Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86462 | Target Info | |||
| Target Name | Transthyretin (TTR) | ||||
| Synonyms |
TBPA; Prealbumin; PALB; ATTR
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| Target Type | Successful Target | ||||
| Gene Name | TTR | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Meclofenamic acid
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Approved | Compound Info | ||
| Synonyms |
Arquel; Meclofenamate; Acide meclofenamique; Acido meclofenamico; Acidum meclofenamicum; Meclophenamic acid; CL 583; INF 4668; Acide meclofenamique [INN-French]; Acido meclofenamico [INN-Spanish]; Acidum meclofenamicum [INN-Latin]; INF-4668; Meclomen (free acid); Meclofenamic acid (USAN/INN); Meclofenamic acid [USAN:INN:BAN]; N-(2,6-Dichloro-3-methylphenyl)anthranilic acid; N-(2,6-Dichloro-m-tolyl)anthranilic acid; N-(3-Methyl-2,6-dichlorophenyl)anthranilic acid; 2-((2,6-Dichloro-3-methylphenyl)amino)benzoic acid; 2-(2,6-Dichloro-3-methylphenyl)aminobenzoic acid; 2-(2,6-dichloro-3-methylanilino)benzoic acid; 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
Triclosan
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Approved | Compound Info | ||
| Synonyms |
triclosan; 3380-34-5; 5-CHLORO-2-(2,4-DICHLOROPHENOXY)PHENOL; 2,4,4'-Trichloro-2'-hydroxydiphenyl ether; Irgasan; Cloxifenolum; Triclosanum; Irgasan DP300; Stri-Dex Face Wash; Phenol, 5-chloro-2-(2,4-dichlorophenoxy)-; Lexol 300; Stri-Dex Cleansing Bar; 5-Chloro-2-(2,4-dichloro-phenoxy)-phenol; Triclosanum [INN-Latin]; CH 3565; DP-300; Caswell No 186A; C12H7Cl3O2; UNII-4NM5039Y5X; HSDB 7194; CHEBI:164200; Ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl; Phenyl ether, 2'-hydroxy-2,4,4'-trichloro-; EINECS 222-182-2; CHEMBL849; EPA; Aquasept; Cliniclean; Cloxifenol; Manusept; Sapoderm; TCL; Trisan; Clearasil DailyFace Wash; Dermtek Brand of Triclosan; GlaxoSmithKline Brand of Triclosan; Microshield T; Oxy Skin Wash; Pharmachem Brand of Triclosan; Reckitt Brand of Triclosan; SSL Brand of Triclosan; Ster Zac Bath Concentrate; SterZac Bath Concentrate; Trans Canaderm Brand of Triclosan; Triclosan Pharmachem Brand; Triclosan Reckitt Brand; IN1424; Irgasan DP 300; CH-3565; Johnson & Johnson Brand of Triclosan; Procter & Gamble Brand of Triclosan; Ster-Zac Bath Concentrate; Stri-Dex cleansing bar (TN); Triclosan (USP/INN); Triclosan [USAN:BAN:INN]; 2,4,4'-Trichloro-2'-hydroxy diphenyl ether; 2-Hydroxy-2',4,4'-trichlorodiphenyl Ether; WL-1001
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| Activity |
IC50 = 53500 nM
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[2] | |||
| Compound Name |
Niflumic Acid
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Approved | Compound Info | ||
| Synonyms |
Actol; Donalgin; Flunir; Forenol; Landruma; NFL; Niflactol; Niflam; Niflugel; Niflumate; Nifluril; Acide niflumique; Acide niflumique [French]; Acido niflumico; Acido niflumico [Italian]; Acidum niflumicum; Nifluminic acid; UPSA Conseil Brand of Niflumic Acid; Upsamedica Brand of Niflumic Acid; N 0630; SC 1332; UP 83; UPSA Brand 1 of Niflumic Acid; UPSA Brand 2 of Niflumic Acid; Acid, Niflumic; Acide niflumique [INN-French]; Acido niflumico [INN-Spanish]; Acidum niflumicum [INN-Latin]; Niflugel (TN); Niflumic acid (INN); Niflumic acid [INN:DCF]; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino; Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-Trifluoromethylanilino)nicotinic Acid; 2-(3-[Trifluoromethyl]anilino)nicotinic acid; 2-(A,A,A-Trifluoro-m-toluidino)nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-[(3-TRIFLUOROMETHYL)PHENYL]AMINO-3-PYRIDINE-CARBOXYLIC ACID; 2-[(3-Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid; 2-[(3-Trifluoromethylphenyl)amino]nicotinic Acid; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid; 2-[alpha,alpha,alpha-trifluoro-m-toluidino]-nicotinic acid; 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID; 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid; 39690A
