Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55922 | Target Info | |||
| Target Name | S-adenosylmethionine decarboxylase proenzyme (AMD1) | ||||
| Synonyms |
SamDC; S-adenosylmethioninedecarboxylase; AdoMetDC; AMD
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|
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| Target Type | Successful Target | ||||
| Gene Name | AMD1 | ||||
| Biochemical Class | Carbon-carbon lyase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 92 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl540653
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392185; BDBM50281293
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-N-[3-Chloro-5-(4-methylphenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097210; BDBM50254957
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-2-N,6-dimethylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098044; BDBM50255071; AKOS019336804
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(4-chlorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101315; BDBM50255017
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-[3,5-Dichloro-4-(difluoromethoxy)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085397; BDBM50254862
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichloro-2,4-difluorophenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091216; BDBM50254873
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-[3-(1-Benzofuran-2-yl)-5-chlorophenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075494; BDBM50255009
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Ditert-butylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097036; BDBM50255077
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichloro-4-methylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089063; BDBM50254860
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
6-Methyl-4-N-(3,4,5-trichlorophenyl)pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060869; BDBM50255078
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|
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| Activity |
IC50 ~ 63000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Amino-8-methylpurin-9-yl)-5-[[3-aminopropyl(methyl)amino]methyl]oxolane-3,4-diol;sulfuric acid
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL956813; CHEMBL515862
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|
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| Activity |
IC50 = 70000 nM
|
[3] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Amino-8-methyl-9H-purin-9-yl)-5-{[(2-aminoethyl)(methyl)amino]methyl}oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL953173; CHEMBL462660; AdoMet substrate analogue, 18f; BDBM28443; (2R,3S,4R,5R)-2-[[2-aminoethyl(methyl)amino]methyl]-5-(6-amino-8-methylpurin-9-yl)oxolane-3,4-diol
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|
||||
| Activity |
IC50 = 88000 nM
|
[3] | |||
| Compound Name |
2'-O,3'-O-Isopropylidene-5'-[[(1R)-4alpha-aminooxy-2-cyclopenten-1beta-yl]thio]-5'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392222
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|
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| Activity |
Ki = 95200 nM
|
[4] | |||
| Compound Name |
CID 25233958
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL952194; CHEMBL474137
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|
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| Activity |
IC50 = 157000 nM
|
[3] | |||
| Compound Name |
4-N-(3,5-Dichloro-4-fluorophenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069538; BDBM50254859
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|
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| Activity |
IC50 ~ 160000 nM
|
[2] | |||
| Compound Name |
Chembl607699
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392211; BDBM50366314
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|
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| Activity |
IC50 = 178600 nM
|
[1] | |||
| Compound Name |
4-N-(3-Chloro-5-naphthalen-2-ylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066551; BDBM50254816
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-6-morpholin-4-ylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065694; BDBM50254903
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
2-N-(3,5-Dichlorophenyl)pyridine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079101; BDBM50254907; AKOS010979679
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]-5-chlorophenyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095453; BDBM50254980
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N-(3,5-Dimethylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079024; SCHEMBL9379068; BDBM50254843; ZINC43532131; AKOS015938218; 4-N-(3,5-dimethylphenyl)-6-methylpyrimidine-2,4-diamine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-[3,5-Bis(trifluoromethyl)phenyl]-5-chlorophenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094087; BDBM50254988
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(3,4-dichlorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076960; BDBM50254984
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-Chloro-4-N-(3,5-dichlorophenyl)pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
NSC682521; CHEMBL52943; 6-chloro-N4-(3,5-dichlorophenyl)pyrimidine-2,4-diamine; 2,4-Pyrimidinediamine, 6-chloro-N4-(3,5-dichlorophenyl)-; KS-00003K6C; ZINC1648702; BDBM50254904; AKOS016028494; MCULE-6979623236; NSC-682521; NCI60_029524; 2-amino-4-chloro-6-(3,5-dichloroanilino)pyrimidine; N'-(3,5-Dichlorophenyl)-6-chloro-2,4-pyrimidinediamine; 2-Amino-4-chloro-6-(3', 5'-dichloroanilino) pyrimidine; 6-Chloro-N~4~-(3,5-dichlorophenyl)-2,4-pyrimidinediamine
