Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61243 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 7 (mGluR7) | ||||
| Synonyms |
mGluR7; GPRC1G
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | GRM7 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 34 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LY354740
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|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Eglumetad; Eglumegad; 176199-48-7; (1S,2S,5R,6S)-2-aminobicyclo[310]hexane-2,6-dicarboxylic acid; Eglumegad [INN]; UNII-ONU5A67T2S; LY-354740; LY 354740; ONU5A67T2S; CHEMBL8759; Eglumegad (INN); (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; (1S,2S,5R,6S)-2-Amino-bicyclo[310]hexane-2,6-dicarboxylic acid; [3H]Eglumegad; LY366563; Eglumetad [USAN:INN]; (+)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 40F; PubChem18158; Eglumegad; Eglumegad [USAN]; Eglumegad hydrate; Eglumetad hydrate; LY 314582; LY 366563; LY314582; Eglumegad (USAN); LY-314582; LY-354740 monohydrate; LY-366563; Eglumetad (INN/USAN); (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid hydrate; (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid monohydrate; 2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; [3H]eglumegad
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
CPCCOEt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327783; 179067-99-3; AC1O3E8H; 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester; SCHEMBL12648369; MolPort-003-940-874; CPCCOEt, > AKOS024456339; LP00300; NCGC00024948-02; KB-49121; AS-16761; L000202; SR-01000597466; SR-01000597466-1; BRD-A05729358-001-01-2; ethyl (7E)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
SIB-1757
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|
Investigative | Compound Info | ||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
LY-389795
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88999; LY389795; LY-389795; GTPL3349; BDBM50089897; LY 389795; (4S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid(LY389795)
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
LY-379268
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Investigative | Compound Info | ||
| Synonyms |
LY 379268; LY-379268; CHEMBL275079; LY379268; 191471-52-0; SCHEMBL2454646; GTPL1394; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; CTK8F0567; DTXSID90436637; ZINC3952369; BDBM50074749; FCH888149; AKOS006306876; API0003234; NCGC00159572-01; LS-98795; RT-013615; LY-379,268; B7061; J-012378; 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-methyl-6-(phenylethynyl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
2-Methyl-6-(phenylethynyl)pyridine; MPEP; 96206-92-7; 6-Methyl-2-(phenylethynyl)pyridine; 2-methyl-6-(2-phenylethynyl)pyridine; UNII-7VC0YVI27Y; 7VC0YVI27Y; CHEMBL66654; CHEBI:64159; Pyridine, 2-methyl-6-(phenylethynyl)-; Tocris-1212; AC1MHGB1; Lopac-M-5435; Lopac0_000738; MLS006011229; SCHEMBL103061; 2-Picoline, 6-phenylethynyl-; GTPL1426; DTXSID9043982; MolPort-003-958-770; HMS3651F13; 2-Methyl-6-phenylethynyl-pyridine; ZINC2581406; BCP05962; ZX-AN014840; 2-methyl-6-(phenylethynyl)-pyridine; s2809; HY-14609A; 2151AH
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
SIB-1893
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Investigative | Compound Info | ||
| Synonyms |
SIB 1893; SIB-1893; 2-methyl-6-(2-phenylethenyl)pyridine; 6266-99-5; SIB1893; 2-methyl-6-[(E)-2-phenylethenyl]pyridine; 7370-21-0; CHEMBL88612; MLS002607995; (E)-2-methyl-6-styrylpyridine; [E]-2-Methyl-6-[2-phenylethenyl]pyridine; (E)-2-Methyl-6-[2-phenylethenyl]pyridine; SR-01000076143; Lopac0_001171; Pyridine,2-methyl-6-(2-phenylethenyl)-; AC1NSKMI; AC1Q4VO3; GTPL1432; CHEBI:93178; BDBM86715; MolPort-003-959-634; HMS3263L03; ZINC3941522; 2-[(E)-Styryl]-6-methylpyridine; NSC36665; SIB 1893, >99%, solid; Tox21_501171
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(R,S)-4-phosphonophenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(RS)-PPG; 120667-15-4; 2-amino-2-(4-phosphonophenyl)acetic acid; CHEMBL277475; AC1ND7MS; (RS)PPG; (RS) PPG; C8H10NO5P; (RS)-4-Phosphonophenylglycine; GTPL1406; SCHEMBL9150881; CTK8F0597; (R,S)-4-PPG; MolPort-003-983-668; BN0429; BDBM50004881; AKOS015911887; Amino-(4-phosphono-phenyl)-acetic acid; NCGC00025051-02; RT-015313; V2034; Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG); SR-01000597406; 667P154; L000025; SR-01000597406-1; J-004376
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|
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| Activity |
Ki = 185000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[[(3-fluoro-4-hydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077705; BDBM50255407
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|
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| Activity |
EC50 = 51200 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[[(R)-(3-fluoro-4-hydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096644; BDBM50255414
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|
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| Activity |
EC50 = 53800 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072316; BDBM50255340
