TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T44614	Plasmodium Cysteine protease falcipain-2	B01HTQ	Chembl4224700	Investigative	145968500	C29H26ClN3O3	500	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NN(C(C3)C4=CC=C(C=C4)Cl)C(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B02GID	(3Z)-6-Chloro-3-[(dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one	Investigative	13339465; 54511056	C11H11ClN2O	222.67	CN(C)/C=C\\1/C2=C(C=C(C=C2)Cl)NC1=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B0CD6E	Benzyl (3S)-3-[[(3S)-1-acetyloxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate	Investigative	76328858	C31H32N2O6	528.6	CC(=O)OCC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)[C@@H]2CC3=CC=CC=C3CN2C(=O)OCC4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B0HXN2	1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-(4-(furan-2-ylmethyl)-5-hydroxy-4H-1,2,4-triazol-3-ylthio)ethanone	Investigative	2814162	C17H15N3O5S	373.4	C1COC2=C(O1)C=CC(=C2)C(=O)CSC3=NNC(=O)N3CC4=CC=CO4	IC50 = 52300 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B0KN3R	(E)-1-(4-Methoxyphenyl)-3-(2-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231266	C19H16O3	292.3	COC1=CC=C(C=C1)C(=O)/C=C/C2=CC=CC=C2OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B0ZGO4	Methyl (E)-4-[[2-[(3R)-3-(cyclohexylcarbamoyloxymethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798902	C30H34N4O6	546.6	COC(=O)/C=C/CNC(=O)CN1C2=CC=CC=C2C(=N[C@@H](C1=O)COC(=O)NC3CCCCC3)C4=CC=CC=C4	Ki = 89000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B1HLE0	[(3S)-2-Oxo-5-phenyl-3-[[3-(phenylmethoxycarbonylamino)bicyclo[2.2.1]hept-5-ene-2-carbonyl]amino]pentyl] acetate	Investigative	76314407	C29H32N2O6	504.6	CC(=O)OCC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)C2C3CC(C2NC(=O)OCC4=CC=CC=C4)C=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B24CAP	(E)-1-(2,4-Dimethoxyphenyl)-3-(3-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231306	C20H18O4	322.4	COC1=CC(=C(C=C1)C(=O)/C=C/C2=CC(=CC=C2)OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B24GNQ	Trisubsituted thiazole, 23	Investigative	71463493	C25H27N3O2S2	465.6	C1=CC=C(C=C1)CCCSCC(=O)NC2=NC(=C(S2)CCC(=O)N)/C=C/C3=CC=CC=C3	IC50 = 55200 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B28WZH	(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	137643756	C26H30N4O5	478.5	CC(C)C[C@@H](C(=O)N[C@@H](CCC1=CC=CC=C1)/C=C/C#N)NC(=O)OCC2=CC=C(C=C2)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B2AIM6	(R)-Methyl4-(2-(3-((butylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate	Investigative	49798901	C28H32N4O6	520.6	CCCCNC(=O)OC[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)CC(=O)NC/C=C/C(=O)OC	Ki ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B2UGC3	(2S)-2-[[(2S)-2-[[(2S)-2-(Dimethylamino)-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-N-[(2S)-5-[(2S,3S)-3-methoxy-2-methyl-5-oxopyrrolidin-1-yl]-5-oxopentan-2-yl]-4-methylpentanamide;2,2,2-trifluoroacetic acid	Investigative	145948250	C32H56F3N5O8	695.8	C[C@H]1[C@H](CC(=O)N1C(=O)CC[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C)OC.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B2Z8AT	(3Z)-3-[(Dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one	Investigative	728912; 3028974	C11H12N2O	188.23	CN(C)/C=C\\1/C2=CC=CC=C2NC1=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B30WTH	(E)-3-(4-Methoxyphenyl)-1-(4-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46230576	C19H16O3	292.3	COC1=CC=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B38UDT	Benzyl (4S)-4-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate	Investigative	76321694	C25H30N2O6	454.5	CC1(N([C@@H](CO1)C(=O)N[C@@H](CCC2=CC=CC=C2)C(=O)CO)C(=O)OCC3=CC=CC=C3)C	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B3AT0I	Benzyl (2S,4R)-4-hydroxy-2-[[(3S)-1-morpholin-4-yl-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	76310780	C28H35N3O6	509.6	