TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T32137	NADPH oxidase 1	B0EDY7	(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718020	C25H28BrNO2	454.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC5=C(C=C4)OCO5)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	B0EDY7	(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718020	C25H28BrNO2	454.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC5=C(C=C4)OCO5)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	B0QXJ4	(5Z)-5-[(2,3-Dihydroxyphenyl)methylidene]-1-methyl-3-(4-methylphenyl)-2-sulfanylideneimidazolidin-4-one	Investigative	127045569	C18H16N2O3S	340.4	CC1=CC=C(C=C1)N2C(=O)/C(=C/C3=C(C(=CC=C3)O)O)/N(C2=S)C	Ki = 50300 nM	Poor binder
T32137	NADPH oxidase 1	B5QM1U	(1R,8S,10S)-3,6-Dibromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	1014304	C17H21Br2N	399.2	CC(=C)C[C@H]1[C@H]2C3=C(C=CC(=C3[C@@H](N1)CC2(C)C)Br)Br	IC50 = 60000 nM	Poor binder
T32137	NADPH oxidase 4	B5S1QE	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	1226613	C17H22BrN	320.3	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	B6IH9K	(1R,8S,10S)-3-Bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718025	C24H27BrFN	428.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC(=CC=C4)F)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	B6IH9K	(1R,8S,10S)-3-Bromo-9-[(3-fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718025	C24H27BrFN	428.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC(=CC=C4)F)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	B90QAX	(1R,8S,10S)-9-(1,3-Benzodioxol-5-ylmethyl)-3-(3,4-dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	118718039	C31H31Cl2NO2	520.5	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3[C@@H](N1CC4=CC5=C(C=C4)OCO5)CC2(C)C)C6=CC(=C(C=C6)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BB8Y4U	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(thiophen-3-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	127024185	C22H26BrNS	416.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CSC=C4)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BD3V6I	(1R,8S,10S)-3-Bromo-9-(1H-indol-3-ylmethyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718012	C26H29BrN2	449.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CNC5=CC=CC=C54)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BGN4K6	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(quinolin-4-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718011	C27H29BrN2	461.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC=NC5=CC=CC=C45)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BKM31W	3-[[(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazole	Investigative	118718021	C22H27BrN2O	415.4	CC1=CC(=NO1)CN2[C@H]3CC([C@@H]([C@@H]2CC(=C)C)C4=C3C=CC=C4Br)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BKM31W	3-[[(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-trien-9-yl]methyl]-5-methyl-1,2-oxazole	Investigative	118718021	C22H27BrN2O	415.4	CC1=CC(=NO1)CN2[C@H]3CC([C@@H]([C@@H]2CC(=C)C)C4=C3C=CC=C4Br)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BLUZ80	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718026	C22H32BrN	390.4	CCCCCN1[C@H]2CC([C@@H]([C@@H]1CC(=C)C)C3=C2C=CC=C3Br)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BLUZ80	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718026	C22H32BrN	390.4	CCCCCN1[C@H]2CC([C@@H]([C@@H]1CC(=C)C)C3=C2C=CC=C3Br)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BLWB78	(1R,8S,10S)-11,11-Dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	7233583	C17H23N	241.37	CC(=C)C[C@H]1[C@H]2C3=CC=CC=C3[C@@H](N1)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BO1WY2	(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	86301661	C23H25Cl2N	386.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3[C@@H](N1)CC2(C)C)C4=CC(=C(C=C4)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BO1WY2	(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	86301661	C23H25Cl2N	386.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3[C@@H](N1)CC2(C)C)C4=CC(=C(C=C4)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BPOU20	(1R,8S,10S)-9-[(3-Fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	118718002	C24H28FN	349.5	CC(=C)C[C@H]1[C@H]2C3=CC=CC=C3[C@@H](N1CC4=CC(=CC=C4)F)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BPOU20	(1R,8S,10S)-9-[(3-Fluorophenyl)methyl]-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	118718002	C24H28FN	349.5	CC(=C)C[C@H]1[C@H]2C3=CC=CC=C3[C@@H](N1CC4=CC(=CC=C4)F)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BWO30C	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-(thiophen-2-ylmethyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718027	C22H26BrNS	416.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1CC4=CC=CS4)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BX2CN8	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-methylsulfonyl-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718052	C18H24BrNO2S	398.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1S(=O)(=O)C)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BY17KM	(1R,8S,10S)-3-Bromo-11,11-dimethyl-10-(2-methylpropyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718001	C17H24BrN	322.3	CC(C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1)CC2(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BY27KU	(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	118718040	C28H35Cl2N	456.5	CCCCCN1[C@H]2CC([C@@H]([C@@H]1CC(=C)C)C3=C(C=CC=C23)C4=CC(=C(C=C4)Cl)Cl)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 4	BY27KU	(1R,8S,10S)-3-(3,4-Dichlorophenyl)-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-pentyl-9-azatricyclo[6.2.2.02,7]dodeca-2,4,6-triene	Investigative	118718040	C28H35Cl2N	456.5	CCCCCN1[C@H]2CC([C@@H]([C@@H]1CC(=C)C)C3=C(C=CC=C23)C4=CC(=C(C=C4)Cl)Cl)(C)C	IC50 ~ 100000 nM	Poor binder
T32137	NADPH oxidase 1	BZ9CS4	(1R,8S,10S)-3-Bromo-9-(4-fluorophenyl)sulfonyl-11,11-dimethyl-10-(2-methylprop-2-enyl)-9-azatricyclo[6.2.2.02,7]dodeca-2(7),3,5-triene	Investigative	118718053	C23H25BrFNO2S	478.4	CC(=C)C[C@H]1[C@H]2C3=C(C=CC=C3Br)[C@@H](N1S(=O)(=O)C4=CC=C(C=C4)F)CC2(C)C	IC50 ~ 100000 nM	Poor binder