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|
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| Activity |
EC50 = 62000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081842; BDBM50255347
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|
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| Activity |
EC50 = 63000 nM
|
[2] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99462; BDBM50072168; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-propylcyclopropane-1-carboxylic acid
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| Activity |
IC50 = 67820 nM
|
[3] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060360; SCHEMBL4091107; SCHEMBL10027439; BDBM50255339
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| Activity |
EC50 = 69000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089515; CHEMBL557573; SCHEMBL4084993; BDBM50174524; BDBM50314793; (S)-3-amino-3-carboxypropyl-2''-carboxyethyl phosphinic acid; (S)-2-Amino-4-(3-oxo-3-hydroxypropylhydroxyphosphinyl)butanoic acid; (S)-2-Amino-4-[(2-carboxy-ethyl)-hydroxy-phosphinoyl]-butyric acid; dihydrochloride
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|
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| Activity |
EC50 = 89000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(5-nitrothiophen-2-yl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090179; SCHEMBL4084361; BDBM50255397
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064187; SCHEMBL10000471; BDBM50255336
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-[4-nitro-3-(trifluoromethyl)phenyl]methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078629; SCHEMBL4089668; BDBM50255415
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094636; SCHEMBL8232961; BDBM50255293
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8839; LY-389795; SCHEMBL2450641; CTK1A0220; DTXSID40436647; BDBM50074750; (1beta,5beta)-4-Amino-2-thiabicyclo[3.1.0]hexane-4beta,6beta-dicarboxylic acid; (1R,4S,5S,6S)-4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylicacid, 4-amino-, (1R,4S,5S,6S)-
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|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-Amino-4-[[(4-fluoro-3-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091029; SCHEMBL13774934; BDBM50255390
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-methoxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063720; BDBM50255342
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-morpholin-4-yl-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082270; SCHEMBL4103522; BDBM50255333
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[[(3,4-dihydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094241; SCHEMBL10000474; BDBM50255334
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(2,3,4,5,6-pentafluorophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061016; SCHEMBL4084757; BDBM50255369
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082813; BDBM50255391
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-[3-nitro-4-(trifluoromethyl)phenyl]methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063142; SCHEMBL8241633; BDBM50255337
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085750; BDBM50255437
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072781; BDBM50255389
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-methoxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085327; BDBM50255346
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088782; SCHEMBL4095288; BDBM50255406
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[[(4-chloro-3-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083240; SCHEMBL4085091; BDBM50255338
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|
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| Activity |
EC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085558; BDBM50255348
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|
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| Activity |
EC50 = 100000 nM
|
[2] | |||
| Compound Name |
4-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095462; SCHEMBL4085528; BDBM50255416
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| Activity |
EC50 = 169000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
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Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
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| Activity |
EC50 > 500000 nM
|
[5] | |||
| Compound Name |
ACPT-I
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Investigative | Compound Info | ||
| Synonyms |
1-aminocyclopentane-1,3,4-tricarboxylic acid
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| Activity |
EC50 = 280000 nM
|
[2] | |||
| Compound Name |
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
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Investigative | Compound Info | ||
| Synonyms |
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid; (2R,4R)-APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid; 169209-63-6; 2R,4R-APDC; CHEMBL40086; CHEBI:40139; EN300-88063; 2R, 4R-APDC monohydrate; 52A; 4-amino-2,4-pyrrolidinedicarboxylic acid; AC1NSJRT; AC1Q4UAD; SCHEMBL158843; 2R, 4R-APDC; (2R,3R)-APDC; GTPL1392; CTK0E5090; DTXSID10415500; MolPort-003-982-102; BDBM50052398; ZINC32628523; SBB067830; MFCD16875409; AKOS015916056; AKOS015854214; RTC-065564; FCH3884669; NCGC00025040-02; LY314593; AJ-85443; SC-48823; TC-065564; B6634
