Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T39054 | Target Info | |||
Target Name | dUTP pyrophosphatase (DUT) | ||||
Synonyms |
Deoxyuridine 5' triphosphate nucleotidohydrolase, mitochondrial; DUT
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Target Type | Clinical trial Target | ||||
Gene Name | DUT | ||||
Biochemical Class | Acid anhydrides hydrolase | ||||
UniProt ID |
Poor Binders of This Target (in total, 33 binders) | Download | Top | |||
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Compound Name |
1-[2-(trityloxy)ethoxymethyl]uracil
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Investigative | Compound Info | ||
Synonyms |
1-[2-(trityloxy)ethoxymethyl]uracil; CHEMBL424704; SCHEMBL912787; US8530490, Comparative 1; QEKAGWDUKXATPZ-UHFFFAOYSA-N; BDBM50190553
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
1-[5-[[Tert-butyl(dimethyl)silyl]oxymethyl]-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL198656; BDBM50173555; 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione
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Activity |
Ki = 56400 nM
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[2] | |||
Compound Name |
1-[2-(Tert-butyldimethylsilyloxyethoxy)methyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL213682; BDBM50190551
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Activity |
Ki = 63000 nM
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[3] | |||
Compound Name |
1-[4-(Benzhydrylamino)butyl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420339; BDBM50439345; ZINC96283129
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Activity |
Ki = 63000 nM
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[4] | |||
Compound Name |
1-(3-Tert-butyldimethylsilyloxypropyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL441534; SCHEMBL3083444; BDBM50190534; 1-[3-[tert-butyl(dimethyl)silyl]oxypropyl]pyrimidine-2,4-dione
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Activity |
Ki = 73000 nM
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[3] | |||
Compound Name |
1-[4-Acetyloxy-3-(tritylaminomethyl)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL208621; SCHEMBL12268318; BDBM50190564
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Activity |
Ki = 74000 nM
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[3] | |||
Compound Name |
Rac-1-[2-(Carboxy)-4-(triphenylmethyl)aminobutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766652; BDBM50341705
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Activity |
Ki = 90000 nM
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[5] | |||
Compound Name |
N-Tert-butyl-4-(2,4-dioxopyrimidin-1-yl)butanamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2048444; BDBM50386620
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Activity |
IC50 = 97000 nM
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[6] | |||
Compound Name |
US8530490, Comparative 2
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Investigative | Compound Info | ||
Synonyms |
SCHEMBL1408937; CHEMBL3664501; BDBM101908
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Activity |
IC50 = 97200 nM
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[7] | |||
Compound Name |
Rac-1-[2-(Acetamide)-4-(triphenylmethyl)aminobutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766653; BDBM50341704
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Activity |
Ki = 98000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(N-Methylpiperazine)amido-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766642; BDBM50341696
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Methylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766647; BDBM50341710
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-(2-Morpholinamido-4-trityloxybutyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766640; BDBM50341698
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-benzyl 4-(4-(tert-butyldiphenylsilyloxy)-2-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)butanoyl)piperazine-1-carboxylate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766650; BDBM50341707
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Hydroxyethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766643; BDBM50341695
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-(2-Amido-4-trityloxybutyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766635; BDBM50341703
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Carboxy)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766645; BDBM50341693
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
2',5'-Dideoxy-5'-[(Diphenylmethyl)amino]uridine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420340; BDBM50439344; Q27459744; 1-[(2R,4S,5R)-5-[(benzhydrylamino)methyl]-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione; DU3
