| Activity |
IC50 = 124000 nM
|
[2] | |||
| Compound Name |
AGK2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AGK-2; AGK 2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; CHEMBL112265; 352549-39-4; CBMicro_001045; Cambridge id 5870454; AC1N6ME3; Oprea1_743470; SCHEMBL251128; CTK1B0687; DTXSID20401358; MolPort-000-735-346; HMS1632P07; SMSF0008851; STL525366; BDBM50178767; carboxamido-1,2,3-tetrahydrocarbazole; AKOS004917884; CB02357; BIM-0000968.P001; SR-01000154363; SR-01000154363-1; 1H-Carbazole-1-carboxamide, 2,3,4,9-tetrahydro-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone; CHEMBL226115; (4-chlorophenyl)(4-(8-nitroquinolin-5-yl)piperazin-1-yl)methanone; (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone; Methanone,(4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-; (4-chlorophenyl)[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone; ACMC-20ejph; CBMicro_046888; Oprea1_532455; SCHEMBL6267516; CTK4A9445; DTXSID30398200; HMS3261L20; ZINC4543674; Tox21_500619; BDBM50216685; CPNQ, >=98% (HPLC), solid; MFCD02039810; STK148613; AKOS000424462; CCG-221923; LP00619; MCULE-5005665656; SDCCGSBI-0046858.P002; NCGC00186018-01; NCGC00261304-01; ST073924; BIM-0046858.P001; B7209; EU-0040310; SR-01000452429; J-003317; SR-01000452429-1; BRD-K04722205-001-01-1; Q27216092; 4-chlorophenyl 4-(8-nitro(5-quinolyl))piperazinyl ketone; Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(2-(1-(Thieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl)ethyl)pivalamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338821; SCHEMBL16023502; BDBM50431098; ZINC95591886; DA-27476; 2,2-dimethyl-N-[2-(1-thieno[3,2-d]pyrimidin-4-ylpiperidin-4-yl)ethyl]propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Cyano-N-(quinolin-8-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225914; SCHEMBL10065537; DTXSID70360825; ZINC943066; SMSF0008510; BDBM50216687; AKOS001021423; CB00298; ST50077821; F0344-1620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(Ethylamino)thieno[3,2-d]pyrimidine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332048; SCHEMBL16023443; BDBM50431111; ZINC95588965; DA-22207; FT-0758725; Thieno[3,2-d]pyrimidine-6-carboxamide, 4-(ethylamino)-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228175; ZINC943069; SMSF0008610; BDBM50216691; AKOS001027775; CB00087; ST50077786; 3-(5-(2-CHLOROPHENYL)-2-FURYL)-2-CYANO-N-(5-QUINOLINYL)ACRYLAMIDE; (2E)-3-[5-(2-chlorophenyl)(2-furyl)]-2-cyano-N-(5-quinolyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(Azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-308B6B695N; C19H21BrN2O3S; CHEMBL3222141; 308B6B695N; 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide; 3-(azepane-1-sulfonyl)-N-(3-bromophenyl)benzamide; Oprea1_876929; MLS006011706; SIRT2 Inhibitor II, AK-7; SCHEMBL1095726; DTXSID30194926; HMS3740I05; HMS3886F07; BCP09325; EX-A4162; ZINC1159030; BDBM50008859; MFCD03140195; s5914; AKOS001632674; Benzamide, N-(3-bromophenyl)-3-((hexahydro-1H-azepin-1-yl)sulfonyl)-; CS-3223; MCULE-6804773508; NE52645; AK-7, >=98% (HPLC); NCGC00347936-01; NCGC00347936-06; BS-16806; DA-35352; HY-16691; SMR004703433; EU-0004902; FT-0702786; Y1898; A12904; AB00115363-01; SR-01000432494; 3-(1-azepanylsulfonyl-)-N-(3-bromophenyl)benzamide; SR-01000432494-1; Q27255930; N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-(4-(2-pivalamidoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338820; SCHEMBL16023444; BDBM50431099; ZINC95592542; DA-21543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(5-(2-Chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225971; (E)-3-(5-(2-chlorophenyl)furan-2-yl)-2-cyano-N-(quinolin-8-yl)acrylamide; ZINC943061; BDBM50216686; AKOS002185214; ST50077790; F0344-1610; (2E)-3-[5-(2-chlorophenyl)(2-furyl)]-2-cyano-N-(8-quinolyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4217034
