Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32137 | Target Info | |||
| Target Name | NADPH oxidase (NOX) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 19 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-1-methyl-3-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827688; BDBM50190341
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|
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| Activity | NADPH oxidase 1 |
Ki = 50300 nM
|
[1] | ||
| Compound Name |
(1R,8S,10S)-3,6-Dibromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347492; BDBM50497262; ZINC19691566
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|
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| Activity | NADPH oxidase 1 |
IC50 = 60000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347542; SCHEMBL17600685; BDBM50497259
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347491; SCHEMBL17600687; BDBM50497268; ZINC19691570
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|
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| Activity | NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347549; SCHEMBL17600675; BDBM50497261
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4-dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347566; SCHEMBL17600684; BDBM50497258
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(thiophen-3-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3733336
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-9-(1H-indol-3-ylmethyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347525; SCHEMBL17600672; BDBM50497266
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(quinolin-4-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347524; SCHEMBL17600679; BDBM50497264
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
3-[[(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347543; BDBM50497272
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|
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| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347550; BDBM50497271
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-11,11-Dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347501; SCHEMBL17600674; ZINC4434665; BDBM50497267
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347554; SCHEMBL17600682; BDBM50497263
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-9-[(3-Fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347503; SCHEMBL17600673; BDBM50497265
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(thiophen-2-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347551; SCHEMBL17600683; BDBM50497270
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-methylsulfonyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347583; SCHEMBL17600677; BDBM50497273
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|
||||
| Activity | NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylpropyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347502; BDBM50497257
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|
||||
| Activity | NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347567; SCHEMBL17600680; BDBM50497260
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| NADPH oxidase 4 |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1R,8S,10S)-3-Bromo-9-(4-fluorophenyl)sulfonyl-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3347584; SCHEMBL17600686; BDBM50497269
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|
||||
| Activity | NADPH oxidase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors. Bioorg Med Chem. 2016 Sep 15;24(18):4144-4151. | ||||
| REF 2 | WO patent application no. 2014179592A1, TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS | ||||
| REF 3 | Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm. 2013 Jul;4(7):1085-1092. | ||||
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