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Activity |
Ki ~ 100000 nM
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[4] | |||
Compound Name |
Rac-1-[2-(Methoxyethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766641; BDBM50341697
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
(2S,3S,5R)-N-Benzhydryl-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolane-2-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420333; BDBM50439336
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Activity |
Ki ~ 100000 nM
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[4] | |||
Compound Name |
Rac-benzyl 2-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-(tritylamino)butyl carbonate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766651; BDBM50341706
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Carboxyethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766644; BDBM50341694
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(tert-Butyldiphenylsilyloxyethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766637; BDBM50341701
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-(2-Dimethylamido-4-trityloxybutyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766636; BDBM50341702
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(N,N-Dimethylaminoethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766639; BDBM50341699
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Ethylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766648; BDBM50341709
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Carboethoxyethylamido)-4-trityloxybutyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766638; BDBM50341700
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Acetamide)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766646; BDBM50341692
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
Rac-1-[2-(Diethylamido)-4-(tert-butyldiphenylsilyloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1766649; BDBM50341708
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Activity |
Ki ~ 100000 nM
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[5] | |||
Compound Name |
1-[4-(Tert-Butyl-dimethyl-silanyloxy)-5-hydroxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
SCHEMBL9342019; CHEMBL3143781; CHEMBL363828; CTK2G8041; DTXSID90439421; BDBM50173573; 3'-O-t-Butyldimethylsilyl-2'-deoxyuridine; 2'-Deoxy-3'-O-(tert-butyldimethylsilyl)uridine; Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-
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Activity |
Ki = 119000 nM
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[2] | |||
Compound Name |
[(2R,3S,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl diphenyl phosphate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3143775; BDBM50027180
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Activity |
Ki = 135000 nM
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[2] | |||
Compound Name |
1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL369937; dUTPase inhibitor, 2; SCHEMBL3582941; BDBM50173546; 1-[5-(trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione
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Activity |
Ki = 157000 nM
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[2] | |||
Compound Name |
5'O-Trityl-2',3'-dideoxy-2',3'-didehydrouridine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1807019; SCHEMBL8541641; CTK2F0569; DTXSID10454858; BDBM50348776; 5'-O-Trityl-2',3'-dideoxy-2',3'-didehydrouridine; Uridine, 2',3'-didehydro-2',3'-dideoxy-5'-O-(triphenylmethyl)-; 1-[(2R,5S)-5-(trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione
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Activity |
Ki = 157000 nM
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[8] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 87 non binders) | Download | Top | |||
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Compound Name |
1-[4-[Tert-butyl(dimethyl)silyl]oxy-5-[(diphenoxyphosphorylamino)methyl]oxolan-2-yl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL197449; BDBM50173570
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Activity |
Ki = 232000 nM
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[2] | |||
Compound Name |
1-[2-(Hydroxymethyl)-4-(trityloxy)butyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL385167; BDBM50190565
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Activity |
Ki = 260000 nM
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[3] | |||
Compound Name |
N-[3-(2,4-Dioxopyrimidin-1-yl)propyl]-2,2-diphenyl-acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420344; BDBM50439340
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Activity |
Ki = 286000 nM
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[4] | |||
Compound Name |
Octahydro-2,4-methano-indene-2-carboxylic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester
