Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65818 | Target Info | |||
| Target Name | Endoplasmic reticulum aminopeptidase 2 (ERAP2) | ||||
| Synonyms |
Leukocyte-derived arginine aminopeptidase; LRAP; L-RAP
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | ERAP2 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 25 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-methylbutanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416586; BDBM50076965
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[[4-amino-3-[[(2S)-2-amino-4-methylpentanoyl]amino]benzoyl]amino]hexanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416582; BDBM50076957
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|
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
2-[[[1-Amino-2-(2-methylpropylamino)ethyl]-hydroxyphosphoryl]methyl]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805028; BDBM50170881
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| Activity |
Ki = 55300 nM
|
[2] | |||
| Compound Name |
Methyl 3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414595; BDBM50076973
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|
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
Methyl 3-amino-4-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416699; BDBM50077069
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|
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
2-[[4-(Aminomethyl)phenyl]methyl]-3-[(1-amino-3-pyridin-4-ylpropyl)-hydroxyphosphoryl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828715; BDBM50190113
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|
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| Activity |
Ki = 65200 nM
|
[2] | |||
| Compound Name |
Benzyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416719; BDBM50077121
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|
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
Methyl 4-amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416566; BDBM50076745
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416686; BDBM50077023
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416587; BDBM50076966
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-Benzyl-2-[(4-fluorophenyl)methyl]-N'-hydroxypropanediamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180993; BDBM50400206
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(3,4-diaminobenzoyl)amino]-3-(1H-indol-3-yl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416705; BDBM50077116
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[3-Amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416710; BDBM50077119
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 3-amino-4-[[(2S)-2-amino-4-methylpentanoyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416700; BDBM50077098
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-(4-hydroxyphenyl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420384; BDBM50439351
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[[3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl]amino]-3-methylbutanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416709; BDBM50077118
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-amino-4-(4-phenylmethoxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416687; BDBM50077024
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl (2S)-6-amino-2-[[3-amino-4-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]benzoyl]amino]hexanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416718; BDBM50076983
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-Amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416690; BDBM50077030
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420386; BDBM50439349
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-Amino-3-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416574; BDBM50076816
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benzyl (2S)-2-[[4-amino-3-[[(2S)-2-aminohexanoyl]amino]benzoyl]amino]-3-methylbutanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416689; BDBM50077026
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-Amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl]amino]-3-(1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3416688; BDBM50077025
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2420387; BDBM50439348
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[1-Amino-2-(benzylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805986; BDBM50170891
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|
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| Activity |
Ki = 106000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[1-Amino-2-(2-aminoethylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806100; SCHEMBL3222743; BDBM50170899
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[1-Amino-2-(methylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804959; BDBM50170886
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
2-[[3-(Aminomethyl)phenyl]methyl]-3-[(1-amino-3-pyridin-3-ylpropyl)-hydroxyphosphoryl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827529; BDBM50190108
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
Phosphonic acid, (1-amino-3-phenylpropyl)-
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090914; (1-amino-3-phenylpropyl)phosphonic acid; 1-amino-3-phenylpropylphosphonic acid; ACMC-20ln9n; SCHEMBL6518228; CTK2J4470; DTXSID20456207; BDBM50316049; 1(rs)-amino-3-phenylpropanephosphonic acid
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
Leucine Phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
[(1R)-1-amino-3-methylbutyl]phosphonic acid; CHEMBL40422; SCHEMBL1191426; CTK5F9334; DTXSID20332198; ZINC2047807; BDBM50190109; MFCD00797886; DB02386; (R)-1-Amino-(3-methylbutyl)phosphonic acid; Phosphonic acid,[(1R)-1-amino-3-methylbutyl]-; ETHYL5-(2-BROMOACETYL)ISOXAZOLE-3-CARBOXYLATE; Q27093390
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[1-Amino-2-(oxolan-2-ylmethylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805487; BDBM50170895
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
(1-Amino-2-morpholin-4-ylethyl)phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805587; BDBM50170901
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[(1S)-1-Amino-3-methylbutyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL288165; Phosphonic acid,P-[(1S)-1-amino-3-methylbutyl]-; (S)-1-PHOSPHONO-3-METHYL-BUTYLAMINE; CTK5F9333; ZINC1707645; BDBM50190114; MFCD00797887; [(S)-1-Amino-3-methylbutyl]phosphonic acid; (S)-1-Amino-(3-methylbuthyl)phosphonic acid; Q27453362
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[1-Amino-2-(propylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805557; BDBM50170888
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[1-Amino-2-[2-(dimethylamino)ethylamino]ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805964; BDBM50170898
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
2-[[(1-Amino-3-phenylpropyl)-hydroxyphosphoryl]methyl]-3-(3,5-dimethylphenyl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355107; BDBM50025049
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
[1-Amino-2-(1-phenylethylamino)ethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804861; BDBM50170892
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
2-[[4-(Aminomethyl)phenyl]methyl]-3-[(1-amino-3-phenylpropyl)-hydroxyphosphoryl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355109; BDBM50025066
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Compound Name |
2-[[3-(Aminomethyl)phenyl]methyl]-3-[(1-amino-3-phenylpropyl)-hydroxyphosphoryl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355108; BDBM50025050
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|
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| Activity |
Ki > 250000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem. 2015 Feb 12;58(3):1524-43. | ||||
| REF 2 | Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4122-6. | ||||
| REF 3 | Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency. ACS Med Chem Lett. 2017 Feb 21;8(3):333-337. | ||||
| REF 4 | Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. | ||||
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