Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72458 | Target Info | |||
| Target Name | Melanocortin receptor 4 (MC4R) | ||||
| Synonyms |
MC4-R
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|
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| Target Type | Successful Target | ||||
| Gene Name | MC4R | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 67 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S,4R)-N,4-Dibenzyl-1-[(2R)-5-(diaminomethylideneamino)-2-[(2-naphthalen-2-ylacetyl)amino]pentanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193902; BDBM50167682
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(2R)-2-Amino-N-[(2R)-1-cyclohexyl-5-(diaminomethylideneamino)pentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257040; BDBM50372557
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S,4S)-N,4-Dibenzyl-1-[(2S)-5-(diaminomethylideneamino)-2-[(2-naphthalen-2-ylacetyl)amino]pentanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439522; BDBM50167683
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256630; BDBM50372553
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|
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-N-[3-cyclohexyl-4-(1,2,4-triazol-1-yl)butyl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403722; BDBM50372552
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
Nalpha-(2-Naphthylmethyl)-D-Arg-L-Trp-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL447178; MK-30A; BDBM50111179
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|
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| Activity |
Ki = 56000 nM
|
[3] | |||
| Compound Name |
1-[3-[(2-Naphthylmethyl)amino]propyl]guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269689; BDBM50111155; N-{3-[(Naphthalen-2-ylmethyl)-amino]-propyl}-guanidine
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|
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| Activity |
Ki = 56000 nM
|
[4] | |||
| Compound Name |
N-[(2R)-3-(4-Chlorophenyl)-1-(4-cyclohexyl-4-oxidopiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363757; BDBM50151508
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|
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| Activity |
Ki = 57000 nM
|
[5] | |||
| Compound Name |
(E)-N-(5-Aminopentyl)-N-((E)-2-chloro-3-phenylallyl)-3-(1H-indol-3-yl)acrylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238134; BDBM50217712
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|
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| Activity |
Ki = 59000 nM
|
[6] | |||
| Compound Name |
N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393359; BDBM50217651
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|
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| Activity |
Ki = 62000 nM
|
[6] | |||
| Compound Name |
(R)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9138; MK-14; BDBM50111193; Nalpha-(2-Naphthylmethyl)-D-tryptophanamide
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|
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| Activity |
Ki = 64000 nM
|
[3] | |||
| Compound Name |
N-(2-Aminoethyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235797; BDBM50217716
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|
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| Activity |
Ki = 66000 nM
|
[6] | |||
| Compound Name |
Nalpha-(2-Naphthylmethyl)-L-arginine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1159698
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|
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| Activity |
Ki = 66000 nM
|
[3] | |||
| Compound Name |
(E)-N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396303; BDBM50217691
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|
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| Activity |
Ki = 67000 nM
|
[6] | |||
| Compound Name |
4-(2-Naphthylmethyl)-1-piperazinecarboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8561; BDBM50111168; 4-Naphthalen-2-ylmethyl-piperazine-1-carboxamidine
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|
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| Activity |
Ki = 68000 nM
|
[4] | |||
| Compound Name |
2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14,17,23-trimethyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084386; BDBM50263852
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|
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| Activity |
Ki = 69183.1 nM
|
[7] | |||
| Compound Name |
N-(1H-Indole-3-ylmethyl)-N-(1-naphthylmethyl)-L-argininamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113280; BDBM50451493
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|
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| Activity |
Ki = 70000 nM
|
[4] | |||
| Compound Name |
N-(3-Aminopropyl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238180; BDBM50217768
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|
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| Activity |
Ki = 74000 nM
|
[6] | |||
| Compound Name |
N-(5-Aminopentyl)-2-(1H-indol-3-yl)-N-(3-phenylpropyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237052; BDBM50217719
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|
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| Activity |
Ki = 77000 nM
|
[6] | |||
| Compound Name |
N-(4-(Diethylamino)benzyl)-4-(1H-indol-3-yl)-N-pentylbutanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237478; BDBM50217774
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|
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| Activity |
Ki = 78000 nM
|
[6] | |||
| Compound Name |
N-(3-Aminopropyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393918; BDBM50217661
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|
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| Activity |
