Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T57316 | Target Info | |||
| Target Name | Sphingomyelin phosphodiesterase 2 (SMPD2) | ||||
| Synonyms |
SMPD2; Neutral sphingomyelinase; NSMase; N-SMase; Lyso-platelet activating factor-phospholipase C; Lyso-PAF-PLC
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| Target Type | Literature-reported Target | ||||
| Gene Name | SMPD2 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(2R,3R,4R)-1,1-Difluoro-2,4-dihydroxy-3-(hexadecanoylamino)-4-phenylbutyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL419642; BDBM50122310; ((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-dihydroxy-4-phenyl-butyl)-phosphonic acid
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| Activity |
IC50 = 99000 nM
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[1] | |||
| Compound Name |
[(3S,4R)-1,1-Difluoro-3-(hexadecanoylamino)-4-hydroxy-4-phenylbutyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
inhibitor A [PMID: 12482429]; CHEMBL310981; GTPL8847; BDBM50122309; Q27078063; ((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydroxy-4-phenyl-butyl)-phosphonic acid
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| Activity |
IC50 = 181000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
{2-[((E)-(3S,4R)-1,1-Difluoro-4-hydroxy-3-octadecanoylamino-nonadec-5-enyl)-hydroxy-phosphinoyloxy]-ethyl}-trimethyl-ammonium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77022; BDBM50122311
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| Activity |
IC50 = 400000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity. Bioorg Med Chem Lett. 2003 Jan 20;13(2):229-36. | ||||
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