Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90782 | Target Info | |||
| Target Name | P2Y purinoceptor 6 (P2RY6) | ||||
| Synonyms |
P2Y6; P2RY6; Adenosine P2Y6 receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | P2RY6 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Acid blue 25
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Investigative | Compound Info | ||
| Synonyms |
Acid Blue 25; 6408-78-2; C.I. ACID BLUE 25; UNII-S2E15W6FSN; S2E15W6FSN; W-110136; CHEMBL256057; 2-Anthracenesulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-, sodium salt (1:1); EINECS 229-068-1; EC 229-068-1; 2-Anthracenesulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-(phenylamino)-, monosodium salt; C20H13N2NaO5S; SCHEMBL790822; DTXSID2044711; CTK8F7553; Sodium 1-amino-9,10-dioxo-4-phenylaminoanthracene-2-sulphonate; MFCD00001214; Acid Blue 25, Dye content 45 %; AKOS015894441; AN-19165; Q394; I04-8965; sodium 1
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| Activity |
IC50 = 84600 nM
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[1] | |||
| Compound Name |
2-amino-uridine-5'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
iso-CMP; compound 13g [PMID: 21417463]
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
6-Hydroxyuridine-5'-Phosphate
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Investigative | Compound Info | ||
| Synonyms |
6-hydroxy-UMP; 6-HYDROXYURIDINE-5'-PHOSPHATE; 6-hydroxyuridine 5'-(dihydrogen phosphate); CHEMBL383923; 29741-00-2; Prfb acid; 1lor; 1dqx; 1eix; 6-hydroxyuridine 5'-phosphate; AC1Q69HY; AC1L4PT5; 5'-Uridylic acid,6-hydroxy-; SCHEMBL2130675; 5'-Uridylic acid, 6-hydroxy-; CTK4G3746; DTXSID50183892; Phosphoribofuranosylbarbituric acid; BDBM50199178; 6-Hydroxyuridine 5'-phosphoric acid; DB02890; 6-HYDROXYURIDINE-5''-PHOSPHATE; Barbituric acid ribonucleoside 5'-phosphate; 1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5''-monophosp
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Tetrasodium;4-[[3-formyl-4-hydroxy-5-methyl-2-(phosphonatooxymethyl)phenyl]diazenyl]benzene-1,3-disulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477339
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| Activity |
IC50 = 69000 nM
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[4] | |||
| Compound Name |
Cytidine-5'-diphosphate
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Investigative | Compound Info | ||
| Synonyms |
Cytidine 5'-diphosphate; Cytidine diphosphate; Cytidine 5'-(trihydrogen diphosphate); Cytidine coenzyme; Cytidine 5'-pyrophosphate; 5'-CDP; Cytidine 5'-diphosphoric acid; Cytidine 5'-pyrophosphoric acid; UNII-1ZH821MXU5; cytidine-diphosphate; BRN 0063920; CYTIDINE, 5'-(TRIHYDROGEN PYROPHOSPHATE); Cytidine pyrophosphate; Cytidine 5'-diphosphate disodium; 1ZH821MXU5; CHEMBL425252; EINECS 200-557-1; C9H15N3O11P2; Cytidine 5 -diphosphate; [3h]cytidine diphosphate; bmse000272; Cytidine 5''-pyrophosphate; 4-25-00-03675 (Beilstein Handbook Reference); Cytidine pyrophosphate (6CI); SCHEMBL154172; Cytidine 5''-diphosphoric acid; 3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide; SCHEMBL20609277; CTK5A8067; 5''-CDP; DTXSID501014481; ZINC8215624; BDBM50194153; Cytidine5'-(trihydrogen diphosphate); MFCD00066486; AKOS016010110; DB04555; cytidine 5''-(trihydrogen diphosphate); Cytidine 5'-(trihydrogen pyrophosphate); cytidine, 5'-(trihydrogen diphosphate); AS-11807; Cytidine, 5''-(trihydrogen pyrophosphate); Cytidine 5'-(trihydrogen diphosphate) (9CI); C00112; Cytidine 5'-(trihydrogen pyrophosphate) (8CI); Cytidine, mono(trihydrogen diphosphate) (ester); Cytidine 5 inverted exclamation mark -diphosphate; 393C594; Q416847; Cytidine 5'-(trihydrogen diphosphate-P-32P) (9CI); CYTIDINE 5-DIPHOSPHATE, PERIODATEOXIDIZ ED SODIUM; 689C62C2-5E68-4D32-9718-800937EE9942
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| Activity |
EC50 = 88000 nM
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[5] | |||
| Compound Name |
((2R,3S,4R,5R)-3,4-Dihydroxy-5-(2-(methylamino)-4-oxopyrimidin-1(4H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767423; BDBM50341894
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-(beta-D-Ribofuranosyl)-2-thio-uracil-5'-phosphate
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Investigative | Compound Info | ||
| Synonyms |
2-Thiouridine 5'-phosphate; CHEMBL384771; Polys2U; Poly-2-thiouridylic acid; 2-Thiouridine5'-phosphate; 2-thiouridine-5'-phosphate; SCHEMBL1881780; DTXSID60961901; 2-Thiouridine 5'-phosphoric acid; BDBM50199180; ZINC13517211; 5'-Uridylic acid, 2-thio-, homopolymer; Q27465498; 1-(BETA-D-RIBOFURANOSYL)-2-THIO-URACIL-5''-PHOSPHATE; 4-Hydroxy-1-(5-O-phosphonopentofuranosyl)pyrimidine-2(1H)-thione; 2-thio-1-beta-D-ribofuranosyl(3H)pyrimidine-2,4-dione 5''-monophosphate; 1-(5-O-phosphono-beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
5'-Uridylic acid, 3-(2-oxo-2-phenylethyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215381; CTK3I0370; DTXSID20475413; BDBM50199174; 3-phenacyl-1-beta-D-ribofuranosylpyrimidine-2,4-dione 5''-monophosphate
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-Propylthio-1-beta-D-ribofuranosylpyramidine-4-one-5''-diphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767411; BDBM50341882
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Ethylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767418; BDBM50341889
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Methylamino-1-beta-D-ribofuranosylpyrimidine-4-one-5''-diphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767416; BDBM50341887
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Amino-1-beta-D-ribofuranosylpyrimidine-4-one-5''-diphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767415; BDBM50341886
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
6-Propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-triphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL425805; BDBM50199172
