Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28887 | Target Info | |||
| Target Name | Histone deacetylase 8 (HDAC8) | ||||
| Synonyms |
Histone deacetylase-8; HDACL1; HD8; CDA07
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| Target Type | Clinical trial Target | ||||
| Gene Name | HDAC8 | ||||
| Biochemical Class | Carbon-nitrogen hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 96 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Romidepsin
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|
Approved | Compound Info | ||
| Synonyms |
Chromadax; Istodax; Antibiotic FR 901228; FK 228; FK228; FR 901228; FR901228; HDInhib_000006; Chromadax (TN); FK-228; FK-901228; FR-901228; Istodax (TN); Romidepsin (USAN); Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (35)-disulfide; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide; (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Valproate
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Approved | Compound Info | ||
| Synonyms |
99-66-1; Dipropylacetic acid; Depakine; Depakene; 2-Propylvaleric acid; Ergenyl; Di-n-propylacetic acid; Mylproin; Pentanoic acid, 2-propyl-; 4-Heptanecarboxylic acid; Propylvaleric acid; n-Dipropylacetic acid; Myproic Acid; Di-n-propylessigsaure; n-DPA; Dipropylacetate; Convulex; Depakin; Vupral; Acido valproico; Acide valproique; Acidum valproicum; Stavzor; Avugane; Baceca; Kyselina 2-propylvalerova; 2-n-Propyl-n-valeric acid; Acetic acid, dipropyl-; Abbott 44090; Valproinsaeure; Savicol; Convulsofin; Deproic; VPA; Depakin chrono; Dipropyl Acetate; Med Valproic; Valproic acid USP; Valproic acid USP24; Acide valproique [INN-French]; Acido valproico [INN-Spanish]; Acidum valproicum [INN-Latin]; Alti-Valproic; Depakote (TM); Dom-Valproic; G2M-777; Kyselina 2-propylvalerova [Czech]; N-DPA; N-Dipropylacetic acid; Novo-Valproic; Nu-Valproic; PMS-Valproic Acid; Penta-Valproic; Valproic acid (USP); Di-n-propylessigsaeure; Di-n-propylessigsaure [German]; Valproic acid [USAN:INN:BAN]; Valproic Acid, SodiumSalt (2:1); 2 PP (base)
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| Activity |
IC50 = 103000 nM
|
[2] | |||
| Compound Name |
SNDX-275
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Phase 3 | Compound Info | ||
| Synonyms |
Entinostat; Histone Deacetylase Inhibitor I; IN1470; MS 275; SNDX 275; MS 27-275; Ms-275; Entinostat (USAN/INN); MS-27-275; Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate; Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate; Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Pyridin-3-ylmethyl{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate; Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester; Carbamic acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl ester; Entinostat, SNDX-275, MS-27-275, MS-275; N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide; N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide; Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl ester; 3-Pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate
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| Activity |
IC50 = 63400 nM
|
[3] | |||
| Compound Name |
Phenylbutyrate
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Phase 2 | Compound Info | ||
| Synonyms |
Benzenebutyric acid; Phenyl butanoate; Phenyl butyrate; HDInhib_000004; Butanoic acid, phenyl ester; Butyric acid, phenyl ester; FR-2080; Gamma-Phenylbutyric acid; Omega-Phenylbutanoic acid; GAMMA-PHENYL-BUTYRIC ACID; Butyric acid, 4-phenyl-(8CI); 1-Phenylbutyric acid; 4-PHENYL-BUTANOIC ACID; 4-PHENYLBUTYRIC ACID; 4-Phenylbutanoic acid; 4-phenylbutans; 4-phenylbutyrate
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| Activity |
IC50 = 93000 nM
|
[2] | |||
| Compound Name |
N-(2-aminophenyl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)nicotinamide; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(4-hydroxybiphenyl-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269935; N-(4-hydroxybiphenyl-3-yl)benzamide; SCHEMBL5724398; BDBM50232005
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(4-aminobiphenyl-3-yl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL255805; N-(4-aminobiphenyl-3-yl)nicotinamide; BDBM50232035
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(4-aminobiphenyl-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
N-(4-aminobiphenyl-3-yl)benzamide; CHEMBL271741; 3max; SCHEMBL16380794; BDBM50232053; N-(4-amino-biphenyl-3-yl)-benzamide
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256440; N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide; SCHEMBL1066609
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-(2-aminophenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
