Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72335 | Target Info | |||
| Target Name | Bacterial Lethal factor (Bact lef) | ||||
| Synonyms |
lef; Anthrax lethal toxin endopeptidase component; Anthrax lethal factor; ALF
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | Bact lef | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 140 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Chloro-3-[5-[(E)-2-cyano-3-morpholin-4-yl-3-oxoprop-1-enyl]furan-2-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384761
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-Chloro-4-methyl-N-(thiophen-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538881; BDBM50294384
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(Benzo[d]thiazol-2-yl)-4''-chlorobiphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557083; BDBM50294379
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4''-Methoxy-N-(thiophen-2-yl)biphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560224; BDBM50294385
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)-3a,4,5,6,7,7a-hexahydro-1-benzothiophen-2-yl]-4-(4-chlorophenyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560217; BDBM50294381
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(2-(Benzo[d]thiazol-2-yl)ethyll)-4''-methoxybiphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563358; BDBM50294382
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)-3a,4,5,6,7,7a-hexahydro-1-benzothiophen-2-yl]-4-(4-methoxyphenyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552306; BDBM50294380
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4''-Chloro-N-(thiophen-2-yl)biphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569369; BDBM50294386
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(Benzo[d]thiazol-2-yl)-4''-methoxybiphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557082; BDBM50294378
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)thiopen-2-yl)-4-(2-methoxyphenoxy)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552104; BDBM50294375
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[3-(1,3-Benzothiazol-2-yl)thiophen-2-yl]-5-methyl-1-phenylpyrazole-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562992; BDBM50294376; N-(3-(Benzo[d]thiazol-2-yl)thiopen-2-yl)-5-methyl-1-phenyl-1H-pyrazole-4-sulfonamide
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Chloro-5-[5-[(E)-[2-(3-chloro-4-methylphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215832
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|
||||
| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)thiophen-2-yl)furan-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560843; BDBM50294377
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(2-(Benzo[d]thiazol-2-yl)ethyll)-4''-chlorobiphenyl-4-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538449; BDBM50294383
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(4-methoxypyridin-3-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098974; BDBM50444759
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)thiopen-2-yl)-3-chloro-2-methylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552047; BDBM50294374
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|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Chloro-2-(4-(4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy)-phenyl)-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597398; BDBM50308043
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|
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| Activity |
IC50 = 51000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)isoquinoline-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098140; BDBM50444741
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|
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| Activity |
IC50 = 52000 nM
|
[3] | |||
| Compound Name |
6-(4,5-Dihydro-1H-imidazol-2-yl)-2-[5-[4-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-2-yl]-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603251; BDBM50308045; 6-(4,5-Dihydroimidazol-2-yl)-2-(5-(4-(4,5-dihydroimidazol-2-yl)phenoxy)pyridine-2-yl)indole
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|
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| Activity |
IC50 = 55000 nM
|
[4] | |||
| Compound Name |
(E)-N-(4-Amino-2-methylquinolin-6-yl)-3-(4-methoxyphenyl)prop-2-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098986; BDBM50444733
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|
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| Activity |
IC50 = 55000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[(4-Fluoro-3-methylphenyl)sulfonyl-(2-phenylmethoxyethyl)amino]-N-hydroxypropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3634960; BDBM50133321
