Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T44614 | Target Info | |||
| Target Name | Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) | ||||
| Synonyms |
Falcipain 2; Cysteine proteinase falcipain 2a
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| Target Type | Literature-reported Target | ||||
| Gene Name | Malaria CPF2 | ||||
| Biochemical Class | Protease | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 67 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3Z)-6-Chloro-3-[(dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
(Z)-6-Chloro-3-((dimethylamino)methylene)indolin-2-one; CHEMBL1689597; (3Z)-6-chloro-3-[(dimethylamino)methylidene]-1,3-dihydro-2H-indol-2-one; SCHEMBL10398762; ALBB-015371; BBL032307; BDBM50339257; MFCD13176395; STK939870; ZINC36047691; AKOS005174865; VS-11150; (3Z)-6-chloro-3-(dimethylaminomethylidene)-1H-indol-2-one; (Z/E)-6-chloro-3-((dimethylamino)methylene)indolin-2-one; 6-chloro-3-[(Z)-1-(dimethylamino)methylidene]-1H-indol-2-one; (3Z)-6-chloro-3-[(dimethylamino)methylidene]-2,3-dihydro-1H-indol-2-one; 2H-indol-2-one, 6-chloro-3-[(dimethylamino)methylene]-1,3-dihydro-, (3Z)-
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzyl (3S)-3-[[(3S)-1-acetyloxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120838; BDBM50448257
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(3S)-2-Oxo-5-phenyl-3-[[3-(phenylmethoxycarbonylamino)bicyclo[2.2.1]hept-5-ene-2-carbonyl]amino]pentyl] acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120845; BDBM50448250
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090306; BDBM50258545
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[(2S)-2-(Dimethylamino)-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-5-[(2S,3S)-3-methoxy-2-methyl-5-oxopyrrolidin-1-yl]-5-oxopentan-2-yl]-4-methylpentanamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358131
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(3Z)-3-[(Dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
3-[(dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one; CHEMBL1689595; MFCD00665175; (3Z)-3-(dimethylaminomethylidene)-1H-indol-2-one; MLS000540292; SCHEMBL397664; CHEMBL1719082; HMS2280C08; ALBB-015564; BDBM50339255; ZINC12339965; AKOS005175223; N,N-dimethylaminomethylene-2-indolinone; SMR000125549; 3-((Dimethylamino)methylene)indolin-2-one; R3621; ST51001561; 2H-976; (Z)-3-((Dimethylamino)methylene)indolin-2-one; (Z/E)-3-(N,N-Dimethylaminomethylene)indolin-2-one; 3-[(dimethylamino)methylene]-1H-benzo[d]azolidin-2-one; (3Z)-3-[(Dimethylamino)methylene]-1H-indole-2(3H)-one; 2H-Indol-2-one, 3-[(dimethylamino)methylene]-1,3-dihydro-; (3Z)-3-[(dimethylamino)methylidene]-2,3-dihydro-1H-indol-2-one; 2H-indol-2-one, 3-[(dimethylamino)methylene]-1,3-dihydro-, (3Z)-
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzyl (4S)-4-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120833; BDBM50448262
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzyl (2S,4R)-4-hydroxy-2-[[(3S)-1-morpholin-4-yl-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120850; BDBM50448245
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzyl (2S,4R)-2-[[(3S)-1-acetylsulfanyl-2-oxo-5-phenylpentan-3-yl]carbamoyl]-4-hydroxypyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120849; BDBM50448246
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Trisubsituted thiazole, 15
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260629; BDBM93125
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099269; BDBM50258537
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Benzyl (4S)-4-[[(3S)-1-acetyloxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120832; BDBM50448263
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzyl N-[(1S,6R)-6-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]cyclohex-3-en-1-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120836; BDBM50448259
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081250; BDBM50258524
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Benzyl N-[(1S,2R)-2-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]cyclopentyl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120837; BDBM50448258
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(Z/E)-7-Chloro-3-((dimethylamino)methylene)indolin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1689598; SCHEMBL10399806; BDBM50339258
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl (E,4S)-4-[[(2S)-2-[(4-nitrophenyl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-6-phenylhex-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093034; BDBM50258500
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060936; BDBM50258541
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(E,2S)-5-[[(2S)-1-(Benzylamino)-1-oxopropan-2-yl]amino]-5-oxopent-3-en-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-dimethylazanium;2,2,2-trifluoroacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358138; BDBM50033672
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Chlor-3-dimethylaminomethylenoxindol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1689596; SCHEMBL10399722; BDBM50339256; ZINC66112362; AKOS016359643; (Z/E)-5-chloro-3-((dimethylamino)methylene)indolin-2-one
