Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T31309 | Target Info | |||
| Target Name | Apoptosis regulator Bcl-2 (BCL-2) | ||||
| Synonyms |
Bcl-2
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| Target Type | Successful Target | ||||
| Gene Name | BCL2 | ||||
| Biochemical Class | B-cell lymphoma Bcl-2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 55 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
EPICATECHIN
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Phase 2 | Compound Info | ||
| Synonyms |
(-)-Epicatechin; Epicatechin; 490-46-0; L-Epicatechin; (-)-Epicatechol; l-Acacatechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; Epicatechol; l-Epicatechol; (-)epicatechin; (2R,3R)-(-)-Epicatechin; UNII-34PHS7TU43; epi-Catechin; epi-Catechol; CCRIS 7097; EINECS 207-710-1; NSC 81161; Epicatechol, (-)-; CHEBI:90; 34PHS7TU43; PFTAWBLQPZVEMU-UKRRQHHQSA-N; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; AK105372; C15H14O6
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
SAR-405838
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Phase 1 | Compound Info | ||
| Synonyms |
AT-219; MI-147; MI-219; MI-319; MI-43; MI-5; MI-63; MI-772; MI-773; MI-519-64; P53-HDM2 protein interaction inhibitors (cancer); P53-HDM2 protein interaction inhibitors (cancer), Ascenta/Sanofi; P53-HDM2 protein interaction inhibitors (cancer), Ascenta/sanofi-aventis
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[(4S)-4-[(4-Bromophenyl)methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-chloro-3-nitrophenyl)sulfonyl-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629653; BDBM50130198
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373713
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)sulfonyl-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629655; BDBM50130196
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(2-Fluoropyridin-4-yl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629649; BDBM50130202
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Nvp-cgm097
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Investigative | Compound Info | ||
| Synonyms |
CGM097; CGM-097; CGM 097; NVP-CGM-097; NVP CGM097; UNII-4UF6MSL0ZH; 4UF6MSL0ZH; C38H47ClN4O4; SCHEMBL2391192; SCHEMBL2391196; CHEMBL3601398; SCHEMBL18458199; KS-00000TSY; BDBM162123; BCP18308; EX-A1059; MFCD28144684; s7875; NVP-CGM097 (CGM-097); AKOS030526402; ZINC253387855; CCG-270337; CS-3138; NCGC00390552-01; AC-32967; AS-75288; HY-15954; W5747; J3.509.326E; A16326; US9051279, 106; Q27454942
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[(4S)-4-[[4-(4-chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628509; BDBM50130059
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629647; BDBM50130046
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
(S)-2-[(4S)-4-Benzyl-2,5-dioxoimidazolidin-1-yl]-3-phenylpropionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629645; NSC609515; ZINC1611205; BDBM50130044; NSC-609515
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
[4-[[(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]phenyl] acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629667; BDBM50130053
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[(4S)-4-[[4-(4-chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-3-methylbutanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629665; BDBM50130051
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(3-Methylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629648; BDBM50130047
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-(4-Chloro-3-nitrophenyl)sulfonyl-2-[(4S)-4-[[4-(2-fluoropyridin-4-yl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629664; BDBM50130050
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
(2S)-N-(Benzenesulfonyl)-2-[(4S)-4-[[4-(2-fluoropyridin-4-yl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629662; BDBM50130194
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
Spirocyclic Oxazolidin-4-one, 18
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376696; BDBM21404
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| Activity |