N-(2-aminophenyl)benzamide; 2'-AMINOBENZANILIDE; 721-47-1; CHEMBL405072; AC1LFSYX; AC1Q5NOK; ACMC-1AE0C; Oprea1_478192; MLS000084661; SCHEMBL407834; N-(2-amino-phenyl)-benzamide; AC1Q514U; Benzamide, N-(2-aminophenyl)-; CTK2H2825; DTXSID60353948; RFDVMOUXHKTCDO-UHFFFAOYSA-N; MolPort-001-783-352; ZINC225957; HMS2355D18; STL497474; BDBM50232046; AKOS000133162; MCULE-5545982713; NE17312; SMR000019009; TC-170926; KB-298435; ST51030142; EN300-31745; SR-01000389415; AE-641/00785046
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-hydroxy-2,2-diphenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
Diphenylacetohydroxamic acid; 4099-51-8; N-Hydroxy diphenylacetamide; CHEMBL396097; NSC44620; benzeneacetamide, n-hydroxy-; A-phenyl-; N-Hydroxydiphenylacetamide; BENZENEACETAMIDE,N-HYDROXY-A-PHENYL-; AC1Q5QC3; SCHEMBL2839032; CTK8I6435; DTXSID10286297; AC1L6390; ZINC4522248; NSC-44620; BDBM50207561; MFCD16314231; AKOS022308585; Diphenylacetohydroxamic acid, >
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| Activity |
IC50 = 66000 nM
|
[6] | |||
| Compound Name |
Carbamic acid,N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-,methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398420; Carbamic acid, N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-, methyl ester; SCHEMBL4314772; BDBM50229192; ZINC29039034; Methyl {4-[(4-amino-3-biphenylyl)carbamoyl]benzyl}carbamate; [4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid methyl ester; methyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamate; N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(2-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104197; BDBM50235702
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(2-methylphenyl)octanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080874; BDBM50235706
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
Benzyl (2S)-4-[5-[(2-amino-5-phenylphenyl)carbamoyl]pyridin-2-yl]-2-methylpiperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437029; SCHEMBL4534462; BDBM50374011
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-[4-(Dimethylamino)phenyl]-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066515; BDBM50235703
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
N-(3-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093113; BDBM50235705
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-(4-fluorophenyl)-N'-hydroxyoctanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079958; BDBM50235708
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
Ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399494; SCHEMBL8101991; BDBM50229197; ethyl N-[[4-[(2-amino-5-thiophen-2-ylphenyl)carbamoyl]phenyl]methyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(4-methoxyphenyl)octanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095542; BDBM50235707
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
Methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400721; SCHEMBL4323563; BDBM50229193; ZINC29039255; AKOS016360308; DA-16374; FT-0749974; methyl N-[[4-[(2-amino-5-thiophen-2-ylphenyl)carbamoyl]phenyl]methyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(2-Amino-5-thiophen-2-ylphenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL271949; SCHEMBL1067101; BDBM50374007
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(3-methylphenyl)octanediamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098910; BDBM50235701
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| Activity |
Ki ~ 50000 nM
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[8] | |||
| Compound Name |
Thailandepsin A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1836142; BDBM50354088
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Hydroxy-2-(4-methoxyphenyl)-1,3-oxazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3769415; BDBM50148619
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| Activity |
IC50 = 50940 nM
|
[9] | |||
| Compound Name |
N-(2-Aminophenyl)-4-((4-(3-fluorophenyl)-2-oxazoline-2-yl)aminomethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605497; BDBM50113967
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| Activity |
IC50 = 52200 nM
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[10] | |||
| Compound Name |
N-[(2S)-1-(Hydroxyamino)-1-oxo-3-[4-(2-phenylethoxy)phenyl]propan-2-yl]-4-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148012; BDBM50391634
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| Activity |
IC50 = 52500 nM
|
[11] | |||
| Compound Name |
3-(4-Formyl-1-methylpyrrol-2-yl)-N-hydroxypropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL539664; BDBM50486570
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| Activity |
IC50 = 52560 nM
|
[12] | |||
| Compound Name |
Tert-butyl 8-[4-[(3,5-dimethylphenyl)methoxy]anilino]-8-oxooctanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170172; BDBM50397363
