Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78915 | Target Info | |||
| Target Name | Tryptophan 5-hydroxylase 1 (TPH1) | ||||
| Synonyms |
Tryptophan 5-monooxygenase 1; TRPH; TPRH
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| Target Type | Clinical trial Target | ||||
| Gene Name | TPH1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Chloro-L-phenylalanine
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Investigative | Compound Info | ||
| Synonyms |
L-4-Chlorophenylalanine; H-Phe(4-Cl)-OH; (S)-2-amino-3-(4-chlorophenyl)propanoic acid; (2S)-2-amino-3-(4-chlorophenyl)propanoic acid; L-p-Chlorophenylalanine; UNII-SNM151OE2C; (S)-fenclonine; L-Phenylalanine, 4-chloro-; MFCD00063065; L-PCPA; Phenylalanine, 4-chloro-; 4-Chloro-3-phenyl-L-alanine; SNM151OE2C; L-PHE(4-CL)-OH; CHEMBL412813; P-CHLORO-L-PHENYLALANINE; (2S)-2-azanyl-3-(4-chlorophenyl)propanoic acid; Fenclonine, (S)-; 4-CHLORO-PHE-OH; MFCD00079675; EINECS 238-023-5; 4-Cl-Phe; PubChem12305; PubChem17995; 4-Cl-Phe-OH; H-D-Phe(4Cl)-OH; L-4-Chloro phenylalanine; (2S)-2-amino-3-(4-chlorophenyl)propionic acid; SCHEMBL26383; L-4-Chlorophenylalanine, 98%; CTK0E0510; DTXSID10161813; ZINC156102; KS-00000FL0; ANW-58528; BDBM50145657; AKOS010367583; AB02502; AC-5844; ACN-026509; DS-16206; SC-10557; ST074559; AB0012810; AM20060507; CS-0030550; K-4548; 173C398; A807704; A807799; J-300386; Q27120767; UNII-R5J7E3L9SP component NIGWMJHCCYYCSF-QMMMGPOBSA-N
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1124-9. | ||||
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