Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T91331 | Target Info | |||
| Target Name | Fibroblast growth factor receptor 3 (FGFR3) | ||||
| Synonyms |
JTK4; FGFR-3; CD333
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| Target Type | Successful Target | ||||
| Gene Name | FGFR3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-[6-[3-(trifluoromethyl)phenyl]-1H-indol-2-yl]methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676319; SCHEMBL10002755; BDBM130805; US8829199, 21
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
5-[5-Amino-4-(1H-indole-2-carbonyl)pyrazol-1-yl]-1,3-dihydrobenzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952373; BDBM50197688
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
OC1=CC=C(C=C1)C1=CC=C2C=Nnc2=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061296; SCHEMBL14663812; BDBM50280101
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| Activity |
IC50 = 51000 nM
|
[3] | |||
| Compound Name |
Chembl4162722
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280108
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4173432
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280107
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4163123
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280106
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4171043
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50280104
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 8829199B2, Aminopyrazole derivative | ||||
| REF 2 | Discovery of [5-Amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone (CH5183284/Debio 1347), An Orally Available and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor. J Med Chem. 2016 Dec 8;59(23):10586-10600. | ||||
| REF 3 | Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ACS Med Chem Lett. 2017 Nov 11;8(12):1264-1268. | ||||
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