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
6-Propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217391; BDBM50199182
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
[(2R,3S,5R)-5-[6-(Methylamino)purin-9-yl]-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL129841; MRS 2179; MRS-2179; CHEMBL1096400; MRS 2179 ammonium salt; Lopac0_000756; SCHEMBL134008; DTXSID701016926; ZINC3985980; BDBM50118229; BDBM50318029; n6-methyl-2'-deoxyadenosine-3',5'-bisphosphate; J-000339
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| Activity |
EC50 ~ 100000 nM
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[6] | |||
| Compound Name |
2-Benzylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767420; BDBM50341903
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[(1R,2R,4S,5S)-4-[2-Chloro-6-(methylamino)purin-9-yl]-2-phosphonooxy-1-bicyclo[3.1.0]hexanyl]methyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3085531; BDBM50026893
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| Activity |
EC50 ~ 100000 nM
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[6] | |||
| Compound Name |
2-Phenylethylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767421; BDBM50341891
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
[[(3Ar,4R,6R,6aR)-4-(2,4-dioxo-6-propyl-1H-pyrimidin-3-yl)-2-hydroxy-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217370; BDBM50199187; 6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 2'',3''-(cyclic phosphate) 5''-triphosphate
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N(3)-Methyluridine 5'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215940; N(3)-methyl-UMP; 3-N-methyluridine-5 '-phosphate; N(3)-methyluridine 5'-phosphate; BDBM50199190; 3-METHYLURIDINE-5'-MONOPHOSHATE; 3-METHYLURIDINE-5''-MONOPHOSHATE; 3-methyluridine 5'-(dihydrogen phosphate); Q27105026; 3-methyl-1-beta-D-ribofuranosyl-pyrimidine-2,4-dione 5''-monophosphate
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
1-beta-D-Ribofuranosyl(3H)pyrimidine-2,4,6-trione 5''-triphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL436959; BDBM50199188
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-Methylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767417; BDBM50341888
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Thiouridine-5'-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1230331; 1-(5-O-Phosphono-beta-D-ribofuranosyl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one; 4-Thiouridylic acid; 4-thio-UMP; S4UMP; 4-thiouridine monophosphate; 5'-Uridylic acid, 4-thio-; 4-Thiouracil 5'-monophosphate; SCHEMBL1402556; 4-Thiouridine 5'-phosphoric acid; 4-THIOURIDINE-5''-PHOSPHATE; BDBM50341895; ZINC13518042; 4-THIOURIDINE-5''-MONOPHOSPHATE; Q27454935
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| Activity |
EC50 ~ 100000 nM
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[2] | |||
| Compound Name |
({[({[(2R,3S,4R,5R)-4-Amino-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL385098; 2'NH2-UTP; SCHEMBL716498; BDBM50205405; 2'-amino-2'-deoxyuridine-5'-triphosphate; uridine 5'-(tetrahydrogen triphosphate), 2'-amino-2'-deoxy-
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| Activity |
EC50 ~ 100000 nM
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[7] | |||
| Compound Name |
Sodium;1-amino-9,10-dioxo-4-[4-(pyridin-3-ylmethylsulfanyl)anilino]anthracene-2-sulfonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090874; BDBM50237573
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
[[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[[[[(2S,3R,4S,5S)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113398; BDBM50403875
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| Activity |
EC50 ~ 100000 nM
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[9] | |||
| Compound Name |
6-Methyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 5''-monophosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215263; BDBM50199179
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| Activity |
EC50 ~ 100000 nM
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[3] | |||
| Compound Name |
Azane;tert-butyl [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162552
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| Activity |
EC50 = 108000 nM
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[10] | |||
| Compound Name |
Disodium;[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfonato phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3604024; BDBM50114076
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| Activity |
IC50 = 112000 nM
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[11] | |||
| Compound Name |
Click to Show/Hide
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Compound Info | |||
| Activity |
EC50 ~ 100000 nM
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[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. J Med Chem. 2011 Feb 10;54(3):817-30. | ||||
| REF 2 | Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. | ||||
| REF 3 | Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. | ||||
| REF 4 | Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem. 2008 Aug 14;51(15):4518-28. | ||||
| REF 5 | Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43. | ||||
| REF 6 | Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93. | ||||
| REF 7 | Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. | ||||
| REF 8 | Development of Potent and Selective Antagonists for the UTP-Activated P2Y 4 Receptor. J Med Chem. 2017 Apr 13;60(7):3020-3038. | ||||
| REF 9 | Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. Bioorg Med Chem Lett. 2001 Jan 22;11(2):157-60. | ||||
| REF 10 | Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. | ||||
| REF 11 | Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists. Bioorg Med Chem. 2015 Sep 1;23(17):5764-73. | ||||
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