Ki = 81000 nM
|
[6] | |||
| Compound Name |
Tert-butyl 3-(2-(4-acetylphenylamino)-6-(diisopentylcarbamoyl)-1H-benzo[d]imidazol-1-yl)propylcarbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397140; BDBM50215818; ZINC28823390
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|
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| Activity |
Ki = 85113.8 nM
|
[8] | |||
| Compound Name |
(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235355; BDBM50217758
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|
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| Activity |
Ki = 87000 nM
|
[6] | |||
| Compound Name |
(R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-carbamoyl)-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8287; BDBM50111157
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|
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| Activity |
Ki = 89000 nM
|
[4] | |||
| Compound Name |
N-(3-Aminopropyl)-2-naphthalenemethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8201; BDBM50111154; N*1*-Naphthalen-2-ylmethyl-propane-1,3-diamine
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|
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| Activity |
Ki = 94000 nM
|
[4] | |||
| Compound Name |
(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(4-nitrophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393382; BDBM50217755
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|
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| Activity |
Ki = 96000 nM
|
[6] | |||
| Compound Name |
N-(4-Guanidino-butyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236022; SCHEMBL7858101; BDBM50217732; N-[4-(diaminomethylideneamino)butyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
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|
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| Activity |
Ki = 96000 nM
|
[6] | |||
| Compound Name |
(E)-N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-((Z)-2-methyl-3-phenylallyl)acrylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238136; BDBM50217683
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|
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| Activity |
Ki = 99000 nM
|
[6] | |||
| Compound Name |
(2S)-2-Acetamido-N-[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-iodophenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287325; BDBM50017132
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-Benzyl-N-{[carbamoylmethyl-((R)-1-phenyl-ethyl)-carbamoyl]-methyl}-2-(3-guanidino-propylamino)-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL30677; BDBM50126396
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-Benzyl-N-[(benzyl-carbamoylmethyl-carbamoyl)-methyl]-2-(3-guanidino-propylamino)-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440102; BDBM50126394
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
CID 90643809
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287329; BDBM50017136
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
CID 90643803
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287323; BDBM50017130
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083048; BDBM50263851
Click to Show/Hide
|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429742; BDBM50372556
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2R)-2-Amino-N-[(2R)-5-(diaminomethylideneamino)-1-phenylpentan-2-yl]-3-(4-fluorophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258295; BDBM50372554
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[2-[(2R)-2-[(2-Acetyl-3,4-dihydro-1H-isoquinoline-3-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287346; BDBM50017168
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[Benzyl-(2-{[2-(3-guanidino-propylamino)-acetyl]-phenethyl-amino}-acetyl)-amino]-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31566; BDBM50126397
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
CID 90643804
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287324; BDBM50017131
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|
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-[3-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,37S,40S,43S,46S)-43-Benzyl-4,19-bis[(2S)-butan-2-yl]-34-(3-carbamimidamidopropyl)-28-[(1S)-1-hydroxyethyl]-22-(hydroxymethyl)-46-(1H-imidazol-5-ylmethyl)-37-(1H-indol-3-ylmethyl)-25-methyl-3,6,12,18,21,24,27,30,33,36,39,42,45,48-tetradecaoxo-50,51-dithia-2,5,11,17,20,23,26,29,32,35,38,41,44,47-tetradecazatetracyclo[29.17.4.07,11.013,17]dopentacontan-40-yl]propyl]guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094606; BDBM50263840
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|
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| Activity |
EC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-[(2S)-2-[[(2R)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3287071; BDBM50017149
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(3-Aminopropyl)-1H-indole-3-methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8552; BDBM50111164; AKOS011608229; N*1*-(1H-Indol-3-ylmethyl)-propane-1,3-diamine
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| Activity |
Ki = 104000 nM
|
[4] | |||
| Compound Name |
Nalpha-(2-Naphthylmethyl)-L-Arg-L-Trp-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8720; MK-29A; BDBM50111180
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|
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| Activity |
Ki = 105000 nM
|
[3] | |||
| Compound Name |
N-(2-Aminoethyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237719; BDBM50217725
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|
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| Activity |
Ki = 106000 nM
|
[6] | |||
| Compound Name |