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| Activity |
IC50 = 53200 nM
|
[13] | |||
| Compound Name |
N-(2-Aminophenyl)-4-((4,4-diphenyl-2-oxazoline-2-yl)aminomethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605504; BDBM50113970
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| Activity |
IC50 = 53500 nM
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[10] | |||
| Compound Name |
N-Hydroxy-2-pyrazin-2-yl-1,3-thiazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3771210; BDBM50148606
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| Activity |
IC50 = 61420 nM
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[9] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4S)-4-benzyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605501; BDBM50113958
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| Activity |
IC50 = 63000 nM
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[10] | |||
| Compound Name |
2-Azidoethyl 8-[4-[(3-azido-5-methoxyphenyl)methoxy]anilino]-8-oxooctanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170173; BDBM50397359
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| Activity |
IC50 = 67500 nM
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[13] | |||
| Compound Name |
N-(2-Aminophenyl)-7,7-di(1H-indol-3-yl)heptanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL564916; ST-3071; SCHEMBL1308188; BDBM50297448
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| Activity |
IC50 = 74000 nM
|
[14] | |||
| Compound Name |
Chembl4173739
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Investigative | Compound Info | ||
| Activity |
IC50 = 75200 nM
|
[15] | |||
| Compound Name |
N-(2-Aminophenyl)-4-(((R)-4-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605495; BDBM50113962
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| Activity |
IC50 = 80700 nM
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[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[4-[4-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605498; BDBM50113968; N-(2-Aminophenyl)-4-((4-(4-trifluoromethylphenyl)-2-oxazoline-2-yl)aminomethyl)benzamide
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| Activity |
IC50 = 82100 nM
|
[10] | |||
| Compound Name |
(2S)-N-Hydroxy-2-[(4-methylphenyl)sulfonylamino]-3-[4-(2-phenylethoxy)phenyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2148015; BDBM50391620
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| Activity |
IC50 = 82500 nM
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[11] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4S)-4-(4-hydroxyphenyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605499; BDBM50113969
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| Activity |
IC50 = 83300 nM
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[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-(((S)-4-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605494; BDBM50113965
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| Activity |
IC50 = 88000 nM
|
[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-(((S)-4-benzyl-2-oxazoline-2-yl)thiomethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605493; BDBM50113955
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| Activity |
IC50 = 88000 nM
|
[10] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(6-phenylhexyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800385; BDBM50348387
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Pimelic Diphenylamide 106
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Investigative | Compound Info | ||
| Synonyms |
TC-H 106; N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide; N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII; RGFA-8; SCHEMBL1065609; CHEMBL3940985; DTXSID10581754; EX-A916; TC-H106; BDBM207628; HMS3648I10; BCP16854; US9265734, RGFA8; 1900AH; MFCD17010287; s6738; ZINC34997445; AKOS024458065; CCG-208665; CS-5229; TC-H 106;Pimelic Diphenylamide 106; AK222718; AS-56015; HY-19348; FT-0700415; n1-(2-aminophenyl)-n7-p-tolylheptanediamide; EC-000.2470; Pimelic Diphenylamide 106, >=98% (HPLC); SR-01000946373; SR-01000946373-1; N-(4-Methylphenyl)-N'-(2-aminophenyl)heptanediamide; N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide; Q27165947; N~1~-(2-Aminophenyl)-N~7~-(4-methylphenyl)heptanediamide
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| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
N-[(2S)-1-[[6-(2-Amino-4-fluoroanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102988; BDBM50242039
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| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Pyridin-3-ylmethyl N-[[4-[(3-aminophenyl)carbamoyl]phenyl]methyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99737; SCHEMBL1435352; BDBM50472343; N-(3-Aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-{[2-(4-Tert-butylphenyl)-2-oxoethyl]sulfanyl}-6-methyl-3,4-dihydropyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800374; ZINC9143521; BDBM50348375; AKOS034466005; MCULE-3132766776; Z56923981