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Hydroxy-phenyl)-3-(3-hydroxy-phenylsulfamoyl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222709; ChemDiv2_003207; Cambridge id 5210772; Oprea1_672119; Oprea1_839926; CBDivE_007277; MLS001204767; HMS1378B17; HMS2815L18; ZINC754839; BDBM50157747; AKOS000727586; SMR000504857; EU-0000103; AB00075218-01; N-(3-Hydroxyphenyl)-3-{[(3-hydroxyphenyl)amino]sulfonyl}benzamide
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Trisubsituted thiazole, 17
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260631; BDBM93127
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[(4-Fluorobenzyl)sulfonyl]-N''-[(thien-2-ylcarbonyl)oxy]ethanimidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204452; BDBM50183396; CCG-45846; MCULE-4281872775; SR-01000635591-1
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|
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
(Z/E)-3-(Benzylthiomethylene)indolin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1689600; BDBM50339260
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl (E,4S)-6-phenyl-4-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]hex-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082758; BDBM50258542
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Trisubsituted thiazole, 16
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260630; BDBM93126
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Benzyl (2S)-2-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120829; BDBM50448266
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzyl (2S)-2-[[(3S)-1-acetylsulfanyl-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120831; BDBM50448264
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074432; BDBM50258492
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Trisubsituted thiazole, 20
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260632; BDBM93128
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-Methyl-3-(N,N-dimethylamino)methyleneindol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1689599; BDBM50339259; (Z/E)-3-((dimethylamino)methylene)-1-methylindolin-2-one
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Trisubsituted thiazole, 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260635; BDBM93130
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Trisubsituted thiazole, 30
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260636; BDBM93131
Click to Show/Hide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Benzyl N-[1-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-4-oxocyclohexyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120840; BDBM50448255
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Benzyl (3S)-3-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120839; BDBM50448256
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(E,2S)-5-[[(2S)-1-[(2S,4S)-4-Hydroxy-2-methoxycarbonylpyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-5-oxopent-3-en-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-dimethylazanium;2,2,2-trifluoroacetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358139; BDBM50033669
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-(4-(furan-2-ylmethyl)-5-hydroxy-4H-1,2,4-triazol-3-ylthio)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204850; MLS001181790; HMS1663N22; HMS2869A21; BDBM50183398; ZINC15923286; CCG-252960; MCULE-7096962543; SMR000567587
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| Activity |
IC50 = 52300 nM
|
[7] | |||
| Compound Name |
Diethyl 2-(2-(naphthalen-1-ylcarbamoyl)hydrazinyl)-2-oxoethylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376232; ZINC2896175; BDBM50157742; MCULE-5028034982; SR-01000210228; SR-01000210228-1
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| Activity |
IC50 = 53400 nM
|
[6] | |||
| Compound Name |
N''-Benzylidene-2-(3-((4-methylthiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204973; BDBM50183371; CCG-246467
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| Activity |
IC50 = 54300 nM
|
[7] | |||
| Compound Name |
Trisubsituted thiazole, 23
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2260634; BDBM93129
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| Activity |
IC50 = 55200 nM
|
[5] | |||
| Compound Name |
2-[(6-Oxo-4-propyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222707; 2-(4-hydroxy-6-propylpyrimidin-2-ylthio)-N-phenylacetamide; Cambridge id 6101675; Cambridge id 6502007; SCHEMBL20511123; ZINC6147493; 2-[(4-oxo-6-propyl-1H-pyrimidin-2-yl)sulfanyl]-N-phenylacetamide; BDBM50157751; STK142994; STK212032; AKOS002354579; AKOS003262077; MCULE-3463471978; ST037320; SR-01000530267; SR-01000530267-1; Z56951625; 2-[(4-hydroxy-6-propylpyrimidin-2-yl)thio]-N-phenylacetamide; 2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]-N-phenylacetamide
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| Activity |
IC50 = 59900 nM
|
[6] | |||
| Compound Name |
N'-[(E)-(2,4-Dihydroxyphenyl)methylidene]-2-(quinolin-2-ylsulfanyl)acetohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222708; BDBM50157761; STK750354; MCULE-2573606527; N''-(2,4-dihydroxybenzylidene)-2-(quinolin-2-ylthio)acetohydrazide