C1COCCN1CC(=O)[C@H](CCC2=CC=CC=C2)NC(=O)[C@@H]3C[C@H](CN3C(=O)OCC4=CC=CC=C4)O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B3D8QF	(E)-3-(4-Methoxyphenyl)-1-(3-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231349	C19H16O3	292.3	COC1=CC=C(C=C1)/C=C/C(=O)C2=CC(=CC=C2)OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B3TL8A	Benzyl (2S,4R)-2-[[(3S)-1-acetylsulfanyl-2-oxo-5-phenylpentan-3-yl]carbamoyl]-4-hydroxypyrrolidine-1-carboxylate	Investigative	76336145	C26H30N2O6S	498.6	CC(=O)SCC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)[C@@H]2C[C@H](CN2C(=O)OCC3=CC=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B3UG6R	Chembl4228548	Investigative	145968902	C28H27N3O2	437.5	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NN(C(C3)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B4TX7C	Trisubsituted thiazole, 15	Investigative	71463489	C27H33NO2S2	467.7	C1=CC=C(C=C1)CCCSCC(=O)CCC2=NC(=C(S2)CCCO)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B4Z3FC	(E)-1-(4-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one	Investigative	46230577	C21H20O5	352.4	COC1=C(C(=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)OCC#C)OC)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B5NKE6	Benzyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	137659286	C26H31N3O3	433.5	CC(C)C[C@@H](C(=O)N[C@@H](CCC1=CC=CC=C1)/C=C/C#N)NC(=O)OCC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B5S2UW	Benzyl (4S)-4-[[(3S)-1-acetyloxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate	Investigative	76332528	C27H32N2O7	496.6	CC(=O)OCC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)[C@@H]2COC(N2C(=O)OCC3=CC=CC=C3)(C)C	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B5Z0JY	Benzyl N-[(1S,6R)-6-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]cyclohex-3-en-1-yl]carbamate	Investigative	76332529	C26H30N2O5	450.5	C1C=CC[C@@H]([C@@H]1C(=O)N[C@@H](CCC2=CC=CC=C2)C(=O)CO)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B67FWS	N'-[(E)-(2,4-Dihydroxyphenyl)methylidene]-2-(quinolin-2-ylsulfanyl)acetohydrazide	Investigative	135478389	C18H15N3O3S	353.4	C1=CC=C2C(=C1)C=CC(=N2)SCC(=O)N/N=C/C3=C(C=C(C=C3)O)O	IC50 = 63400 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B6R2CF	(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	137647856	C34H33N3O7S	627.7	C1=CC=C(C=C1)CC[C@@H](/C=C/S(=O)(=O)C2=CC=CC=C2)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B6SA3Q	Benzyl N-[(1S,2R)-2-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]cyclopentyl]carbamate	Investigative	76336143	C25H30N2O5	438.5	C1C[C@H]([C@H](C1)NC(=O)OCC2=CC=CC=C2)C(=O)N[C@@H](CCC3=CC=CC=C3)C(=O)CO	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B6XI2Y	Diethyl 2-(2-(naphthalen-1-ylcarbamoyl)hydrazinyl)-2-oxoethylphosphonate	Investigative	2246214	C17H22N3O5P	379.3	CCOP(=O)(CC(=O)NNC(=O)NC1=CC=CC2=CC=CC=C21)OCC	IC50 = 53400 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B70EXU	(Z/E)-7-Chloro-3-((dimethylamino)methylene)indolin-2-one	Investigative	13339466; 54370560	C11H11ClN2O	222.67	CN(C)/C=C\\1/C2=C(C(=CC=C2)Cl)NC1=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B75VWS	Methyl (E,4S)-4-[[(2S)-2-[(4-nitrophenyl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-6-phenylhex-2-enoate	Investigative	137653242	C30H31N3O7	545.6	COC(=O)/C=C/[C@H](CCC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B7CK5Q	(E)-3-(2,4-Dimethoxyphenyl)-1-(2-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231347	C20H18O4	322.4	COC1=CC(=C(C=C1)/C=C/C(=O)C2=CC=CC=C2OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B7CVN6	Benzyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	137637025	C29H29N3O3	467.6	C1=CC=C(C=C1)CC[C@@H](/C=C/C#N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B8CWK7	[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(E,2S)-5-[[(2S)-1-(Benzylamino)-1-oxopropan-2-yl]amino]-5-oxopent-3-en-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-dimethylazanium;2,2,2-trifluoroacetate	Investigative	118722667; 