Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77546 | Target Info | |||
| Target Name | Diamine oxidase (AOC1) | ||||
| Synonyms |
Kidney amine oxidase; KAO; Histaminase; Amiloride-binding protein; AOC1; ABP
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| Target Type | Literature-reported Target | ||||
| Gene Name | AOC1 | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(Aminomethyl)-N-(cyclohexylmethyl)pyridin-3-amine;hydrate;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL541126
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[1-Acetyl-5-(2-methylphenyl)-2-pyrazoline-3-yl]resorcinol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331650; BDBM50121456; 1-[3-(2,4-Dihydroxy-phenyl)-5-o-tolyl-4,5-dihydro-pyrazol-1-yl]-ethanone
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| Activity |
Ki = 100000 nM
|
[2] | |||
| Compound Name |
2-Methylaminobenzylamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536949
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Aminomethyl)-N,N-dicyclopentylpyridin-3-amine;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL559376
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Ethylaminobenzylamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557976
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[4-(Aminomethyl)-5-(4-hydroxybutoxy)pyridin-3-yl]oxybutan-1-ol;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536484
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2-[4-(Aminomethyl)-5-(2-hydroxyethoxy)pyridin-3-yl]oxyethanol;trihydrate;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536719
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
1-(3,5-Diethoxypyridin-4-yl)methanamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL537401
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
1-[3,5-Bis(t-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539362
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
1-[3-(Benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536951
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
1-[3,5-Bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538353
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| Activity |
IC50 = 1000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases. J Med Chem. 2005 Feb 10;48(3):664-70. | ||||
| REF 2 | Inhibition of amine oxidases activity by 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3629-33. | ||||
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