Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68320 | Target Info | |||
| Target Name | X-prolyl aminopeptidase 2 (XPNPEP2) | ||||
| Synonyms |
mAmP; Xaa-Pro aminopeptidase 2; X-Pro aminopeptidase 2; Membrane-bound aminopeptidase P; Membrane-bound AmP; Membrane-bound APP; Aminoacylproline aminopeptidase
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| Target Type | Literature-reported Target | ||||
| Gene Name | XPNPEP2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 44123747
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
(2S)-1-[(2S,3S)-3-Amino-2-hydroxy-5-methylhexanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL309274; BDBM50078390
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| Activity |
IC50 = 58000 nM
|
[2] | |||
| Compound Name |
(S)-1-[(S)-1-((2S,3R)-3-Amino-2-hydroxy-4-phenyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78699; BDBM50078394
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| Activity |
IC50 = 79000 nM
|
[2] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-N-[(2S)-1-Amino-1-oxopropan-2-yl]-1-(2-sulfanylcyclopentanecarbonyl)pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL79083; BDBM50078396; (S)-1-(2-Mercapto-cyclopentanecarbonyl)-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-ethyl)-amide
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| Activity |
IC50 = 300000 nM
|
[2] | |||
| Compound Name |
(2S)-1-[(2S,4R)-1-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-4-hydroxypyrrolidine-2-carbonyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369857
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| Activity |
IC50 = 470000 nM
|
[2] | |||
| Compound Name |
(2S)-1-[(3R,4S)-4-Amino-3-hydroxy-6-methylheptanoyl]-N-[(2S)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL78482; BDBM50078399
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(2S)-1-Amino-1-oxopropan-2-yl]-1-[2-(hydroxycarbamoyl)cyclohexanecarbonyl]pyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL80368; BDBM50078395
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| Activity |
IC50 > 1300000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
| REF 2 | Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem. 1999 Jul 1;42(13):2394-402. | ||||
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