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Investigative | Compound Info | ||
Synonyms |
CHEMBL198043; BDBM50173545
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Activity |
Ki = 298000 nM
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[2] | |||
Compound Name |
1-[2-(Benzoyloxyethoxy)methyl]uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL11415; BDBM50028515; Benzoic acid 2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester
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Activity |
Ki = 311000 nM
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[3] | |||
Compound Name |
1-(3-Trityloxypropyl)pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL378229; 1-(3-trityloxypropyl)uracil; SCHEMBL912708; BDBM50190541
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Activity |
Ki = 313000 nM
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[3] | |||
Compound Name |
Sulfamic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3143774; CHEMBL199137; BDBM50173568
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Activity |
Ki = 324000 nM
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[2] | |||
Compound Name |
Hexadecanoic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester
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Investigative | Compound Info | ||
Synonyms |
CHEMBL194480; dUTPase inhibitor, 4; BDBM50173554
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Activity |
Ki = 350000 nM
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[2] | |||
Compound Name |
1-(6-Triphenylsilyloxyhexyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL212690; 1-(6-triphenylsilyloxyhexyl)pyrimidine-2,4-dione; SCHEMBL913217; 1-(6'-Triphenylsilyloxyhexyl)uracil; BDBM50190562
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Activity |
Ki = 383000 nM
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[3] | |||
Compound Name |
1-(4-Fluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL197951; SCHEMBL13444847; BDBM50173550
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Activity |
Ki = 457000 nM
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[2] | |||
Compound Name |
1-{(2S,5S)-4-Fluoro-5-[(trityloxy)methyl]tetrahydrofuran-2-YL}pyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
Synonyms |
2,3-DEOXY-3-FLUORO-5-O-TRITYLURIDINE; CHEMBL209720; SCHEMBL3571173; BDBM50190544; DB04685; 2',3'-dideoxy-3'-fluoro-5'-O-trityluridine; Q27095432
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Activity |
Ki = 457000 nM
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[8] | |||
Compound Name |
N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-benzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL198168; BDBM50173572
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Activity |
Ki = 469000 nM
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[2] | |||
Compound Name |
1-(6-Trityloxyhexyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL378414; 1-(6-trityloxyhexyl)pyrimidine-2,4-dione; SCHEMBL12268297; BDBM50190558
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Activity |
Ki = 476000 nM
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[3] | |||
Compound Name |
1-(4-Benzoyloxybutyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL211683; BDBM50190535
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Activity |
Ki = 496000 nM
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[3] | |||
Compound Name |
1-(6-Hydroxyhexyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL211389; 1-(6'-hydroxyhexyl)uracil; SCHEMBL913371; 2,4(1H,3H)-Pyrimidinedione, 1-(6-hydroxyhexyl)-; BDBM50190561; 1-(6-hydroxyhexyl)pyrimidine-2,4-dione
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Activity |
Ki = 636000 nM
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[3] | |||
Compound Name |
[5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl aminosulfonylcarbamate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL194479; BDBM50173543
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Activity |
Ki = 799000 nM
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[2] | |||
Compound Name |
1-((2R,4S,5R)-5-((Tert-butyldiphenylsilyloxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL513890; SCHEMBL3567686; BDBM50266744; 5'-O-(tert-Butyldiphenylsilyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
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Activity |
Ki = 806000 nM
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[9] | |||
Compound Name |
Dutpase inhibitor, 7
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Investigative | Compound Info | ||
Synonyms |
CHEMBL370908; BDBM50173532; 1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
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Activity |
Ki = 808000 nM
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[2] | |||
