Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65200 | Target Info | |||
| Target Name | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | ||||
| Synonyms |
HSD11B1; 11beta-HSD1A; 11HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1; 11-DH; 11 beta-hydroxysteroid dehydrogenase type 1
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| Target Type | Clinical trial Target | ||||
| Gene Name | HSD11B1 | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 29 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Go-Y022
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|
Investigative | Compound Info | ||
| Synonyms |
Go-Y022; CHEMBL128729; 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one; (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one; Hylin; AC1O6FK4; 1,5-Bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one; SCHEMBL1493282; ZINC6483730; BDBM50067028; 1,5-Bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one; 1,5-bis-(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one; (1E,4E)-1,5-bis(4-hydroxy-3-methoxy-phenyl)penta-1,4-dien-3-one
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| Activity |
IC50 = 70901 nM
|
[1] | |||
| Compound Name |
1-(4-(2-(p-Toluidino)-2-oxoethoxy)-2,3-dibromo-5-ethoxybenzylidene)semicarbazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL470948; BDBM50244255; STK400447; AKOS000303774
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(4-Ethyl-piperazin-1-yl)-(3-hydroxy-adamantan-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395391; BDBM50207775; AKOS034527391; AB00981978-01
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| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
Cyclohexyl(4-ethylpiperazin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248168; Cambridge id 6869150; SCHEMBL10282316; BDBM50207802; ZINC19954198; AKOS003801579; 1-cyclohexanecarbonyl-4-ethylpiperazine; MCULE-4461455147
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|
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| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
3-Chloro-2-methyl-N-(4-methyl-oxazol-2-yl)-benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL196015; BDBM50167722
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|
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| Activity |
IC50 = 58700 nM
|
[4] | |||
| Compound Name |
(4-Benzenesulfonyl-piperazin-1-yl)-(3-p-tolyl-adamantan-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247380; BDBM50207778; AKOS007986133
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|
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| Activity |
IC50 = 64000 nM
|
[3] | |||
| Compound Name |
(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763512; BDBM50145436
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|
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| Activity |
IC50 = 74000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-N-[1-(1-Adamantyl)ethyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765140; BDBM50145442
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|
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| Activity |
IC50 = 85000 nM
|
[5] | |||
| Compound Name |
1-(Benzenesulfonyl)-3,3-dimethylbutan-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL240980; 3,3-dimethyl-1-(phenylsulfonyl)butan-2-one; SCHEMBL6129827; ZINC395146; 1-(PHENYLSULFONYL)PINACOLONE; BDBM50212523; STK205549; AKOS003310254; MCULE-9649625326; 1-(Phenylsulfonyl)-3,3-dimethyl-2-butanone; 3,3-dimethyl-1-(phenylsulfonyl)-2-butanone; AP-853/42162480
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|
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| Activity |
IC50 = 90000 nM
|
[6] | |||
| Compound Name |
(1S,5R)-N-[(6,6-Dimethyl-2-bicyclo[3.1.1]heptanyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765321; BDBM50145443
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| Activity |
IC50 = 94000 nM
|
[5] | |||
| Compound Name |
1-Benzoyl-4-ethylpiperazine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL247969; (4-ethylpiperazin-1-yl)-phenylmethanone; SCHEMBL4293002; ZINC6046607; BDBM50207759; AKOS002704839; MCULE-7232058770; (4-ethylpiperazin-1-yl)(phenyl)methanone
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-(Adamantane-1-carbonyl)-4-benzoylpiperazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394930; SMR000067796; Oprea1_061269; Oprea1_796737; MLS000098850; MLS002635352; HMS2333D11; ZINC4162417; BDBM50207764; AKOS000560567; MCULE-6148373315; SR-01000326152; SR-01000326152-1; Z26979726; [4-(adamantane-1-carbonyl)-piperazin-1-yl]-phenyl-methanone
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Cyclohexyl-1-(4-ethylpiperazin-1-yl)ethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247769; BDBM50207782; AKOS016609570; MCULE-5447028906
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(Phenylsulfonyl)-4-(trifluoromethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391616; SCHEMBL19248164; BDBM50212546
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-(4-Ethylpiperazin-1-yl)-2,2-dimethylpropan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392198; SCHEMBL10162925; BDBM50207796; ZINC20356150; AKOS003798196; MCULE-4742797902