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
Diclofenac
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Approved | Compound Info | ||
| Synonyms |
Diclofenac (sodium matrix patch, pain)
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| Compound Name |
Aceclofenac
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Approved | Compound Info | ||
| Synonyms |
Airtal; Barracan; Biofenac; Bristaflam; Falcol; Gerbin; Preservex; YT-919
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| Activity |
IC50 = 170000 nM
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[1] | |||
| Compound Name |
Gemfibrozil
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Approved | Compound Info | ||
| Synonyms |
ApoGemfibrozil; Ausgem; Bolutol; Brozil; Cholespid; Clearol; Decrelip; Elmogan; Fetinor; Fibratol; Fibrocit; GFZ; Gemd; Gemfibril; Gemfibromax; Gemfibrosil; Gemfibrozilo; Gemfibrozilum; Gemhexal; Gemlipid; Gemnpid; GenGemfibrozil; Genlip; Gozid; Hidil; Hipolixan; Innogem; Innogen; Ipolipid; Jezil; Lanaterom; Lifibron; Lipazil; Lipigem; Lipira; Lipizyl; Lipozid; Lipur; Litarek; Lopid; Micolip; Normolip; NuGemfibrozil; Pilder; Polyxit; Progemzal; Reducel; Regulip; Renabrazin; Sinelip; Synbrozil; Taborcil; Tentroc; Trialmin; Alphapharm Brand of Gemfibrozil; Apo Gemfibrozil; Apotex Brand of Gemfibrozil; Bayvit Brand of Gemfibrozil; Bexal Brand of Gemfibrozil; Biochemie Brand of Gemfibrozil; Bull Brand of Gemfibrozil; Cantabria Brand of Gemfibrozil; Chem mart Brand of Gemfibrozil; Chem mart Gemfibrozil; DBL Gemfibrozil; Douglas Brand of Gemfibrozil; Farmasierra Brand of Gemfibrozil; Faulding Brand of Gemfibrozil;Ferrer Brand of Gemfibrozil; Gemfibrozilo Bayvit; Gemfibrozilo Bexal; Gemfibrozilo Ur; Gen Gemfibrozil; GenRX Gemfibrozil; Genpharm Brand of Gemfibrozil; Gevilon Uno; Healthsense Brand of Gemfibrozil; Healthsense Gemfibrozil; Hexal Brand of Gemfibrozil; Ipsen Brand of Gemfibrozil; Lipox Gemfi; Lopid R; Menarini Brand of Gemfibrozil; Novo Gemfibrozil; Novopharm Brand of Gemfibrozil; Nu Gemfibrozil; Nu Pharm Brand of Gemfibrozil; PMS Gemfibrozil; Parke Davis Brand of Gemfibrozil; Pfizer Brand of Gemfibrozil; Pharmascience Brand of Gemfibrozil; Quimifar Brand of Gemfibrozil; SBPA Gemfibrozil; Sigma Brand of Gemfibrozil; TAD Brand of Gemfibrozil; Terry White Chemists Brand of Gemfibrozil; Terry White Chemists Gemfibrozil; United Drug Brand of Gemfibrozil; Warner Lambert Brand of Gemfibrozil; CI719; Gemfi 1A Pharma; Apo-Gemfibrozil; Bayvit, Gemfibrozilo; Gem-S; Gemfibrozil, GenRX; Gemfibrozil, Healthsense; Gemfibrozil, SBPA; Gemfibrozilo [INN-Spanish]; Gemfibrozilum [INN-Latin]; Gen-Fibro;Gen-Gemfibrozil; Jezil (TN); Lopid (TN); Low-Lip; Novo-Gemfibrozil; Nu-Gemfibrozil; Nu-Pharm Brand of Gemfibrozil; PMS-Gemfibrozil; TEVA-A; WL-Gemfibrozil; Warner-Lambert Brand of Gemfibrozil; GEMFIBROZIL (SEE ALSO PEROXISOME PROJECT (GEMFIBROZIL)); Gemfibrozil [USAN:BAN:INN]; Gen-Fibro (TN); PEROXISOME PROJECT (GEMFIBROZIL) (SEE ALSO GEMFIBROZIL); Gemfibrozil (JAN/USP/INN); Gemcor, Lopid, Jezil,Gen-Fibro, Gemfibrozil; 1A Brand of Gemfibrozil; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid; 5-(2,5-Dimethyl-Phenoxy)-2,2-Dimethyl-Pentanoic Acid; 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid; 5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
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| Activity |
IC50 = 180000 nM
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[1] | |||
| Compound Name |
3,4-Dihydroxycinnamic Acid
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Phase 4 | Compound Info | ||
| Synonyms |
