Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75015 | Target Info | |||
| Target Name | Pancreatic eIF2-alpha kinase (HsPEK) | ||||
| Synonyms |
PERK; HsPEK; Eukaryotic translation initiation factor 2-alpha kinase 3
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| Target Type | Literature-reported Target | ||||
| Gene Name | EIF2AK3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407846; BDBM50072075; MFCD27977960; ZINC97974823
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[2-Amino-4-Methyl-3-(2-Methylquinolin-6-Yl)benzoyl]-1-Methyl-2,5-Diphenyl-1,2-Dihydro-3h-Pyrazol-3-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407862; BDBM50072036; ZINC223063193; NCGC00480730-01; J3.503.450A; Q27454272; 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1-methyl-2,5-diphenyl-1H-pyrazole-3(2H)-one
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[2-Amino-4-methyl-3-(2-methyl-1,3-benzothiazol-6-yl)benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407856; BDBM50072030
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[5-(4-Amino-2,7-dimethylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-1-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407863; BDBM50072038
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[2-Amino-4-methyl-3-[2-(trifluoromethyl)-1,3-benzothiazol-6-yl]benzoyl]-1-methyl-2,5-diphenylpyrazol-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407861; BDBM50072035
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J Med Chem. 2015 Feb 12;58(3):1426-41. | ||||
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