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| Activity |
IC50 = 63400 nM
|
[6] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-3-(cyclohexylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171094; BDBM50322348
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| Activity |
Ki = 89000 nM
|
[8] | |||
| Compound Name |
Chembl4224700
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461238
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(E)-1-(4-Methoxyphenyl)-3-(2-prop-2-ynoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597892; BDBM50415549
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(2,4-Dimethoxyphenyl)-3-(3-prop-2-ynoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597625; BDBM50415545
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(R)-Methyl4-(2-(3-((butylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171093; BDBM50322347
Click to Show/Hide
|
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-3-(4-Methoxyphenyl)-1-(4-prop-2-ynoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL606235; BDBM50415534
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-(4-Methoxyphenyl)-1-(3-prop-2-ynoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596611; BDBM50415537
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4228548
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461231
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(E)-1-(4-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL592303; BDBM50415532
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-(2,4-Dimethoxyphenyl)-1-(2-prop-2-ynoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL597220; BDBM50415539
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4226325
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461228
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(E)-3-(2-Prop-2-ynoxyphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597896; BDBM50415547
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Methyl (E)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-5-(4-methoxyphenyl)-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171634; BDBM50322344
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
(E)-3-(2,4-Dimethoxyphenyl)-1-(4-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL592268; BDBM50415533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(2-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596610; BDBM50415538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(3-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589904; BDBM50415535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(4-Methoxyphenyl)-3-(3-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597624; BDBM50415546; ZINC45357885
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-(4-Prop-2-ynoxyphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597017; BDBM50415541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4228230
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(E)-1-(2,4-Dimethoxyphenyl)-3-(2-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589509; BDBM50415548
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-(2,4-Dimethoxyphenyl)-1-(3-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589903; BDBM50415536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-(4-Methoxyphenyl)-1-(2-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597219; BDBM50415540; (e)-3-(4-methoxyphenyl)-1-(2-(prop-2-yn-1-yloxy)phenyl)prop-2-en-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(4-Methoxyphenyl)-3-(4-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL589510; BDBM50415543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-1-(2,4-Dimethoxyphenyl)-3-(4-prop-2-ynoxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602103; BDBM50415542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Methyl 1-[2-[[(2S)-1-[[(2S)-1-[[(1S)-2-[(2S)-2-[(4-fluorophenoxy)methyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3409911; BDBM50074134
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011 Mar;46(3):927-33. | ||||
| REF 2 | Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of alpha-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1274-9. | ||||
| REF 3 | Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem. 2017 Aug 24;60(16):6911-6923. | ||||
| REF 4 | Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem. 2014 Dec 26;57(24):10557-63. | ||||
| REF 5 | Design, Synthesis and Evaluation of Trisubstituted Thiazoles Targeting?Plasmodium Falciparum?Cysteine Proteases. Med Chem Res. 2005;14:74-105. | ||||
| REF 6 | Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database. J Med Chem. 2004 Dec 16;47(26):6609-15. | ||||
| REF 7 | Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem. 2006 Mar 9;49(5):1576-84. | ||||
| REF 8 | Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):4928-38. | ||||
| REF 9 | Designing novel inhibitors against falcipain-2 of Plasmodium falciparum. Bioorg Med Chem Lett. 2018 May 15;28(9):1566-1569. | ||||
| REF 10 | Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 1;20(3):942-4. | ||||
| REF 11 | Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents. Bioorg Med Chem. 2015 May 1;23(9):2221-40. | ||||
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