1-[3-[(1H-Indole-3-ylmethyl)amino]propyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8742; BDBM50111169; N-{3-[(1H-Indol-3-ylmethyl)-amino]-propyl}-guanidine
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|
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| Activity |
Ki = 107000 nM
|
[4] | |||
| Compound Name |
N-(4-Aminobutyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237687; BDBM50217767
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|
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| Activity |
Ki = 111000 nM
|
[6] | |||
| Compound Name |
N-(4-Guanidino-butyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235802; SCHEMBL7866114; BDBM50217754; N-[4-(diaminomethylideneamino)butyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
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| Activity |
Ki = 116000 nM
|
[6] | |||
| Compound Name |
N-((1R,2R)-2-Aminocyclohexyl)-N-cinnamyl-4-(1H-indol-3-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL268395; BDBM50217701
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|
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| Activity |
Ki = 116000 nM
|
[6] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(naphthalen-2-ylmethyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8045; SCHEMBL7866517; ZINC2470883; BDBM50111160; CCG-21696; STK145901; AKOS001663451; MCULE-4974518103; NCGC00312134-01; EU-0046826; N-(2-Naphthylmethyl)-1H-indole-3-ethanamine; AB01159365-02; [2-(1H-indol-3-yl)ethyl](2-naphthylmethyl)amine; [2-(1H-Indol-3-yl)-ethyl]-naphthalen-2-ylmethyl-amine; Z323162460; [2-(1H-indol-3-yl)ethyl][(naphthalen-2-yl)methyl]amine
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| Activity |
Ki = 118000 nM
|
[4] | |||
| Compound Name |
N2-(2-Naphthylmethyl)-L-ornithine allyl ester
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Investigative | Compound Info | ||
| Synonyms |
MK-42; CHEMBL1159703
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|
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| Activity |
Ki = 127000 nM
|
[3] | |||
| Compound Name |
(S)-5-Guanidino-2-[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-pentanoic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8676; MK-28; BDBM50111185
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|
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| Activity |
Ki = 134000 nM
|
[3] | |||
| Compound Name |
(S)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9274; BDBM50111202; Nalpha-(2-Naphthylmethyl)-L-tryptophanamide
Click to Show/Hide
|
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| Activity |
Ki = 139000 nM
|
[3] | |||
| Compound Name |
N-(2-Aminoethyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236447; SCHEMBL7864880; BDBM50217747
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|
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| Activity |
Ki = 140000 nM
|
[6] | |||
| Compound Name |
N-(2-Carbamimidamidoethyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235147; BDBM50217751; N-[2-(diaminomethylideneamino)ethyl]-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
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|
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| Activity |
Ki = 149000 nM
|
[6] | |||
| Compound Name |
(2S,4S)-4-Hydroxy-N-[2-(1H-imidazol-5-yl)ethyl]-1-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9048; MK-69; BDBM50111189; N-[2-(1H-Imidazole-4-yl)ethyl]-1-(2-naphthylmethyl)-4alpha-hydroxy-L-prolinamide
Click to Show/Hide
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| Activity |
Ki = 150000 nM
|
[3] | |||
| Compound Name |
N-(3-Guanidino-propyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235592; SCHEMBL7869175; BDBM50217675; N-[3-(diaminomethylideneamino)propyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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| Activity |
Ki = 150000 nM
|
[6] | |||
| Compound Name |
N-(4-Aminobutyl)-3-(1H-indol-3-yl)-N-(1-phenylpropyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236003; BDBM50217761
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| Activity |
Ki = 158000 nM
|
[6] | |||
| Compound Name |
(1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8208; BDBM50111162; N-(1-Naphthylmethyl)-1H-indole-3-methanamine
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| Activity |
Ki = 161000 nM
|
[4] | |||
| Compound Name |
2-(1H-Indol-3-yl)-N-(1H-indol-3-ylmethyl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269653; Cambridge id 5569632; SCHEMBL798249; ZINC2738721; BDBM50111161; STK090651; AKOS003260951; MCULE-6799391488; (2-indol-3-ylethyl)(indol-3-ylmethyl)amine; ST45146358; AB00089669-01; N-(1H-Indole-3-ylmethyl)-1H-indole-3-ethanamine; [2-(1H-Indol-3-yl)-ethyl]-(1H-indol-3-ylmethyl)-amine
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||||
| Activity |
Ki = 161000 nM
|
[4] | |||
| Compound Name |
N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237314; SCHEMBL7864860; BDBM50217643
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| Activity |
Ki = 161000 nM
|
[6] | |||
| Compound Name |
N-(3-Aminopropyl)-4-(1H-indol-3-yl)-N-phenethylbutanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237530; BDBM50217645; N-(3-aminopropyl)-4-(1H-indol-3-yl)-N-(2-phenylethyl)butanamide
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||||
| Activity |
Ki = 164000 nM
|
[6] | |||
| Compound Name |
2-(4-Hydroxybenzyl)-N-(4-aminobutyl)-N-isopropyl-1H-indole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236629; BDBM50217752
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||||
| Activity |
Ki = 165000 nM
|
[6] | |||
| Compound Name |
(2R)-1-[2-(1H-Indol-3-yl)ethyl]-N-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113644; MK-50; BDBM50451496; N-(2-Naphthylmethyl)-1-[2-(1H-indole-3-yl)ethyl]-D-prolinamide