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| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
LY307452
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Investigative | Compound Info | ||
| Synonyms |
LY-307452; LY-307,452; LY 307452
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| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
(2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442076; BDBM50207814
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| Activity |
EC50 = 700000 nM
|
[6] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093081; BDBM50255290
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| Activity |
EC50 = 295000 nM
|
[2] | |||
| Compound Name |
(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40123; SCHEMBL187449; BDBM50069111; ZINC13797034; 2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid; (2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid
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| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(5-nitrothiophen-3-yl)methyl]phosphoryl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061423; BDBM50255292; LSP-1-3081
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| Activity |
EC50 = 418000 nM
|
[2] | |||
| Compound Name |
(1S,2R)-1-Amino-2-(phosphonomethyl)cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229697; BDBM50217031; (1S,2R)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid
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| Activity |
EC50 = 602000 nM
|
[7] | |||
| Compound Name |
(1S,2S)-1-Amino-2-(phosphonomethyl)cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227288; SCHEMBL1249489; BDBM50217030; (1S,2S)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid; (1S,2S)-1-amino-2-(phosphonomethyl)cyclopropane-1-carboxylic acid
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| Activity |
EC50 = 625000 nM
|
[7] | |||
| Compound Name |
(S)-2-Amino-2-((1R,2S)-2-phosphonocyclopropyl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL197976; BDBM50175072; (S)-Amino(2beta-phosphonocyclopropane-1alpha-yl)acetic acid
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| Activity |
EC50 = 700000 nM
|
[8] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(2-cyanoethyl)pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312682; BDBM50426290
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| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482081; BDBM50252049; ZINC40934632; (1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid
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| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(S)-2-Amino-2-((1S,2R)-2-phosphonocyclopropyl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199626; BDBM50175073; (S)-Amino(2alpha-phosphonocyclopropane-1beta-yl)acetic acid
Click to Show/Hide
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| Activity |
EC50 > 1000000 nM
|
[8] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(2-aminoethyl)pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312684; BDBM50426288
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| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(3-nitrophenyl)methyl]phosphoryl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093492; SCHEMBL8238927; BDBM50255388
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| Activity |
EC50 > 1000000 nM
|
[2] | |||
| Compound Name |
(4r)-4-{3-[Hydroxy(Methyl)amino]-3-Oxopropyl}-L-Glutamic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312403; 3ZA; BDBM50426285; Q27454276
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| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
1,2,4-Butanetricarboxylic acid, 4-amino-, (2S,4S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479797; BDBM50252047; (2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid; (2S,4S)-4-aminobutane-1,2,4-tricarboxylic acid
Click to Show/Hide
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| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(2S,4R)-2-Amino-4-(3-aminopropyl)pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312685; BDBM50426287
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||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
2-Amino-2-[(1R,2R,3S)-2-phenyl-3-phosphonocyclopropyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392420; BDBM50207811; (2S,1''R,2''S,3''R)-2-(2''-phosphono-3''-phenylcyclopropyl)glycine
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||||
| Activity |
EC50 > 1000000 nM
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[6] | |||
| Compound Name |
(1R,2S)-2-Amino-2-carboxycyclopropane-1-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347670; ZINC39058088
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||||
| Activity |
EC50 > 1000000 nM
|
[10] | |||
| Compound Name |
2-Amino-2-[(1S,2S,3R)-2-phenyl-3-phosphonocyclopropyl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392419; BDBM50207813; (2S,1''S,2''R,3''S)-2-(2''-phosphono-3''-phenylcyclopropyl)glycine