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-(Benzylamino)propionohydroxamic acid monohydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078522; Propanamide, N-hydroxy-3-[(phenylmethyl)amino]-; Propionohydroxamic acid, 3-(benzylamino)-, monohydrochloride; DTXSID60946374; BDBM50457058; 3-(Benzylamino)-N-hydroxypropanimidic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[2-(4-Methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800242; BDBM50348389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-Phenyl-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100631; BDBM50472340
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[4-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800248; SCHEMBL17382802; BDBM50348395
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-carbonylamino)heptylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492174; BDBM50250151
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6-(Acetyl-hydroxy-amino)-hexanoic acid phenylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138293; TWZ-101; BDBM50138417
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(3-Methyl-2-aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99853; BDBM50472334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[4-[2-[(4-Methyl-6-oxo-1H-pyridin-2-yl)oxy]acetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800247; BDBM50348394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-phenylbutyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800384; BDBM50348385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
1-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)propan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800381; BDBM50348382; STL267143; AKOS008981021; AKOS016354209; MCULE-9373031239; 6-methyl-2-[(2-oxopropyl)sulfanyl]pyrimidin-4(3H)-one; 1-[(4-Oxo-6-methyl-3,4-dihydropyrimidine-2-yl)thio]-2-propanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[2-(3-Hydroxyphenyl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800245; BDBM50348392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[1-Hydroxy-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]ethyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800249; BDBM50348396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800377; SCHEMBL17382809; BDBM50348378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Pyridin-3-ylmethyl N-[[4-[(4-aminophenyl)carbamoyl]phenyl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100925; SCHEMBL1435653; BDBM50472333; N-(4-Aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(R)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492140; BDBM50250098
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000531589; CHEMBL1722433; SMR000136527; 2-[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)thio]-N-(2-phenylethyl)acetamide; Oprea1_304490; cid_892234; BDBM96613; HMS2466G16; STK116346; ZINC18093765; AKOS000716785; AKOS001049225; MCULE-1856560484; SR-01000264561; SR-01000264561-1; Z56847664; 2-[(4-keto-6-methyl-1H-pyrimidin-2-yl)thio]-N-phenethyl-acetamide; 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide; 2-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)thio]-N-(2-phenylethyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
8-(Acetyl-hydroxy-amino)-octanoic acid phenylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138626; TWZ-103; BDBM50138418
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800376; BDBM50348377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-{4-[2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetyl]-phenyl}-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800244; Oprea1_373990; Oprea1_543124; ZINC841137; BDBM50348391; STK285981; AKOS001628005; MCULE-9514505423; N-(4-{[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}phenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[(2S)-1-[[6-(2-Amino-5-thiophen-2-ylanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065117; BDBM50242038
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800250; 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)-1-phenylethanone; 6-methyl-2-(2-oxo-2-phenylethylthio)-3-hydropyrimidin-4-one; NSC338484; CBKinase1_000908; CBKinase1_013308; Cambridge id 5509606; IFLab1_000456; CTK0H7748; DTXSID70319010; HMS1413E16; ZINC9446020; BDBM50348397; SBB085164; STK830457; STL281533; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3,4-dihydropyrimidin-4-one; AKOS000565987; AKOS001012387; AKOS003626716; MCULE-4095585670; NSC-338484; IDI1_008675; ST50113123; 2-Benzoylmethylmercapto-4-methyl-6-oxypyrimidin; AB00087040-01; SR-01000416787; SR-01000416787-1; BRD-K22643941-001-01-6; Z56767694; F0176-0059; 6-methyl-2-(2-oxo-2-phenylethyl-thio)pyrimidin-4(3h)-one; 6-methyl-2-[(2-oxo-2-phenylethyl)thio]-4(1H)-pyrimidinone; 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-phenylethanone; 6-METHYL-2-((2-OXO-2-PHENYLETHYL)THIO)-4(3H)-PYRIMIDINONE; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-4(3H)-pyrimidinone; 6-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-Methyl-N-[4-[2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800251; BDBM50348372
