Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E3NT
|
|||
| Former ID |
DIB018775
|
|||
| Drug Name |
AGK2
|
|||
| Synonyms |
AGK-2; AGK 2
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C23H13Cl2N3O2
|
|||
| Canonical SMILES |
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
|
|||
| InChI |
1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
|
|||
| InChIKey |
SVENPFFEMUOOGK-SDNWHVSQSA-N
|
|||
| CAS Number |
CAS 304896-28-4
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
1471919, 3402748, 8058490, 10130499, 26698117, 37091766, 48768232, 76422017, 87226560, 87950519, 90340935, 103517897, 104091025, 105574931, 110880364, 121362060, 130888503, 135698375, 137446706, 137927670, 143996525, 162248137, 163565071, 163598364, 163685831, 172649932, 172821421, 175608069, 177748612, 198987897, 227349208, 249565779, 252157114, 252457236
|
|||
| ChEBI ID |
CHEBI:94578
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | NAD-dependent deacetylase sirtuin-2 (SIRT2) | Target Info | Inhibitor | [2] |
| Pathway Interaction Database | Signaling events mediated by HDAC Class III | |||
| Signaling events mediated by HDAC Class I | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The Sir2 family of protein deacetylases. Annu Rev Biochem. 2004;73:417-35. | |||
| REF 2 | Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.