Caffeic acid; caffeic acid; 3,4-Dihydroxycinnamic acid; 331-39-5; 3-(3,4-dihydroxyphenyl)acrylic acid; 501-16-6; (E)-3-(3,4-dihydroxyphenyl)acrylic acid; 3,4-Dihydroxybenzeneacrylic acid; (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid; trans-caffeic acid; trans-Caffeate; 3,4-Dihydroxy-trans-cinnamate; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-; Cinnamic acid, 3,4-dihydroxy-; 3-(3,4-Dihydroxyphenyl)propenoic acid; UNII-U2S3A33KVM; 3-(3,4-Dihydroxyphenyl)-2-propenoic acid; 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
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| Activity |
EC50 = 97000 nM
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[3] | |||
| Compound Name |
1H-Indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Isatin; 91-56-5; Indoline-2,3-dione; 2,3-Indolinedione; INDOLE-2,3-DIONE; 2,3-Dioxoindoline; Isatine; Pseudoisatin; Isatic acid lactam; Tribulin; Isotin; 2,3-Diketoindoline; Isatinic acid anhydride; 2,3-Ketoindoline; o-Aminobenzoylformic anhydride; 2,3-Dioxo-2,3-dihydroindole; 2,3-dihydro-1H-indole-2,3-dione; NSC 9262; UNII-82X95S7M06; EINECS 202-077-8; BRN 0383659; AI3-03111; CHEMBL326294; 2,3-dihydroindole-2,3-dione; CHEBI:27539; JXDYKVIHCLTXOP-UHFFFAOYSA-N; MFCD00005718; 82X95S7M06; 84788-92-1; Isatin, 98%
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-5-Iodo-3-(4-iodophenylimino)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571597; BDBM50301390
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(4-Iodo-phenylimino)-5-methyl-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL570847; Oprea1_462568; Oprea1_533359; ZINC4697734; BDBM50301388; AKOS000610999; MCULE-7871761662; SR-01000312225; SR-01000312225-1; (E/Z)-3-(4-iodophenylimino)-5-methylindolin-2-one; (3E)-3-[(4-Iodophenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one #
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-5-Bromo-3-(4-iodophenylimino)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571813; BDBM50301389; AKOS003804796
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
5-Bromo-3-(4-methoxy-phenylimino)-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572223; (3Z)-5-bromo-3-[(4-methoxyphenyl)imino]-1,3-dihydro-2H-indol-2-one; NSC201446; DTXSID60308019; HMS1662I18; BDBM50301383; STK257558; ZINC18024285; AKOS000605786; AKOS003336571; CCG-241985; MCULE-1339199232; NSC-201446; NCI60_001676; DS-004137; ST50255405; (E/Z)-5-bromo-3-(4-methoxyphenylimino)indolin-2-one; 3-(4-Methoxyphenylimino)-5-bromo-1H-indole-2(3H)-one; 5-bromo-3-[(4-methoxyphenyl)azamethylene]-1H-benzo[d]azolin-2-one; (3E)-5-bromo-3-[(4-methoxyphenyl)imino]-1,3-dihydro-2H-indol-2-one; 2H-INDOL-2-ONE,5-BROMO-1,3-DIHYDRO-3-[(4-METHOXYPHENYL)IMINO]-
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-5-Iodo-3-(phenylimino)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576111; SCHEMBL12235592; BDBM50301378
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(Phenylimino)oxindole
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Investigative | Compound Info | ||
| Synonyms |
3-(Phenylimino)-2-indolinone; 2-INDOLINONE, 3-(PHENYLIMINO)-; (3E)-3-(phenylimino)-1,3-dihydro-2H-indol-2-one; 2H-Inden-2-one, 1,3-dihydro-3-(phenylimino)-; MLS002920119; CHEMBL227491; (E)-3-(Phenylimino)indolin-2-one; 3-(phenylimino)indolin-2-one; 3-(phenylazamethylene)-1H-benzo[d]azolin-2-one; NSC 131622; AI3-51432; 1,3-Dihydro-3-(phenylimino)-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(phenylimino)-; NSC131622; Enamine_005045; 3-phenyliminoindolin-2-one; 3-phenylimino-2-oxoindoline; Oprea1_869175; ARONIS019248; CTK1C3943; DTXSID50187476; HMS1408F07; 2-Indolinone, 3- (phenylimino)-; ALBB-016882; KS-00004B8X; (Z)-3-(phenylimino)indolin-2-one; BDBM50198047; CCG-55254; MFCD00859189; SBB083404; STK010013; ZINC13465608; (E/Z)-3-(phenylimino)indolin-2-one; AKOS000486085; AKOS003236137; MCULE-3573008446; NSC-131622; IDI1_007632; 3-(Phenylimino)-1H-indole-2(3H)-one; SMR001797716; R3916; ST45033109; 2H-Inden-2-one,3-dihydro-3-(phenylimino)-; 2H-Indol-2-one,3-dihydro-3-(phenylimino)-; 3-(phenylimino)-1,3-dihydro-2H-indol-2-one; SR-01000644289-1; (3Z)-3-(Phenylimino)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(Phenylimino)-1,3-dihydro-2H-indol-2-one #; 2H-Indol-2-one, 1,3-dihydro-3-(phenylimino)- (9CI); 2H-indol-2-one, 1,3-dihydro-3-(phenylimino)-, (3E)-
