Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T29144 | Target Info | |||
| Target Name | Arginase (ARG) | ||||
| Synonyms |
L-arginase; Canavanase; Arginine transamidinase; Arginine amidinase
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | ARG1; ARG2 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-6-borono-2-(2-hydroxyethyl)hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348494; BDBM50431957
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| Activity | Arginase 2 |
IC50 = 57000 nM
|
[1] | ||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4250607
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462601
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| Activity | Arginase 1 |
Ki = 275000 nM
|
[2] | ||
| Arginase 2 |
Ki = 322000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326091; SCHEMBL10207709; BDBM50427902; ZINC170183245
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| Activity | Arginase 1 |
IC50 > 300000 nM
|
[3] | ||
| Arginase 2 |
IC50 > 300000 nM
|
[3] | |||
| Compound Name |
2-Amino-L-histidine
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|
Investigative | Compound Info | ||
| Synonyms |
2-AMINOHISTIDINE; L-2-aminohistidine; L-Histidine, 2-amino-; CHEMBL1099167; 2-aminohistidin; SCHEMBL59809; CTK1C1260; BDBM50316607; MFCD09038806; ZINC26286704; AKOS006331149; Q27458209; (2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid; (2S)-3-(2-amino-1H-imidazol-5-yl)-2-azaniumylpropanoate; (S)-2-Amino-3-(2-amino-1H-imidazol-4-yl)propanoic acid
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| Activity | Arginase 1 |
Ki = 300000 nM
|
[4] | ||
| Compound Name |
Chembl4238387
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50462600
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|
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| Activity | Arginase 1 |
Ki = 382000 nM
|
[2] | ||
| Arginase 2 |
Ki = 437000 nM
|
[2] | |||
| Compound Name |
(S)-2-Amino-5-(imidazol-2-ylamino)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099171; SCHEMBL20539968; BDBM50316604; (2S)-2-amino-5-(1H-imidazol-2-ylamino)pentanoic acid
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| Activity | Arginase 1 |
Ki = 500000 nM
|
[4] | ||
| Compound Name |
(2s)-2-Amino-4-(2-Amino-1h-Imidazol-5-Yl)butanoic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
2-aminohomohistidine; CHEMBL1099168; SCHEMBL18071081; BDBM50316606; Q27467888; (2S)-2-Amino-4-(2-amino-1H-imidazole-5-yl)butanoic acid
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| Activity | Arginase 1 |
Ki = 3000000 nM
|
[4] | ||
| Compound Name |
1H-Imidazol-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
2-Aminoimidazole; 1H-Imidazol-2-ylamine; 1h-imidazole-2-amine; CHEMBL291627; 2-amino imidazole; EINECS 231-751-4; PubChem23659; 1H-Imidazol-2-yl-ammonium; 2-Aminoimidazole, AldrichCPR; CTK2I0235; DTXSID60227953; ACN-C000865; ACT02002; ALBB-027298; EBD17860; AC-051; ANW-46684; BBL029017; BDBM50316608; MFCD00792530; STL146908; ZINC17380534; AKOS000112995; AB07116; AM82001; MCULE-6371804569; 4-AMINO-2,6-DINITROBENZOICACID; AK-84416; SC-20096; AB0026665; DB-020523; BB 0262960; CS-0054070; FT-0650418; W8384; 114279-EP2295432A1; 114279-EP2298743A1; 450I937; AL-398/25017027; Q-200237; Q27452839
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|
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| Activity | Arginase 1 |
Ki = 3600000 nM
|
[4] | ||
| Compound Name |
2-Amino-5-(2-aminoimidazol-4-yl)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1099170; BDBM50316605
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|
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| Activity | Arginase 1 |
Ki > 80000000 nM
|
[4] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2027-30. | ||||
| REF 2 | Rational design of novel irreversible inhibitors for human arginase. Bioorg Med Chem. 2018 Aug 7;26(14):3939-3946. | ||||
| REF 3 | Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80. | ||||
| REF 4 | 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53(10):4266-76. | ||||
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