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4128509
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276139
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2-Cyano-N-(quinolin-5-yl)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225797; SCHEMBL10065540; ZINC943067; BDBM50216688; AKOS001027800; 2-CYANO-N-(5-QUINOLINYL)-3-(5-(3-(TRIFLUOROMETHYL)PHENYL)-2-FURYL)ACRYLAMIDE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4218670
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-Chlorothieno[3,2-d]pyrimidine-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2332049; MFCD28098923; SCHEMBL16011549; BDBM50431110; ZINC95587098; BS-15119; DA-39503; SY265452; FT-0767097; Thieno[3,2-d]pyrimidine-6-carboxamide, 4-chloro-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4211748
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390332; ZINC943073; SMSF0008652; BDBM50216693; STK841558; AKOS001027776; CB00144; (2E)-2-cyano-3-[5-(2,3-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Cyano-3-(5-(2,3-dichlorophenyl)furan-2-yl)-N-(quinolin-8-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226027; SMSF0008553; ZINC1751305; BDBM50216690; AKOS002185154; CB00152; ST50077753; (2E)-3-[5-(2,3-dichlorophenyl)(2-furyl)]-2-cyano-N-(8-quinolyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[4-[2-(2,2-Dimethylpropanoylamino)ethyl]piperidin-1-yl]thieno[3,2-d]pyrimidine-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338819; SCHEMBL16023441; BDBM50431100; ZINC95591497; DA-21541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4218205
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-6-Acetamido-2-[[(2S)-2-[[(2S)-2,6-diacetamidohexanoyl]amino]-6-[(2-iodoacetyl)amino]hexanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885246; BDBM50209631
Click to Show/Hide
|
||||
| Activity |
IC50 = 54200 nM
|
[8] | |||
| Compound Name |
(3S,16S)-3-[4-(Ethanethioylamino)butyl]-2,5,10-trioxo-1,4,7,11-tetrazacyclohexadecane-16-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935689; BDBM50197511
Click to Show/Hide
|
||||
| Activity |
IC50 = 56900 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(2S)-5-Acetamido-1-amino-1-oxopentan-2-yl]-6-(carbamothioylamino)-2-[[(2S)-2,5-diacetamidopentanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814814; BDBM50350509
Click to Show/Hide
|
||||
| Activity |
IC50 = 57200 nM
|
[10] | |||
| Compound Name |
5-[[3-[(4-Thiophen-2-ylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805479; SCHEMBL18340667; BDBM50168493
Click to Show/Hide
|
||||
| Activity |
IC50 = 66400 nM
|
[11] | |||
| Compound Name |
Tenovin-6
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Tenovin 6; CHEMBL595354; MFCD11976906; C25H34N4O2S; 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide; Tnv 6; SCHEMBL907478; US8501991, Tenovin 6; BDBM99917; CTK8E8404; AOB3690; DTXSID50647242; EX-A350; HMS3648C14; HMS3652F12; BCP08547; 2064AH; ZINC43196009; AKOS026750220; CCG-208692; CS-1976; NCGC00263616-04; AC-32966; AS-16762; DA-48390; HY-15510; QC-10485; AB0098114; Tenovin6 ;Tenovin 6;Tnv-6; Tnv6;Tnv 6; FT-0708864; SW220061-1; A12305; SR-01000946351; J-000331; SR-01000946351-1; Q27147321
Click to Show/Hide
|
||||
| Activity |
IC50 = 82650 nM
|
[6] | |||
| Compound Name |
5-[[3-[(4-Phenoxybenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804901; SCHEMBL18340495; BDBM50168851
Click to Show/Hide
|
||||
| Activity |
IC50 = 85800 nM
|
[11] | |||
| Compound Name |
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SirReal2; SirReal 2; CHEMBL3770903; C22H20N4OS2; SCHEMBL20609259; SirReal2, >=98% (HPLC); ZINC818861; BDBM50148781; s7845; STL019057; AKOS000651216; CCG-268892; MCULE-6908094772; NCGC00387496-01; NCGC00387496-03; HY-100591; CS-0019744; ST50111553; AB00358713-02; Q27454123; F1762-0644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(5-{3-[(1-Benzyl-1h-1,2,3-Triazol-4-Yl)methoxy]benzyl}-1,3-Thiazol-2-Yl)-2-[(4,6-Dimethylpyrimidin-2-Yl)sulfanyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Sirt2-IN-1; CHEMBL4228286; BDBM50459842; HY-112427; CS-0046043; Q27455747