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-3-(4-Iodophenylimino)-1-methylindolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL577756; Oprea1_238856; BDBM50301387
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-5-Iodo-3-(4-methoxyphenylimino)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572224; BDBM50301384
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(3Z)-3-[(4-Iodophenyl)imino]-1,3-dihydro-2H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576687; Oprea1_071905; Oprea1_174336; ARONIS017924; ZINC6534236; BDBM50301386; STK063331; AKOS000485157; AKOS003241074; AKOS034472534; MCULE-2496747500; KS-00004A86; (E/Z)-3-(4-iodophenylimino)indolin-2-one; ST45031918; 3-(4-Iodophenylimino)-1H-indole-2(3H)-one; Z57198456; 3-[(4-iodophenyl)azamethylene]-1H-benzo[d]azolin-2-one; 3-[(4-iodophenyl)imino]-1,3-dihydro-2H-indol-2-one; 3-[(4-iodophenyl)imino]-2,3-dihydro-1H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(3Z)-3-[(4-Methoxyphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571589; Oprea1_425795; CTK2F0852; ZINC66358; DTXSID00347028; BDBM50301382; STK253000; AKOS003260152; AKOS003746646; CCG-279609; MCULE-1520044849; 3-[(4-methoxyphenyl)imino]-5-methyl-1H-indol-2-one; (E/Z)-3-(4-methoxyphenylimino)-5-methylindolin-2-one; Indol-2(3H)-one, 3-(4-methoxyphenylimino)-5-methyl-; 2H-Indol-2-one, 1,3-dihydro-3-[(4-methoxyphenyl)imino]-5-methyl-; (3Z)-3-[(4-Methoxyphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-one #; 3-((4-METHOXYPHENYL)IMINO)-5-METHYL-1,3-DIHYDRO-2H-INDOL-2-ONE
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
(E/Z)-3-(4-Iodophenylimino)-5-nitroindolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL570287; Oprea1_084788; BDBM50301376
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
2H-Indol-2-one, 1,3-dihydro-3-[(4-methoxyphenyl)imino]-5-nitro-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL570031; CBDivE_002552; CTK1E0782; DTXSID50407469; ZINC5249189; BDBM50301385; AKOS024357975; MCULE-9134058003; ST50986747; (E/Z)-3-(4-methoxyphenylimino)-5-nitroindolin-2-one; 3-(4-Methoxyphenylimino)-5-nitro-1,3-dihydroindol-2-one; 3-[(4-methoxyphenyl)azamethylene]-5-nitro-1H-benzo[d]azolin-2-one; 3-[(4-Methoxyphenyl)imino]-5-nitro-1,3-dihydro-2H-indol-2-one
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
3-(4-Methylanilino)indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
3-[(4-methylphenyl)amino]indol-2-one; CHEMBL571380; (3E)-3-[(4-methylphenyl)imino]-1,3-dihydro-2H-indol-2-one; MLS001181915; SMR000567637; (3Z)-3-[(4-Methylphenyl)imino]-1,3-dihydro-2H-indol-2-one; NSC298520; Oprea1_142688; CBDivE_000601; 3-(p-toluidino)indol-2-one; cid_326728; SCHEMBL12584950; SCHEMBL16445154; BDBM66793; CTK1D6594; 3-(4-methylanilino)-2-indolone; DTXSID80316010; HMS1608I09; ALBB-016883; 3-(p-Tolylamino)-2H-indol-2-one; BDBM50301379; MFCD00443382; SBB083405; STK725176; ZINC12447517; (E)-3-(p-Tolylimino)indolin-2-one; 3-(4-Methylphenylimino)indolin-2-one; AKOS001267965; AKOS001586934; AKOS030699073; CCG-277051; MCULE-9286673329; NSC-298520; (E/Z)-3-(p-tolylimino)indolin-2-one; 3-p-Tolylimino-1,3-dihydro-indol-2-one; Indol-2(3H)-one, 3-(4-tolylimino)-; DS-014008; ST4032793; EU-0067031; R3020; BIM-0207653.0001; MLS-0326244.0001; 3-[(4-methylphenyl)imino]-1,3-dihydro-2H-indol-2-one; 3-[(4-methylphenyl)azamethylene]-1H-benzo[d]azolin-2-one; Indol-2(2H)-one, 1,3-dihydro-3[(4-methylphenyl)imino]-; 3-[(4-methylphenyl)azamethylene]-1H-benzo[d]azolidin-2-one; (3Z)-3-[(4-Methylphenyl)imino]-1,3-dihydro-2H-indol-2-one #; 2H-indol-2-one, 1,3-dihydro-3-[(4-methylphenyl)imino]-, (3E)-