Click to Show/Hide
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||||
| Activity |
EC50 > 1000000 nM
|
[6] | |||
| Compound Name |
(2S,4R)-2-Amino-4-[3-(hydroxyamino)-3-oxopropyl]pentanedioic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2312683; BDBM50426289
Click to Show/Hide
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||||
| Activity |
EC50 > 1000000 nM
|
[9] | |||
| Compound Name |
(S)-3,5-Dihydroxyphenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(S)-3,5-DHPG; S-DHPG; L-3,5-Dihydroxyphenylglycine; C8H9NO4; UNII-CF5G2G268A; CHEMBL39221; 3,5-Dihydroxy-L-phenylglycine; CF5G2G268A; (S)-3,5 DHPG; (S)-3,5-Dihydroxyphenylglycine hydrate; Benzeneacetic acid, alpha-amino-3,5-dihydroxy-, (alphaS)-; (2r)-Amino(3,5-Dihydroxyphenyl)Acetic Acid; (2S)-amino(3,5-dihydroxyphenyl)ethanoic acid; (S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid; (S)-3,5-dihydroxyphenylglycine zwitterion; Tocris-0342; Tocris-0805; Lopac-D-3689; C12026; 3,5-Dihydroxy-phenylglycine; Lopac0_000328; (2S)-2-amino-2-(3,5-dihydroxyphenyl)acetic acid; SCHEMBL12648471; (s)-3,5-dihydroxylphenylglycine; CTK8F0556; DTXSID20904031; HMS3261A17; HMS3266F22; HMS3411L21; HMS3675L21; ZINC968043; Dihydroxyphenylglycine, (S)-3,5-; Tox21_500328; BDBM50079183; MFCD11044457; AKOS006239507; amino(3,5-dihydroxyphenyl)acetic acid; CCG-204423; DB04228; LP00328; SDCCGSBI-0050316.P002; NCGC00015338-01; NCGC00015338-02; NCGC00024545-01; NCGC00024800-01; NCGC00024800-02; NCGC00024800-03; NCGC00024800-04; NCGC00024800-05; NCGC00024800-10; NCGC00261013-01; HY-12598; Amino-(3,5-dihydroxy-phenyl)-acetic acid; J516.528H; (2S)-amino(3,5-dihydroxyphenyl)acetic acid; B6459; CS-0012064; EU-0100328; (S)-Amino-(3,5-dihydroxy-phenyl)-acetic acid; D 3689; SR-01000075813; SR-01000597444; Amino-(3,5-dihydroxy-phenyl)-acetic acid(S-DHPG); J-009981; SR-01000075813-1; SR-01000597444-1; Q27095051; UNII-5YR2N37E6D component HOOWCUZPEFNHDT-ZETCQYMHSA-N
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| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
2-Amino-2,3-methano-4-phosphonobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL287703; (1R,2R)-1-amino-2-(phosphonomethyl)cyclopropane-1-carboxylic acid; (1R,2R)-1-amino-2-(phosphonomethyl)cyclopropanecarboxylic acid; 2-Ampba; DTXSID80928258; BDBM50089518; 1-amino-2-(phosphonomethyl)cyclopropane-1-carboxylic acid; (1R,2R)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid; Cyclopropanecarboxylic acid, 1-amino-2-(phosphonomethyl)-, trans-(+-)-
Click to Show/Hide
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| Activity |
EC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(1S,2S)-1-Amino-2-(carboxymethyl)cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CTK0H1302; CHEMBL3347671; DTXSID20472068; ZINC32629480; AKOS026740805; Cyclopropaneaceticacid, 2-amino-2-carboxy-, (1S,2S)-
Click to Show/Hide
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| Activity |
EC50 > 1000000 nM
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[10] | |||
| Compound Name |
(2S)-2-Amino-4-[hydroxy-[hydroxy-(5-nitrofuran-2-yl)methyl]phosphoryl]butanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067923; SCHEMBL4094703; BDBM50255396
Click to Show/Hide
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||||
| Activity |
EC50 = 1970000 nM
|
[2] | |||
| Compound Name |
(1R,2S)-1-Amino-2-(phosphonomethyl)cyclopropanecarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL34880; BDBM50089516; (1R,2S)-1-amino-2-phosphonomethylcyclopropane-carboxylic acid
Click to Show/Hide
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| Activity |
EC50 > 3000000 nM
|
[7] | |||
| Compound Name |
2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315268; (S)-Homo-AMPA; NCGC00024946-01; Tocris-1026; SCHEMBL12506417; BDBM50060719; (s)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; (S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid; 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid(S-homo-AMPA)
Click to Show/Hide
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||||
| Activity |
Ki > 5000000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. | ||||
| REF 2 | Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. | ||||
| REF 3 | 2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2849-54. | ||||
| REF 4 | Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40. | ||||
| REF 5 | Metabotropic glutamate receptors: novel targets for drug development. J Med Chem. 1995 Apr 28;38(9):1417-26. | ||||
| REF 6 | Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first clas... Bioorg Med Chem. 2007 May 1;15(9):3161-70. | ||||
| REF 7 | Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists. J Med Chem. 2007 Jul 26;50(15):3585-95. | ||||
| REF 8 | Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Bioorg Med Chem Lett. 2006 Jan 1;16(1):196-9. | ||||
| REF 9 | New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III. J Med Chem. 2016 Feb 11;59(3):914-24. | ||||
| REF 10 | A highly selective agonist for the metabotropic glutamate receptor mGluR2. Medchemcomm. 2011;2:1120-4. | ||||
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