Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55260 | Target Info | |||
| Target Name | Protein phosphatase 1A (PPM1A) | ||||
| Synonyms |
Protein phosphatase IA; Protein phosphatase 2C isoform alpha; PP2C-alpha
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| Target Type | Clinical trial Target | ||||
| Gene Name | PPM1A | ||||
| Biochemical Class | PP2C family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-({4-[(5-[4-(Dimethylamino)phenyl]-6-(ethoxycarbonyl)-7-methyl-3-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]phenoxy}methyl)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360905; AO-081/15385001; BDBM50031906; AKOS003229435
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| Activity |
IC50 = 67800 nM
|
[1] | |||
| Compound Name |
(S)-2-[(R)-2-(2-{[(R)-4-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-carboxy-butyryl]-methyl-amino}-acryloylamino)-1-oxo-propylamino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317067; BDBM50135676
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-dimethylcarbamoyl-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329271; BDBM50135677
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-dimethylcarbamoyl-butyric acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327726; BDBM50135680
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-{[1-((R)-1-carboxy-ethylcarbamoyl)-vinyl]-methyl-carbamoyl}-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87923; BDBM50135675
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| Activity |
IC50 = 140000 nM
|
[2] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-[(R)-2-(2-{[(R)-4-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-carboxy-butyryl]-methyl-amino}-acetylamino)-1-oxo-propylamino]-4-methyl-pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321558; BDBM50135679
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| Activity |
IC50 = 230000 nM
|
[2] | |||
| Compound Name |
(R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-{[((R)-1-carboxy-ethylcarbamoyl)-methyl]-methyl-carbamoyl}-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98772; BDBM50135678
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|
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| Activity |
IC50 = 280000 nM
|
[2] | |||
| Compound Name |
(R)-2-((4E,6E)-(2S,3S,8S,9S)-3-Acetylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-{[((R)-1-carboxy-ethylcarbamoyl)-methyl]-methyl-carbamoyl}-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100202; BDBM50135674
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| Activity |
IC50 = 400000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem. 2014 Nov 26;57(22):9309-22. | ||||
| REF 2 | Linearized and truncated microcystin analogues as inhibitors of protein phosphatases 1 and 2A. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2903-6. | ||||
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