EC50 ~ 50000 nM
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[4] | |||
| Compound Name |
Piperazine analogue, 22
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437146; BDBM21409
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[(4S)-4-[(4-Bromophenyl)methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629646; BDBM50130045
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-3-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629666; BDBM50130052
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
Piperazine analogue, 20
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL385104; BDBM21407
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| Activity |
EC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[(4S)-4-Benzyl-2,5-dioxoimidazolidin-1-yl]-N-(4-chloro-3-nitrophenyl)sulfonyl-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629651; BDBM50130200
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-(Benzenesulfonyl)-2-[(4S)-4-[[4-(3-methylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629658; BDBM50130195
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-hydroxyphenyl)-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628508; BDBM50130057
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-(Benzenesulfonyl)-2-[(4S)-4-benzyl-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629650; BDBM50130201
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4S)-4-[[4-(2-Fluoropyridin-4-yl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)sulfonyl-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629663; BDBM50130049
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-(Benzenesulfonyl)-2-[(4S)-4-[(4-bromophenyl)methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629652; BDBM50130199
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
5-Methyl-N-phenyl-1-(2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-1H-pyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL464440; BDBM50254577
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| Activity |
IC50 = 50000 nM
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[6] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3628510; BDBM50130193
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| Activity |
Ki ~ 50000 nM
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[3] | |||
| Compound Name |
2-[1-Hydroxy-4-(thiophen-2-ylsulfonylamino)naphthalen-2-yl]sulfanylacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030270; SCHEMBL2244145; BDBM50013839; CCG-23228; STK918344; MCULE-1114821633; EU-0048437; 2-(1-hydroxy-4-(thiophene-2-sulfonamido)naphthalen-2-ylthio)acetic acid; ({1-hydroxy-4-[(thiophen-2-ylsulfonyl)amino]naphthalen-2-yl}sulfanyl)acetic acid
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| Activity |
Ki = 54650 nM
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[7] | |||
| Compound Name |
2-[5-(Diphenylmethylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylpentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439400; BDBM50202274
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| Activity |
Ki = 57800 nM
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[8] | |||
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-4-methylthiobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL241897; BDBM50202278
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| Activity |
Ki = 69600 nM
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[8] | |||
| Compound Name |
5-(4-Bromobenzylidene)-3-(1-morpholino-1-oxo-3-phenylpropan-2-yl)-4-oxo-2-thioxothiazolidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243203; BDBM50202285
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| Activity |
Ki = 70000 nM
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[8] | |||
| Compound Name |
4-(4-Chlorophenyl)-1-[(3s)-3,4-Dihydroxybutyl]-N-[3-(4-Methylpiperazin-1-Yl)propyl]-3-Phenyl-1h-Pyrrole-2-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063880; BDBM50388980; Q27458226; B50
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| Activity |
Ki = 78000 nM
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[9] | |||
| Compound Name |