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|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Difluorophenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091476; BDBM50254847; AKOS019329764
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
5-[(2-Amino-6-methylpyrimidin-4-yl)amino]-1-N,3-N-bis(3,5-dichlorophenyl)benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078068; BDBM50254842
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-Methyl-N~4~-[2-(methylthio)phenyl]-2,4-pyrimidinediamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075637; BDBM50254885; ZINC72436884; MCULE-2231792978; 6-methyl-N~4~-[2-(methylthio)phenyl]-2,4-pyrimidinediamine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Ethyl-5-(4-fluorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076932; BDBM50255045
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
(3-Amino(4-pyridyl))(3,5-dichlorophenyl)amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059586; BDBM50254916; SBB079823; ZINC20585283; N4-(3,5-Dichlorophenyl)pyridine-3,4-diamine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-6-propan-2-ylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103496; BDBM50254889
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(pentafluoro-lambda6-sulfanyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097380; BDBM50254824
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-Methyl-4-N-[3-(pentafluoro-lambda6-sulfanyl)phenyl]pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086885; BDBM50254844
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(2-Bromophenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090135; NSC47526; SCHEMBL13963116; DTXSID80919989; ZINC1679314; BDBM50254886; NSC-47526; MCULE-9371112851; N~4~-(2-bromophenyl)-6-methyl-2,4-pyrimidinediamine; n4-(2-bromo-phenyl)-6-methyl-pyrimidine-2,4-diamine; N~4~-(2-Bromophenyl)-6-methylpyrimidine-2,4(1H,3H)-diimine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(3-Chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077598; BDBM50254887; ZINC72438118; MCULE-4727152343; N~4~-(3-chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)pyridine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095601; BDBM50254915
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Fluorophenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081461; SCHEMBL13963117; BDBM50254846; ZINC72434268; MCULE-7150574408; N~4~-(3-fluorophenyl)-6-methyl-2,4-pyrimidinediamine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Diphenylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085620; BDBM50254833
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-Methyl-N4-(o-tolyl)pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070810; SCHEMBL9878839; BDBM50254884; ZINC39109558; MCULE-5078643759; 6-methyl-N~4~-(2-methylphenyl)-2,4-pyrimidinediamine
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|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)pyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095744; BDBM50255046; AKOS019336497
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(2,3-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095580; BDBM50254875; ZINC72441677; MCULE-7623534283; N~4~-(2,3-dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-(1-Benzothiophen-2-yl)-5-chlorophenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066991; BDBM50255010
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Chloro-5-pyrimidin-5-ylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082507; BDBM50255014
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(4-Chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070829; BDBM50254821; ZINC72437465; MCULE-6806538546; N~4~-(4-chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(4-phenylphenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074190; BDBM50254981
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-N-(3,5-Dichlorophenyl)pyridine-2,6-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102548; BDBM50254906; AKOS019214350
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Chloro-5-phenanthren-9-ylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076249; BDBM50254989
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(1-methylpyrazol-4-yl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100524; BDBM50255011
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(5-Chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085770; BDBM50255105; ZINC72437244; MCULE-4324635279; N~4~-(5-chloro-2-methylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
5-[(2-Amino-6-methylpyrimidin-4-yl)amino]benzene-1,3-dicarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094595; BDBM50254832
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-[4-(dimethylamino)phenyl]phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102144; BDBM50255019
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[4-(3,5-Dichlorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102502; BDBM50254945
Click to Show/Hide
|
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| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
6-Methyl-N~4~-[4-(trifluoromethyl)phenyl]-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078225; SCHEMBL13963113; BDBM50255016; ZINC72441251; MCULE-4880271567; 6-methyl-N~4~-[4-(trifluoromethyl)phenyl]-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Bromo-5-chlorophenyl)-2-methylpyrimidine-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069289; BDBM50255072
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N-(3,5-Dichlorophenyl)-6-methylpyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087899; BDBM50254917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-[4-chloro-3-(trifluoromethyl)phenyl]phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096838; BDBM50254985
