Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67812 | Target Info | |||
| Target Name | Mannoside acetylglucosaminyltransferase 2 (MGAT2) | ||||
| Synonyms |
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; Beta-1,2-N-acetylglucosaminyltransferase II; Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
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| Target Type | Patented-recorded Target | ||||
| Gene Name | MGAT2 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US9828369, Example 155
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736062; SCHEMBL17558302; BDBM360598; methyl 3-(8-((3-(2,3- dichlorophenyl)ureido)methyl)isoquinolin- 5-yl)benzoate
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
[(3R)-1-[2-[(1S)-1-(4-Chloropyrazol-1-yl)ethyl]-1H-imidazo[4,5-b]pyridin-5-yl]piperidin-3-yl]-pyrrolidin-1-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893203; SCHEMBL15322898; BDBM215629; US9296745, 196-A; US9296745, 196-B
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
Chembl4280459
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
3-Ethyl-N,3-dimethyl-2,5-dioxo-N-phenyl-1,4-dihydro-1,4-benzodiazepine-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2376311; BDBM50433279
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-(3-Ethyl-3-methyl-2,5-dioxo-1,4-dihydro-1,4-benzodiazepin-7-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2376319; BDBM50433280
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-(4-Chlorophenyl)-2,5-dioxospiro[1,4-dihydro-1,4-benzodiazepine-3,1'-cyclobutane]-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2376318; BDBM50433281
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors. J Med Chem. 2015 Dec 10;58(23):9345-53. | ||||
| REF 2 | Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile. Medchemcomm. 2016 Nov 22;8(4):771-779. | ||||
| REF 3 | Identification and design of a novel series of MGAT2 inhibitors. Bioorg Med Chem Lett. 2013 May 1;23(9):2721-6. | ||||
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