Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66383 | Target Info | |||
| Target Name | Complement factor D (CFD) | ||||
| Synonyms |
Properdin factor D; PFD; DF; C3 convertase activator; Adipsin
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| Target Type | Clinical trial Target | ||||
| Gene Name | CFD | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4161639
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|
Investigative | Compound Info | ||
| Synonyms |
3-[3-(aminomethyl)phenyl]-~{N}-[(1~{S})-1,2,3,4-tetrahydronaphthalen-1-yl]benzamide; BDBM50333109; E82
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| Activity |
IC50 = 54000 nM
|
[1] | |||
| Compound Name |
Chembl4169870
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|
Investigative | Compound Info | ||
| Synonyms |
(2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]-3-methyl-butanoic acid; BDBM50332957; E88
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| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
Chembl4163988
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50331392; E7W
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| Activity |
IC50 = 84000 nM
|
[1] | |||
| Compound Name |
Chembl4161222
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50330412
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| Activity |
IC50 = 98000 nM
|
[1] | |||
| Compound Name |
Chembl4170258
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50333119; E8B
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|
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| Activity |
IC50 = 120000 nM
|
[1] | |||
| Compound Name |
Chembl4176751
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50333118
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| Activity |
IC50 = 140000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4159632
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50330953
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|
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| Activity |
IC50 = 257000 nM
|
[1] | |||
| Compound Name |
Chembl4166600
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50330772
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| Activity |
IC50 = 310000 nM
|
[1] | |||
| Compound Name |
Chembl4176735
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50332295
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| Activity |
IC50 = 690000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett. 2018 Apr 24;9(5):490-495. | ||||
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