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(Benzenesulfonyl)-3-chlorobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391978; Oprea1_634065; Oprea1_769323; ZINC267737; 3-chloro-N-(phenylsulfonyl)benzamide; BDBM50212537; N-(3-Chlorobenzoyl)benzenesulfonamide; AKOS001036924; MCULE-8943538559; Z56664810
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(Phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239675; BDBM50212542
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|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
N-(Benzenesulfonyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(phenylsulfonyl)benzamide; n-benzoylbenzenesulfonamide; CHEMBL241149; N-Benzoyl-benzenesulfonamide; NSC23395; Oprea1_040067; Oprea1_327131; MLS000523362; SCHEMBL174010; N-benzoyl-1-benzenesulfonamide; IFLab1_000581; DTXSID00956972; HMS1413K09; HMS2419E10; phenyl-N-(phenylsulfonyl)carboxamide; BDBM50212539; NSC-23395; STK400715; ZINC16771374; AKOS000620772; AKOS001022912; MCULE-6069765809; IDI1_008800; SMR000123340; N-(Benzenesulfonyl)benzenecarboximidic acid; ST50031988; AE-641/00206028; SR-01000395733; SR-01000395733-1; Z56664837
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Benzamide, N-[(4-methylphenyl)sulfonyl]-
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|
Investigative | Compound Info | ||
| Synonyms |
N-Tosylbenzamide; N-BENZOYL-4-METHYL-BENZENESULFONAMIDE; N-(4-methylphenyl)sulfonylbenzamide; CHEMBL241150; N-[(4-methylphenyl)sulfonyl]benzamide; Benzamide, N-((4-methylphenyl)sulfonyl)-; N-benzoyl-4-methylbenzenesulfonamide; NSC67180; EINECS 230-202-6; NSC 67180; NCIOpen2_002916; Oprea1_203506; Oprea1_874102; N-(p-tolylsulfonyl)-benzamide; N-Benzoyl-p-toluenesulfonamide; SCHEMBL5931087; DTXSID2064527; CTK5D1046; N-((p-Tolyl)sulphonyl)benzamide; ZINC92231; BDBM50212528; MFCD00431862; NSC-67180; AKOS001022054; CCG-250126; DS-7051; MCULE-1806992064; N-[(P-TOLYL)SULFONYL]BENZAMIDE; AK140447; Benzamide,N-[(4-methylphenyl)sulfonyl]-; SR-01000446765; SR-01000446765-1; BRD-K50927196-001-01-0; F0898-0188
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245954; SMR000013476; 1-(1-adamantylcarbonyl)-4-phenylpiperazine; TimTec1_003642; Oprea1_456377; Oprea1_657192; MLS000075047; MLS002538627; HMS1544F12; HMS2343J21; ZINC4083212; BDBM50207791; STK080899; adamantanyl 4-phenylpiperazinyl ketone; AKOS000655448; MCULE-8518706354; ST052840; 1-(adamantane-1-carbonyl)-4-phenylpiperazine; AB00407452-08; AO-365/40118306; BRD-K77110549-001-01-6; Z27769992; (4-phenylpiperazin-1-yl)(tricyclo[3.3.1.1~3,7~]dec-1-yl)methanone
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[2-Chloro-6-(4-methyl-oxazol-2-ylsulfamoyl)-phenyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371050; BDBM50167719
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[2-Chloro-6-(4-methyl-oxazol-2-ylsulfamoyl)-phenyl]-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194096; BDBM50167725
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(4-Chlorophenyl)sulfonylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189770; N-(4-chlorophenylsulfonyl)benzamide; N-Benzoyl-4-chlorobenzenesulfonamide; NSC144078; Oprea1_418153; MLS000776566; SCHEMBL9176247; DTXSID40301543; HMS1775H21; HMS2702M07; ZINC242291; BDBM50154511; N-Benzoyl-4-chloro-benzenesulfonamide; AKOS001022055; MCULE-7830489798; NSC-144078; Benzamide,n-[(4-chlorophenyl)sulfonyl]-; SMR000371820; Benzamide, N-[(p-chlorophenyl)sulfonyl]-; DS-006548; EU-0000852
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Cyclopropyl(4-ethylpiperazin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246745; SCHEMBL7903517; BDBM50207793; ZINC22251131; AKOS003801665
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372623; BDBM50167724
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|
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
1-(Adamantane-1-carbonyl)-4-(benzenesulfonyl)piperazine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396926; ZINC5392574; BDBM50207762; AKOS017070799; MCULE-5517615728; Z29406230; adamantan-1-yl-(4-benzenesulfonyl-piperazin-1-yl)-methanone
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765510; BDBM50145435
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|
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| Activity |
IC50 = 121000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-N-[5-(4-Chlorophenyl)-1,3-thiazol-2-yl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764221; BDBM50145439
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|
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| Activity |
IC50 = 122000 nM
|
[5] | |||
| Compound Name |
(2R)-4-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)phenyl]-cis-2,6-dimethylmorpholine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558695; SCHEMBL3222419; BDBM50295389
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| Activity |
IC50 = 185000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 58 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763813; BDBM50145437
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|
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| Activity |
IC50 = 245000 nM
|
[5] | |||
| Compound Name |
1,1-Dioxo-2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]-1,2-benzothiazol-3-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763599; BDBM50145429
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|
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| Activity |
IC50 = 341000 nM
|
[5] | |||
