Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T74363 | Target Info | |||
| Target Name | Urokinase plasminogen activator surface receptor (PLAUR) | ||||
| Synonyms |
Urokinase-type plasminogen activator receptor; Urokinase plasminogen activator receptor; Monocyte activation antigenMo3; CD87 antigen; CD87
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| Target Type | Successful Target | ||||
| Gene Name | PLAUR | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-{3-[3-(Ethoxycarbonyl)piperidin-1-yl]-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl}-beta-alanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206351; BDBM50401183; MCULE-3167490465; EU-0087910
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
3-[(3-Bromo-4-hydroxy-6,7-dimethyl-9,10-dioxoanthracen-1-yl)amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206362; BDBM50401176
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
Methyl 3-[[12-(azepan-1-yl)-8-oxo-15-oxa-14-azatetracyclo[7.6.1.02,7.013,16]hexadeca-1(16),2,4,6,9,11,13-heptaen-10-yl]amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206355; SCHEMBL12498973; BDBM50401179
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-{[6-Oxo-3-(4-oxopiperidin-1-yl)-6H-anthra[1,9-cd]isoxazol-5-yl]amino}benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206352; ZINC3742054; BDBM50401182; CCG-125560; MCULE-8399592466; EU-0021200
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[(3-Bromo-4-hydroxy-6-methyl-9,10-dioxoanthracen-1-yl)amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206361; BDBM50401177
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| Activity |
IC50 = 146000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43R,49S)-25-(4-Aminobutyl)-49-benzyl-4,19-bis[(2S)-butan-2-yl]-34-[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239127; BDBM50421510
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| Activity |
Ki = 500000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor. Bioorg Med Chem. 2012 Aug 1;20(15):4760-73. | ||||
| REF 2 | Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2515-9. | ||||
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