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Bromo-5-(pentafluoro-lambda6-sulfanyl)phenyl]-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070203; BDBM50254818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichloro-4-morpholin-4-ylphenyl)-6-methylpyrimidine-2,4-diamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088343; BDBM50254863
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
2-[(2-Amino-6-methylpyrimidin-4-yl)amino]-4,6-dichlorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063951; BDBM50255103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Bromo-5-butoxyphenyl)-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063716; BDBM50255075
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
2-Amino-4-phenylamino-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl-4-N-phenylpyrimidine-2,4-diamine; 6-methyl-N4-phenylpyrimidine-2,4-diamine; MLS000577547; 2-amino-4-anilino-6-methylpyrimidine; 6-methyl-4-phenylaminopyrimidin-2-amine; SMR000185537; 2,4-Pyrimidinediamine,6-methyl-N4-phenyl-; 6-methyl-N~4~-phenyl-2,4-pyrimidinediamine; 6-METHYL-N4-PHENYL-2,4-PYRIMIDINEDIAMINE; Pyrimidine, 2-amino-4-anilino-6-methyl-; CBMicro_018682; 2,4-Pyrimidinediamine, 6-methyl-N4-phenyl-; Cambridge id 5346865; Oprea1_573662; Oprea1_866435; cid_608203; SCHEMBL3500070; CHEMBL1717325; BDBM73476; CTK5E4975; DTXSID40345942; HMS2436E18; ZINC271571; CCG-6869; AKOS006223669; 6-methyl-N-phenylpyrimidine-2,4-diamine; 4-phenylamino-2-amino-6-methylpyrimidine; BIM-0018667.P001; 6-methyl-N4-phenyl-pyrimidine-2,4-diamine; DB-081522; FT-0693962; 6-Methyl-N~4~-phenylpyrimidine-2,4-diamine; (2-amino-6-methyl-pyrimidin-4-yl)-phenyl-amine; SR-01000206051; SR-01000206051-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(2,5-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074340; NSC44190; ZINC1676606; BDBM50254874; NSC-44190; MCULE-2903774238; N~4~-(2,5-dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(3,4-Difluorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067304; BDBM50254946; ZINC72436911; MCULE-4059936339; N~4~-(3,4-difluorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-(2,1,3-Benzoxadiazol-5-yl)-5-chlorophenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077575; BDBM50254990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3,5-Bis(trifluoromethyl)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068581; BDBM50254828; ZINC225842390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(4-Bromo-2-fluorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081289; BDBM50254888; ZINC72436896; AKOS019327278; MCULE-5427226825; N~4~-(4-bromo-2-fluorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Bromo-5-ethylphenyl)-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082809; BDBM50254825
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3,5-Dichloro-4-(dimethylamino)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099923; BDBM50254820
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(4-Chlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N~4~-(4-chlorophenyl)-6-methyl-2,4-pyrimidinediamine; CHEMBL1391744; N4-(4-Chlorophenyl)-6-methyl-2,4-pyrimidinediamine; N4-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine; SMR000180465; MLS000327490; 4-N-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine; N4-(4-chloro-phenyl)-6-methyl-pyrimidine-2,4-diamine; KS-00001RFP; HMS2425M09; ZINC4038247; BDBM50254942; MFCD05974911; AKOS000111541; MCULE-4209369255; BB 0238493; SR-01000308909; 10X-0819; N-(4-chlorophenyl)-6-methylpyrimidine-2,4-diamine; SR-01000308909-1; N*4*-(4-Chloro-phenyl)-6-methyl-pyrimidine- 2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-4-N,6-dimethylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062599; BDBM50254822
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(2-chlorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075596; BDBM50254982
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichloro-4-piperidin-1-ylphenyl)-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072534; BDBM50254872
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
Dimethyl 5-[(2-amino-6-methylpyrimidin-4-yl)amino]benzene-1,3-dicarboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067134; SCHEMBL13312580; CNI-H3094; BDBM50255076; dimethyl 5-[(2-amino-6-methyl-pyrimidin-4-yl)amino]benzene-1,3-dicarboxylate; methyl 3-((2-amino-6-methylpyrimidin-4-yl)amino)-5-(methoxycarbonyl)benzoate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-2-N,2-N,6-trimethylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080016; BDBM50254940
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-6-methylpyridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068229; BDBM50255050
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-[2-Chloro-5-(trifluoromethyl)phenyl]-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060875; BDBM50255015; ZINC72437614; AKOS019330954; MCULE-5380587391; N~4~-[2-chloro-5-(trifluoromethyl)phenyl]-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)pyrimidine-2,4,6-triamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090335; BDBM50254941; AKOS019336891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[(3,5-Dichlorophenyl)methyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100742; BDBM50255073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(4-Isopropylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069015; BDBM50254944; ZINC72446763; MCULE-8846650537; N~4~-(4-isopropylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