Compound Name |
1-(3-Benzoyloxypropyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL209179; BDBM50190546
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Activity |
Ki = 898000 nM
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[3] | |||
Compound Name |
1-((2R,4S,5R)-4-Hydroxy-5-((triphenylsilyloxy)methyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL211446; SCHEMBL3582829; BDBM50190545; 5'-O-Triphenylsilyl-2'-deoxyuridine; 1-[(2R,4S,5R)-4-hydroxy-5-(triphenylsilyloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
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Activity |
Ki = 909000 nM
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[3] | |||
Compound Name |
1-(4-Tert-butyldiphenylsilyloxyhexyl)uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL211847; SCHEMBL12268311; BDBM50190563
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Activity |
Ki > 1000000 nM
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[3] | |||
Compound Name |
Dutpase inhibitor, 6
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Investigative | Compound Info | ||
Synonyms |
CHEMBL195997; BDBM50173567; 1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-fluoro-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
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Activity |
Ki > 1000000 nM
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[2] | |||
Compound Name |
1-[N-(3-Triphenylmethylaminopropyl)-acetamide] uracil
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Investigative | Compound Info | ||
Synonyms |
CHEMBL518751; BDBM50266848
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Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
N-[3-(2,4-Dioxopyrimidin-1-yl)propyl]-2,2,2-triphenyl-acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420336; BDBM50439339
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Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
1-(5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL175267; NSC175992; SCHEMBL13444838; BDBM50173559; NSC-175992; 1-(5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,3H)-dione
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Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(3-Hydroxypropyl)-2,4(1H,3H)-pyrimidinedione
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Investigative | Compound Info | ||
Synonyms |
CHEMBL211810; 1-(3-hydroxypropyl)pyrimidine-2,4-dione; 1-(3-hydroxypropyl)uracil; 1-(3'-hydroxypropyl)uracil; 1-(3-hydroxypropyl)-uracil; SCHEMBL3079985; CTK2I1059; BDBM50190560; ZINC35904583; AKOS013122580; 2,4(1H,3H)-Pyrimidinedione, 1-(3-hydroxypropyl)-; Z2488948504; 1-(3-hydroxypropyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
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Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
Pentanoic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143779; CHEMBL370429; BDBM50173558
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-(3-Hydroxypropyl)-2,2,2-triphenyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420342; BDBM50439342
Click to Show/Hide
|
||||
Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
Chembl426653
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143773; BDBM50173552
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(5-Trityloxypentyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-(5-trityloxypentyl)uracil; CHEMBL377472; SCHEMBL913176; BDBM50190550; 1-[5-(trityloxy)pentyl]-1,2,3,4-tetrahydro-2,4-pyrimidinedione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
Chembl380564
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143776; BDBM50173549
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-[N-(3-Triphenylmethylaminobutyl)-acetamide] uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479101; BDBM50266849
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
N-[3-(3-Benzoyl-2,4-dioxopyrimidin-1-yl)propyl]-2,2,2-triphenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420343; BDBM50439341; N-[3-(3-benzoyl-2,4-dioxo-pyrimidin-1-yl)propyl]-2,2,2-triphenyl-acetamide
Click to Show/Hide
|
||||
Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
Chembl436503
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143770; BDBM50173557
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-[5-[(Diphenoxyphosphorylamino)methyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL194269; BDBM50173551
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-(3-Hydroxypropyl)-2,2-diphenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420341; SCHEMBL7603553; BDBM50439343; ZINC19780776; AKOS017107122; N-(3-hydroxypropyl)-2,2-diphenyl-acetamide
Click to Show/Hide
|
||||
Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
1-[N-Hydroxyethyl-N-(triphenylmethyl amino) ethyl-acetamide] uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL475961; BDBM50266875
