Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38301 | Target Info | |||
| Target Name | Ribonucleoside-diphosphate reductase M2 (RRM2) | ||||
| Synonyms |
Ribonucleotide reductase small subunit; Ribonucleotide reductase small chain; Ribonucleoside-diphosphate reductase subunit M2; RR2
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| Target Type | Successful Target | ||||
| Gene Name | RRM2 | ||||
| Biochemical Class | CH/CH(2) oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Hnash
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067105; 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide; 2-Hydroxy-1-naphthaldehyde salicyloylhydrazone; 2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone; BDBM50247408; STK236025; ZINC27500599; AKOS000981521; ST51005172; SR-01000203650; SR-01000203650-1; BRD-K05576192-001-01-5; 2-hydroxy-N'-[(2-hydroxy-1-naphthyl)methylene]benzohydrazide; 2-Hydroxy-N'-[(E)-(3-hydroxy-2-naphthyl)methylene]benzohydrazide; 2-Hydroxy-N'-[(E)-(2-hydroxy-1-naphthyl)methylidene]benzohydrazide #; Benzoic acid, 2-hydroxy-, ((2-hydroxy-1-naphthalenyl)methylene)hydrazide; N-[(1E)-2-(2-hydroxynaphthyl)-1-azavinyl](2-hydroxyphenyl)carboxamide
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| Activity |
IC50 = 123000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase. J Med Chem. 2018 Feb 8;61(3):666-680. | ||||
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