| Compound Name |
4-[[2-[6-(4-Fluorophenyl)-1,1-dioxo-1,2,6-thiadiazinan-2-yl]acetyl]amino]adamantane-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036241; CHEMBL3663662; SCHEMBL15419898; BDBM167434; BDBM50384534; US9073906, 44
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| Activity |
IC50 = 351000 nM
|
[8] | |||
| Compound Name |
1-(1-Adamantyl)-3-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402465; BDBM50436981
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|
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| Activity |
IC50 = 403700 nM
|
[9] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764012; BDBM50145445
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,3As,5aS,6S,7R,9aS)-7-methyl-1-propan-2-yl-2,3,3a,4,5a,6,8,9-octahydro-1H-cyclopenta[c][1]benzofuran-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763488; BDBM50145472
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R,8R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765626; BDBM50145508
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(2S,3R,5'S,6'R)-5',6'-Dihydroxy-1'-methylspiro[1,2-dihydroindene-3,4'-cyclohexene]-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764859; BDBM50145462
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,4'S,5R,6S)-4'-(Hydroxymethyl)-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765438; BDBM50145501
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-N-[(3,5-Difluorophenyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765258; BDBM50145441
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764356; BDBM50145433
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765604; BDBM50145446
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764965; BDBM50145447
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
[(1S,5R)-8-Methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-1-yl]methanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765092; BDBM50145579
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5R,9S)-9-acetyloxy-8-methylidene-1-propan-2-ylspiro[4.5]decane-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763525; BDBM50145476
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2S,2'S,5S,5'S,6S)-2'-(Hydroxymethyl)-2-methyl-5'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,1'-cyclopentane]-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764618; BDBM50145474
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R,8S,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765756; BDBM50145484
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5S)-8-methylidene-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765682; BDBM50145479
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|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764519; BDBM50145575
Click to Show/Hide
|
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
4-Methoxy-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764563; BDBM50145432
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
2-[[(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765656; BDBM50145430
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-[[Tert-butyl(dimethyl)silyl]oxymethyl]-8-methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-10-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765104; BDBM50145578
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764025; BDBM50145449
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,5R,7S)-7-acetyloxy-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765467; BDBM50145536
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5S,7S,8R)-7-acetyloxy-8-hydroxy-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764479; BDBM50145478
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R,8R)-1-[[Tert-butyl(dimethyl)silyl]oxymethyl]-8-hydroxy-8-methyl-4-propan-2-ylspiro[4.5]deca-3,9-dien-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764932; BDBM50145500
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,4S,5S,8R,10R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]decane-8,10-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763510; BDBM50145469
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(Hydroxymethyl)-4-phenylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763916; BDBM50145580
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,5R)-4-methylidene-8-oxospiro[4.5]dec-9-ene-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763272; BDBM50145577
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(Naphthalen-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764111; BDBM50145450
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5R,9S)-9-acetyloxy-8-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765212; BDBM50145477
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S)-1-(Hydroxymethyl)-4-propan-2-ylspiro[4.5]dec-3-en-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764064; BDBM50145502
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5S)-8-oxo-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763401; BDBM50145480
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(2S,2'S,3R,3'R,4'S)-2',3'-Dihydroxy-4'-methylspiro[1,2-dihydroindene-3,1'-cyclohexane]-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765659; BDBM50145461