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|
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| Activity |
IC50 = 57000 nM
|
[5] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(4-bromo-2-methoxyphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099013; BDBM50444766
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|
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| Activity |
IC50 = 58000 nM
|
[3] | |||
| Compound Name |
3-[1-(3-Hydroxyphenyl)-5-(2-thienyl)pyrrol-2-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
3-(1-(3-hydroxyphenyl)-5-(thiophen-2-yl)-1H-pyrrol-2-yl)propanoic acid; 3-[1-(3-hydroxyphenyl)-5-(thiophen-2-yl)-1H-pyrrol-2-yl]propanoic acid; CHEMBL215949; ZINC31870; HMS1786G08; STK278362; AKOS001043798; MCULE-4352349412; ST044398; EU-0081284
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
2-(4-Methoxyphenyl)-6-(4,5-dihydro-1H-imidazol-2-yl)-1Hindole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597610; BDBM50308041
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|
||||
| Activity |
IC50 = 61000 nM
|
[4] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-[(2-chlorophenyl)methyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098983; BDBM50444750
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|
||||
| Activity |
IC50 = 61000 nM
|
[3] | |||
| Compound Name |
N-(2,4,5-Trihydroxyphenethyl)oleamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399925; BDBM50215902
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|
||||
| Activity |
IC50 = 70000 nM
|
[6] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-phenoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099020; BDBM50444747
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|
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| Activity |
IC50 = 70000 nM
|
[3] | |||
| Compound Name |
2-[(5Z)-4-Oxo-2-sulfanylidene-5-(1,3-thiazol-2-ylmethylidene)-1,3-thiazolidin-3-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Rhodanine-thiazole analogue 13; BDBM8448; CHEMBL373276; SCHEMBL13056347
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|
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| Activity |
IC50 = 72400 nM
|
[7] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-benzoylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099021; BDBM50444746
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|
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| Activity |
IC50 = 73000 nM
|
[3] | |||
| Compound Name |
(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-iodo-4-methoxyphenyl)prop-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933865; BDBM50360392; STK288035; ZINC13943922; AKOS000417983; NCGC00330396-01; AB01325241-02
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|
||||
| Activity |
IC50 = 74000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(4-chloro-2-methoxyphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099012; BDBM50444706
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|
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| Activity |
IC50 = 78000 nM
|
[3] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(4-phenylphenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098977; BDBM50444756
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|
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| Activity |
IC50 = 79000 nM
|
[3] | |||
| Compound Name |
(4-Oxo-5-thiophen-2-ylmethylene-2-thioxo-thiazolidin-3-yl)-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM8445; C10H7NO3S3; CHEMBL380982; SCHEMBL6885407; Rhodanine-thiophene analogue 10; ZINC966927; MFCD01654150; AKOS000121761; EN300-00725; AB00089135-01; SR-01000213212; SR-01000213212-1; [(5Z)-4-Oxo-5-(2-thienylmethylene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
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|
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| Activity |
IC50 = 79400 nM
|
[7] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)quinoline-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099026; BDBM50444740
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|
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| Activity |
IC50 = 81000 nM
|
[3] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(4-propan-2-ylphenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098981; BDBM50444752
Click to Show/Hide
|
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| Activity |
IC50 = 83000 nM
|
[3] | |||
| Compound Name |
Ethyl 4-[(4-amino-2-methylquinolin-6-yl)carbamoylamino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098979; BDBM50444754
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|
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| Activity |