2-Amino-4-(3-bromophenyl)amino-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059490; SCHEMBL13963108; BDBM50254845; ZINC72437053; MCULE-4810194061; 4-N-(3-bromophenyl)-6-methylpyrimidine-2,4-diamine; N~4~-(3-bromophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(3-chlorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104159; BDBM50254983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-[(2-Amino-6-methylpyrimidin-4-yl)amino]-2,6-dichlorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092402; BDBM50255079
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichlorophenyl)-6-(trifluoromethyl)pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074309; BDBM50255047
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Bromo-5-(2-methylpropoxy)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091530; BDBM50254827
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-(3,5-Dichlorophenyl)sulfanyl-6-methylpyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084298; BDBM50254823
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(3-chloro-4-fluorophenyl)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075300; BDBM50255020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(2,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091688; BDBM50255104; ZINC72442253; AKOS019327574; MCULE-3826214291; N~4~-(2,4-dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3,5-Dichloro-4-phenoxyphenyl)-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064702; BDBM50254861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-[3-Chloro-5-(4-methoxyphenyl)phenyl]-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062674; BDBM50254956
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-N-(3-Chloro-5-fluorophenyl)-6-methylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070569; BDBM50254848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
N~4~-(4-Ethylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096276; BDBM50254943; ZINC60805716; AKOS017272773; MCULE-7738186342; N~4~-(4-ethylphenyl)-6-methyl-2,4-pyrimidinediamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
4-(3-Chlorophenylamino)-6-methylpyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104760; NSC47525; SCHEMBL20354975; DTXSID20999023; ZINC1679313; BDBM50254819; NSC-47525; AKOS015937866; N-(3-chlorophenyl)-6-methylpyrimidine-2,4-diamine; N4-(3-chlorophenyl)-6-methylpyrimidine-2,4-diamine; N~4~-(3-Chlorophenyl)-6-methylpyrimidine-2,4(1H,3H)-diimine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Compound Name |
2-N-(3,5-Dichlorophenyl)-6-methylpyridine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103347; BDBM50254817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 180000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl1163096
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392218; BDBM50366315
Click to Show/Hide
|
||||
| Activity |
IC50 = 204800 nM
|
[1] | |||
| Compound Name |
Chembl541928
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392189; BDBM50281292
Click to Show/Hide
|
||||
| Activity |
Ki = 246600 nM
|
[1] | |||
| Compound Name |
Chembl605698
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392208; BDBM50366318
Click to Show/Hide
|
||||
| Activity |
Ki = 415000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Amino-8-ethylpurin-9-yl)-5-[[3-aminopropyl(methyl)amino]methyl]oxolane-3,4-diol;sulfuric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL952742; CHEMBL472730
Click to Show/Hide
|
||||
| Activity |
IC50 = 420000 nM
|
[3] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-(methylamino)-9H-purin-9-yl]-5-{[(3-aminopropyl)(methyl)amino]methyl}oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461966; AdoMet substrate analogue, 18a; BDBM28439
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[3] | |||
| Compound Name |
Chembl605899
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392206; BDBM50366320
Click to Show/Hide
|
||||
| Activity |
Ki = 478000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-{[(3-aminopropyl)(methyl)amino]methyl}oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL995958; CHEMBL460737; AdoMet substrate analogue, 18d; BDBM28441
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
Chembl606102
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392204; BDBM50366317
Click to Show/Hide
|
||||
| Activity |
Ki = 669000 nM
|
[5] | |||
| Compound Name |
Chembl605267
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392209; BDBM50366316
Click to Show/Hide
|
||||
| Activity |
Ki = 960000 nM
|
[5] | |||
| Compound Name |
[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[(3R,5S)-5-carboxypyrrolidin-3-yl]-methylsulfanium;hydrogen sulfate;sulfuric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1791405
Click to Show/Hide
|
||||
| Activity |
Ki = 1070000 nM
|
[5] | |||
| Compound Name |
[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-[(5S)-5-carboxypyrrolidin-3-yl]-methylsulfanium;hydrogen sulfate;sulfuric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3392205; CHEMBL1791405; BDBM50366319
Click to Show/Hide
|
||||
| Activity |
Ki = 1207000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | alpha-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase. Bioorg Med Chem Lett. 1993 Dec;3(12):2811-6. | ||||
| REF 2 | Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. J Med Chem. 2018 Feb 8;61(3):1182-1203. | ||||
| REF 3 | New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. | ||||
| REF 4 | S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem. 1995 May 12;38(10):1770-7. | ||||
| REF 5 | Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents. Bioorg Med Chem Lett. 1993 Feb;3(2):147-52. | ||||
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