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||||
| Activity |
Ki = 166000 nM
|
[3] | |||
| Compound Name |
N-[(2R)-3-(4-Chlorophenyl)-1-(4-oxido-4-phenylpiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362010; BDBM50151503
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||||
| Activity |
Ki = 169000 nM
|
[5] | |||
| Compound Name |
N-(2-Guanidino-ethyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235590; SCHEMBL7866522; BDBM50217664; N-[2-(diaminomethylideneamino)ethyl]-4-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)butanamide
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||||
| Activity |
Ki = 179000 nM
|
[6] | |||
| Compound Name |
N-(2-Guanidino-ethyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238353; BDBM50217672; N-[2-(diaminomethylideneamino)ethyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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||||
| Activity |
Ki = 179000 nM
|
[6] | |||
| Compound Name |
N-(4-Guanidino-butyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393532; SCHEMBL7864892; BDBM50217723; N-[4-(diaminomethylideneamino)butyl]-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide
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||||
| Activity |
Ki = 182000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nalpha-(1H-Indole-3-ylmethyl)-L-Arg-L-Trp-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267007; MK-29B; BDBM50111190
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| Activity |
Ki = 205000 nM
|
[3] | |||
| Compound Name |
N-(4-Aminobutyl)-N-isopropyl-1H-indole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396179; BDBM50217668
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||||
| Activity |
Ki = 222000 nM
|
[6] | |||
| Compound Name |
N-(3-Guanidinopropyl)-1-(2-naphthylmethyl)-4alpha-hydroxy-L-prolinamide
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Investigative | Compound Info | ||
| Synonyms |
MK-70; CHEMBL1159700
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||||
| Activity |
Ki = 279000 nM
|
[3] | |||
| Compound Name |
(R)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL9219; MK-15; BDBM50111188; Nalpha-(1H-Indole-3-ylmethyl)-3-(2-naphthyl)-D-alaninamide
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||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
(S)-2-[(1H-Indol-3-ylmethyl)-amino]-3-naphthalen-2-yl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428480; MK-16; BDBM50111197; Nalpha-(1H-Indole-3-ylmethyl)-3-(2-naphthyl)-L-alaninamide
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||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
3-(Piperazin-1-ylmethyl)-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
3-Piperazin-1-ylmethyl-1H-indole; CHEMBL276397; 1H-Indole,3-(1-piperazinylmethyl)-; ACMC-1C6NR; SCHEMBL948663; CTK4A8882; ALBB-009662; 1-(1H-Indole-3-ylmethyl)piperazine; BDBM50111159; STK505991; ZINC22924625; AKOS005172105; QC-9778; AC-26732; AB0097921; FT-0723189; 746P666; 1H-indole, 3-(1-piperazinylmethyl)-, hydrochloride
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| Activity |
Ki > 1000000 nM
|
[4] | |||
| Compound Name |
4-(1H-Indole-3-ylmethyl)-1-piperazinecarboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8598; BDBM50111171; 4-(1H-Indol-3-ylmethyl)-piperazine-1-carboxamidine
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| Activity |
Ki > 1000000 nM
|
[4] | |||
| Compound Name |
(R)-5-Guanidino-2-[(naphthalen-2-ylmethyl)-amino]-pentanoic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266055; MK-20; BDBM50111196; Nalpha-(2-Naphthylmethyl)-D-argininamide
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||||
| Activity |
Ki > 1000000 nM
|
[3] | |||
| Compound Name |
N-(1-Naphthylmethyl)-N-(2-naphthylmethyl)amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8129; Oprea1_758708; MLS000859006; HMS2798P17; ZINC4343360; BDBM50111163; MCULE-1376042569; SMR000459185; N-(2-Naphthylmethyl)-1-naphthalenemethanamine; Naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-amine
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||||
| Activity |
Ki > 1000000 nM
|
[4] | |||
| Compound Name |
1-(Naphthalen-2-ylmethyl)piperazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8756; 1-Naphthalen-2-ylmethyl-piperazine; Oprea1_775617; SCHEMBL593143; 1-(2-naphthylmethyl)-piperazine; 1-(beta-napthylmethyl)piperazine; CTK2E5435; DTXSID20358696; BDBM50111166; STL321465; ZINC20790799; AKOS009158679; 1-(2-NAPHTHYLMETHYL)PIPERAZINE; 1-[(naphthalen-2-yl)methyl]piperazine; MCULE-4088318939; NE51610; Piperazine, 1-(2-naphthalenylmethyl)-; DB-110844; BB 0249443; EN300-81737; Z1250089962
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and evaluation of proline based melanocortin receptor ligands. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2819-23. | ||||
| REF 2 | Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1223-8. | ||||
| REF 3 | N-alkylaminoacids and their derivatives interact with melanocortin receptors. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1039-42. | ||||
| REF 4 | Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1035-8. | ||||
| REF 5 | New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J Med Chem. 2004 Aug 26;47(18):4613-26. | ||||
| REF 6 | Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core. Bioorg Med Chem. 2007 Sep 1;15(17):5787-810. | ||||
| REF 7 | Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1. J Med Chem. 2018 Apr 26;61(8):3674-3684. | ||||
| REF 8 | Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4464-70. | ||||
| REF 9 | Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). J Med Chem. 2014 Jun 12;57(11):4615-28. | ||||
| REF 10 | Peptoid mimics of agouti related protein. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1409-13. | ||||
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