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
1-(5-Triphenylsilanyloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL197786; BDBM50173535
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(6-Benzoyloxyhexyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL211066; BDBM50190559
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-[N-(Triphenylmethylaminoethyl)-N-(aminoethyl) acetamide] uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL478252; BDBM50266873
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
5'-O-Triisopropylsilyl-2'-deoxyuridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143785; SCHEMBL3576738; BDBM50027181; 1-[(2R,4S,5R)-4-hydroxy-5-[tri(propan-2-yl)silyloxymethyl]oxolan-2-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-[3-(Tert-butyl diphenyl silanyloxy)-propyl]-2-uracil acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL475993; BDBM50266820
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
1-(4-Benzyloxycarbonylaminobutyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL209860; BDBM50190566
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-(4-Hydroxybutyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-(4'-Hydroxybutyl)uracil; CHEMBL214059; 1-(4-hydroxybutyl)pyrimidine-2,4-dione; SCHEMBL913206; CTK1B0937; DTXSID50493504; BDBM50190540; AKOS013124484; 1-(4-Hydroxybutyl)pyrimidine-2,4(1H,3H)-dione; 2,4(1H,3H)-Pyrimidinedione, 1-(4-hydroxybutyl)-
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
2',3'-Didehydro-2',3'-dideoxyuridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione; CHEMBL89637; 1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2',3'-Dideoxy-2',3'-didehydrouridine; ddeUrd; 2',3'-Dideoxyuridinene; SCHEMBL543443; DTXSID50208453; ZINC137875; BDBM50013115; MFCD03424302; AKOS025401704; AC-24683; CS-0100830; Uridine, 2',3'-didehydro-2',3'-dideoxy-; 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione (ddeUrd)
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-{4-(Tert-Butyl-dimethyl-silanyloxy)-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL196381; BDBM50173536
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(4-Fluoro-5-triphenylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL197837; BDBM50173533
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
Triphenylmethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Triphenylcarbinol; Trityl alcohol; Tritanol; Triphenylmethyl alcohol; triphenyl carbinol; Triphenyl methanol; Triphenyl-methanol; Methanol, triphenyl-; Benzenemethanol, .alpha.,.alpha.-diphenyl-; MFCD00004445; UNII-U97Q0OU9KB; Fimasartan Impurity L; diphenyl-phenyl carbinol; Triphenylmethanol, 97%; NSC 4050; U97Q0OU9KB; CHEMBL118166; triphenylmethan-1-ol; Ph3C-Oh; MFCD10565638; tritylalcohol; Trityl alcohol; EINECS 200-988-5; Trt-OH; Benzenemethanol, alpha,alpha-diphenyl-; Ph3COH; PubChem16669; ACMC-1BLZG; AI3-08929; CUPRICFLUOROSILICATE; SCHEMBL700; KSC378Q4T; Methanol, triphenyl- (8CI); AMBZ0207; DTXSID0058803; BDBM23784; CTK2H8849; LZTRCELOJRDYMQ-UHFFFAOYSA-; NSC4050; Triphenylmethanol / Tritylmethanol; NSC-4050; ANW-36898; SBB057388; STK370823; ZINC51498203; AKOS002265728; .alpha.,.alpha.-Diphenyl-benzylalcohol; AM85903; MCULE-5562347436; KS-0000091Y; Triphenylmethyl-containing compound, 13; AK116973; AS-11948; BP-12571; SC-15981; SY025338; DB-056145; FT-0631329; ST50754320; Triphenylmethanol, purum, >=98.0% (HPLC); AR-360/42760202; U-45483; Q-201895; Q2735403; F1908-0150; Trityl alcohol resin (100-200 mesh, 1.2-2.0 mmol/g); Trityl alcohol resin (100-200 mesh, 2.1-4.0 mmol/g); Trityl alcohol resin (200-400 mesh, 1.2-2.0 mmol/g); Triphenylmethanol, United States Pharmacopeia (USP) Reference Standard; Zidovudine impurity D, European Pharmacopoeia (EP) Reference Standard
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-[(E)-4-Trityloxy-2-butenyl]uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL209610; SCHEMBL913714; SCHEMBL913715; BDBM50190552; 1-[(E)-4-trityloxybut-2-enyl]pyrimidine-2,4-dione; 1-[(E)-4-(Trityloxy)-2-butenyl]-1,2,3,4-tetrahydro-2,4-pyrimidinedione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[8] | |||
Compound Name |
1-(4-Tert-butyloxycarbamatebutyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL209787; BDBM50190554
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-[N-(2-Triphenylmethylaminoethyl)-acetamide] uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL479100; BDBM50266847
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
1-[5-(Benzylamino-methyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL364710; dUTPase inhibitor, 11; BDBM50173576
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-[N-(Triphenylmethyl) diaminodi (n-propyl) acetamide] uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL474269; BDBM50266874
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