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide; CHEMBL446446; (Z)-non-2-enoic acid; Oprea1_323938; MLS001163802; SCHEMBL1873844; CTK1C1311; DTXSID50394183; HMS2873H18; 1658AJ; BDBM50178766; MFCD00846509; STK524333; AKOS005458227; MCULE-1772644300; SB36878; SMR000539218; FT-0701854; 2-Chloro-5,6,7,8,9,10-hexahydro-cycloheptabindole-6-carboxylic acid amide; 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[3-[1-(2-Cyclopentylethyl)-1H-1,2,3-triazole-4-yl]anilino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236132; A1B11; 2-{3-[1-(2-Cyclopentyl-ethyl)-1H-[1,2,3]triazol-4-yl]-phenylamino}-benzamide; BDBM50004135; ZINC169312798
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-(4-Bromopyridine-3-yl)-3-(naphthalene-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358391; BDBM50041529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4170094
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50449710; L5C
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-((2-Methoxynaphthalen-1-yl)methyl)-7-((pyridin-3-ylmethyl)amino)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3h)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ICL-SIRT078; CHEMBL3769975; SCHEMBL17713120; BDBM50148827
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-[[[4-Oxo-3-(quinolin-8-ylmethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-7-yl]amino]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101347; BDBM50501437
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Chembl4227437
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MZ-242; BDBM50459845
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(S)-Benzyl 6-ethanethioamido-1-oxo-1-(phenylamino)hexan-2-ylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584353; SCHEMBL8079485; BDBM50300464; benzyl N-[(2S)-1-anilino-6-(ethanethioylamino)-1-oxohexan-2-yl]carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SIRT1-IN-1; CHEMBL115600; SMR000041923; ChemDiv3_015530; Oprea1_169494; MLS000036457; SCHEMBL8244015; HMS1517B20; HMS2582N08; HMS3448P13; BDBM50178773; STL336698; AKOS021714064; MCULE-4334993191; HY-136199; CS-0120561; SR-01000001381; SR-01000001381-2; (6-Methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)formamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SirReal-1; CHEMBL3769988; N-(5-Benzylthiazol-2-yl)-2-((4,6-dimethylpyrimidin-2-yl)thio)acetamide; BAS 09687674; SirReal1; ZINC818843; BDBM50148776; STL019032; AKOS000651417; MCULE-7999871379; J3.601.436I; Q27454126; N-[(4,6-Dimethyl-2-pyrimidinylthio)acetyl]-5-benzylthiazole-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Chembl4225505
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50459843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Sirt2-PROTAC-1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PROTAC Sirt2 Degrader-1; CHEMBL4225467; BDBM50459841; HY-103636; CS-0028486
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[4-(1-Benzyl-1H-1,2,3-triazole-4-yl)anilino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236133; A2B57; 2-[4-(1-Benzyl-1H-[1,2,3]triazol-4-yl)-phenylamino]-benzamide; BDBM50004137; ZINC169312799
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Phenyl N-[1-anilino-6-(heptanethioylamino)-1-oxohexan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972352; SCHEMBL18103199; BDBM234207; US9359293, TH
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[2] | |||
| Compound Name |
4-[[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]carbamoyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805568; SCHEMBL18340130; BDBM50168845
