Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86350 | Target Info | |||
| Target Name | Erbb3 tyrosine kinase receptor (Erbb-3) | ||||
| Synonyms |
Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB3; C-erbB-3 protein
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| Target Type | Clinical trial Target | ||||
| Gene Name | ERBB3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(3,4-Dichlorophenyl)-3-naphthalen-2-yl-3,4-dihydropyrazole-2-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2325087; BDBM50427228
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| Activity |
IC50 = 51700 nM
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[1] | |||
| Compound Name |
3-(4-Methoxyphenyl)-5-(1-naphthyl)-2-pyrazoline-1-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2325106; BDBM50427230
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| Activity |
IC50 = 55600 nM
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[1] | |||
| Compound Name |
5-(4-Methylphenyl)-3-naphthalen-2-yl-3,4-dihydropyrazole-2-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324873; BDBM50427229
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| Activity |
IC50 = 63200 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents. Bioorg Med Chem. 2013 Mar 1;21(5):1050-63. | ||||
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