Apogossypol
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Investigative | Compound Info | ||
| Synonyms |
(+)-Apogossypol; 5,5'-Diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexaol; Apogossypol;NSC736630; NSC-736630; (2,2'-Binaphthalene)-1,1',6,6',7,7'-hexol, 5,5'-diisopropyl-3,3'-dimethyl-; Apogossypol; NSC736630; CHEMBL551288; CNDO-103; SCHEMBL2513478; BDBM31802; DTXSID60197162; BCP32267; ZINC5159961; NSC736630; 5,5'-Diisopropyl-3,3'-dimethyl-(2,2'-binaphthalene)-1,1',6,6',7,7'-hexol; A16316; Racemic Apogossypol, stabilized with ascorbic acid; (+)-5,5'-Diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,6,7,1',6',7'-hexaol; (+/-)-5,5'-Diisopropyl-3,3'-dimethyl-[2,2']binaphthalenyl-1,6,7,1',6',7'-hexaol
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| Activity |
IC50 = 80000 nM
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[10] | |||
| Compound Name |
4-[4-[[4-[4-(Dimethylamino)-1-hydroxy-1-phenylbutyl]phenoxy]methyl]phenyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271331; BDBM50329383; 4''-((4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)phenoxy)methyl)biphenyl-4-carboxylic acid
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| Activity |
Ki = 83000 nM
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[11] | |||
| Compound Name |
1-(2-Ethoxyphenyl)-2-[3-methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-4-yl]ethane-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417401; BDBM50078021
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| Activity |
Ki ~ 100000 nM
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[12] | |||
| Compound Name |
4-[2-(2-Ethoxyphenyl)acetyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417400; BDBM50078020
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| Activity |
Ki ~ 100000 nM
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[12] | |||
| Compound Name |
4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-pyridin-4-ylphenyl)-5-methyl-1H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417404; BDBM50078024
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| Activity |
Ki ~ 100000 nM
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[12] | |||
| Compound Name |
Epicatechin
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Investigative | Compound Info | ||
| Synonyms |
L-Epicatechin; 2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; DL-Catechin; (+/-)-Catechin; 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; Catechin (hydrate); 2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; epi-Catechol; (+/-)-Epicatechin; (+)-Catechin;Cianidanol;Catechuic acid; (-)-3,5,7,3',4'-PENTAHYDROXYFLAVAN; l-Epicatechol; DL-Catechin; Racemic catechin; dl-Catechin; dl-Catechol; rac-Catechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; Epicatechol, (-)-; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R,3S)-rel-; 2-(3,4-Dihydroxyphenyl)chromane-3,5,7-triol; (2R,3R)-(-)-Epicatechin; catechins; Catachin; MFCD00075648; NSC 81161; NCGC00015215-02; EINECS 241-357-4; NSC 81162; 2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol #; Prestwick3_000817; Epicatechin, (+/-)-; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; (-)-CATECHINHYDRATE; SCHEMBL19411; BSPBio_000713; BPBio1_000785; CHEMBL206452; SCHEMBL10001669; DTXSID10859304; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3R)-; HMS1664H16; 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-; BDBM50479045; MFCD00066757; AKOS016009549; cis-(1)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; (+)-3,3',4',5,7-Flavanpentol; MCULE-4219942050; NCGC00015215-03; NCGC00015215-04; NCGC00095270-01; NCGC00095270-02; AK-77017; AK105372; AK111290; BS-15212; SC-65140; SC-86438; DB-017858; DB-050100; AB00513926; FT-0604384; FT-0613995; FT-0614024; FT-0636422; (-)-cis-3,3',4',5,7-Pentahydroxyflavane; (?)-cis-3,3',4',5,7-Pentahydroxyflavane; C17590; BRD-A61899133-002-02-2; Q51617472; 714E3A52-14F7-4C41-BF5D-1DAA0C81FCC5
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(2-Tert-butyl-benzenesulfonyl)-phenyl]-2,3,4-trimethoxyl-5-(2-isopropyl-benzyl)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL216213; SCHEMBL15313803; BDBM50196031