IC50 = 87000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-1-benzofuran-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099027; BDBM50444739
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|
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| Activity |
IC50 = 90000 nM
|
[3] | |||
| Compound Name |
8-[(4-Fluoro-3-methylphenyl)sulfonyl-[(2R)-1-(hydroxyamino)-1-oxopropan-2-yl]amino]octanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3634972; BDBM50133309
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|
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| Activity |
IC50 = 91000 nM
|
[5] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(4-fluorophenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098980; BDBM50444753
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|
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| Activity |
IC50 = 95000 nM
|
[3] | |||
| Compound Name |
N-(3-Chloro-4-methylphenyl)thiophene-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558100; Cambridge id 6296523; ZINC2970862; BDBM50294367; STK415246; AKOS000383496; MCULE-2548882714; ST50857865; AB00032805-01; AB00032805-02; (3-chloro-4-methylphenyl)(2-thienylsulfonyl)amine; Z45634880
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N1-(6-(6-(4,5-Dihydro-1H-imidazol-2-yl)benzo[b]thiophen-2-yl)-pyridine-3-yl)ethane-1,2-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606405; BDBM50308046
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2,3-dimethoxyphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099003; BDBM50444715
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-[5-(furan-2-yl)thiophen-2-yl]prop-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933884; BDBM50360387
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(1,4,5,6-Tetrahydropyrimidin-2-yl)-2-[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenyl]-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1163029; BDBM50378660
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(5-(4-Cyanophenoxy)pyridin-2-yl)-1H-indole-6-carbonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599436; BDBM50308050
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-(1,4,5,6-Tetrahydropyrimidin-2-yl)-2-[5-[4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenoxy]pyridin-2-yl]-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598622; BDBM50308047; 6-(3,4,5,6-Tetrahydropyrimidin-2-yl)-2-(4-(4-(3,2,5,6-tetrahydropyrimidin-2-yl)phenoxy)phenyl)indole
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(3-methoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099001; BDBM50444717
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-bromo-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933867; ZINC5285657; BDBM50360396; STL432712; AKOS000431385; ST50986724; (2E)-2-benzimidazol-2-yl-3-(3-bromo-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(2-Methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611079; BI-90H9; BDBM50310148
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3-chloro-4-fluorobenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560618; BDBM50294359
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933870; (2E)-2-(1H-benzimidazol-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile; HMS557N12; CCG-7770; BDBM50360399; PHG 00727; STK096605; ZINC12367931; AKOS000431744; NCGC00342526-01; BIM-0019893.P001; AB01334571-02; F1736-2179; 3-(3,4-Dimethoxyphenyl)-2-(1H-benzoimidazole-2-yl)propenenitrile; (E)-2-(1H-benzo[d]imidazol-2-yl)-3-(3,4-dimethoxyphenyl)acrylonitrile; (E)-1-(1H-1,3-benzimidazol-2-yl)-2-(3,4-dimethoxyphenyl)-1-ethenyl cyanide
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3,4-Dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599111; BI-90H10; BDBM50310146
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(5-chloro-2-methoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099011; BDBM50444707
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-(2,4-Dichlorophenoxy)phenyl)-6-(4,5-dihydro-1H-imidazol-2-yl)-1H-indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598002; BDBM50308032
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-(2-chlorophenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098971; BDBM50444762
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
CID 50943150
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933882; BDBM50360393; (E)-2-(1H-benzimidazol-2-yl)-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(5-bromo-2-methoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099010; BDBM50444708
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(4-methoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099000; BDBM50444718
