Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T62391 | Target Info | |||
| Target Name | Glutamate receptor AMPA 3 (GRIA3) | ||||
| Synonyms |
Glutamate receptor ionotropic, AMPA 3; GluRK3; GluRC; GluR3; GluA3; GRIA3; AMPAselective glutamate receptor 3
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| Target Type | Successful Target | ||||
| Gene Name | GRIA3 | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
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Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
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| Activity |
EC50 = 67000 nM
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[1] | |||
| Compound Name |
2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL154700; 2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid; SCHEMBL6431740; ZINC1491954; BDBM50137125; AKOS012857302; 2-[3-(3-Bromo-phenyl)-ureido]-4-chloro-benzoic acid
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
4-Chloro-2-(naphthalen-2-ylcarbamoylamino)benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL346524; SCHEMBL3959804; CTK2A8003; DTXSID90436076; BDBM50137124; ZINC13531921; 4-chloro-2-(3-(naphthalen-2-yl)ureido)benzoic acid; 4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid; Benzoic acid, 4-chloro-2-[[(2-naphthalenylamino)carbonyl]amino]-
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-3-(4-bromo-3-hydroxyisoxazol-5-YL)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73698; (RS)-4-Bromo-homo-ibotenic acid; (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID; Bromohomoibotenic acid; 2-amino-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoic acid; SCHEMBL5280594; SCHEMBL13957643; CTK5E3726; DTXSID30991699; (+/-)-4-Bromohomoibotenic acid; BDBM50017244; AB44069; (+/-)-4-Bromohomoibotenic acid, solid; ST50405217; 3-(4-Bromo-3-hydroxy-1,2-oxazol-5-yl)alanine; Q27458524; 2-azaniumyl-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoate; 2-Amino-3-(4-bromo-3-hydroxy-isoxazol-5-yl)-propionic acid; 5-Isoxazolepropanoicacid, a-amino-4-bromo-2,3-dihydro-3-oxo-; (R,S)-2-amino-3-(4-bromo-3-hydroxy-5-isoxazolyl)propionic acid; 2-AMINO-3-(4-BROMO-3-HYDROXYISOXAZOL-5-YL)PROPANOICACID; 2-amino-3-(4-bromo-3-oxo-2,3-dihydroisoxazol-5-yl)propanoic acid; 2-AMINO-3-(4-BROMO-3-HYDROXY-1,2-OXAZOL-5-YL)PROPANOIC ACID
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| Activity |
EC50 = 202000 nM
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[3] | |||
| Compound Name |
(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542242
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| Activity |
Ki = 247000 nM
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[4] | |||
| Compound Name |
(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL372643; BDBM50166285; 2-amino-3-(3-hydroxy-5-(2-propyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid; 2-Amino-3-[3-hydroxy-5-(2-propyl-2H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid
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| Activity |
EC50 = 450000 nM
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[1] | |||
| Compound Name |
2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL193087; BDBM50166287; (RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid; 2-Amino-3-[3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid
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| Activity |
EC50 = 700000 nM
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[1] | |||
| Compound Name |
(RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL388746; BDBM50211399
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| Activity |
EC50 = 1000000 nM
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[1] | |||
| Compound Name |
Cl-HIBO
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72366; 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid; (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID; SCHEMBL1055865; 4-CHLOROHOMOIBOTENIC ACID; CTK8F8718; (2S)-2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid; BDBM50128264; AKOS024456741; AB17833; C-355; SR-01000597512; SR-01000597512-1; (R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionate; 2-Amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)-propionic acid; 2-amino-3-(4-chloro-3-oxo-1,2-oxazol-5-yl)propanoic acid.; 2-AMINO-3-(4-CHLORO-3-HYDROXY-1,2-OXAZOL-5-YL)PROPANOIC ACID
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| Activity |
EC50 = 2700000 nM
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[3] | |||
| Compound Name |
2-Amino-3-[3-hydroxy-5-(1-methyl-1H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL317790; SCHEMBL13319946; BDBM50059674; (RS)-2-amino-3-[3-hydroxy-5-(1-methyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid
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| Activity |
EC50 > 3000000 nM
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[1] | |||
| Compound Name |
2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370941; BDBM50166286; (RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid; 2-Amino-3-[5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxy-isoxazol-4-yl]-propionic acid
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| Activity |
EC50 = 6.31E+13 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. J Med Chem. 2007 Aug 23;50(17):4177-85. | ||||
| REF 2 | 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. J Med Chem. 2003 Dec 18;46(26):5834-43. | ||||
| REF 3 | Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7. | ||||
| REF 4 | Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine. J Med Chem. 2002 Sep 26;45(20):4383-6. | ||||
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