Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63024 | Target Info | |||
| Target Name | NF-kappa-B-activating kinase (TBK1) | ||||
| Synonyms |
TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
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| Target Type | Patented-recorded Target | ||||
| Gene Name | TBK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4287847
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19181431; BDBM357899; US10214536, Compound 117
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| Activity |
IC50 = 85113.8 nM
|
[1] | |||
| Compound Name |
Chembl4279379
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19196842; BDBM357930; US10214536, Compound 297
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| Activity |
IC50 = 95499.26 nM
|
[1] | |||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4279336
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19182073; BDBM357871; US10214536, Compound 40
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| Activity |
IC50 = 257039.58 nM
|
[1] | |||
| Compound Name |
Chembl4293403
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19180105; BDBM357893; US10214536, Compound 74
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| Activity |
IC50 = 489778.82 nM
|
[1] | |||
| Compound Name |
Chembl4277195
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19181441; BDBM50469230
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| Activity |
IC50 = 524807.46 nM
|
[1] | |||
| Compound Name |
Chembl4281788
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19180392; BDBM357897; US10214536, Compound 81
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| Activity |
IC50 = 630957.34 nM
|
[1] | |||
| Compound Name |
Chembl4290544
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19180142; BDBM357905; US10214536, Compound 246; 2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
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| Activity |
IC50 = 2818382.93 nM
|
[1] | |||
| Compound Name |
Chembl4295050
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19181474; BDBM357903; US10214536, Compound 243a; 2-Amino-7-isopentyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid
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| Activity |
IC50 = 10715193.05 nM
|
[1] | |||
| Compound Name |
Chembl4287304
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19182150; BDBM357862; US10214536, Compound 15
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| Activity |
IC50 = 19054607.18 nM
|
[1] | |||
| Compound Name |
Chembl4287123
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL19182270; BDBM50469228
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| Activity |
IC50 = 50118723.36 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKK for the treatment of obesity. Bioorg Med Chem. 2018 Nov 1;26(20):5443-5461. | ||||
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