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| Activity |
IC50 ~ 100000 nM
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[13] | |||
| Compound Name |
2-[3-(3-Aminophenyl)-5-hydroxyphenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417406; BDBM50078026
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| Activity |
Ki ~ 100000 nM
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[12] | |||
| Compound Name |
4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-thiophen-2-ylphenyl)-5-methyl-1H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417405; BDBM50078025
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| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
(+)-Gallocatechin
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Investigative | Compound Info | ||
| Synonyms |
Gallocatechin; (+)-gallocatechol; Gallocatechol; d-Gallocatechin; UNII-HEJ6575V1X; (2R,3S)-gallocatechin; CHEMBL125743; HEJ6575V1X; (2R,3S)-2-(3,4,5-trihydroxyphenyl)chromane-3,5,7-triol; dl-Gallocatechin; (2R,3S)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol; 2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-,(2R,3S)-; (+-)-Gallocatechin; (+-)-Gallocatechol; Gallocatechol, (+-)-; Casuarin; C15H14O7; NSC674038; NSC 674038; MEGxp0_000240; SCHEMBL3872234; (2R,3S)-(+)-gallocatechin; ACon1_000994; HY-N0521A; DTXSID10914220; ZINC3870338; BDBM50135165; LMPK12020002; (2R,3S)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; AKOS022180463; ACN-047610; CCG-267530; MCULE-4522193885; NSC-674038; NCGC00169777-01; NCI60_026203; CS-0022247; S9048; W1563; C12127; (2R,3S)-flavan-3,3',4',5,5',7-hexol; (2R,3S)-flavan-3,5,7,3',4',5'-hexol; (+)-trans-3,3',4',5,5',7-Hexahydroxyflavan; (2R,3S)-2-(3,4,5-Trihydroxy-phenyl)-chroman-3,5,7-triol; (2R,3S)-2-(3,4,5-Trihydroxy-phenyl)-1-benzopyran-3,5,7-triol; (2R*,3S*)- 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol; (2R*,3S*)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (2R,3S)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; 2H-1-Benzopyran-3,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-trans-); rel-(2R,3S)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Theaflavin digallte
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402609
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| Activity |
Ki ~ 100000 nM
|
[14] | |||
| Compound Name |
(R)-4-(4-(Dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063881; SCHEMBL376632; BDBM50388981; ZINC65740484
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitro-N-phenylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063890; SCHEMBL12685615; BDBM50388978
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||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Epigallocatechin
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Investigative | Compound Info | ||
| Synonyms |
(-)-Epigallocatechin; Epigallocatechol; epi-Gallocatechin; L-Epigallocatechin; Antiscurvy factor C2; (-)-Epigallocatechol; l-Epigallocatechol; Gallocatechol; (-)-3,3',4',5,5',7-Flavanhexol; 3,3',4',5,5',7-Flavanhexol; 2,3-cis-epigallocatechin; UNII-7Z197MG6QL; (2R,3R)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; CHEMBL47386; 7Z197MG6QL; (-)-cis-3,3',4',5,5',7-Hexahydroxyflavane; (2R,3R)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol; MFCD00075939; 2-(3,4,5-TRIHYDROXY-PHENYL)-CHROMAN-3,5,7-TRIOL; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; (2R,3R)-2-(3,4,5-trihydroxyphenyl)chromane-3,5,7-triol; Galloepicatechin; Factor C2 (antiscurvy); Antiscurvy factor C(sub 2); CCRIS 5441; (-)-epi-Gallocatechin; (-)-Epigallocatechin(EGC); C15H14O7; Teacatechin II; NSC674039; 1-epi-3',4',5,5',7-Pentahydroxy-3-Flavan; (-) epigallocatechin; (-)-3,5,7,3',4',5'-Hexahydroxylflavan; epigallocatechin (egc); Spectrum_000806; (-)-Epigallocatechin,; SpecPlus_000269; GC; (-)-gallocatechin; Spectrum2_000703; Spectrum3_000248; Spectrum4_000950; Spectrum5_000889; SCHEMBL19553; BSPBio_001636; KBioGR_001540; KBioSS_001286; SPECTRUM205113; DivK1c_006365; SPBio_000885; BCBcMAP01_000207; KBio1_001309; KBio2_001286; KBio2_003854; KBio2_006422; KBio3_001136; DTXSID40891550; HY-N0225; KS-00000L8I; ZINC3870336; (-)-Epigallocatechin