145948258	C42H68F3N7O8	856	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)/C=C/C(=O)N[C@@H](C)C(=O)NCC1=CC=CC=C1)[NH+](C)C.C(=O)(C(F)(F)F)[O-]	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B8R7WG	5-Chlor-3-dimethylaminomethylenoxindol	Investigative	13339468; 53970952	C11H11ClN2O	222.67	CN(C)/C=C\\1/C2=C(C=CC(=C2)Cl)NC1=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B9LST5	N''-Benzylidene-2-(3-((4-methylthiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetohydrazide	Investigative	9584421	C22H19N5O2S	417.5	CC1=CSC(=N1)CN2C(=O)C3=CC=CC=C3C(=N2)CC(=O)N/N=C/C4=CC=CC=C4	IC50 = 54300 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	B9VCF0	Chembl4226325	Investigative	145969487	C29H27N3O3	465.5	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NN(C(C3)C4=CC=CC=C4)C(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BB40UZ	(E)-3-(2-Prop-2-ynoxyphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one	Investigative	46231304	C21H20O5	352.4	COC1=C(C(=C(C=C1)C(=O)/C=C/C2=CC=CC=C2OCC#C)OC)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BBM97K	2-[(6-Oxo-4-propyl-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide	Investigative	135406805	C15H17N3O2S	303.4	CCCC1=CC(=O)NC(=N1)SCC(=O)NC2=CC=CC=C2	IC50 = 59900 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BCXB42	Methyl (E)-4-[[2-[(3R)-3-[[4-chloro-2-(trifluoromethyl)phenyl]carbamoyloxymethyl]-5-(4-methoxyphenyl)-2-oxo-3H-1,4-benzodiazepin-1-yl]acetyl]amino]but-2-enoate	Investigative	49798882	C32H28ClF3N4O7	673	COC1=CC=C(C=C1)C2=N[C@@H](C(=O)N(C3=CC=CC=C32)CC(=O)NC/C=C/C(=O)OC)COC(=O)NC4=C(C=C(C=C4)Cl)C(F)(F)F	Ki ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BE4LV3	(E)-3-(2,4-Dimethoxyphenyl)-1-(4-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46216667	C20H18O4	322.4	COC1=CC(=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BEFI48	N-(3-Hydroxy-phenyl)-3-(3-hydroxy-phenylsulfamoyl)-benzamide	Investigative	1069242	C19H16N2O5S	384.4	C1=CC(=CC(=C1)S(=O)(=O)NC2=CC(=CC=C2)O)C(=O)NC3=CC(=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BER76T	(E)-1-(2-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one	Investigative	46231348	C21H20O5	352.4	COC1=C(C(=C(C=C1)/C=C/C(=O)C2=CC=CC=C2OCC#C)OC)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BGC85L	Trisubsituted thiazole, 17	Investigative	71463491	C27H32N2O2S2	480.7	C1=CC=C(C=C1)CCCSCC(=O)CCC2=NC(=C(S2)CCC(=O)N)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BI6NK5	2-[(4-Fluorobenzyl)sulfonyl]-N''-[(thien-2-ylcarbonyl)oxy]ethanimidamide	Investigative	5839370	C14H13FN2O4S2	356.4	C1=CSC(=C1)C(=O)O/N=C(/CS(=O)(=O)CC2=CC=C(C=C2)F)\\N	IC50 = 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BJ09KU	(Z/E)-3-(Benzylthiomethylene)indolin-2-one	Investigative	51355958; 57398858	C16H13NOS	267.3	C1=CC=C(C=C1)CS/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BJ1A0W	Methyl (E,4S)-6-phenyl-4-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]hex-2-enoate	Investigative	59907274	C30H32N2O5	500.6	COC(=O)/C=C/[C@H](CCC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BK1HV9	Trisubsituted thiazole, 16	Investigative	71463490	C27H31NO2S2	465.7	C1=CC=C(C=C1)CCCSCC(=O)CCC2=NC(=C(S2)CCC=O)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BN65OG	Benzyl (2S)-2-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	76310777	C24H28N2O5	424.5	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)N[C@@H](CCC3=CC=CC=C3)C(=O)CO	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BN90VO	Benzyl (2S)-2-[[(3S)-1-acetylsulfanyl-2-oxo-5-phenylpentan-3-yl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	76314405	C26H30N2O5S	482.6	CC(=O)SCC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BNG1Y2	(E)-1-(3-Prop-2-ynoxyphenyl)-3-(2,3,4-trimethoxyphenyl)prop-2-en-1-one	Investigative	46230575	C21H20O5	352.4	COC1=C(C(=C(C=C1)/C=C/C(=O)C2=CC(=CC=C2)OCC#C)OC)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BNJ1W6	(E)-1-(4-Methoxyphenyl)-3-(3-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231305	