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(Tert-butylcarbonylmethylthio)-4-hydroxy-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800382; Maybridge1_007088; CTK6C4190; HMS561K04; BDBM50348383; SBB099296; ZINC13468269; AKOS008981059; CCG-244729; MCULE-6331991984; 1-(4-hydroxy-6-methylpyrimidin-2-ylthio)-3,3-dimethylbutan-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800375; 2-[2-(4-chlorophenyl)-2-oxoethylthio]-6-methyl-3-hydropyrimidin-4-one; BAS 00853818; MLS001143876; CTK6G9149; CCG-304; BDBM50348376; SBB085170; STL281529; STL330245; ZINC17750270; AKOS000565394; AKOS001021795; AKOS003625541; MCULE-8980888190; SMR000473315; ST50113505; AE-641/01210025; SR-01000637247-1; 1-(4-Chlorophenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)ethan-1-one; 1-(4-chlorophenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)thio]ethanone; 2-((2-(4-Chlorophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(3H)-one; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methyl-4(3H)-pyrimidinone; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(1H)-one; 2-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Nampt-IN-3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065412; BDBM50241438; HY-108701; CS-0030130
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Hdac3-IN-T326
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622375; N-(2-Aminophenyl)-5-(1-(3-nitrophenethyl)-1H-1,2,3-triazol-4-yl)thiophene-2-carboxamide; BDBM50121211; T-326; N-(2-aminophenyl)-5-[1-[2-(3-nitrophenyl)ethyl]triazol-4-yl]thiophene-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1307946; SMR000104980; CBMicro_000564; Oprea1_387281; Oprea1_513871; MLS000109033; REGID_for_CID_722456; HMS2167C19; HMS3314O04; SMSF0007972; ZINC8632101; BDBM50348374; STK927199; STL281551; AKOS000566015; AKOS002232718; AKOS008969277; CB01814; MCULE-2661039450; BIM-0000433.P001; ST50112774; AB00097791-01; AB00097791-06; SR-01000417195; SR-01000417195-1; 2-[2-(4-methoxyphenyl)-2-oxoethylthio]-6-methyl-3-hydropyrimidin-4-one; 2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-carbonylamino)heptylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491926; BDBM50250100
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491130; BDBM50249973; (2S)-N-(3-Biphenylyl)-2-(benzoylamino)-7-(dihydroxyboryl)heptanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(4-Methyl-2-aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317252; BDBM50472332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
HDAC3-IN-T247; CHEMBL3622374; SCHEMBL18208054; BDBM50121210; MFCD29089340; T 247; T-247; N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)triazol-4-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)oxy]acetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800246; BDBM50348393
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Methyl 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800380; methyl 2-(6-methyl-4-oxo-3-hydropyrimidin-2-ylthio)acetate; BDBM50348381; SBB062603; STK641838; STL281936; ZINC13739146; AKOS002262380; AKOS002308199; AKOS008981057; MCULE-6551097558; 2-Methoxycarbonylmethylenethio-6-methyluracil; ST50186106; methyl [(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetate; methyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]acetate; [(4-Oxo-3,4-dihydro-6-methylpyrimidine-2-yl)thio]acetic acid methyl ester; METHYL ((4-METHYL-6-OXO-1,6-DIHYDRO-2-PYRIMIDINYL)THIO)ACETATE; Methyl [(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetate #
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209453; CHEMBRDG-BB 6606317; MLS001212148; SMR000518041; 1-(3,4-Dihydroxy-phenyl)-2-(4-hydroxy-6-methyl-pyrimidin-2-ylsulfanyl)-ethanone; 1-(3,4-Dihydroxyphenyl)-2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)ethanone; Cambridge id 6606317; Oprea1_441814; cid_687937; SCHEMBL17382815; BDBM55151; CTK4I6835; DTXSID20350771; KUC104368N; BDBM50477568; MFCD02366437; STK770887; ZINC18163844; 2-[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one; AKOS000563316; AKOS001653377; AKOS008967906; KSC-10-146; MCULE-3270859217; W-9419; 2-[[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio]-6-methyl-1H-pyrimidin-4-one; 2-{[2-(3,4-dihydroxyphenyl)-2-oxoethyl]thio}-6-methylpyrimidin-4(3H)-one; 1-(3,4-dihydroxyphenyl)-2-(4-hydroxy-6-methyl-pyrimidin-2-yl)sulfanyl-ethanone; 1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methyl-2-pyrimidinyl)thio]ethanone; 2-[[2-(3,4-dihydroxyphenyl)-2-keto-ethyl]thio]-6-methyl-1H-pyrimidin-4-one; 2-{[2-(3,4-dihydroxyphenyl)-2-oxoethyl]sulfanyl}-6-methylpyrimidin-4(3H)-one; Ethanone, 1-(3,4-dihydroxyphenyl)-2-[(4-hydroxy-6-methyl-2-pyrimidinyl)thio]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Methyl 7-anilino-7-oxoheptyl(hydroxy)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL138090; TWZ-106; BDBM50138411