from green tea; BDBM50187665; CCG-38353; LMPK12020004; s3922; AKOS015965244; CS-3762; DB03823; DS-5807; NSC-674039; SDCCGMLS-0066479.P001; SMP1_000114; NCGC00179131-01; NCGC00179131-02; (-)-Epigallocatechin, analytical standard; NCI60_026204; SC-20992; (3,3',4',5,5',7-Hexahydroxyflavan); (-)-Epigallocatechin, 95%, from green tea; E1084; N2414; A12045; C12136; (-)-cis-3,3',4',5,5',7-Hexahydroxyflavan; 970E741; SR-05000002564; Q-200003; Q3044728; SR-05000002564-1; Q51617505; (-)-Epigallocatechin, >=95% (HPLC), from green tea; (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol; C24E9F59-8F06-44E2-B2DE-FF132A8774F3; Epigallocatechin, primary pharmaceutical reference standard; UNII-T432289GYZ component XMOCLSLCDHWDHP-IUODEOHRSA-N; (-)cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; 2H-1-Benzopyran-3,7-triol, 3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-, (2R-cis)-
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-phenylphenyl)-5-methyl-1H-pyrazol-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3417403; BDBM50078023
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||||
| Activity |
Ki ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL394857; ZINC1748030; BDBM50202284
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||||
| Activity |
Ki = 115000 nM
|
[8] | |||
| Compound Name |
Antimycin A3
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Investigative | Compound Info | ||
| Synonyms |
Blastomycin; Antimycin A3b; Blastmycin; Purothionin AII; UNII-97YBD5W80B; NSC58239; 97YBD5W80B; CHEMBL436605; A 80021F34; A1-Purothionin; SCHEMBL158729; DTXSID7037189; ZINC4212164; BDBM50107132; NSC-58239; NCI60_004417; Q27272047; UNII-7JMI3P2Y5R component PVEVXUMVNWSNIG-PDPGNHKXSA-N; UNII-8S75R39Y6J component PVEVXUMVNWSNIG-PDPGNHKXSA-N; WLN: T9OV EOVTJ CMVR CQ DMVH& D1 G4 HOVX1&1&1 I1; Threonine, 2-(1,2-dihydroxypropyl)hexanoate, 7-lactone, isovalerate
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||||
| Activity |
Ki = 124000 nM
|
[8] | |||
| Compound Name |
4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitro-N-(4-piperazin-1-ylphenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2063891; BDBM50388979
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||||
| Activity |
Ki = 138000 nM
|
[9] | |||
| Compound Name |
2-[2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256858; BDBM50372174
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| Activity |
Ki = 161000 nM
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[15] | |||
| Compound Name |
4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2374449; BDBM50024671
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| Activity |
Ki = 169000 nM
|
[16] | |||
| Compound Name |
Chelerythrine chloride
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Investigative | Compound Info | ||
| Synonyms |
Chelerythrinechloride; Chelerythrine hydrochloride; UNII-7IC98TZ0PZ; Chelerythrine (chloride); 7IC98TZ0PZ; CHEMBL258893; 1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridiniumchloride; MFCD00060717; 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride; 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride; 3895-92-9 (chloride); 34316-15-9 (cation).; C21H18ClNO4; 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine HCl; NSC646662; 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride; Chelerythrine, chloride; EINECS 223-444-9; NSC 36405; SR-01000075750; Chelerythrine cloride; Chelerythrine, hydrochloride; SCHEMBL195109; KS-00001CVS; DTXSID70893481; BCPP000287; HMS3229C07; HMS3260B04; HMS3672K05; NSC36405; Tox21_500241; NSC-36405; AKOS016010038; BCP9000516; CCG-206741; CS-0205; LP00241; NSC-646662; NCGC00093703-01; NCGC00260926-01; AK115162; AS-17480; HY-12048; SC-76777; BCP0726000282; DB-049354; Chelerythrine Chloride - CAS 3895-92-9; EU-0100241; FT-0602998; V0358; Chelerythrine, hydroxide, hydrochloride (8CI); A10196; C 2932; W-5057; Q-100414; Q-200824; Q-200825; SR-01000075750-1; Q27268347; [1,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-, chloride; 1,2-DIMETHOXY-N-METHYL-[1,3]BENZODIOXOLO[5,6-C]PHE; 1,2-dimethoxy-n-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
