Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T51597 | Target Info | |||
| Target Name | Acidic mammalian chitinase (CHIA) | ||||
| Synonyms |
Lung-specific protein TSA1902; CHIA; AMCase
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| Target Type | Literature-reported Target | ||||
| Gene Name | CHIA | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[[4-[(5-Methyl-1,2-oxazol-3-yl)sulfamoyl]phenyl]carbamothioyl]prop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413403; ZINC4347159; BDBM50438374; CCG-250796; MCULE-9027203002
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| Activity |
IC50 = 80000 nM
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[1] | |||
| Compound Name |
NC1=NNC(=N1)N1CCC(CC1)NC(=O)NC1=CC=C(Br)C=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059615; SCHEMBL16825693; BDBM50243702
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
NC1=NNC(=N1)N1CCC(CC1)C(=O)NCC1=CC=C(Br)C=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071558; SCHEMBL16825712; BDBM50243809
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
CN(CC1CCN(CC1)C1=NC(N)=NN1)CC1=CC=C(Br)C=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079129; SCHEMBL16826174; BDBM50243716
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
NC1=NNC(=N1)N1CCC(CC1)NC(=O)CC1=CC=C(Br)C=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087924; SCHEMBL16825818; BDBM50243703
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-[(E)-(3-Ethoxy-4-hydroxy-5-nitrophenyl)methylideneamino]-3-prop-2-enylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413404; BDBM50438373; ZINC19793745
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
NC1=NNC(=N1)N1CCC(CNC(=O)C2=CC=C(Br)C=C2)CC1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103374; SCHEMBL16825729; BDBM50243741
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-({4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}carbamothioyl)cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2413405; ARONIS004736; KS-00003XFR; ZINC2135762; BDBM50438372; STK051309; AKOS000494536; MCULE-3961046787; AN-329/41575051; SR-01000012743; SR-01000012743-1
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
NC1=NNC(=N1)N1CCC(CC1)N(S(=O)(=O)CC1=CC=C(C=C1)Br)C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095625; SCHEMBL16826403; BDBM50243808
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2-Piperazin-1-ylnicotinamide
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Investigative | Compound Info | ||
| Synonyms |
2-(piperazin-1-yl)nicotinamide; 2-(1-PIPERAZINYL)NICOTINAMIDE; 2-(piperazin-1-yl)pyridine-3-carboxamide; 2-piperazin-1-ylpyridine-3-carboxamide; 2-(1-Piperazino)nicotinamide; CHEMBL47688; MFCD08061093; 2-(1-Piperazinyl)-3-pyridinecarboxamide; 2-Piperazin-1-yl-nicotinamide; ACMC-1BJDR; SCHEMBL4538970; AMPD00269; CTK5F8323; DTXSID80588472; ALBB-012279; ANW-66578; BDBM50027028; CP0032; STL089981; ZINC12359875; AKOS000141213; MCULE-5432751294; 2-Piperazin-1-ylnicotinamide, AldrichCPR; AS-59610; SC-19543; DB-002161; AM20061565; FT-0683126; T3563; Y6448; EN300-59610; A10399; Y-3657; 394P647; Q-103353; Z1222278663; 3-pyridinecarboxamide, 2-(1-piperazinyl)-, dihydrochloride
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| Activity |
IC50 = 101700 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Kinetin
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Approved | Compound Info | ||
| Synonyms |
Kinerase (TN)
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| Activity |
IC50 > 1000000 nM
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[4] | |||
| Compound Name |
Acetazolamide
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Approved | Compound Info | ||
| Synonyms |
