Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67818 | Target Info | |||
| Target Name | P2Y purinoceptor 1 (P2RY1) | ||||
| Synonyms |
P2Y1; P2Y(1) receptor; P2RY1; Adenosine P2Y1 receptor
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| Target Type | Literature-reported Target | ||||
| Gene Name | P2RY1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
INS 316
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Discontinued in Phase 3 | Compound Info | ||
| Synonyms |
Uridine 5'-triphosphate; uridine 5'-triphosphate; uridine triphosphate; 63-39-8; Uteplex; UTP; Uridine 5'-(tetrahydrogen triphosphate); 5'-UTP; Uridine 5'-triphosphoric acid; H4utp; UNII-UT0S826Z60; BRN 0071520; INS316; EINECS 200-558-7; uridine-5'-triphosphate; CHEMBL336296; CHEBI:15713; UT0S826Z60; Uridine5'-(tetrahydrogen triphosphate); [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate; uridine5'-triphosphate; uridintriphosphat; uridine tetrahydrogen
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| Activity |
EC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Uridine-5'-Diphosphate
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Investigative | Compound Info | ||
| Synonyms |
Uridine 5'-diphosphate; URIDINE DIPHOSPHATE; 58-98-0; Uridine 5'-(trihydrogen diphosphate); uridine-5'-diphosphate; UDP; UNII-5G0F599A1Y; 5'-UDP; Uridine 5'-pyrophosphate; EINECS 200-409-6; Uridine 5'-pyrophosphoric acid; CHEMBL130266; CHEBI:17659; 5G0F599A1Y; uridine-diphosphate; ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate; Uridine Pyrophosp
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| Activity |
EC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Methyl 1-[2-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3104630; BDBM50445204
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| Activity |
IC50 = 54200 nM
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[2] | |||
| Compound Name |
1-(3,5-Difluorophenyl)-3-[4-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071536
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Compound Name |
[(4-{[(3,4-Dimethylisoxazol-5-yl)amino]sulfonyl}phenyl)amino]-N-(3-chloropheny l)carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2071533; ZINC950164; STL482234; AKOS001680091; MCULE-7789404844; ST50202762; SR-01000150770; SR-01000150770-1; 4-{[(3-chlorophenyl)carbamoyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
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| Activity |
Ki ~ 100000 nM
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[3] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hexasodium;8-[[4-fluoro-3-[[3-[[3-[[2-fluoro-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate
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Investigative | Compound Info | ||
| Synonyms |
NF157; CHEMBL413145
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| Activity |
IC50 = 1819700.86 nM
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[4] | |||
| References | Top | ||||
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| REF 1 | Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93. | ||||
| REF 2 | Conformationally constrained ortho-anilino diaryl ureas: discovery of 1-(2-(1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a potent, selective, and bioavailable P2Y1 antagonist. J Med Chem. 2013 Nov 27;56(22):9275-95. | ||||
| REF 3 | Virtual screening leads to the discovery of novel non-nucleotide P2Y receptor antagonists. Bioorg Med Chem. 2012 Sep 1;20(17):5254-61. | ||||
| REF 4 | Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48(22):7040-8. | ||||
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