Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68668 | Target Info | |||
| Target Name | Golgi alpha-mannosidase II (MAN2A1) | ||||
| Synonyms |
Mannosyloligosaccharide 1,31,6alphamannosidase; Mannosidase alpha class 2A member 1; Man II; MAN2A1; Alphamannosidase 2; AMan II
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| Target Type | Discontinued Target | ||||
| Gene Name | MAN2A1 | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Benzyl-N-[[[(2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl]methylamino]methyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207395; BDBM50402979
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| Activity |
Ki = 64910 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-[[[(1R)-1-Phenyl-2-phenylmethoxyethyl]amino]methyl]pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206818; BDBM50402972
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| Activity |
Ki = 68270 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-[[(1-Hydroxy-1,1-diphenylpropan-2-yl)amino]methyl]pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207393; BDBM50402981
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| Activity |
Ki = 80850 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-[(1-Phenylethylamino)methyl]pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207394; BDBM50402980
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| Activity |
Ki = 82350 nM
|
[1] | |||
| Compound Name |
(2R)-2alpha-(2-Anilinoethyl)-3beta,4beta-pyrrolidinediol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207398; BDBM50402976
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| Activity |
Ki = 123030 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-(Benzylamino-methyl)-pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363475; CTK1A8739; DTXSID00438228; BDBM50168993; (2R,3R,4S)-2-((Benzylamino)methyl)pyrrolidine-3,4-diol; (2R)-2alpha-(Benzylaminomethyl)-3beta,4beta-pyrrolidinediol; 3,4-Pyrrolidinediol, 2-[[(phenylmethyl)amino]methyl]-, (2R,3R,4S)-
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| Activity |
Ki = 152470 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R,3R,4S)-2-(1,2-Dihydroxyethyl)pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207397; BDBM50402977
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| Activity |
Ki = 229380 nM
|
[1] | |||
| Compound Name |
(2R)-2alpha-[(2-Thienylmethyl)aminomethyl]-3beta,4beta-pyrrolidinediol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207391; BDBM50402983
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| Activity |
Ki = 232800 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-(((Furan-2-ylmethyl)amino)methyl)pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207390; BDBM50402984; (2R)-2alpha-(Furfurylaminomethyl)-3beta,4beta-pyrrolidinediol
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| Activity |
Ki = 292020 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-((Cyclopentylamino)methyl)pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206828; BDBM50402986; (2R)-2alpha-(Cyclopentylaminomethyl)-3beta,4beta-pyrrolidinediol
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| Activity |
Ki = 332950 nM
|
[1] | |||
| Compound Name |
(2R)-2alpha-(2,2-Dihydroxyethyl)-3beta,4beta-pyrrolidinediol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206815; BDBM50402975
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| Activity |
Ki = 437720 nM
|
[1] | |||
| Compound Name |
2-[((S)-1-Hydroxy-ethylamino)-methyl]-pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206826; BDBM50402988; CHEMBL312569; BDBM50104304; (2R)-2alpha-[[(R)-1-Hydroxyethyl]aminomethyl]-3beta,4beta-pyrrolidinediol
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| Activity |
Ki = 450360 nM
|
[1] | |||
| Compound Name |
(3R,4S)-Pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
cis-Pyrrolidine-3,4-diol; (3S,4R)-Pyrrolidine-3,4-diol; CIS-3,4-DIHYDROXYPYRROLIDINE; 3,4-Pyrrolidinediol, (3R,4S)-rel-; CHEMBL2207396; 3,4-Pyrrolidinediol,(3R,4R)-; SCHEMBL48795; (3R,4S)pyrrolidine-3,4-diol; CTK4B7379; DTXSID90537032; KS-000007QJ; KS-000007QK; (3S)-3alpha,4alpha-Pyrrolidinediol; 5860AA; ANW-72033; BDBM50402978; MFCD09910269; ZINC18284972; AKOS006310246; MCULE-8087937166; BS-12763
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| Activity |
Ki = 530610 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S)-2-((((1H-Imidazol-1-yl)methyl)amino)methyl)pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2207392; BDBM50402982; (2R)-2alpha-[(1H-Imidazole-1-ylmethyl)aminomethyl]-3beta,4beta-pyrrolidinediol
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| Activity |
Ki = 567640 nM
|
[1] | |||
| Compound Name |
2-[((R)-1-Hydroxy-ethylamino)-methyl]-pyrrolidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206827; BDBM50402987; CHEMBL79763; BDBM50104301; (2R)-2alpha-[[(S)-1-Hydroxyethyl]aminomethyl]-3beta,4beta-pyrrolidinediol
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| Activity |
Ki = 683000 nM
|
[1] | |||
| Compound Name |
2alpha-(Aminomethyl)pyrrolidine-3beta,4beta-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2206825; BDBM50402989; AKOS006337970; (2R,3R,4S)-2-(aminomethyl)pyrrolidine-3,4-diol
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| Activity |
Ki = 1310000 nM
|
[1] | |||
| Compound Name |
1,4-Dideoxy-1,4-imino-D-ribitol
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Investigative | Compound Info | ||
| Synonyms |
IMINORIBITOL; (2R,3R,4S)-2-(hydroxymethyl)pyrrolidine-3,4-diol; CHEMBL261634; 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R,3R,4S)-; 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, (2R-(2a,3b,4b))-; 2-HYDROXYMETHYL-PYRROLIDINE-3,4-DIOL; 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, [2R-(2a,3b,4b)]-; (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol; SCHEMBL1223493; ZINC1492232; BDBM50234567; AKOS006350495; J-500976; Q27461466; (2R,3R,4S)-rel-2-(hydroxymethyl)-3,4-pyrrolidinediol; rel-(2R,3R,4S)-2-(Hydroxymethyl)pyrrolidine-3,4-diol
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| Activity |
Ki = 1430000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Virtual screening and QSAR study of some pyrrolidine derivatives as alpha-mannosidase inhibitors for binding feature analysis. Bioorg Med Chem. 2012 Dec 15;20(24):6945-59. | ||||
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