1-[2-(Azidomethyl)-4-(trityloxy)butyl]uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL209757; BDBM50190536
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
5'-O-Benzoyl-2'-deoxyuridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143780; Uridine, 2'-deoxy-, 5'-benzoate; CHEMBL426284; SCHEMBL9811618; 5'-O-benzoyl-2'-desoxyuridine; CTK0F7399; BDBM50173556; [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl benzoate
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
Sulfamic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143784; CHEMBL370850; BDBM50173565
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
Triphenylsilanol
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
Hydroxytriphenylsilane; Silanol, triphenyl-; Triphenylhydroxysilane; Silane, (hydroxytriphenyl)-; Silane, hydroxytriphenyl-; MFCD00002102; UNII-AZC8O4TTX4; Triphenyl-Silanol; Silanol, 1,1,1-triphenyl-; Si(OH)Ph3; AZC8O4TTX4; CHEMBL378228; hydroxy(triphenyl)silane; EINECS 212-339-3; NSC 12564; C18H16OSi; BRN 0985007; AI3-51277; triphenylhydroxysilane;; Silanol, triphenyl-,; Triphenylsilanol, 98%; (Hydroxytriphenyl)silane; ACMC-209pge; AMTSi074; C14549; DSSTox_CID_16545; DSSTox_GSID_36545; SCHEMBL49883; 4-16-00-01480 (Beilstein Handbook Reference); KSC167E2N; DTXSID1036545; EBD3127; NSC12564; Tox21_304018; ANW-37260; BDBM50190539; NSC-12564; AKOS015855544; ZINC169745035; FS-5118; KS-0000090Z; NCGC00357231-01; AK-54083; SY023514; DB-030497; CS-0128938; FT-0632961; Z-3423; 791T311; J-525127; Q2453936; F0001-2082
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
Chembl194968
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143771; BDBM50173571
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL194902; BDBM50173564
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-Trityl-4-(uracil-1-yl)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2420334; BDBM50439337; 4-(2,4-dioxopyrimidin-1-yl)-N-trityl-butanamide
Click to Show/Hide
|
||||
Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
1-[6-(Tritylamino)hexyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-(6-tritylaminohexyl)uracil; CHEMBL211120; SCHEMBL912617; 1-(6'-Tritylaminohexyl)uracil; BDBM50190568; 1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[8] | |||
Compound Name |
(Diethoxy-phosphoryl)-acetic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143777; CHEMBL198870; BDBM50173553
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-[4-(Tert-butoxycarbonylamino)-3-(trityloxymethyl)butyl]-
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL212459; BDBM50190533
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-(5-Hydroxypentyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL212427; 1-(5-hydroxypentyl)pyrimidine-2,4-dione; SCHEMBL913034; BDBM50190542; AKOS013123716; 1-(5-Hydroxypentyl)-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-(6-(Tert-butyldiphenylsilylamino)hexyl)pyrimidine-2,4(1H,3H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL515610; BDBM50266819
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
5'-O-(Tert-Butyldiphenylsilyl)-2',3'-didehydro-2',3'-dideoxyuridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1807018; BDBM50348775
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[8] | |||
Compound Name |
N-[4-(Tert-butyl diphenyl silanyloxy)-butyl]-2-uracil acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL477035; BDBM50266846
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL194845; BDBM50173547
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(4-Triphenylsilyloxybutyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL387177; 1-(4-triphenylsilyloxybutyl)pyrimidine-2,4-dione; SCHEMBL913571; 1-(4'-Triphenylsilyloxybutyl)uracil; BDBM50190567
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-(4-Trityloxybutyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-(4-trityloxybutyl)uracil; CHEMBL211067; 1-(4'-Trityloxybutyl)uracil; SCHEMBL913645; BDBM50190530
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
Sulfamic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL197746; BDBM50173537
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-[4-(Tert-Butyl-dimethyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143782; CHEMBL382493; BDBM50173542
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
Dutpase inhibitor, 5
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL371690; SCHEMBL13444835; BDBM50173540; 1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-dihydro-furan-2-yl]-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
({[5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}carbonyl)(sulfamoyl)azanide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3144294; BDBM50173534
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
2-Diethoxyphosphoryl-N-[[5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL194650; BDBM50173561