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[11] | |||
| Compound Name |
5-((1-Benzyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203539; SCHEMBL13848145; BDBM50400726; STK712145; STL148947; ZINC01839069; ZINC17194778; AKOS000411048; AKOS005750442; MCULE-7810132475; AB00092468-01; F0777-1498
Click to Show/Hide
|
||||
| Activity |
IC50 = 116300 nM
|
[17] | |||
| Compound Name |
4-[(2-Chloro-6-hydroxyquinolin-5-yl)methyl]-5-(4-propan-2-ylphenyl)-1,2-dihydropyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233748; BDBM50004795
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[18] | |||
| Compound Name |
3-[(2-Methoxynaphthalen-1-yl)methyl]-7-[(4-methoxyphenyl)methylamino]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091659; SCHEMBL17723184; BDBM50501455
Click to Show/Hide
|
||||
| Activity |
IC50 = 177400 nM
|
[15] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 28 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Resveratrol
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[19] | |||
| Compound Name |
CAMBINOL
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
cambinol; 14513-15-6; SIRT1/2 Inhibitor IV, Cambinol; NSC112546; NSC-112546; NSC-1125476; 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone; 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one; 5-(2-Hydroxy-naphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one; Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone; AC1MMYEF; NCIStruc2_001159; NCIStruc1_001428; SCHEMBL2538372; CHEMBL491960; CTK8G3107; BDBM29040
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[18] | |||
| Compound Name |
US9359293, TA
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL18103200; CHEMBL3892393; BDBM234205; US9359293, TA
Click to Show/Hide
|
||||
| Activity |
IC50 > 205000 nM
|
[2] | |||
| Compound Name |
SRT1720
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
925434-55-5; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide; SRT 1720; SRT-1720; SRT1720; CHEMBL257991; N-[2-[3-(1-PIPERAZINYLMETHYL)IMIDAZO[2,1-B]THIAZOL-6-YL]PHENYL]-2-QUINOXALINECARBOXAMIDE; N-(2-{3-[(Piperazin-1-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)quinoxaline-2-carboxamide; Tafluprost enone; N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide; IASPBORHOMBZMY-UHFFFAOYSA-N
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[19] | |||
| Compound Name |
5-[[3-(Adamantane-1-carbonylamino)phenyl]methoxy]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806274; SCHEMBL18340336; BDBM50168839
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-3-(4-methylphenyl)-2H-1,2-oxazol-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233749; BDBM50004887
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[18] | |||
| Compound Name |
Thiomyristoyl
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4129995; benzyl (S)-(1-oxo-1-(phenylamino)-6-tetradecanethioamidohexan-2-yl)carbamate; EX-A4227; BDBM50276140; MFCD30738003; s8245; ZINC616570764; CCG-270137; CS-6258; BS-15398; HY-101278; benzyl N-[(2S)-1-anilino-1-oxo-6-(tetradecanethioylamino)hexan-2-yl]carbamate
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[7] | |||
| Compound Name |
Tert-butyl N-[4-[(3-cyanophenyl)carbamoylamino]-2,2-dimethyl-3,4-dihydrochromen-6-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102380; BPDZ711; BPDZ 711; BPDZ-711; BDBM50267646; J3.655.329D; N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
N-[3-[(5-Carbamoylpyridin-3-yl)oxymethyl]phenyl]-6-thiophen-2-ylpyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805578; SCHEMBL18339922; BDBM50168930
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
5-[[3-[(4-Phenylbenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805001; SCHEMBL18339338; BDBM50168494
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