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-(4-Carbamoylphenoxy)phenyl)-1H-indole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604103; BDBM50308049
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methyl-6-quinolinyl)-3-phenylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87699; BDBM50444729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-methylphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099006; BDBM50444712
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-chlorophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099005; BDBM50444713
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3-chlorobenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562423; BDBM50294362
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-4-fluoro-N-(4-fluorophenylsulfonyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549762; BDBM50294373
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(3-chloro-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933868; BDBM50360397; ZINC13401606; AKOS000609922
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609039; BI-90H6; BDBM50310142
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-Phenylthiophene-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-phenyl-2-thiophenesulfonamide; Thiophene-2-sulfonic acid phenylamide; CHEMBL569370; phenyl thienylsulfonamide; SCHEMBL4709087; CTK1B3682; DTXSID80354331; 2-Thiophenesulfonamide, N-phenyl-; ZINC249412; BDBM50294370; STL137310; AKOS000383391; CCG-127809; MCULE-9666916123; AQ-390/12072029
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(1H-benzo[g]indol-3-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933881; BDBM50360410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(4,6-dichloropyrimidin-5-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933877; BDBM50360406
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(1H-Benzimidazol-2-yl)-3-(3-chloro-4-hydroxy-5-methoxyphenyl)acrylonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933871; ZINC4169992; BDBM50360400; STL169503; AKOS000411972; BIM-0033713.P001; AB00096912-01; AK-968/12164078; (2E)-2-(1H-benzimidazol-2-yl)-3-(3-chloro-4-hydroxy-5-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-(2-methoxyphenyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098972; BDBM50444761
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-2-Quinolin-2-yl-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933889; BDBM50360391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-4-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551171; BDBM50294357
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[4-(4-Fluorophenoxy)phenyl]-1H-indole-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599856; BDBM50308052
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2E)-2-(1H-Benzimidazol-2-yl)-3-(3-iodophenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933866; ZINC4997459; BDBM50360395; STL431062; AKOS000432969; ST45021038; (2E)-2-benzimidazol-2-yl-3-(3-iodophenyl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551098; BDBM50294355
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-propoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099015; BDBM50444764
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(5E)-5-[[5-[2-Chloro-5-(trifluoromethyl)phenyl]furan-2-yl]methylidene]-2-imino-1-methylimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197810
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(2-chloro-5-phenylpyridin-3-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933876; BDBM50360405
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-[4-(3-bromo-4-hydroxy-5-methoxyphenyl)phenyl]prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933872; BDBM50360401
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-(1,4,5,6-Tetrahydropyrimidin-2-yl)-2-(4-(4-(1,4,5,6-tetrahydropyrimidin-2-yl)phenoxy)phenyl)-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597792; BDBM50308039
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(4-Methoxyphenyl)-1H-indole-6-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598634; BDBM50308055
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099022; BDBM50444745
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-Sec-Butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599518; BI-98A10; BDBM50310147
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(4-Fluorophenyl)-1H-indole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605845; BDBM50308053
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3-(trifluoromethyl)-N-(3-(trifluoromethyl)phenylsulfonyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541200; BDBM50294371