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| Activity |
Ki = 171000 nM
|
[8] | |||
| Compound Name |
2-Propenyl 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396499; BDBM50202281
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||||
| Activity |
Ki = 192000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 18 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
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Investigative | Compound Info | ||
| Synonyms |
5731-10-2; 4-(4-Fluorophenyl)benzoic acid; 4'-Fluoro-biphenyl-4-carboxylic acid; 4'-fluorobiphenyl-4-carboxylic acid; 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID; 4'-Fluoro-biphenyl-4-carboxylic aci; 4'-Fluoro-[1,1'-biphenyl]-4-carboxylic acid; CHEMBL106708; MFCD01631909; 4-(4-Fluorophenyl)benzoic acid, 97%; 4'-fluoro[1,1'-biphenyl]-4-carboxylic acid; 4FC; 4'-fluoro(1,1'-biphenyl)-4-carboxylic acid; 1ysg; 4-Biphenyl-4'-fluoro-carboxylicacid; 4-Biphenyl-4'-fluoro-carboxylic acid; PubChem10277; 1,5-dibenzoyloxybenzene
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| Activity |
IC50 = 300000 nM
|
[17] | |||
| Compound Name |
Ethyl (2S)-2-[(5Z)-5-[[4-[[4-[(Z)-[3-[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]phenoxy]methoxy]phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL404644; BDBM50372173
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||||
| Activity |
Ki = 226000 nM
|
[15] | |||
| Compound Name |
2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL272110; BDBM50372175
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| Activity |
Ki = 243000 nM
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[15] | |||
| Compound Name |
Ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257687; BDBM50372172
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| Activity |
Ki = 260000 nM
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[15] | |||
| Compound Name |
Prop-2-enyl (2S)-2-(5-benzhydrylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396500; BDBM50202276; 2-propenyl 2-[5-biphenylmethylidene-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoate
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| Activity |
Ki = 260000 nM
|
[8] | |||
| Compound Name |
2-[5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-glutaric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL390913; BDBM50202273
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| Activity |
Ki = 320000 nM
|
[8] | |||
| Compound Name |
(4S)-4,8-Dihydroxy-3,4-dihydro-2H-naphthalen-1-one
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Investigative | Compound Info | ||
| Synonyms |
Isosclerone; CHEMBL3318321; (-)-Regiolone; SCHEMBL6281138; (4s)-4,8-dihydroxy-1-tetralone; (4S)-4,8-dihydroxytetralin-1-one; BDBM50049521; ZINC13460027; (S)-4,8-Dihydroxy-3,4-dihydronaphthalen-1(2H)-one
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| Activity |
Ki = 474760 nM
|
[18] | |||
| Compound Name |
2-[2-[(2S)-2-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoyl]oxyethoxy]ethyl (2S)-2-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402066; BDBM50372179
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| Activity |
Ki > 1000000 nM
|
[15] | |||
| Compound Name |
3,7-Dimethyl-benzofuran-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3,7-dimethyl-1-benzofuran-2-carboxylic acid; 3,7-dimethylbenzofuran-2-carboxylic acid; CHEMBL2314507; SCHEMBL11748492; CTK7J1247; DTXSID40390336; ZINC4502750; 5405AD; BDBM50424722; AKOS000360032; MCULE-7987044630; NE30358; NCGC00327699-01; ST086603; 3,7-dimethylbenzo[b]furan-2-carboxylic acid; EN300-53340; AB01323190-02; 3,7-dimethyl-1-benzofuran-2-carboxylic acid, AldrichCPR; F2169-0501; Z803145518
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| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
2-Propenyl 2-[5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl]-3-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243411; BDBM50202270
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| Activity |