(s)-8-Bromo-6-chloro-2-pentylchroman-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164016; SCHEMBL17389374; BDBM50395320; (2S)-8-bromo-6-chloro-2-pentyl-2,3-dihydrochromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
5-[[3-[(4-Phenylmethoxybenzoyl)amino]phenyl]methoxy]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806073; SCHEMBL18339833; BDBM50168871
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
4-[(2-Hydroxy-3-methoxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233742; BDBM50004777
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[18] | |||
| Compound Name |
8-[4-Methyl-3-[(5Z)-5-[(Z)-[5-[[2-methyl-5-[(4,6,8-trisulfo-2H-naphthalen-1-ylidene)carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]cyclohexa-2,4-dien-1-ylidene]carbamoyl]iminocyclohexa-1,3-diene-1-carbonyl]iminocyclohexa-1,4-diene-1-carbonyl]imino-7H-naphthalene-1,3,5-trisulfonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3040216; BDBM50179360
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
4-[(6-Bromo-2-hydroxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-1,2-dihydropyrazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233739; BDBM50004765
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[18] | |||
| Compound Name |
(2S)-N-[(2S)-6-Acetamido-1-amino-1-oxohexan-2-yl]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]octanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814816; BDBM50350511
Click to Show/Hide
|
||||
| Activity |
IC50 = 213500 nM
|
[21] | |||
| Compound Name |
N-[1-(5-Carbamoyl-3-pyridyloxy)-5-naphthyl]-3-nitro-4-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343651; BDBM50030107
Click to Show/Hide
|
||||
| Activity |
IC50 = 232000 nM
|
[22] | |||
| Compound Name |
2-Anilinobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(phenylamino)benzamide; Benzamide, 2-(phenylamino)-; Benzamide, o-anilino-; CHEMBL561194; BRN 0782669; Anilinobenzamide; NSC75183; 2-Phenylaminobenzamide; 2-phenylamino-benzamide; 3-14-00-00903 (Beilstein Handbook Reference); ARONIS26963; SCHEMBL1318994; DTXSID50153151; KUC112561N; BENZAMIDE,2-(PHENYLAMINO)-; KS-00000S3U; KS-000048GW; ZINC1674116; BDBM50297159; MFCD00476529; NSC-75183; AKOS005279221; DS-8370; MCULE-6691808486; KSC-321-003; AK145944; DS-009752; BRD-K79647146-001-01-2
Click to Show/Hide
|
||||
| Activity |
IC50 = 235000 nM
|
[23] | |||
| Compound Name |
3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SRT1460; SRT-1460; SRT 1460; CHEMBL254156; SCHEMBL1302286; CTK8B7551; DTXSID40636044; ANW-57653; BDBM50228364; MFCD19053214; s6880; ZINC29043683; AKOS016001432; DB-079334; HY-124037; CS-0084007; FT-0751517; J-511115; BRD-K20979596-019-01-6
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[19] | |||
| Compound Name |
Ethyl 3-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-3-oxopropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170193; BDBM50396055
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[16] | |||
| Compound Name |
2-[3-(3-Fluorophenethyloxy)phenylamino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152621; 2-{3-(3-fluorophenethyloxy)phenylamino}benzamide; SCHEMBL16011487; BDBM50392055; 2-[3-[2-(3-fluorophenyl)ethoxy]anilino]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[24] | |||
| Compound Name |
(R)-N-(2-(3-((3-Hydroxypyrrolidin-1-yl)methyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-naphthamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SRT2183; SRT-2183; CHEMBL403308; SCHEMBL1325303; HMS3886H08; EX-A4217; BDBM50376978; s8270; ZINC29043608; CCG-269435; AC-33072; HY-19759; CS-0016574; Q7392861
Click to Show/Hide
|
||||
| Activity |
EC50 > 300000 nM
|
[19] | |||
| Compound Name |
2-((3-Phenethoxyphenyl)Amino)Benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152613; 2-[[3-(2-Phenylethoxy)phenyl]amino]benzamide; SCHEMBL17713131; 2-(3-phenethoxyphenylamino)benzamide; BDBM50392111; 2-[3-(Phenethyloxy)phenylamino]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[24] | |||
