Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79591 | Target Info | |||
| Target Name | Thyroid hormone receptor alpha (THRA) | ||||
| Synonyms |
V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR7; EAR-7; C-erbA-alpha; C-erbA-1
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|
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| Target Type | Successful Target | ||||
| Gene Name | THRA | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 120 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(Dimethylamino)-1-(4-((1-ethylpiperidin-4-yl)methyl)phenyl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551244; BDBM50295020
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(2-(dimethylamino)-4-(hexyloxy)phenyl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552742; BDBM50295007
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(3-Chlorophenylamino)-1-(4-(hexyloxy)phenyl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540227; BDBM50295016
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(4-(4-propylpiperazin-1-yl)phenyl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560310; BDBM50295021
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(3-(4-(Hexyloxy)phenyl)-3-oxopropyl)pyrrolidine-2,5-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551046; BDBM50295018
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(4''-(hexyloxy)biphenyl-4-yl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561653; BDBM50295009
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Butyl-3-(4-(3-(dimethylamino)propanoyl)phenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560675; BDBM50295023
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(4-(hexyloxy)phenyl)-2-phenylpropan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550766; BDBM50295013
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(4-(hexyloxy)phenyl)-2-methylpropan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570307; BDBM50295011
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-(Hexyloxy)phenyl)-3-(phenylamino)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550841; BDBM50295015
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-((Dimethylamino)methyl)-1-(4-(hexyloxy)phenyl)-3-methylbutan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550765; BDBM50295012
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-(Dimethylamino)-1-(2-(hexyloxy)-4-methylphenyl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560148; BDBM50295006
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-(Hexyloxy)phenyl)-3-(1H-imidazol-1-yl)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560309; BDBM50295017
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-(Hexyloxy)phenyl)-3-(methyl(phenyl)amino)propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541227; BDBM50295014
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Heptylphenyl)-2-methylprop-2-en-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
Enone, 4c; CHEMBL237605; BDBM18828; MFCD28103932; ZINC14968966; 1-(4-Heptyl-phenyl)-2-methyl-propenone
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|
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| Activity |
IC50 = 52900 nM
|
[2] | |||
| Compound Name |
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348879; BDBM50431578
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|
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| Activity |
IC50 = 58000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-(4-phenylpiperazin-1-yl)propyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348894; BDBM50431563
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[(3-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349028; BDBM50431528
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(4-Methylpiperidin-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348920; BDBM50431537
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348867; BDBM50431590
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[(3-Fluorophenyl)methyl-methylamino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348911; BDBM50431546
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-N-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349037; BDBM50431614
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[4-(4-Fluorophenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349053; BDBM50431598
Click to Show/Hide
|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(4-Methylpiperazin-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348883; BDBM50431574
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-piperidin-1-ylmethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349054; BDBM50431597
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(1,3-Dihydroisoindol-2-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348902; BDBM50431555
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[Benzyl(methyl)amino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348927; BDBM50431530
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348878; BDBM50431579
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(Dibenzylamino)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349029; BDBM50431527
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[4-(2-Fluorophenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348896; BDBM50431561
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(N-propylanilino)ethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348926; BDBM50431531
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(4-phenylpiperazin-1-yl)butyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348914; BDBM50431543
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[(3-Fluorophenyl)methyl]-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349046; BDBM50431605
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[Di(propan-2-yl)amino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348876; BDBM50431581
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]butyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348918; BDBM50431539
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|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
2,3-Dihydroindol-1-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349056; BDBM50431594
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
1,3-Dihydroisoindol-2-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349057; BDBM50431593
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]propyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348898; BDBM50431559
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[4-(4-Methylphenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348895; BDBM50431562
Click to Show/Hide
|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-(2-oxo-2-piperidin-1-ylethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349036; BDBM50431615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(1,3-Dihydroisoindol-2-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348922; BDBM50431535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348906; BDBM50431551
