Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64725 | Target Info | |||
| Target Name | Fatty acid desaturase 2 (FADS2) | ||||
| Synonyms |
FADS2; Delta-6 desaturase; Delta(6) fatty acid desaturase; Delta(6) desaturase; D6D
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| Target Type | Literature-reported Target | ||||
| Gene Name | FADS2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 46916548
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1938871; SCHEMBL1394287; BDBM50362583
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MK-8245
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Phase 2 | Compound Info | ||
| Synonyms |
MK-8245; 1030612-90-8; MK8245; MK 8245; UNII-537E7QE8LX; 537E7QE8LX; CHEMBL1938870; 5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid; 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-;2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-; 2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid; UJEAABFSXKCSGI-UHFFFAOYSA-N; C17H16BrFN6O4; MLS006011144
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| Activity |
IC50 > 100000000 nM
|
[2] | |||
| Compound Name |
4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-1,3,4-thiadiazol-2-yl]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153600; SCHEMBL473046; BDBM50393165; 2-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-5-(2H-tetrazol-5-yl)-1,3,4-thiadiazole
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| Activity |
IC50 > 100000000 nM
|
[2] | |||
| Compound Name |
1-[5-(2H-Tetrazol-5-yl)-1,3,4-thiadiazol-2-yl]-4-[2-(trifluoromethyl)phenoxy]piperidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153599; 1-[5-(2H-Tetrazol-5-yl)-1,3,4-thiadiazol-2-yl}-4-[2-(trifluoromethyl)phenoxy]piperidine; SCHEMBL473002; BDBM50393164; 2-(2H-tetrazol-5-yl)-5-[4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl]-1,3,4-thiadiazole
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| Activity |
IC50 > 100000000 nM
|
[2] | |||
| Compound Name |
MF-438
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Investigative | Compound Info | ||
| Synonyms |
UNII-HI3FN320OX; HI3FN320OX; CHEMBL594902; SCHEMBL4265051; EX-A4365; BDBM50305768; s6842; HY-15822; CS-0009306; Q27279943
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| Activity |
IC50 > 100000000 nM
|
[2] | |||
| Compound Name |
2-(5-(5-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
MK-8245 analog; CHEMBL2153601; SCHEMBL473026; CTK8B8771; DTXSID80648363; BCP06568; ABP000773; ANW-61221; BDBM50393166; ZINC43195877; AKOS016003537; DA-48257; FT-0754490; J-516606
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| Activity |
IC50 > 100000000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. | ||||
| REF 2 | Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96. | ||||
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