Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62206 | Target Info | |||
| Target Name | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | ||||
| Synonyms |
Subtilisin/kexin-like protease PC9; Proprotein convertase 9; PC9; Neural apoptosis-regulated convertase 1; NARC1; NARC-1
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | PCSK9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-Acetylamino-3-[4-(oxiran-2-ylmethoxy)phenyl]propionic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL42526; BDBM50014066; 2-Acetylamino-3-(4-oxiranylmethoxy-phenyl)-propionic acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 200000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phenyl Boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phenylboronic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 470000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | O'-(epoxyalkyl)tyrosines and (epoxyalkyl)phenylalanine as irreversible inactivators of serine proteases: synthesis and inhibition mechanism. J Med Chem. 1990 Jun;33(6):1620-34. | ||||
| REF 2 | Diphenylborinic acid is a strong inhibitor of serine proteases. Bioorg Med Chem Lett. 1994 Oct 20;4(20):2417-20. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.