Click to Show/Hide
|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[Benzyl(methyl)amino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348909; BDBM50431548
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(2,3-Dihydroindol-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348901; BDBM50431556
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[Benzyl(methyl)amino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348871; BDBM50431586
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Benzyl-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349044; BDBM50431607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(2-Methyl-2,3-dihydroindol-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348903; BDBM50431554
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|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[4-(4-Fluorophenyl)piperazin-1-yl]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348897; BDBM50431560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
1-(4-Methylsulfonyl-3-nitrobenzoyl)-N,N-di(propan-2-yl)piperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349049; BDBM50431602
Click to Show/Hide
|
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| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349035; BDBM50431616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[Di(propan-2-yl)amino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348893; BDBM50431564
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[Benzyl(methyl)amino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348888; BDBM50431569
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N,N-Dibenzyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349047; BDBM50431604
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(3,4-Dihydro-2H-quinolin-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348904; BDBM50431553
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(1-Adamantylamino)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348905; BDBM50431552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348880; BDBM50431577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[(2-Fluorophenyl)methyl-methylamino]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348910; BDBM50431547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(2,3-Dihydroindol-1-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349038; BDBM50431613
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperidin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349030; BDBM50431526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(1-Adamantylamino)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348924; BDBM50431533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348872; BDBM50431585
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Benzyl-1-(4-methylsulfonyl-3-nitrobenzoyl)-N-phenylpiperidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349043; BDBM50431608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-N-[2-(2-methyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349040; BDBM50431611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-(4-phenylpiperazin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349050; BDBM50431601
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-(3-oxo-3-piperidin-1-ylpropyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348899; BDBM50431558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-4-methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349031; BDBM50431525
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
(4-Methylpiperazin-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2346688; BDBM50431595
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348877; BDBM50431580
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[(2-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349027; BDBM50431529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-(4-oxo-4-piperidin-1-ylbutyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348919; BDBM50431538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[(2-Fluorophenyl)methyl]-N-methyl-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349045; BDBM50431606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[1-(4-Methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]-(4-phenylpiperidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349048; BDBM50431603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349034; BDBM50431617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-(1-Adamantyl)-1-(4-methylsulfonyl-3-nitrobenzoyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349041; BDBM50431610
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[4-(4-Methylphenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348915; BDBM50431542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[4-(2-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349033; BDBM50431523
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(N-propylanilino)butyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348908; BDBM50431549
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(N-Benzylanilino)-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348870; BDBM50431587
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
3,4-Dihydro-1H-isoquinolin-2-yl-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349042; BDBM50431609
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[4-(4-Fluorophenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348917; BDBM50431540
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(2,3-Dihydroindol-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348921; BDBM50431536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-Methyl-N-[2-[4-(4-methylphenyl)piperazin-1-yl]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349032; BDBM50431524
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(2-Methyl-2,3-dihydroindol-1-yl)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348923; BDBM50431534
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-[(2-Fluorophenyl)methyl-methylamino]-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348889; BDBM50431568
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348925; BDBM50431532
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(4-Methylpiperidin-1-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348900; BDBM50431557
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
(2-Methyl-2,3-dihydroindol-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349058; BDBM50431592
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[4-oxo-4-(4-phenylpiperidin-1-yl)butyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348913; BDBM50431544
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[3-(3,4-Dihydro-1H-isoquinolin-2-yl)-3-oxopropyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348885; BDBM50431572