Ki > 1000000 nM
|
[8] | |||
| Compound Name |
3-Chloro-6-methylbenzo[b]thiophene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-chloro-6-methyl-1-benzothiophene-2-carboxylic acid; 3-Chloro-6-methylbenzothiophene-2-carboxylic acid; 3-Chloro-6-methyl-benzo[b]thiophene-2-carboxylic acid; CHEMBL2314523; ACMC-20an6a; CBMicro_023300; SCHEMBL417349; CTK1C0981; DTXSID10355679; ZINC327857; ACT07951; ALBB-000953; 4179AB; BBL013609; BDBM50424723; CCG-10571; GEO-00712; MFCD00687576; SBB006957; STK372259; AKOS000267335; MCULE-3549045158; VS-03886; BIM-0023181.P001; ST45231718; EN300-69909; W-7481; 3-CHLORO-6-METHYLBENZO(B)THIOPHENE-2-CA&; AG-690/36719028; SR-01000412394; 3-Chloro-6-methylbenzo thiophene-2-carboxylic acid; SR-01000412394-1; W-200316; 3-chloro-6-methylbenzo [b]thiophene-2-carboxylic acid; 3-chloro-6-methylbenzo[b]thio-phene-2-carboxylic acid; Benzo[b]thiophene-2-carboxylicacid, 3-chloro-6-methyl-; Z228588844; 3-Chloro-6-methylbenzo[b]thiophene-2-carboxylic acid, 97%; (2-METHOXYCARBONYL)PHENYL-2-,3,4,6-TETRA-O-ACETYL-BETA-D-GLUCOPYRANOSE
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| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
3-(1-Naphthylmethylsulfanyl)-1H-1,2,4-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314513; 5-[(1-naphthylmethyl)sulfanyl]-1H-1,2,4-triazole; ZINC3176387; BDBM50424717; STK978340; AKOS000616471; AKOS001624374; MCULE-5838210029; AF-399/37297047; SR-01000429828; SR-01000429828-1; 5-((naphthalen-1-ylmethyl)thio)-1H-1,2,4-triazole; 1H-1,2,4-Triazole, 3-[(1-naphthalenylmethyl)thio]-; 3-[(naphthalen-1-ylmethyl)sulfanyl]-4H-1,2,4-triazole; F0910-1198
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| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
3-(4-Chloro-3,5-dimethylphenoxy)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314512; BDBM50424718; ZINC11800214; AKOS000299971
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||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
7-Methyl-3-phenyl-1H-indole-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2314511; SCHEMBL3611265; BDBM50424720; STK319198; ZINC12650903; AKOS002291834; CCG-279122; MCULE-2613330604; 7-methyl-3-phenylindole-2-carboxylic acid; ST50781354
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||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
3,6,7-Trimethyl-benzofuran-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3,6,7-trimethyl-1-benzofuran-2-carboxylic acid; CHEMBL2314508; 3,6,7-trimethylbenzo[b]furan-2-carboxylic acid; CTK7J1246; DTXSID00424464; ZINC4502658; 1401AF; BDBM50424721; SBB027848; STK522124; AKOS000301965; MCULE-2119528168; NCGC00322626-01; ST090114; 3,6,7-Trimethylbenzofuran-2-carboxylic acid; AB01266325-03; BRD-K77466920-001-01-1; Z57904574; F2169-0516
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||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
(4-Chloro-3-methylphenoxy)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
2-(4-chloro-3-methylphenoxy)acetic acid; (4-Chloro-3-methyl-phenoxy)-acetic acid; Acetic acid, (4-chloro-3-methylphenoxy)-; 4-chloro-3-methylphenoxyacetic acid; CHEMBL177299; BRN 1963793; Acetic acid, ((4-chloro-m-tolyl)oxy)-; NSC30119; 4-06-00-02065 (Beilstein Handbook Reference); ARONIS004021; SCHEMBL7493102; CTK5A8926; KS-00003WVV; ZINC38647; DTXSID10207523; 3-methyl-4-chlorophenoxyacetic acid; ALBB-000819; 6151AE; BBL014307; BDBM50424719; MFCD01671841; NSC-30119; SBB009311; STK003435; AKOS000114558; MCULE-5714027283; (4-Chloro-3-methyl-phenoxy)acetic acid; ST054900; VS-04261; AB0153761; BB 0244018; FT-0677822; EN300-00114; W-8530; AN-329/40159148; SR-01000430139; J-501384; SR-01000430139-1; (4-chloro-3-methyl-phenoxy)-acetic acid, AldrichCPR; Z56823032; F0722-7382
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||||
| Activity |
Ki > 1000000 nM
|
[19] | |||
| Compound Name |