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)isoxazol-5-yl)-4''-chlorobiphenyl-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557695; BDBM50294365
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Methyl-3-(trifluoromethyl)phenyl)thiophene-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549884; ZINC8724677; BDBM50294368; AKOS001360776; MCULE-5495260995
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Methoxyphenyl)-1H-indole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598433; BDBM50308054
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(Z)-2-(1H-Indol-2-yl)-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933886; BDBM50360389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-4-tert-butylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560304; BDBM50294360
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1H-Benzoimidazol-2-yl)-3-(3,4,5-trimethoxy-phenyl)-acrylonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933875; (2E)-2-(1H-benzimidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-enenitrile; SCHEMBL12351294; ZINC3908641; BDBM50360404; STK077631; (E)-2-(1H-benzimidazol-2-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-enenitrile; AKOS000518529; NCGC00187508-01; NCGC00187508-02; ST50045498; AB01333548-02; (2E)-2-benzimidazol-2-yl-3-(3,4,5-trimethoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[3-(Trifluoromethyl)phenyl]-2-thiophenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL555957; N-[3-(trifluoromethyl)phenyl]thiophene-2-sulfonamide; N-(3-(trifluoromethyl)phenyl)thiophene-2-sulfonamide; CBMicro_021597; ZINC4905444; BDBM50294369; CCG-13596; STL168318; AKOS000383469; MCULE-5621520272; BIM-0021666.P001; AQ-390/13777238; SR-01000473808; N-(3-Trifluoromethyl)phenyl)thiophene-2-sulfonamide; SR-01000473808-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-(1,3-benzodioxol-5-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098976; BDBM50444757
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-4-morpholin-4-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099025; BDBM50444742
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2-ethoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099014; BDBM50444765
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098988; NSC33351; DTXSID80283778; BDBM50444731; NSC-33351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)isoxazol-5-yl)-4''-methoxybiphenyl-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550437; BDBM50294364
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(1,3-Benzothiazol-2-yl)thiophen-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(Benzo[d]thiazol-2-yl)thiophen-2-amine; 3-(1,3-Benzothiazole-2-yl)thiophene-2-amine; C11H8N2S2; Maybridge1_008598; CHEMBL2374314; CTK7E1805; HMS565O18; DTXSID80370718; ZINC114945; 3-benzothiazol-2-yl-2-thienylamine; 3240AB; MFCD02180788; SBB097974; AKOS000175812; CCG-255402; MCULE-6399934949; 2-amino-3-(benzothiazol-2-yl)thiophene; 2-(2-Aminothien-3-yl)-1,3-benzothiazole; DB-025936; FT-0613486; F2146-0115
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(1H-Benzoimidazol-2-yl)-3-(5-methyl-thiophen-2-yl)-acrylonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000178508; MLS000568256; CHEMBL118009; BDBM49541; cid_5738327; HMS2503I19; ZINC4453110; STK287653; (E)-2-(1H-benzimidazol-2-yl)-3-(5-methylthiophen-2-yl)prop-2-enenitrile; AKOS000417229; ST089746; (E)-2-(1H-benzimidazol-2-yl)-3-(5-methyl-2-thienyl)acrylonitrile; (2E)-2-(1H-benzimidazol-2-yl)-3-(5-methylthiophen-2-yl)prop-2-enenitrile; (2E)-2-benzimidazol-2-yl-3-(5-methyl(2-thienyl))prop-2-enenitrile; (E)-2-(1H-benzimidazol-2-yl)-3-(5-methyl-2-thiophenyl)-2-propenenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-[4-(1H-imidazol-2-yl)phenyl]prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933874; BDBM50360403
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(2,5-dimethoxyphenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099002; BDBM50444716
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-(1,3-benzodioxol-5-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098989; BDBM50444730
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Chloro-4-[4-[6-(4,5-dihydro-1H-imidazol-2-yl)-1H-indol-2-yl]phenoxy]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597802; BDBM50308036; 2-(4-(2-Chloro-4-cyanophenoxy)phenyl)-6-(4,5-dihydro-1Himidazol-2-yl)indole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[4-[4-[6-(5-Hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)-1H-indol-2-yl]phenoxy]phenyl]-1,4,5,6-tetrahydropyrimidin-5-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604498; BDBM50308058
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[2-[3-[(4-Amino-2-methylquinolin-6-yl)amino]-3-oxopropyl]phenyl] benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099004; BDBM50444714
