Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T33931 | Target Info | |||
| Target Name | Lethal(3)malignant brain tumor-like 3 (L3MBTL3) | ||||
| Synonyms |
MBT1; MBT-1; Lethal(3)malignant brain tumor-like protein 3; L(3)mbt-like protein 3; KIAA1798; H-l(3)mbt-like protein 3
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| Target Type | Literature-reported Target | ||||
| Gene Name | L3MBTL3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Maprotiline
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Approved | Compound Info | ||
| Synonyms |
Deprilept; Dibencycladine; Maprotilin; Maprotilina; Maprotilinum; Maprotylina; Maprotylina [Polish]; TBB066626; BA-34276; Deprilept (TN); Ludiomil (TN); Maprotilina [INN-Spanish]; Maprotiline (USAN); Maprotilinum [INN-Latin]; Psymion (TN); Ba-34,276; Maprotiline [USAN:BAN:INN]; N-Methyl-9,10-ethanoanthracene-9(10H)-propanamine; N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine; 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine; 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine
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| Activity |
IC50 = 85000 nM
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[1] | |||
| Compound Name |
Oxybutynine
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Investigative | Compound Info | ||
| Synonyms |
5633-20-5; Ditropan; Oxytrol; Oxibutyninum; Oxybutyninum; Oxibutinina; Oxybutyninum [INN-Latin]; Oxybutynine [INN-French]; Oxybutinin; Cystrin; Oxibutinina [INN-Spanish]; Oxybutynin Base; transdermal patch; Lyrinel XL; Oxybutynin [USAN:INN:BAN]; 4-Diethylamino-2-butinyl alpha-cyclohexylmandelat; CCRIS 1923; oxybutynin topical gel; Ditropan Xl; Oxybutynin (Ditropan); HSDB 3270; 4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate; CHEMBL1231; Cyclohexaneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-b
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| Activity |
IC50 ~ 54000 nM
|
[1] | |||
| Compound Name |
4-Methyl-N-[3-(1-pyrrolidinyl)propyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1275727; 4-methyl-N-[3-(pyrrolidin-1-yl)propyl]benzene-1-sulfonamide; 4-methyl-N-(3-(pyrrolidin-1-yl)propyl)benzenesulfonamide; 4-methyl-N-[3-(pyrrolidin-1-yl)propyl]benzenesulfonamide; MLS001195433; KS-00003MRU; HMS2874K16; ZINC4104984; BDBM50330498; STL281986; AKOS000378903; MCULE-6409282363; MS-0130; SMR000550654; SR-01000309738; SR-01000309738-1
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| Activity |
IC50 ~ 57000 nM
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[1] | |||
| Compound Name |
4-(Dimethylamino)butan-2-yl 5-(1-phenylethyl)furan-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1277562; BDBM50330490; STK380642; AKOS000510502; AKOS021993000; MCULE-8738523499; 3-(dimethylamino)-1-methylpropyl 5-(1-phenylethyl)-2-furoate; N,N-dimethyl-3-(5-(1-phenylethyl)furan-2-carbonyloxy)butan-1-aminium
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| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
4-(2-Methoxy-4-methylphenoxy)-N-methylbutan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1275705; ZINC2844245; BDBM50330501; AKOS009116338; MCULE-9972644330
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| Activity |
IC50 = 84000 nM
|
[1] | |||
| Compound Name |
2-Isopropyl-5-(methylamino)-2-o-tolylpentanenitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1275666; BDBM50330492; MCULE-2394449273
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(7-Bromo-3,4-dihydro-2H-1,5-benzodioxepin-8-yl)-3-(dimethylamino)propan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1275668; ZINC5535337; BDBM50330489; 3-(8-bromo-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-N,N-dimethyl-3-oxopropan-1-aminium
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(N-Methylamino)-4-phenylbutane
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Investigative | Compound Info | ||
| Synonyms |
N-methyl-4-phenylbutan-1-amine; CHEMBL45868; methyl(4-phenylbutyl)amine; Benzenebutanamine, N-methyl-; N-methyl-4-phenylbutylamine; N-Methylbenzenebutan-1-amine; SCHEMBL680531; Methyl-(4-phenyl-butyl)-amine; CTK4I6506; ZINC1577516; BDBM50330502; AKOS008105108; MCULE-8773540616; NE26762; BB 0256975; EN300-43876
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Benzylphenoxy)-N-methylbutan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1190869; ZINC2845366; BDBM50330494; AKOS009115887; MCULE-1021325840; NCGC00332723-01; AB00339121-04
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of non-peptide malignant brain tumor (MBT) repeat antagonists by virtual screening of commercially available compounds. J Med Chem. 2010 Nov 11;53(21):7625-31. | ||||
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