3,4-Dichloro-1-benzothiophene-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3,4-dichlorobenzo[b]thiophene-2-carboxylic acid; CHEMBL1612421; 3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid; CBMicro_018065; Cambridge id 6131552; MLS000713830; SCHEMBL1520807; CTK4H2632; DTXSID80356057; HMS2634J24; HMS3363L17; ZINC334753; ALBB-000958; 1010AE; BBL037293; BDBM50424724; CCG-14224; MFCD00617272; SBB039152; STK398090; AKOS000267334; MCULE-9931805377; DA-24760; SC-41294; SMR000273311; VS-14047; BIM-0018114.P001; BB 0256751; FT-0678485; R3534; ST50007713; EN300-30747; 3,4-dichlorobenzo [b]thiophene-2-carboxylic acid; Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-; Z228589014
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| Activity |
Ki > 1000000 nM
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[19] | |||
| Compound Name |
5,6,7,8-Tetrahydro-1-naphthol
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Investigative | Compound Info | ||
| Synonyms |
5,6,7,8-tetrahydronaphthalen-1-ol; 5-Hydroxytetralin; 1-Naphthalenol, 5,6,7,8-tetrahydro-; tetralin-5-ol; 5,6,7,8-Tetrahydro-alpha-naphthol; UNII-1R7B5I98HV; MFCD00001734; 5,6,7,8-tetrahydro-naphthalen-1-ol; 5,6,7,8-tetrahydronaphthol; 5,6,7,8-Tetrahydro-1-naphthalenol; Tetrahydro-.alpha.-naphthol; 1R7B5I98HV; CHEMBL449132; 1-Naphthol, 5,6,7,8-tetrahydro-; Tetrahydro-alpha-naphthol (VAN); EINECS 208-461-1; NSC 28822; Tetrahydro-a-naphthol; PubChem22497; ACMC-20aj2b; SCHEMBL150894; 5,7,8-Tetrahydro-1-naphthol; DTXSID8074570; 1-Naphthol,6,7,8-tetrahydro-; 5,6,7,8-Tetrahydronaphthalenol; 5,6,7,8-tetrahydro-1-naphtol; 5,6,7,8-tetrahyro-1-naphthol; 1,2,3,4-tetrahydro-5-naphthol; 5, 6, 7, 8-tetrahydronaphthol; NSC28822; ZINC3860772; 1-Naphthalenol,6,7,8-tetrahydro-; 5,7,8-Tetrahydro-.alpha.-naphthol; ANW-75633; BBL025814; BDBM50270875; NSC-28822; SBB059308; STL364871; 5,6,7,8 tetrahydronaphthalene-1-ol; 5,6,7,8-tetrahydronaphthalene-1-ol; Naphthalenol, 5,6,7,8-tetrahydro-; AKOS000421212; 5,6,7,8 tetrahydro naphthalene-1-ol; 5,6,7,8-Tetrahydronaphthalen -1-ol; MCULE-8152026704; VZ29826; 5, 6,7,8-Tetrahydro-naphthalen-1-ol; 5,6,7,8-Tetrahydro-.alpha.-naphthol; 5,6,7,8-Tetrahydro-1-naphthalenol #; 1-hydroxy-5,6,7,8-tetrahydronaphthalene; 5,6,7,8-Tetrahydro-1-naphthol, 99%; AS-59852; ST092846; SY049625; 1,2,3,4-Tetrahydro-5-hydroxynaphthalene; 5, 6, 7, 8-Tetrahydro-naphthalen-1-ol; DB-052213; 1-Naphthol, 5,6,7,8-tetrahydro- (8CI); CS-0132457; FT-0619802; T7937; 1-Naphthalenol, 5,6,7,8-tetrahydro- (9CI); W-202998; Q27104561; Z274762958
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| Activity |
IC50 = 4300000 nM
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[17] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
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| REF 2 | Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5. | ||||
| REF 3 | Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. Bioorg Med Chem. 2015 Dec 1;23(23):7359-65. | ||||
| REF 4 | Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. | ||||
| REF 5 | Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58. | ||||
| REF 6 | Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):230-3. | ||||
| REF 7 | 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57(10):4111-33. | ||||
| REF 8 | Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. Bioorg Med Chem. 2007 Mar 1;15(5):2167-76. | ||||
| REF 9 | Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem. 2012 May 24;55(10):4664-82. | ||||
| REF 10 | Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2009 Jul 23;52(14):4511-23. | ||||
| REF 11 | Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. | ||||
| REF 12 | Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. J Med Chem. 2015 Mar 12;58(5):2135-48. | ||||
| REF 13 | Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. | ||||
| REF 14 | Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. | ||||
| REF 15 | Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40. | ||||
| REF 16 | Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem. 2006 Dec 28;49(26):7731-9. | ||||
| REF 17 | Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem. 2011 Apr 28;54(8):2529-91. | ||||
| REF 18 | In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3923-7. | ||||
| REF 19 | Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem. 2013 Jan 10;56(1):15-30. | ||||
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