Acetadiazol; Acetamidothiadiazolesulfonamide; Acetamox; Acetazolam; Acetazolamid; Acetazolamida; Acetazolamidum; Acetazolamine; Acetazoleamide; Acetozalamide; AkZol; ApoAcetazolamide; Atenezol; Cidamex; Dazamide; Defiltran; Dehydratin; Diacarb; Diakarb; Diamox; Didoc; Diluran; Diuramid; Diuramide; Diuriwas; Diutazol; Donmox; Duiramid; Edemox; Eumicton; Fonurit; Glauconox; Glaumox; Glaupax; Glupax; HumaZolamide; Natrionex; Nephramid; Nephramide; Phonurit; Storzolamide; Vetamox; Acetazolamide Apotex Brand; Acetazolamide Chiesi Brand; Acetazolamide Dioptic Brand; Acetazolamide Grin Brand; Acetazolamide ICN Brand; Acetazolamide Jumer Brand; Acetazolamide Llorens Brand; Acetazolamide Medphano Brand; Acetazolamide Novopharm Brand; Acetazolamide Orion Brand; Acetazolamide Wassermann Brand; Ak Zol; Apo Acetazolamide; Apotex Brand of Acetazolamide; Chiesi Brand of Acetazolamide; Ciba Vision Brand of Acetazolamide; DiamoxSequels; Dioptic Brand of Acetazolamide; Grin Brand of Acetazolamide; Huma Zolamide; ICN Brand of Acetazolamide; Jumer Brand of Acetazolamide; Llorens Brand of Acetazolamide; Medphano Brand of Acetazolamide; Monosodium Salt Acetazolamide; Novopharm Brand of Acetazolamide; Orion Brand of Acetazolamide; Storz Brand of Acetazolamide Preparation; Wassermann Brand of Acetazolamide; Wyeth Brand of Acetazolamide Preparation; A 6011; Carbonic anhydrase inhibitor 6063; Acetazolamida [INN-Spanish]; Acetazolamide (AAZ); Acetazolamide, Monosodium Salt; Acetazolamidum [INN-Latin]; Ak-Zol; Apo-Acetazolamide; Carbonic Anhydrase Inhibitor No. 6063; Diamox (TN); Diureticum-holzinger; Huma-Zolamide; SK-acetazolamide; Acetazolamide Sodium, (Sterile); Acetazolamide [INN:BAN:JAN]; Acetazolamide (JP15/USP/INN); 4-Diamox
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| Activity |
IC50 > 1000000 nM
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[4] | |||
| Compound Name |
8-Chlorotheophylline
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Investigative | Compound Info | ||
| Synonyms |
1,3-Dimethyl-8-chloroxanthine; 8-Chloro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; 8-chloro-1,3-dimethyl-7H-purine-2,6-dione; Theophylline, 8-chloro-; 8-Chloro-theophylline; 8-Chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-; UNII-GE2UA340FM; NSC 6113; 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione; GE2UA340FM; CHEMBL88611; MFCD00005581; 8-chloro-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; 8-Chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; chlortheophylline; 8-chlortheophyllin; 8-Chloro-1,3-Dimethyl-2,6-Purinedione; EINECS 201-590-4; C7H7ClN4O2; 8-chloro-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione; chlorotheophylline; 8-chorotheophylline; 8-Chlorotheophyline; PubChem9682; EC 201-590-4; 8-Chloro-1,3-dimethyl-2,6(1H,3H)-purinedione; Oprea1_038673; Oprea1_741931; SCHEMBL411139; ACMC-209q50; DTXSID5043764; 1,3-dimethyl 8-chloro xanthine; NSC6113; KS-000012OA; NSC-6113; ANW-38146; BBL009700; BDBM50331852; SBB003404; STK701164; AKOS000119705; AKOS005521865; ZINC100018165; DB14132; MCULE-4622251146; NE11863; VZ31020; AS-67718; DB-056856; FT-0631394; ST45128112; 8-chloranyl-1,3-dimethyl-7H-purine-2,6-dione; AB01563382_01; A841253; SR-01000479303; Q4644272; SR-01000479303-1; W-104090; 1H-Purine-2, 8-chloro-3,7-dihydro-1,3-dimethyl-; 8-chloro-1,3-dimethyl-1,3-dihydropurine-2,6-dione; 8-chloro-1,3-dimethyl-3,7-dihydropurine-2,6-dione; 8-chloro-1,3-dimethyl-1,3,7-trihydropurine-2,6-dione; 8-Chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione #; 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl- (9CI); 8-Chloro-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione, AldrichCPR
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| Activity |
IC50 > 2500000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening. Bioorg Med Chem. 2013 Jun 1;21(11):3214-20. | ||||
| REF 2 | Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J Med Chem. 2018 Feb 8;61(3):695-710. | ||||
| REF 3 | Identification and characterization of acidic mammalian chitinase inhibitors. J Med Chem. 2010 Aug 26;53(16):6122-8. | ||||
| REF 4 | Acetazolamide-based fungal chitinase inhibitors. Bioorg Med Chem. 2010 Dec 1;18(23):8334-40. | ||||
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