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1R,9S,12S,13S,14R)-14-Methyl-11-oxatetracyclo[7.7.0.01,12.02,7]hexadeca-2,4,6-triene-13,14-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763945; BDBM50145466
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(2S,3R)-2-(Hydroxymethyl)spiro[1,2-dihydroindene-3,4'-cyclohex-2-ene]-1'-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765443; BDBM50145467
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2R,2'S,5S,5'S,6S)-2'-(Hydroxymethyl)-2-methyl-5'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,1'-cyclopentane]-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764068; BDBM50145473
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(3Ar,5aR,9aR)-1-propan-2-yl-3,3a,5a,6,8,9-hexahydrocyclopenta[c][1]benzofuran-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763445; BDBM50145503
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(Hydroxymethyl)-4-(phenylmethoxymethyl)spiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764226; BDBM50145576
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R,8R,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764331; BDBM50145483
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765185; BDBM50145535
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-8-Oxo-4-propan-2-yl-N-(2-thiophen-2-ylethyl)spiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765590; BDBM50145440
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(2S,3R)-6'-Oxospiro[1,2-dihydroindene-3,3'-cyclohexene]-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763712; BDBM50145463
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(4S,5R)-1-Methyl-4-(hydroxymethyl)spiro[4.5]deca-1,6-diene-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763293; BDBM50145581
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1'S,2S,3R,6'S)-2-(Hydroxymethyl)spiro[1,2-dihydroindene-3,5'-7-oxabicyclo[4.1.0]heptane]-2'-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765260; BDBM50145464
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Tert-butyl-[(1S,4R,4'S,6S)-4'-[[tert-butyl(dimethyl)silyl]oxymethyl]-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-4,5'-cyclopentene]-1-yl]oxy-dimethylsilane
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765723; BDBM50145481
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(4S,5R)-1-Isopropyl-4-(hydroxymethyl)spiro[4.5]deca-1,6-diene-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764924; BDBM50145582
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Tert-butyl N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764151; BDBM50145431
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
4-Amino-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]-N-pyrimidin-2-ylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764299; BDBM50145428
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-4-[2-[Tert-butyl(dimethyl)silyl]oxyethyl]-1-(hydroxymethyl)spiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763867; BDBM50145574
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
Ethyl (1S,4S,5S,7S)-7-acetyloxy-8-methylidene-9-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764551; BDBM50145475
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,3As,5aR,7R,9aS)-7-methyl-1-propan-2-yl-2,3,3a,4,5a,6,8,9-octahydro-1H-cyclopenta[c][1]benzofuran-7-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765130; BDBM50145470
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2S,4'S,5R,6S)-4'-(Hydroxymethyl)-2-methyl-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763959; BDBM50145499
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,4S,5S,8R,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]decane-8,9-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764521; BDBM50145468
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763513; BDBM50145434
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
[(1S,5R)-8,8-Dimethoxy-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764120; BDBM50145537
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R,8R,10R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,10-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765531; BDBM50145482
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,5R)-1-(Ethoxymethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763928; BDBM50145573
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mono-carbonyl curcumin analogues as 11-hydroxysteroid dehydrogenase 1 inhibitors. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4362-6. | ||||
| REF 2 | Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99. | ||||
| REF 3 | Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. | ||||
| REF 4 | Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2865-9. | ||||
| REF 5 | Synthesis and evaluation of colletoic acid core derivatives. Eur J Med Chem. 2016 Mar 3;110:126-32. | ||||
| REF 6 | beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. | ||||
| REF 7 | Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model. J Med Chem. 2009 Sep 10;52(17):5449-61. | ||||
| REF 8 | Synthesis and biological evaluation of cyclic sulfamide derivatives as 11-hydroxysteroid dehydrogenase 1 inhibitors. ACS Med Chem Lett. 2012 Jan 17;3(2):88-93. | ||||
| REF 9 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11-HSD1 inhibitors: potential impact in diabetes. Eur J Med Chem. 2013 Jul;65:403-14. | ||||
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