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-[[5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL372635; BDBM50173538
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
5'-O-(Dimethoxytrityl)-5-(propargyloxy)-2'-deoxyuridine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3143783; 2'-Deoxy-5'-O-p-toluenesulfonyluridine; 5'-O-tosyl-2'-deoxyuridine; CHEMBL196849; SCHEMBL3574798; 5' -O-Tosyl-2'-deoxyuridine; BDBM50173560; ZINC13673329; 5'-o-(p-Toluenesulfonyl)-2'-deoxyuridine
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
1-(5-Triphenylsilyloxypentyl)uracil
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL212175; 1-(5-triphenylsilyloxypentyl)pyrimidine-2,4-dione; SCHEMBL913731; BDBM50190537; 1-(5-Triphenylsilanyloxypentyl)-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[3] | |||
Compound Name |
1-[5-(Tritylamino)pentyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
1-(5-tritylaminopentyl)uracil; CHEMBL376965; SCHEMBL12268289; BDBM50190557; 1-(5-(tritylamino)pentyl)pyrimidine-2,4(1H,3H)-dione; 1-[5-(Tritylamino)-pentyl]-1-H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[9] | |||
Compound Name |
1-{4-Fluoro-5-[(trityl-amino)-methyl]-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL198660; BDBM50173563
Click to Show/Hide
|
||||
Activity |
Ki > 1000000 nM
|
[2] | |||
Compound Name |
N-Benzhydryl-4-(uracil-1-yl)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2048460; BDBM50386635; N-benzhydryl-4-(2,4-dioxopyrimidin-1-yl)butanamide
Click to Show/Hide
|
||||
Activity |
Ki = 1000000 nM
|
[4] | |||
Compound Name |
1-[4-(Tritylamino)butyl]pyrimidine-2,4-dione
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Investigative | Compound Info | ||
Synonyms |
1-(4-tritylaminobutyl)uracil; CHEMBL211181; SCHEMBL913240; 1-(4'-Tritylaminobutyl)uracil; BDBM50190555
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Activity |
Ki > 1000000 nM
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[3] | |||
Compound Name |
[5-(2,4-Dioxopyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methyl diphenyl phosphate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL198661; BDBM50173544
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Activity |
Ki > 1000000 nM
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[2] | |||
Compound Name |
N-[[5-(2,4-Dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl]tricyclo[5.2.1.03,8]decane-1-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL194473; BDBM50173569
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Activity |
Ki > 1000000 nM
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[2] | |||
Compound Name |
N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-4-methyl-benzenesulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL198169; BDBM50173574
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Activity |
Ki > 1000000 nM
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[2] | |||
Compound Name |
5'-O-Acetyl-2'-deoxyuridine
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3143778; CHEMBL197989; SCHEMBL1364671; BDBM50173541; [(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl acetate; Acetic acid 5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester
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Activity |
Ki > 1000000 nM
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[2] | |||
Compound Name |
4-(2,4-Dioxopyrimidin-1-yl)butanoic acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2420335; NSC74247; SCHEMBL13539349; CTK1A7047; DTXSID30291222; BDBM50439338; NSC-74247; DB-128517; 1(2H)-Pyrimidinebutanoicacid, 3,4-dihydro-2,4-dioxo-; 4-(3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)butanoic acid
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Activity |
Ki = 1000000 nM
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[4] | |||
Click to Show/Hide the Information of All Non Binders |
References | Top | ||||
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REF 1 | Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. J Med Chem. 2012 Apr 12;55(7):2970-80. | ||||
REF 2 | Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem. 2005 Sep 22;48(19):5942-54. | ||||
REF 3 | Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95. | ||||
REF 4 | Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorg Med Chem. 2013 Sep 15;21(18):5876-85. | ||||
REF 5 | -Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem. 2011 Apr 1;19(7):2378-91. | ||||
REF 6 | Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors. J Med Chem. 2012 Apr 12;55(7):2960-9. | ||||
REF 7 | US patent application no. 8530490B2, Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity | ||||
REF 8 | Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase. Eur J Med Chem. 2011 Aug;46(8):3309-14. | ||||
REF 9 | Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. Eur J Med Chem. 2009 Feb;44(2):678-88. |
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