Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53469 | Target Info | |||
| Target Name | Caspase-4 (CASP4) | ||||
| Synonyms |
Protease TX; Mih1; ICH2; ICH-2; ICE(rel)-II; ICE and Ced-3 homolog 2; CASP-4
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CASP4 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione; 220510-17-8; 5-(Pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; Isatin Sulfonamide 20; 5-pyrrolidinylsulfonylisatin; AC1N3S5K; 5-pyrrolidin-1-ylsulfonyl-1H-indole-2,3-dione; SCHEMBL2486952; CHEMBL305545; BDBM10309; DTXSID80399500; QKCWUYHXHMXOLG-UHFFFAOYSA-N; ZINC2944777; 5-[1-(pyrrolidinyl)sulfonyl]isatin; 2991AJ; AKOS024262065; AJ-44312; 5-(Pyrrolizinosulfonyl)indoline-2,3-dione; AX8291337; FT-0734877; 5-(Pyrrolidin-1-ylsulfonyl)-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
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[1] | |||
| Compound Name |
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62187; BDBM50297258; 5-{2-[(Methyl-phenyl-amino)-methyl]-pyrrolidine-1-sulfonyl}-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
5-{[(5-{[(2S)-1-Carboxy-3-oxopropan-2-yl]carbamoyl}pyridin-2-yl)methyl]sulfamoyl}-2-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
Pyridine Scaffold 4; BDBM221; CHEMBL358725
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| Activity |
Ki = 92000 nM
|
[2] | |||
| Compound Name |
Inhibitor 47c
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Investigative | Compound Info | ||
| Synonyms |
Thiophene Scaffold 47c; BDBM219; CHEMBL357191
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| Activity |
Ki = 96000 nM
|
[2] | |||
| Compound Name |
Inhibitor 66b
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Investigative | Compound Info | ||
| Synonyms |
Thiophene Scaffold 66b; BDBM226; CHEMBL146453
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. | ||||
| REF 2 | Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem. 2002 Nov 7;45(23):5005-22. | ||||
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