| Compound Name |
N-[4-[[3-[[2-(4,6-Dimethylpyrimidin-2-yl)sulfanylacetyl]amino]phenyl]methoxy]phenyl]thiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070149; SCHEMBL20067968; BDBM50242137
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Nicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
niacinamide; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Papulex; Aminicotin; Amixicotyn; Nicobion; Nicotylamide; Nikotinamid; Savacotyl; Benicot; Dipegyl; Endobion; Hansamid; Pelmine; Nicotinic amide; Delonin amide; Pelonin amide; Vi-Nicotyl; Austrovit PP; Inovitan PP; Vitamin B; Nicosylamide; Nicotilamide; Nicotililamido; Amnicotin; Niacevit; Nicamina; Nicamindon; Nicofort; Nicomidol; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; Nicasir; Nicogen; Nicota; Nicotol; Nicovit; Niko-tamin; 3-Carbamoylpyridine; Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; Nicosan 2; Nicotine amide; beta-Pyridinecarboxamide; Nikotinsaeureamid; Nicotylamidum; Mediatric; Nicotinsaureamid; Pyridine, 3-carbamoyl-; 3-Pyridinecarboxylic acid amide; Nicotinamidum; m-(Aminocarbonyl)pyridine; Acid amide; Factor pp; Nicotinamida; Nicovel; Vitamin B (VAN); Pelmin; Amid kyseliny nikotinove; Witamina PP; PP-Faktor; Amide PP; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Amid kyseliny nikotinove [Czech]; Nicotinamidum [INN-Latin]; Nicotinamida [INN-Spanish]; Nictoamide; CCRIS 1901; Dipigyl; HSDB 1237; Vi-noctyl; AI3-02906; Nicotinamide (Vitamin B3); NSC 13128; b-Pyridinecarboxamide; Niacinamide [USP]; UNII-25X51I8RD4; 3-(aminocarbonyl)pyridine; MFCD00006395; .beta.-Pyridinecarboxamide; CHEMBL1140; MLS000069714; 25X51I8RD4; NSC13128; Niacinamide (USP); NSC-13128; NSC-27452; Nicotinamide, 99%; NCGC00093354-03; NCGC00093354-05; SMR000058212; DSSTox_CID_929; Niacinamide;Nicotinic acid amide;Vitamin B3; WLN: T6NJ CVZ; DSSTox_RID_75873; DSSTox_GSID_20929; Niacinamide [USAN]; Enduramide; B3, Vitamin; Vitamin B 3; B 3, Vitamin; 3 Pyridinecarboxamide; SR-01000721872; Nicotinsaureamid Jenapharm; EINECS 202-713-4; Jenapharm, Nicotinsaureamid; Niacotinamide; Nicotinamid; nicotin-amide; Nicotinsaeureamid; 3-Amidopyridine; DEA No. 1405; Nicotinamide,(S); Vitamin B3 amide; 3-yridinecarboxamide; Nicotinamide [INN]; ACMC-20aizz; Mediatric (Salt/Mix); niacin - Vitamin B3; Opera_ID_775; Niacinamide(Vitamin B3); bmse000281; MolMap_000061; EC 202-713-4; SCHEMBL2926; Nicotinamide (JP17/INN); KSC237G2T; MLS001424246; SCHEMBL6278767; SGCUT00176; ZINC5878; DTXSID2020929; SCHEMBL19978192; BDBM27507; Nicotinamide, niacin, vitamin B3; HMS2052M21; HMS2090B05; HMS2093H03; HMS2236J03; HMS3370F21; HMS3394M21; HMS3655M20; HMS3713B22; HMS3884A16; Pharmakon1600-01505397; BCP07322; HY-B0150; Nicotinamide (Vitamin B3) solution; NSC27452; to_000073; Nicotinamide 1.0 mg/ml in Methanol; Nicotinamide, >=98.5% (HPLC); Nicotinamide, >=99.5% (HPLC); Tox21_111202; Tox21_201716; Tox21_302776; ANW-75549; BBL013003; NSC759115; s1899; SBB004283; STL163867; AKOS005715850; Tox21_111202_1; CCG-101149; CS-1968; DB02701; MCULE-3532732201; NC00399; NSC-759115; Nicotinamide, >=98% (HPLC), powder; NCGC00093354-04; NCGC00093354-06; NCGC00093354-09; NCGC00256432-01; NCGC00259265-01; AS-13845; Nicotinamide, puriss., 99.0-101.0%; SC-18039; Nicotinamide 10 microg/mL in Acetonitrile; Nicotinamide, tested according to Ph.Eur.; SBI-0206826.P001; DB-057754; FT-0631517; FT-0672696; FT-0773644; N0078; N1651; ST51037366; SW197779-3; EN300-15612; Niacinamide, meets USP testing specifications; 3418-EP2281816A1; 3418-EP2281818A1; 3418-EP2285778A1; 3418-EP2287165A2; 3418-EP2295424A1; 3418-EP2307377A1; 3418-EP2307378A1; 3418-EP2308858A1; 3418-EP2308874A1; 3418-EP2311808A1; 3418-EP2311829A1; C00153; D00036; J10422; Nicotinamide (Niacinamide), analytical standard; W-3583; 11783-EP2269610A2; 11783-EP2289510A1; 11783-EP2316457A1; 11783-EP2316458A1; 11783-EP2316825A1; 11783-EP2316826A1; 11783-EP2316827A1; 11783-EP2316828A1; AB00373895-13; AB00373895_15; AB00373895_16; Nicotinamide, Vetec(TM) reagent grade, >=98%; A845925; AC-907/25014114; Q192423; Q-201470; SR-01000721872-3; SR-01000721872-4; SR-01000721872-5; Z33546463; F2173-0513; A186B02E-6C70-4E54-9739-79398D439AAA