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| Activity |
IC50 ~ 50000 nM
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[4] | |||
| Compound Name |
4-(2,4-Dinitrophenoxy)-3-hydroxybenzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392873; SCHEMBL13236327; BDBM50225223
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| Activity |
IC50 = 55000 nM
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[2] | |||
| Compound Name |
Phenethyl Dimethyl Caffeate
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Investigative | Compound Info | ||
| Synonyms |
NSC666253; CHEMBL133642; phenethyl (E)-3-(3,4-dimethoxyphenyl)prop-2-enoate; SCHEMBL14113938; ZINC1642020; BDBM50029206; NSC-666253; .beta.-Phenylethyl 3,4-dimethoxycinnamate; 3,4-Dimethoxycinnamic acid phenethyl ester; Phenethyl 3-(3,4-dimethoxyphenyl)acrylate; CAFFEIC ACID DIMETHYL PHENETHYL ESTER; (E)-phenethyl 3-(3,4-dimethoxyphenyl)acrylate; J-008124; 3-(3,4-Dimethoxyphenyl)propenoic acid phenethyl ester; 3-(3,4-Dimethoxy-phenyl)-acrylic acid phenethyl ester; (E)-3-(3,4-Dimethoxy-phenyl)-acrylic acid phenethyl ester; 2-phenylethyl (E)-3-(3,4-dimethoxyphenyl)prop-2-enoate; 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-, 2-phenylethyl ester
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| Activity |
EC50 = 58000 nM
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[3] | |||
| Compound Name |
Methyl caffeate
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Investigative | Compound Info | ||
| Synonyms |
methyl 3-(3,4-dihydroxyphenyl)acrylate; Caffeic acid methyl ester; (E)-methyl 3-(3,4-dihydroxyphenyl)acrylate; METHYLCAFFEATE; Caffeic acid, methyl ester; UNII-N79173B9HF; methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; Methyl 3,4-dihydroxycinnamate; CHEMBL17001; methyl 3-(3,4-dihydroxyphenyl)prop-2-enoate; methyl (2E)-3-(3,4-dihydroxyphenyl)acrylate; N79173B9HF; methyl (E)-3-(3,4-dihydroxyphenyl)acrylate; methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate; MFCD00210468; 3,4-dihydroxycinnamic acid methyl ester; Caffeic acid methyl; METHYL CAFFEOATE; 3-(3,4-Dihydroxy-phenyl)-acrylic acid methyl ester; E-Caffeic acid methyl ester; (E)-Caffeic acid methyl ester; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, methyl ester, (2E)-; ZINC58222; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, methyl ester; ALBB-024360; 4978AB; BDBM50029209; SBB000325; STK523948; AKOS003263230; MCULE-5269580490; AS-56651; AS-65428; SC-88492; ST094769; Methyl 1-(3',4'-Dihydroxyphenyl)Propenate; R2609; C10477; Methyl 1-(3'',4''-dihydroxyphenyl)propenate; A824271; methyl (E)-3-(3,4-dihydroxyphenyl)-2-propenoate; J-502041; Q6823935; (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid methyl ester; methyl (E)-3-[3,4-bis(oxidanyl)phenyl]prop-2-enoate; (E)-3-(3,4-dihydroxyphenyl)-2-propenoic acid methyl ester; 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-, methyl ester, (E)-
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| Activity |
EC50 = 67000 nM
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| References | Top | ||||
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| REF 1 | Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J Med Chem. 2015 Aug 27;58(16):6507-15. | ||||
| REF 2 | Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem. 2007 Nov 15;50(23):5589-99. | ||||
| REF 3 | Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. J Med Chem. 2014 Nov 13;57(21):8928-35. | ||||
| REF 4 | Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5270-3. | ||||
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