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(1,3-Benzothiazol-2-yl)-4-methylthiophen-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(2-Amino-4-methylthien-3-yl)benzothiazole; 3-(benzo[d]thiazol-2-yl)-4-methylthiophen-2-amine; 2-(2-Amino-4-methylthien-3-yl)-1,3-benzothiazole; 2-Thiophenamine,3-(2-benzothiazolyl)-4-methyl-; Maybridge1_003812; SCHEMBL3713049; CHEMBL2374315; CTK4F1258; HMS552F06; KS-00002AKS; DTXSID80370697; ZINC117161; MFCD02179980; SBB100154; AKOS026675532; CCG-241879; MCULE-8132442980; PS-6013; QC-6099; VT10022; DB-046121; FT-0613485; Y8367; 3-benzothiazol-2-yl-4-methyl-2-thienylamine; A816660; 2-(2-Amino-4-methylthien-3-yl)-1,3-benzothiazol; W-206820; 3-(1,3-benzothiazol-2-yl)-4-methyl-2-thiophenamine; 3-(1,3-benzothiazol-2-yl)-4-methyl-thiophen-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-(4-Amino-2-methylquinolin-6-yl)-3-[(2-methoxyphenyl)methyl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098984; BDBM50444749
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-nitro-1H-indol-3-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933880; BDBM50360409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(4-fluorophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099008; BDBM50444710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-4-(trifluoromethoxy)-N-(4-(trifluoromethoxy)phenylsulfonyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552990; BDBM50294372
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3-chloro-2-fluorobenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563891; BDBM50294351
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-N'-(4-methoxyphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098978; Urea, N-(4-amino-2-methyl-6-quinolinyl)-N'-(4-methoxyphenyl)-; ACMC-20mceo; CTK0G2381; DTXSID70730943; BDBM50444755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2-(Benzo[d]thiazol-2-yl)phenyl)-4''-methoxybiphenyl-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551367; BDBM50294366
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(dimethylamino)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099024; BDBM50444743
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-2-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560421; BDBM50294356
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-phenylphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933873; BDBM50360402; AKOS000959348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1H-Imidazole, 4,5-dihydro-2-(4-(6-(4,5-dihydro-1H-imidazol-2-yl)benzo(b)thien-2-yl)phenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL354449; 6-(2-Imidazolin-2-yl)-2-(4-(2-imidazolin-2-yl)phenyl)benzo(b)thiophene; SCHEMBL12348379; DTXSID40224263; BDBM50378659; 6-(2-imidazolin-2-yl)-2-[4-(2-imidazolin-2-yl)phenyl] benzo[b]thiophene
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(5-thiophen-2-ylfuran-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933885; BDBM50360388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-4-fluorobenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564957; BDBM50294358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(2-(Benzo[d]thiazol-2-yl)phenyl)-4''-chlorobiphenyl-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561305; BDBM50294353
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(3-fluoro-4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933869; BDBM50360398; AKOS008877416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1,3-Benzothiazol-2-yl)-3-(5-thiophen-2-ylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933887; BDBM50360390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(4-(4-Cyanophenoxy)phenyl)-1H-indole-6-carboximidamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597587; BDBM50308057
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(1H-Benzoimidazol-2-yl)-3-thiophen-2-yl-acrylonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000567024; SMR000175048; Cambridge id 5554994; CHEMBL116569; BDBM42055; cid_5334847; HMS552K09; HMS2553D06; (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-ylprop-2-enenitrile; ZINC4301938; AKOS000541721; ST50728509; AB00088886-01; SR-01000046927; SR-01000046927-1; (2E)-2-benzimidazol-2-yl-3-(2-thienyl)prop-2-enenitrile; (E)-2-(1H-benzimidazol-2-yl)-3-(2-thienyl)acrylonitrile; 2-(1H-benzo[d]imidazol-2-yl)-3-(2-thienyl)acrylonitrile; 1H-Benzimidazole-2-acetonitrile, .alpha.-(2-thienylmethylene)-; (2E)-2-(1H-Benzimidazol-2-yl)-3-(2-thienyl)-2-propenenitrile #; (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-yl-2-propenenitrile; (E)-2-(1H-benzimidazol-2-yl)-3-thiophen-2-yl-prop-2-enenitrile; (E)-2-(1H-Benzo[d]imidazol-2-yl)-3-(thiophen-2-yl)acrylonitrile; (2E)-2-(1H-1,3-benzodiazol-2-yl)-3-(thiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(5-Fluoro-2-pyridyl)-6-benzo[b]thiophenecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599053; BDBM50308056