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
6-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1,3-dihydroindol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800378; SCHEMBL17382803; BDBM50348379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[2-(4-Methoxy-6-methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800243; BDBM50348390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Ethyl 4-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-3-oxobutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800383; BDBM50348384; AKOS013207288
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800379; ChemDiv3_001859; SCHEMBL13401534; HMS1478E11; BDBM50348380; ZINC18084678; AKOS001038722; AKOS008966863; CCG-107559; MCULE-5001803542; IDI1_020825; Z56864923
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800373; BDBM50348373
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Pyridin-3-ylmethyl N-[[4-[(2-acetamidophenyl)carbamoyl]phenyl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99835; BDBM50472337; N-[2-(Acetylamino)phenyl]-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S)-2-(Methanesulfonamido)-3-[4-(2-phenylethoxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147950; BDBM50391610
Click to Show/Hide
|
||||
| Activity |
IC50 = 102300 nM
|
[11] | |||
| Compound Name |
N-Benzoyl-O-benzyltyrosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147942; N-Benzoyl-O-benzyl-L-tyrosine; SCHEMBL6182299; BDBM50391632; ZINC33373296; (2S)-2-benzamido-3-(4-phenylmethoxyphenyl)propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 110500 nM
|
[11] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4S)-4-pyridin-3-yl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605500; BDBM50113972
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[(4S)-4-pyridin-3-yl-4,5-dihydro-1,3-oxazol-2-yl]sulfanylmethyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605492; BDBM50113957; N-(2-Aminophenyl)-4-(((S)-4-(3-pyridyl)-2-oxazoline-2-yl)thiomethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4R)-4-(1H-imidazol-5-ylmethyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605508; BDBM50113964
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[10] | |||
| Compound Name |
N-Hydroxy-3-[1-(3-naphthalen-2-ylpropyl)-5-oxo-2H-pyrrol-4-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668018; SCHEMBL2565365; BDBM50336342; N-hydroxy-3-(1-(3-(naphthalen-2-yl)propyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)propanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 119700 nM
|
[25] | |||
| Compound Name |
(2S)-2-Acetamido-3-[4-(2-phenylethoxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147949; BDBM50391622
Click to Show/Hide
|
||||
| Activity |
IC50 = 120900 nM
|
[11] | |||
| Compound Name |
N-(2-Aminophenyl)-4-(((R)-5-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605502; BDBM50113963
Click to Show/Hide
|
||||
| Activity |
IC50 = 173000 nM
|
[10] | |||
| Compound Name |
N-(2-Aminophenyl)-4-[[[(4S)-4-(1H-imidazol-5-ylmethyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605507; BDBM50113954
Click to Show/Hide
|
||||
| Activity |
IC50 = 179000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-Benzamido-3-[4-(2-phenylethoxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147947; BDBM50391635
Click to Show/Hide
|
||||
| Activity |
IC50 = 253400 nM
|
[11] | |||
| Compound Name |
Chembl4285950
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465051
Click to Show/Hide
|
||||
| Activity |
EC50 = 341000 nM
|
[26] | |||
| Compound Name |
(2S)-2-[(4-Methylbenzoyl)amino]-3-[4-(2-phenylethoxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147948; BDBM50391636
Click to Show/Hide
|
||||
| Activity |
IC50 = 385600 nM
|
[11] | |||
| Compound Name |
N-Tosyl-O-benzyl-L-tyrosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147946; BDBM50391613
Click to Show/Hide
|
||||
| Activity |
IC50 = 504700 nM
|
[11] | |||
| Compound Name |
4-Benzyloxy-n-methanesulfonyl-phenylalanine-methylester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147935; SCHEMBL6577060; BDBM50391618; methyl (2S)-2-(methanesulfonamido)-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
||||
| Activity |