C19H16O3	292.3	COC1=CC=C(C=C1)C(=O)/C=C/C2=CC(=CC=C2)OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BNM0X2	(E)-3-(4-Prop-2-ynoxyphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one	Investigative	46231346	C21H20O5	352.4	COC1=C(C(=C(C=C1)C(=O)/C=C/C2=CC=C(C=C2)OCC#C)OC)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BO6LA5	(4-Nitrophenyl)methyl N-[(2S)-1-[[(E,3S)-1-cyano-5-phenylpent-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate	Investigative	137641179	C29H28N4O5	512.6	C1=CC=C(C=C1)CC[C@@H](/C=C/C#N)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BO8NA9	Trisubsituted thiazole, 20	Investigative	71463492	C29H36N2O2S2	508.7	CC(=O)NCCCC1=C(N=C(S1)CCC(=O)CSCCCC2=CC=CC=C2)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BP93HJ	Chembl4228230	Investigative	145971181	C22H23N3O2	361.4	CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)C3=NNC(C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BQ8PU4	(E)-1-(2,4-Dimethoxyphenyl)-3-(2-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231303	C20H18O4	322.4	COC1=CC(=C(C=C1)C(=O)/C=C/C2=CC=CC=C2OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BQBZ04	(E)-3-(2,4-Dimethoxyphenyl)-1-(3-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46230574	C20H18O4	322.4	COC1=CC(=C(C=C1)/C=C/C(=O)C2=CC(=CC=C2)OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BV73WU	(E)-3-(4-Methoxyphenyl)-1-(2-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46216666	C19H16O3	292.3	COC1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BW3X1T	1-Methyl-3-(N,N-dimethylamino)methyleneindol-2-one	Investigative	51355959; 57398857	C12H14N2O	202.25	CN1C2=CC=CC=C2/C(=C/N(C)C)/C1=O	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BW8IF5	Trisubsituted thiazole, 29	Investigative	71463494	C25H29NO2S2	439.6	C1=CC=C(C=C1)CCCSCC(=O)CCC2=NC(=C(S2)CCC3=CC=CC=C3)CO	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BWT52P	Trisubsituted thiazole, 30	Investigative	71463495	C27H31NO3S2	481.7	CC(=O)OCC1=C(SC(=N1)CCC(=O)CSCCCC2=CC=CC=C2)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BX7SY9	(E)-1-(4-Methoxyphenyl)-3-(4-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231308	C19H16O3	292.3	COC1=CC=C(C=C1)C(=O)/C=C/C2=CC=C(C=C2)OCC#C	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BY4TA8	Benzyl N-[1-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-4-oxocyclohexyl]carbamate	Investigative	76310778	C26H30N2O6	466.5	C1CC(CCC1=O)(C(=O)N[C@@H](CCC2=CC=CC=C2)C(=O)CO)NC(=O)OCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BY8FN1	(E)-1-(2,4-Dimethoxyphenyl)-3-(4-prop-2-ynoxyphenyl)prop-2-en-1-one	Investigative	46231345	C20H18O4	322.4	COC1=CC(=C(C=C1)C(=O)/C=C/C2=CC=C(C=C2)OCC#C)OC	IC50 ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BZ0IH7	Methyl 1-[2-[[(2S)-1-[[(2S)-1-[[(1S)-2-[(2S)-2-[(4-fluorophenoxy)methyl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]piperidine-4-carboxylate	Investigative	118731989	C40H56FN5O7	737.9	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2CCC[C@H]2COC3=CC=C(C=C3)F)NC(=O)CN4CCC(CC4)C(=O)OC	Ki ~ 100000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BZA84D	Benzyl (3S)-3-[[(3S)-1-hydroxy-2-oxo-5-phenylpentan-3-yl]carbamoyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate	Investigative	76321697	C29H30N2O5	486.6	C1[C@H](N(CC2=CC=CC=C21)C(=O)OCC3=CC=CC=C3)C(=O)N[C@@H](CCC4=CC=CC=C4)C(=O)CO	IC50 ~ 50000 nM	Poor binder
T44614	Plasmodium Cysteine protease falcipain-2	BZD97L	[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(E,2S)-5-[[(2S)-1-[(2S,4S)-4-Hydroxy-2-methoxycarbonylpyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-5-oxopent-3-en-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-dimethylazanium;2,2,2-trifluoroacetate	Investigative	118722669; 145948260	C41H70F3N7O11	894	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)/C=C/C(=O)N[C@@H](C)C(=O)N1C[C@H](C[C@H]1C(=O)OC)O)[NH+](C)C.C(=O)(C(F)(F)F)[O-]	IC50 ~ 50000 nM	Poor binder