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)furan-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099023; BDBM50444744
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R)-2-[(4-Fluoro-3-methylphenyl)sulfonyl-propan-2-ylamino]-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3634964; BDBM50133317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-3-(3-methoxythiophen-2-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098975; BDBM50444758
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[(5E)-5-[[5-(4-Chlorophenyl)furan-2-yl]methylidene]-1-methyl-4-oxoimidazolidin-2-yl]carbamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3-chloro-2-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560621; BDBM50294352
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
N-(3-(Benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-3,4-dichlorobenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564951; BDBM50294361
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(3-methyl-1-benzothiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933878; BDBM50360407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(4,5-dimethylthiophen-2-yl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1933883; BDBM50360386
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-2-(1H-Benzimidazol-2-yl)-3-(4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116847; HMS552E11; BDBM50360394; STK219590; ZINC12340273; AKOS000431712; MCULE-4847297100; J3.507.122I; AB00083399-01; (2E)-2-(1H-benzimidazol-2-yl)-3-(4-methoxyphenyl)acrylonitrile; (E)-2-(1H-Benzoimidazole-2-yl)-3-(4-methoxyphenyl)acrylonitrile; 2-(1H-BENZIMIDAZOL-2-YL)-3-(4-METHOXYPHENYL)ACRYLONITRILE; (2E)-2-(1H-benzimidazol-2-yl)-3-(4-methoxyphenyl)prop-2-enenitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(4-Amino-2-methylquinolin-6-yl)-2-(2-methoxyphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3098970; BDBM50444763
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(4-(4-(6-(1,4,5,6-Tetrahydropyrimidin-2-yl)benzo[b]thiophen-2-yl)phenoxy)phenyl)-1,4,5,6-tetrahydropyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603464; BDBM50308044
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2R)-2-[3-Acetamidopropyl-(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3634978; BDBM50133303
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[5] | |||
| Compound Name |
2-[(1S,2R,4R,5R)-2-(2-Amino-3H-benzimidazol-5-yl)-5-(diaminomethylideneamino)-4-hydroxycyclohexyl]guanidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203164
Click to Show/Hide
|
||||
| Activity |
Ki = 153700 nM
|
[10] | |||
| Compound Name |
(5E)-5-[[5-(4-Chlorophenyl)furan-2-yl]methylidene]-2-imino-1-methylimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200848
Click to Show/Hide
|
||||
| Activity |
IC50 = 199526.23 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Acetohydroxamic Acid
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
AHA; Acethydroxamsaeure; Acethydroxamsaure; Acetohydroxamate; HAE; Lithostat; Acethydroxamic acid; Acethydroxamsaeure [German]; Acetohydroximic acid; Acetyl hydroxyamino; Acetylhydroxamic acid; Acide acetohydroxamique; Acide acetohydroxamique [French]; Acido acetohidroxamico; Acido acetohidroxamico [Spanish]; Acidum acetohydroxamicum; Acidum acetohydroxamicum [Latin]; Cetohyroxamic acid; Methylhydroxamic acid; SJX HLdmMAH; AHA (TN); Acetic acid, oxime; Acetohydroxamic acid [USAN:INN]; Lithostat (TN); N-Acetyl hydroxyacetamide; N-Acetylhydroxylamine; N-Hydroxyacetamide; N-hydroxyacetimidic acid; N-hydroxyethanimidic acid; S14-0751; Acetohydroxamic acid (USP/INN); Acetamide, N-hydroxy-(9CI)
Click to Show/Hide
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||||
| Activity |
IC50 = 11400000 nM
|
[11] | |||
| Compound Name |
3-Hydroxy-4H-pyran-4-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1649594; 4H-Pyran-4-thione, 3-hydroxy-; 3-hydroxypyran-4-thione; Thiomeconic acid; ACMC-20lkcd; SCHEMBL1298196; CTK2J8099; DTXSID10463243; BDBM50335806
Click to Show/Hide
|
||||
| Activity |
IC50 = 204000 nM
|
[11] | |||
| Compound Name |