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-N-methyl-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349039; BDBM50431612
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[2-[(3-Fluorophenyl)methyl-methylamino]-2-oxoethyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348873; BDBM50431584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-(N-Methylanilino)-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348907; BDBM50431550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[4-(4-Methylphenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349051; BDBM50431600
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
[4-(2-Fluorophenyl)piperazin-1-yl]-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349052; BDBM50431599
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
4-Methylsulfonyl-3-nitro-N-[3-oxo-3-(4-phenylpiperidin-1-yl)propyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348892; BDBM50431565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
(4-Methylpiperidin-1-yl)-[1-(4-methylsulfonyl-3-nitrobenzoyl)piperidin-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349055; BDBM50431596
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
N-[4-[4-(2-Fluorophenyl)piperazin-1-yl]-4-oxobutyl]-4-methylsulfonyl-3-nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348916; BDBM50431541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[3] | |||
| Compound Name |
1-(4-Pentylphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235113
Click to Show/Hide
|
||||
| Activity |
IC50 = 60900 nM
|
[2] | |||
| Compound Name |
N-(4-Hexylphenyl)propiolamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Propiolic acid derivative, 8a; CHEMBL235491; BDBM18853; N-(4-hexylphenyl)prop-2-ynamide; ZINC14969052
Click to Show/Hide
|
||||
| Activity |
IC50 = 68900 nM
|
[2] | |||
| Compound Name |
4-[(5-{[2-(2,4-Dichlorophenyl)-2-oxoethyl]sulfanyl}-1-methyl-1H-pyrrol-2-yl)methyl]-2-methyl-1,2-dihydrophthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
KM-07385; CHEMBL85322; BDBM18912
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[4] | |||
| Compound Name |
1-[4-(2,2-Dimethylpropyl)phenyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237611
Click to Show/Hide
|
||||
| Activity |
IC50 = 69600 nM
|
[2] | |||
| Compound Name |
1-(4-Butylphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237823; SCHEMBL10954360
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[2] | |||
| Compound Name |
1-[4-(2,2-Dimethylpropyl)cyclohexyl]prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394678
Click to Show/Hide
|
||||
| Activity |
IC50 = 75600 nM
|
[2] | |||
| Compound Name |
N-(5,6,7,8-Tetrahydronaphthalen-1-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000032386; N-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-butyramide; CHEMBL394913; HMS2164C14; HMS3317D04; STK027026; ZINC18285120; AKOS005380399; MCULE-1426409901; SMR000008739; SR-01000318036; SR-01000318036-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 85300 nM
|
[2] | |||
| Compound Name |
1-(4-Heptylphenyl)-3-methylbut-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Enone, 4d; CHEMBL396437; BDBM18829; MFCD28408606; ZINC14968970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(4-Propylphenyl)-2-propene-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237822; SCHEMBL4904680; 1-(4-propylphenyl)prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[(4-Hexylphenyl)carbamoyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylamide, 7g; CHEMBL391785; BDBM18852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[(4-Hexylphenyl)carbamoyl]-2-methylidenepropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylamide, 7f; CHEMBL235489; BDBM18851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Acryloylphenyl)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395872
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2E)-1-(4-Heptylphenyl)-3-phenylprop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Enone, 4f; CHEMBL449354; BDBM18831; MFCD28408632; 1-(4-heptylphenyl)-3-phenylprop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Hexylphenyl)-3-methylbut-2-enamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylamide, 7d; CHEMBL394061; BDBM18849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Hexylphenyl)cinnamamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylamide, 7e; CHEMBL235276; BDBM18850; (2E)-N-(4-hexylphenyl)-3-phenylprop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Propenoic acid, 4-propylphenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylate, 6a; 4-propylphenyl prop-2-enoate; CHEMBL394679; SCHEMBL4596017; (4-propylphenyl) prop-2-enoate; BDBM18833
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Fluoro-1-(4-hexylphenyl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-fluoro ketone, 8d; CHEMBL236341; BDBM18856; ZINC14969059
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(4-Hexylphenyl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Enone, 4g; CHEMBL237821; SCHEMBL10883866; BDBM18832; 1-(4-Hexyl-phenyl)-propan-1-one; ZINC5418512; MFCD01095879; AKOS022274309; MCULE-8595163429; ST50973587
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2E)-1-(4-Heptylphenyl)-2-methylbut-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Enone, 4e; CHEMBL237820; BDBM18830; ZINC14968974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Substituted Acrylamide, 7c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398107; BDBM18848; ZINC14969034; (2E)-N-(4-hexylphenyl)but-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Pentylphenyl acrylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Substituted Acrylate, 6c; 4-pentylphenyl prop-2-enoate; CHEMBL237455; SCHEMBL11031162; (4-pentylphenyl) prop-2-enoate; BDBM18835; ZINC14968989
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Bromo-1-(4-hexylphenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
gamma-bromo ketone, 8f; CHEMBL236307; BDBM18858; MFCD28408648; ZINC14969067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3,5-Dibromo-4-ethoxyphenylacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Benzeneacetic acid, 3,5-dibromo-4-ethoxy-; CHEMBL192346; BDBM18898; CTK6G0108; AKOS015964260; 2-(3,5-dibromo-4-ethoxyphenyl)acetic acid; 3,5-Dibromo-4-alkoxyphenylalkanoic Acid, 9a
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem. 2009 Jul 9;52(13):3892-901. | ||||
| REF 2 | Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. | ||||
| REF 3 | Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1891-5. | ||||
| REF 4 | Pharmacophores incorporating numerous excluded volumes defined by X-ray crystallographic structure in three-dimensional database searching: application to the thyroid hormone receptor. J Med Chem. 1998 Jul 2;41(14):2503-12. | ||||
| REF 5 | Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. | ||||
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