Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72849 | Target Info | |||
| Target Name | Adipocyte-derived leucine aminopeptidase (ERAP1) | ||||
| Synonyms |
Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; ERAP1; Aminopeptidase PILS; ARTS-1; ALAP; A-LAP
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ERAP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[[[1-Amino-3-(3-hydroxyphenyl)propyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355102; BDBM50025045
Click to Show/Hide
|
||||
| Activity |
Ki = 87100 nM
|
[1] | |||
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420378; BDBM50439357
Click to Show/Hide
|
||||
| Activity |
IC50 = 95500 nM
|
[2] | |||
| Compound Name |
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416691; BDBM50077027
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[(2R)-2-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]carbamoyl]-4,4-diphenylbutyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096799; BDBM50245427
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[(3,4-Diaminobenzoyl)amino]-3-(1H-indol-3-yl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416706; BDBM50076975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416569; BDBM50077022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[(3,4-diaminobenzoyl)amino]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416703; BDBM50076974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414595; BDBM50076973
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl 4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416572; BDBM50076814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416687; BDBM50077024
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[[3-amino-4-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416718; BDBM50076983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-2-[[3-amino-4-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416725; BDBM50077017
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[(2R)-3-[[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]amino]-2-[(3,5-diphenylphenyl)methyl]-3-oxopropyl]-[(1R)-1-amino-3-phenylpropyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073490; BDBM50245429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Methyl (2S,3R)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-hydroxybutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416589; BDBM50076968
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416580; BDBM50076956
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[3-amino-4-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416723; BDBM50077016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416689; BDBM50077026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416567; BDBM50076796
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl]amino]hexanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416579; BDBM50076955
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416588; BDBM50076967
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 30 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(1S)-1-Amino-3-methylbutyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288165; Phosphonic acid,P-[(1S)-1-amino-3-methylbutyl]-; (S)-1-PHOSPHONO-3-METHYL-BUTYLAMINE; CTK5F9333; ZINC1707645; BDBM50190114; MFCD00797887; [(S)-1-Amino-3-methylbutyl]phosphonic acid; (S)-1-Amino-(3-methylbuthyl)phosphonic acid; Q27453362
Click to Show/Hide
|
||||
| Activity |
Ki = 249000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(2-aminoethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806100; SCHEMBL3222743; BDBM50170899
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(cyclohexylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806072; BDBM50170890
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-Benzyl-3-[1,2-diaminoethyl(hydroxy)phosphoryl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805472; BDBM50170879
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[[4-(aminomethyl)phenyl]methylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804956; BDBM50170877
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(methylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804959; BDBM50170886
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[2-(4-methoxyphenyl)ethylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806197; GTPL9683; BDBM50170878; compound 3v [PMID: 27390066]
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[(4-aminophenyl)methylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805288; BDBM50170875
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(oxolan-2-ylmethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805487; BDBM50170895
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(benzylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805986; BDBM50170891
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
(1-Amino-2-morpholin-4-ylethyl)phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805587; BDBM50170901
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(propylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805557; BDBM50170888
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-(2-methylpropylamino)ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805028; BDBM50170881
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[2-(dimethylamino)ethylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805964; BDBM50170898
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(piperidin-4-ylmethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805338; BDBM50170894
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
(1,2-Diaminoethyl)phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806121; NSC133875; SCHEMBL5359228; CTK4D2238; DTXSID30299960; BDBM50170885; AKOS006360576; NSC-133875; Phosphonic acid,P-(1,2-diaminoethyl)-
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[(1-Amino-3-phenylpropyl)-hydroxyphosphoryl]methyl]-3-(3,5-dimethylphenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355107; BDBM50025049
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(1-phenylethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804861; BDBM50170892
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(hexylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806247; BDBM50170900
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(2-piperazin-1-ylethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806230; BDBM50170871
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-(cyclohexylamino)ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804856; BDBM50170882
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-(propylamino)ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806187; BDBM50170880
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[(2-aminocyclohexyl)amino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805251; BDBM50170896
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
(1-Amino-2-piperidin-1-ylethyl)phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804843; BDBM50170893
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[(4-tert-butylphenyl)methylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805193; BDBM50170873
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-[(4-methoxyphenyl)methylamino]ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805817; BDBM50170876
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(cycloheptylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805573; BDBM50170897
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-(cycloheptylamino)ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805118; BDBM50170883
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
[1-Amino-2-(2-phenylethylamino)ethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805544; BDBM50170874
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-[2-(4-methoxyphenyl)ethylamino]ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805495; BDBM50170884
Click to Show/Hide
|
||||
| Activity |
Ki > 250000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4122-6. | ||||
| REF 2 | Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. | ||||
| REF 3 | 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem. 2015 Feb 12;58(3):1524-43. | ||||
| REF 4 | Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides. J Med Chem. 2016 Oct 13;59(19):9107-9123. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.