Pyrithione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-MERCAPTOPYRIDINE-N-OXIDE; 2-mercaptopyridine n-oxide; Omadine; 1-Hydroxy-2-pyridinethione; 2-Pyridinethiol 1-oxide; Pyridine-2-thiol N-oxide; 2-Pyridinethiol, 1-oxide; 1-Hydroxyl-1H-pyridine-2-thione; 1-hydroxypyridine-2-thione; N-Hydroxypyridine-2-thione; 1-Hydroxy-2(1H)-pyridinethione; 2-Mercaptopyridine monoxide; 1-hydroxypyridine-2(1H)-thione; SQ 2113; 1-Hydroxy-2-(1H)-pyridinethione; 2-MERCAPTOPYRIDINE 1-OXIDE; UNII-6GK82EC25D; MFCD00006196; pyridine-2-thiol 1-oxide; 1-oxidanylpyridine-2-thione; MLS001335994; 6GK82EC25D; CHEMBL1356238; NSC179790; 1-hydroxy-1,2-dihydropyridine-2-thione; 2-SULFANYLPYRIDIN-1-IUM-1-OLATE; SMR000814708; 2-sulfanylpyridin-1-ol; 2-Mercaptopyridine-N-oxide, 99%; 1-hydroxy-1H-pyridine-2-thione; 2-Pyridinethiol-1-oxide; EINECS 214-328-9; EINECS 214-329-4; Pyridine-2-thiol-1-oxide; NSC 179790; BRN 0109936; BRN 0906983; AI3-60234; 2(1H)-Pyridinethione, 1-hydroxy-; pyridinethiol n-oxide; 2-(1H)-Pyridinethione, 1-hydroxy-; 2-Pyridinethiol1-oxide; ACMC-1BNPO; mercaptopyridine-1-oxide; 2-pyridinethiol-N-oxide; 2-Thiopyridine-N-oxide-; mercapto pyridine-1-oxide; 2-mercaptopyridine-1-oxid; 2mercapto pyridine N-oxide; 2-Thiolatopyridine 1-oxide; cid_1570; WLN: T6NYJ AQ BUS; 2-mercapto pyridine N-oxide; 2-mercapto-pyridine-N-oxide; 2-mercapto-pyridine-1-oxide; SCHEMBL24755; SCHEMBL49266; 5-21-07-00150 (Beilstein Handbook Reference); MLS001335993; 1-oxidopyridin-1-ium-2-thiol; 2-PYRIDINETHIOL N-OXIDE; CHEMBL1650619; DTXSID4048010; BDBM60985; CTK4A7674; CTK8A9254; YBBJKCMMCRQZMA-UHFFFAOYSA-; 1-Oxido-2-pyridinyl hydrosulfide; DTXSID00149908; HMS1772L20; ZINC156822; 2(1H)-Pyridinethione,1-hydroxy-; 2-Mercaptopyridine N-oxide, 99%; HY-B1747; ANW-16395; BBL104003; BDBM50366038; SBB065304; STL557814; ZINC13524343; AKOS001147723; AKOS006239794; AB00615; DB06815; NE10429; NSC-179790; SB21519; VP14325; NCGC00246995-01; AS-10952; SC-46446; SC-88136; AB0008461; DB-038047; CS-0013767; FT-0612771; ST51015017; A802495; A802496; J-002710; Q2119951; W-108657; Q27116892
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[12] | |||
| Compound Name |
2-Hydroxypyridine 1-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Pyridinol-1-oxide; 2-Hydroxypyridine N-Oxide; Hydroxypyridinone; 2-Hydroxypyridine-N-oxide; 1-hydroxypyridin-2(1H)-one; Pyridinol, 1-oxide; 2-Pyridinol, 1-oxide; 1-hydroxypyridin-2-one; 2-Pyridinol 1-oxide; 1-hydroxy-1,2-dihydropyridin-2-one; 1-Hydroxy-2-pyridone; MFCD00006195; 2(1H)-Pyridinone, hydroxy-; 2-Pyridinol N-oxide; UNII-YO3915897S; 1-hydroxy-2(1h)-pyridinone; CHEMBL81398; 1-hydroxy-2-(1H)-pyridone; CHEMBL3898657; YO3915897S; Hydroxyl-2-pyridone; 2-Hydroxypyridine-N-oxide, 97%; N-Hydroxyl-2-pyridone; 2-Hydroxypridine-N-oxide; n-hydroxypyridone; n-hydroxy-pyridone; EINECS 212-506-0; NSC406972; N-hydroxy-2-pyridon; N-hydroxy-2-pyridone; pyridin-2-ol 1-oxide; ACMC-1BOLD; 2-HydroxypyridineN-Oxide; 2-hydroxypyridin-1-oxide; 2-hydroxypyridine-1-oxide; 2-hydroxy-pyridin-1-oxide; 2-hydroxy-pyridine N-oxide; 1-hydroxyhydropyridin-2-one; 2-Hydroxy-pyridine-N-oxide; 1-hydroxy-2(1H)-pyridone; NCIOpen2_003773; SCHEMBL40240; KSC120O9N; HPNO; 2-Pyridinol-1-Oxide; SCHEMBL112186; 1-Hydroxypyridine-2(1H)-one; CTK0C0796; CTK7H4052; 2(1H)-Pyridinone, 1-hydroxy-; DTXSID70231622; ZINC331625; ZINC391094; BCP13006; CS-M0760; KS-000008ZZ; ANW-19365; BDBM50057413; BDBM50205814; SBB004329; AKOS000121480; AKOS006273363; AC-5082; LS21131; MCULE-1310193547; NE39440; NSC-406972; AK-46730; AS-17882; BR-46730; SC-45012; SY019070; 2-Pyridinol 1-oxide, >=98.0% (N); AB0004978; DB-025301; AM20061694; FT-0636819; FT-0693752; V2326; M-3607; 67013-EP2298772A1; 67013-EP2308839A1; AC-907/25004409; AC-907/25014064; Pyridinium,1,2-dihydroxy-,1-hydroxide,inner salt; Q-101944; Q27294618; Z1342115512; OXY-PYRION 1-HYDROXY-2(1H)-PYRIDINONE SPECIALITY CHEMICALS
Click to Show/Hide
|
||||
| Activity |
IC50 = 5000000 nM
|
[12] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44. | ||||
| REF 2 | Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors. Bioorg Med Chem. 2009 May 1;17(9):3352-68. | ||||
| REF 3 | Small molecule inhibitors of anthrax lethal factor toxin. Bioorg Med Chem. 2014 Jan 1;22(1):419-34. | ||||
| REF 4 | Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors. J Med Chem. 2010 Mar 11;53(5):2264-76. | ||||
| REF 5 | Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates. J Med Chem. 2015 Nov 12;58(21):8723-33. | ||||
| REF 6 | Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. | ||||
| REF 7 | Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. J Med Chem. 2006 Jan 12;49(1):27-30. | ||||
| REF 8 | Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors. Bioorg Med Chem. 2011 Dec 15;19(24):7338-48. | ||||
| REF 9 | Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. | ||||
| REF 10 | Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1527-31. | ||||
| REF 11 | Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54(2):591-602. | ||||
| REF 12 | Exploring the influence of the protein environment on metal-binding pharmacophores. J Med Chem. 2014 Aug 28;57(16):7126-35. | ||||
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