Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59056 | Target Info | |||
| Target Name | Aldosterone synthase (CYP11B2) | ||||
| Synonyms |
Steroid 18hydroxylase; Cytochrome P450C18; Cytochrome P450Aldo; Cytochrome P450 11B2, mitochondrial; CYPXIB2; CYP11B2; Aldosteronesynthesizing enzyme; ALDOS
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| Target Type | Clinical trial Target | ||||
| Gene Name | CYP11B2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(4-Pyridyl)-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL304903; BDBM50035209; 4-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-pyridine
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
(2Z)-2-(1H-Imidazol-5-ylmethylidene)-3,4-dihydronaphthalen-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL169251; SCHEMBL1340462
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| Activity |
IC50 = 73000 nM
|
[1] | |||
| Compound Name |
5-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-1H-imidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL352645; SCHEMBL7944637; BDBM50049774
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| Activity |
IC50 = 90000 nM
|
[1] | |||
| Compound Name |
CID 71621803
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077246; SCHEMBL15018509; BDBM50268690
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17. J Med Chem. 1996 Feb 16;39(4):834-41. | ||||
| REF 2 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. | ||||
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