Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79027 | Target Info | |||
| Target Name | Cytidine deaminase (CDA) | ||||
| Synonyms |
Cytidine aminohydrolase; CDA
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| Target Type | Clinical trial Target | ||||
| Gene Name | CDA | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cytarabine
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Approved | Compound Info | ||
| Synonyms |
Alexan; AraC; Arabinocytidine; Arabinofuranosylcytosine; Arabinosylcytosine; Arabitin; Aracytidine; Aracytin; Aracytine; Arafcyt; Citarabina; Cytarabin; Cytarabina; Cytarabinoside; Cytarabinum; Cytarbel; Cytonal; Cytosar; Cytosinearabinoside; DepoCyte; Depocyt; Erpalfa; Iretin; Spongocytidine; Tarabine; Udicil; Arabinosyl Cytosine; Cytarabine liposome injection; Cytosine arabinofuranoside; Cytosine arabinose; Cytosine arabinoside; AR3; BTB15125; CHX 3311; U 19920A; Ara-C; Ara-Cytidine; Beta-Ara C; Beta-Arabinosylcytosine; Beta-cytosine arabinoside; Citarabina [INN-Spanish]; Cytarabinum [INN-Latin]; Cytosar-U; Cytosine arabinoside (VAN); Depocyt (TN); Depocyt (liposomal); Intrathecal (injected into the spinal fluid) DepoCyt; U-19920; Beta-D-Arabinosylcytosine; Cytosar-U (TN); Cytosine beta-D-arabinofuranoside; Cytosine beta-D-arabinofuranoside hydrochloride; Cytosine beta-D-arabinoside; Cytosine-beta-arabinoside; Intrathecal cytarabine (also known as ara-C); U-19,920; CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9); Cytarabine (JP15/USP/INN); Cytarabine [USAN:INN:BAN:JAN]; Cytosine 1-beta-D-arabinofuranoside; Cytosine, beta-D-arabinoside; Cytosine-beta-D-arabinofuranoside; Cytosine-1-beta-D-arabinofuranoside; Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine; (beta-D-Arabinofuranosyl)cytosine; 1-.beta.-D-arabinofuranosyl-cytosine; 1-Arabinofuranosylcytosine; 1-beta-D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosylcytosine; 1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside; 1-beta-D-Arabinosylcytosine; 1beta-Arabinofuranasylcytosine; 1beta-D-Arabinofuranosylcytosine; 1beta-D-Arabinosylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-D-arabinofuranosyl-[CAS]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
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| Activity |
Ki = 190000 nM
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[1] | |||
| Compound Name |
2\\'-Deoxy-2\\'-fluorouridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237545; SCHEMBL2713063; BDBM50007027; 2'-Fluoro-2'-deoxy-5,6-dihydrouridine; 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione
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| Activity |
IC50 = 77000 nM
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[2] | |||
| Compound Name |
CID 57704511
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237553; SCHEMBL171923; BDBM50007035; 1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinan-2-one
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237554; SCHEMBL10057619; BDBM50007036
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-((4R,5S)-4,5-Dihydroxy-3-hydroxymethyl-cyclopent-2-enyl)-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315242; BDBM50065261; 1-[(3R)-2-(Hydroxymethyl)-3beta,4beta-dihydroxy-1-cyclopentene-5-yl]pyrimidine-2(1H)-one
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| Activity |
Ki = 100000 nM
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[3] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[(3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608655; BDBM50367035
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| Activity |
Ki = 300000 nM
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[4] | |||
| Compound Name |
1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-YL)-4-hydroxy-tetrahydro-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
TETRAHYDROURIDINE; NSC-112907-D; NSC-112907; SCHEMBL172272; CHEMBL1236475; ZINC1703948; BDBM50007025; U-23284; UNII-0NIZ8H6OL8 component UCKYOOZPSJFJIZ-FMDGEEDCSA-N; (4R)-4-hydroxy-1-beta-D-ribofuranosyltetrahydropyrimidin-2(1H)-one
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| Activity |
Ki = 440000 nM
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[2] | |||
| Compound Name |
4-Amino-1-(3-hydroxy-5-hydroxymethyl-4-methylene-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88675; ACMC-20mvg9; BDBM50007155
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| Activity |
Ki = 1600000 nM
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[1] | |||
| Compound Name |
4-Amino-1-[(4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylideneoxolan-2-yl]pyrimidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL10128; BDBM50421893
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| Activity |
Ki = 7690000 nM
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[1] | |||
| Compound Name |
2'-Deoxy-2'-methylidene-5-fluorocytidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142569; 2-Dmfc; FDMDC; Cytidine,2'-deoxy-5-fluoro-2'-methylene- (9CI); CHEMBL313659; SCHEMBL3876167; CTK4B6305; DTXSID00156197; BDBM50007156; cytidine, 2'-deoxy-2'-methylene-5-fluoro-; Cytidine, 2'-deoxy-5-fluoro-2'-methylene-
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| Activity |
Ki = 25100000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride. J Med Chem. 1991 Aug;34(8):2607-15. | ||||
| REF 2 | Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27;57(6):2582-8. | ||||
| REF 3 | Carbocyclic analogues of the potent cytidine deaminase inhibitor 1-(beta-D-ribofuranosyl)-1,2-dihydropyrimidin-2-one (zebularine). J Med Chem. 1998 Jul 2;41(14):2572-8. | ||||
| REF 4 | Cyclic urea nucleosides. Cytidine deaminase activity as a function of aglycon ring size. J Med Chem. 1981 Jun;24(6):662-6. | ||||
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