IC50 = 753700 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-acetamido-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147939; BDBM50391627
Click to Show/Hide
|
||||
| Activity |
IC50 = 825100 nM
|
[11] | |||
| Compound Name |
N-Acetyl-O-benzyl-L-tyrosine methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147934; BDBM50391628
Click to Show/Hide
|
||||
| Activity |
IC50 = 871500 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-[(4-methylphenyl)sulfonylamino]-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147941; BDBM50391614
Click to Show/Hide
|
||||
| Activity |
IC50 = 961800 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-(methanesulfonamido)-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147940; BDBM50391617
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-benzamido-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147932; BDBM50391633
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S)-2-[(4-Methylbenzoyl)amino]-3-(4-phenylmethoxyphenyl)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147943; BDBM50391637
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-benzamido-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147937; BDBM50391639
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
(2S)-2-[(4-Methylphenyl)sulfonylamino]-3-[4-(2-phenylethoxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147951; BDBM50391629
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-[(4-methylbenzoyl)amino]-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147933; BDBM50391616
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-[(4-methylbenzoyl)amino]-3-[4-(2-phenylethoxy)phenyl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147938; BDBM50391638
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-[(4-methylphenyl)sulfonylamino]-3-(4-phenylmethoxyphenyl)propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147936; SCHEMBL8762284; BDBM50391615
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. J Nat Prod. 2011 Oct 28;74(10):2031-8. | ||||
| REF 2 | Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett. 2010 Oct 8;2(1):39-42. | ||||
| REF 3 | Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors. Eur J Med Chem. 2012 Jul;53:390-7. | ||||
| REF 4 | Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8. | ||||
| REF 5 | Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). | ||||
| REF 6 | Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. | ||||
| REF 7 | Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). Bioorg Med Chem Lett. 2008 Jan 15;18(2):726-31. | ||||
| REF 8 | Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1508-1512. | ||||
| REF 9 | Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors. J Med Chem. 2016 Feb 25;59(4):1545-55. | ||||
| REF 10 | Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. J Med Chem. 2015 Sep 10;58(17):6803-18. | ||||
| REF 11 | Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold. Bioorg Med Chem. 2012 Oct 1;20(19):5738-44. | ||||
| REF 12 | An efficient anticancer histone deacetylase inhibitor and its analogues for human HDAC8. Med Chem Res. 2011 Jan 28;21:568-77. | ||||
| REF 13 | Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6621-7. | ||||
| REF 14 | Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. | ||||
| REF 15 | Rational design and characterization of a DNA/HDAC dual-targeting inhibitor containing nitrogen mustard and 2-aminobenzamide moieties. Medchemcomm. 2017 Dec 27;9(2):344-352. | ||||
| REF 16 | A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4164-9. | ||||
| REF 17 | US patent application no. 9265734B2, Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors | ||||
| REF 18 | Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. Eur J Med Chem. 2017 Jul 7;134:185-206. | ||||
| REF 19 | Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. ACS Med Chem Lett. 2017 Aug 1;8(8):824-829. | ||||
| REF 20 | Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. J Med Chem. 2009 May 14;52(9):2909-22. | ||||
| REF 21 | Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorg Med Chem Lett. 2004 Jan 19;14(2):449-53. | ||||
| REF 22 | Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. J Med Chem. 2017 Oct 12;60(19):7965-7983. | ||||
| REF 23 | Class I HDAC Inhibitors: Potential New Epigenetic Therapeutics for Alcohol Use Disorder (AUD). J Med Chem. 2018 Mar 8;61(5):1745-1766. | ||||
| REF 24 | Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. J Med Chem. 2015 Oct 8;58(19):7611-33. | ||||
| REF 25 | Structure and property based design, synthesis and biological evaluation of -lactam based HDAC inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1218-21. | ||||
| REF 26 | Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors. ACS Med Chem Lett. 2018 Jan 8;9(2):149-154. | ||||
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