Click to Show/Hide
|
||||
| Activity |
IC50 = 377000 nM
|
[26] | |||
| Compound Name |
Chembl4129734
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276142
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
Chembl4128353
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50276141
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(2S)-6-Acetamido-2-[[(2S)-6-[6-(1,3-benzothiazol-2-ylsulfanyl)hexanoylamino]-2-[[(2S)-2,6-diacetamidohexanoyl]amino]hexanoyl]amino]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883974; BDBM50209638
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79. | ||||
| REF 2 | US patent application no. 9359293B2, Methods of treatment using modulators of SIRT2 | ||||
| REF 3 | Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton. Bioorg Med Chem. 2015 Jan 15;23(2):328-39. | ||||
| REF 4 | Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. | ||||
| REF 5 | Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9. | ||||
| REF 6 | Potent sirtuin inhibition with 1,2,5-trisubstituted benzimidazoles. Medchemcomm. 2016;7:2094-9. | ||||
| REF 7 | The mimics of N -acyl-lysine derived from cysteine as sirtuin inhibitors. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2375-2378. | ||||
| REF 8 | Bivalent SIRT1 inhibitors. Bioorg Med Chem Lett. 2017 Jan 15;27(2):180-186. | ||||
| REF 9 | Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N -thioacetyl-lysine. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5234-5239. | ||||
| REF 10 | A mechanism-based potent sirtuin inhibitor containing N-thiocarbamoyl-lysine (TuAcK). Bioorg Med Chem Lett. 2011 Aug 15;21(16):4753-7. | ||||
| REF 11 | 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. J Med Chem. 2016 Apr 14;59(7):2928-41. | ||||
| REF 12 | Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491. | ||||
| REF 13 | Identification of novel SIRT2-selective inhibitors using a click chemistry approach. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1871-4. | ||||
| REF 14 | X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823. | ||||
| REF 15 | Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. J Med Chem. 2017 Mar 9;60(5):1928-1945. | ||||
| REF 16 | SIRT1 modulation as a novel approach to the treatment of diseases of aging. J Med Chem. 2011 Jan 27;54(2):417-32. | ||||
| REF 17 | Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Oct 6;3(12):1050-3. | ||||
| REF 18 | Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. J Med Chem. 2014 Apr 24;57(8):3283-94. | ||||
| REF 19 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. | ||||
| REF 20 | Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines. J Med Chem. 2017 Jun 8;60(11):4714-4733. | ||||
| REF 21 | Potent sirtuin inhibition bestowed by l-2-amino-7-carboxamidoheptanoic acid (l-ACAH), a Nepsilon-acetyl-lysine analog. Medchemcomm. 2011;2:291-9. | ||||
| REF 22 | Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach. J Med Chem. 2014 Oct 23;57(20):8340-57. | ||||
| REF 23 | Development of second generation epigenetic agents. Medchemcomm. 2012;3:135-61. | ||||
| REF 24 | Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. J Med Chem. 2012 Jun 28;55(12):5760-73. | ||||
| REF 25 | Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. Eur J Med Chem. 2017 Jul 7;134:230-241. | ||||
| REF 26 | Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem. 2012 Sep;55:58-66. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.